631 research outputs found

    Enhanced critical current density of YBa2Cu3Ox films grown on Nd1/3Eu1/3Gd1/3Ba2Cu3Ox with nano-undulated surface morphology

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    We report a simple and easily controllable method where a nano-undulated surface morphology of Nd1/3Eu1/3Gd1/3Ba2Cu3Ox (NEG) films leads to a substantial increase in the critical current density in superconducting YBa2Cu3Ox (YBCO) films deposited by pulsed laser deposition on such NEG layers. The enhancement is observed over a wide range of fields and temperatures. Transmission electron microscopy shows that such YBCO films possess a high density of localized areas, typically 20 x 20 nm2 in size, where distortion of atomic planes give rotational (2 to 5 degrees) moire patterns. Their distribution is random and uniform, and expected to be the origin of the enhanced flux pinning. Magneto-optical imaging shows that these films have excellent macroscopic magnetic uniformity.Comment: 4 pages, 4 figure

    Extending CKKW-merging to One-Loop Matrix Elements

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    We extend earlier schemes for merging tree-level matrix elements with parton showers to include also merging with one-loop matrix elements. In this paper we make a first study on how to include one-loop corrections, not only for events with a given jet multiplicity, but simultaneously for several different jet multiplicities. Results are presented for the simplest non-trivial case of hadronic events at LEP as a proof-of-concept

    Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus

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    Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication among tumor-derived MCV. We identified the hVam6p cytoplasmic protein involved in lysosomal processing as a novel interactor with MCV LT but not SV40 LT. hVam6p binds through its clathrin heavy chain homology domain to a unique region of MCV LT adjacent to the retinoblastoma binding site. MCV LT translocates hVam6p to the nucleus, sequestering it from involvement in lysosomal trafficking. A naturally occurring, tumor-derived mutant LT (MCV350) lacking a nuclear localization signal binds hVam6p but fails to inhibit hVam6p-induced lysosomal clustering. MCV has evolved a novel mechanism to target hVam6p that may contribute to viral uncoating or egress through lysosomal processing during virus replication

    New perturbative solutions of the Kerr-Newman dilatonic black hole field equations

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    This work describes new perturbative solutions to the classical, four-dimensional Kerr--Newman dilaton black hole field equations. Our solutions do not require the black hole to be slowly rotating. The unperturbed solution is taken to be the ordinary Kerr solution, and the perturbation parameter is effectively the square of the charge-to-mass ratio (Q/M)2(Q/M)^2 of the Kerr--Newman black hole. We have uncovered a new, exact conjugation (mirror) symmetry for the theory, which maps the small coupling sector to the strong coupling sector (ϕϕ\phi \to -\phi). We also calculate the gyromagnetic ratio of the black hole.Comment: Revtex, 27 page

    Z decays into light gluinos: a calculation based on unitarity

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    The Z boson can decay to a pair of light gluinos through loop-mediated processes. Based on unitarity of the S-matrix, the imaginary part of the decay amplitude is computed in the presence of a light bottom squark. This imaginary part can provide useful information on the full amplitude. Implications are discussed for a recently proposed light gluino and light bottom squark scenario.Comment: 19 pages, LaTeX, 3 figures, submitted to Phys. Rev.

    Effects of assisted reproductive technologies on human sex ratio at birth

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    ObjectiveTo investigate the effect of assisted reproductive technology (ART) treatments on the sex ratio of babies born.DesignAssessment of direct effects of assisted conception through retrospective data analysis on the progeny sex ratio of treated women in the United Kingdom.SettingThe study uses the anonymized register of the Human Fertilisation and Embryology Authority.Patient(s)A total of 106,066 babies of known gender born to 76,994 treated mothers and 85,511 treatment cycles between 2000 and 2010 in the United Kingdom.Intervention(s)Intrauterine insemination, IVF, or intracytoplasmic sperm injection (ICSI).Main Outcome Measure(s)Sex ratio of babies born.Result(s)Intrauterine insemination, IVF, and ICSI lead to different sex ratios, highest after IVF (proportion male = mean 0.521 ± confidence interval 0.0056) and lowest under ICSI embryo transfer (0.493 ± 0.0031). In addition, for both ICSI and IVF, transferring embryos at a later stage (blastocyst) results in approximately 6% more males than after early cleavage-stage ET.Conclusion(s)Because the cumulative number of IVF babies born is increasing significantly in Britain and elsewhere, more research is needed into the causes of gender bias after ART and into the public health impact of such gender bias of offspring born observed on the rest of the population

    A comparative histological study of the osteoderms in the lizards Heloderma suspectum (Squamata: Helodermatidae) and Varanus komodoensis (Squamata: Varanidae)

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    This is the peer reviewed version of the following article: Kirby, A, Vickaryous, M, Boyde, A, et al. A comparative histological study of the osteoderms in the lizards Heloderma suspectum (Squamata: Helodermatidae) and Varanus komodoensis (Squamata: Varanidae). J Anat. 2020; 00: 1– 9. https://doi.org/10.1111/taja.13156 which has been published in final form at https://doi.org/10.1111/taja.13156

    Dynamics of Simple Balancing Models with State Dependent Switching Control

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    Time-delayed control in a balancing problem may be a nonsmooth function for a variety of reasons. In this paper we study a simple model of the control of an inverted pendulum by either a connected movable cart or an applied torque for which the control is turned off when the pendulum is located within certain regions of phase space. Without applying a small angle approximation for deviations about the vertical position, we see structurally stable periodic orbits which may be attracting or repelling. Due to the nonsmooth nature of the control, these periodic orbits are born in various discontinuity-induced bifurcations. Also we show that a coincidence of switching events can produce complicated periodic and aperiodic solutions.Comment: 36 pages, 12 figure

    Pain coping skills training for African Americans with osteoarthritis: Results of a randomized controlled trial

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    African Americans bear a disproportionate burden of osteoarthritis (OA), but they have been underrepresented in trials of behavioral interventions for pain. This trial examined a culturally tailored pain coping skills training (CST) program, compared to a wait list control group, among 248 African Americans with knee or hip OA. The pain CST program involved 11 telephone-based sessions over 3 months. Outcomes were assessed at baseline, 3 months (primary), and 9 months, and included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale (primary outcome), WOMAC total score and function subscale, PROMIS Pain Interference, Short-Form 12 Mental and Physical Composite Subscales, Coping Strategies Questionnaire - Total Coping Attempts, Pain Catastrophizing Scale, Patient Health Questionnaire-8, Arthritis Self-Efficacy Scale, and Patient Global Impression of Arthritis Symptom Change. Linear mixed models were fit for all outcomes. There were no significant between-group differences in WOMAC pain score at 3 months (-0.63 [95% confidence interval -1.45, 0.18]; P = 0.128) or 9 months (-0.84 [95% confidence interval -1.73, 0.06]; P = 0.068). Among secondary outcomes, at 3 months, there were significant differences, in favor of the CST group, for Coping Strategies Questionnaire Total Coping Attempts, Pain Catastrophizing Scale, Arthritis Self-Efficacy, and Patient Global Impression of Arthritis Symptom Change (P < 0.01). Coping Strategies Questionnaire Total Coping Attempts, Arthritis Self-Efficacy, and Patient Global Assessment Change were also significantly improved at 9 months in the CST group, compared with wait list (P < 0.01). The culturally tailored pain CST program did not significantly reduce pain severity but did improve key measures of pain coping and perceived ability to manage pain among African Americans with OA
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