9,650 research outputs found
Primitive erythropoiesis in early chick embryogenesis. II. Correlation between hemoglobin synthesis and the mitotic history.
Primitive erythroblasts in the circulating blood of the chick embryo continue to divide while synthesizing hemoglobin (Hb). Hb measurements on successive generations of erythroblasts show that there is a progressive increase in the Hb content of both interphase and metaphase cells. Furthermore, for any given embryo the Hb content of metaphase cells is always significantly greater than that of interphase cells. The distribution of Hb values for metaphase cells suggests that there are six Hb classes corresponding to the number of cell cycles in the proliferative phase. The location of erythroblasts in the cell cycle was determined by combining Feulgen cytophotometry with thymidine radioautography on the same cells. Measurements of the Hb content for erythroblasts in different compartments of the cell cycle (G1, S, G2, and M) show a progressive increase through the cycle. Thus, the amount of Hb per cell is a function of the number of cell divisions since the initiation of Hb synthesis and, to a lesser degree, the stage of the cell cycle. Earlier generations of erythroblasts synthesize Hb at a faster rate than the terminal generation. Several models have been proposed to explain these findings
Qualitative Evaluation of Web-Based Digital Intervention to Prevent and Reduce Excessive Alcohol Use and Harm Among Young People Aged 14-15 Years: A "Think-Aloud" Study
BACKGROUND: In the United Kingdom, despite some downward trends in alcohol use among young people, over one-fifth of young people reported excessive alcohol use in the past month, which is associated with short- and long-term harm to health. Digital interventions to reduce alcohol use, such as websites, among young people present an appealing and cost-effective mode of intervention that can be integrated into the education system. However, relatively few school-based digital alcohol-focused interventions have been developed and evaluated for young people in the United Kingdom. OBJECTIVE: This study aims to develop a novel web-based intervention, Rethink Alcohol, to prevent and reduce excessive alcohol use and related harm among young people aged between 14 and 15 years, and explore the views of young people, teachers, and youth workers in relation to the content, design, and usability of the intervention. METHODS: Intervention development followed the person-based approach, using theories of social norms and social influence. Qualitative "Think-Aloud" interviews, either one-to-one or paired, were conducted while participants perused and worked through the web-based intervention, talking aloud. Participants included 20 young people (12 female, 8 male), 5 youth workers (4 female, 1 male), 3 teachers (2 male, 1 female), and 1 (male) clinical professional, recruited via youth groups and professional networks. Interviews were audio recorded, transcribed verbatim, and analyzed thematically. RESULTS: The prototype web-based intervention included normative feedback, information, a quiz, interactive activities, and scenarios. On a rating scale of impressions from poor (1) to excellent (5), participants gave an average score of 3.6/5. A total of 5 themes were identified: content, credibility of the website, making the website easy to understand, design and navigation, and suitability for the audience. These themes reflected views that the content was interesting, credible, informative, and embodied a neutral and nonjudgmental tone, but stronger messaging was needed regarding social pressures and short-term risks regarding safety and risk behavior alongside clarity around pathways of risk; credibility and trustworthiness of information were critical features, determined in part, by the professionalism of design and referencing of sources of information provided; and messages should be succinct and come to life through design and interactive features. CONCLUSIONS: Together, the data illustrated the importance and challenge of communicating nuanced alcohol-focused public health messages to young people in concise, clear, nonjudgmental, and appealing ways. Young people report interest in clear, credible, neutral, and interactive messages regarding social pressures and short-term risks of alcohol use via a web-based intervention. There is scope for optimization and feasibility testing of the Rethink Alcohol intervention
Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer
<b>Background</b>: A pronounced tumour inflammatory infiltrate is known to confer a good outcome in colorectal cancer. Klintrup and colleagues reported a structured assessment of the inflammatory reaction at the invasive margin scoring low grade or high grade. The aim of the present study was to examine the prognostic value of tumour inflammatory infiltrate in node-negative colorectal cancer.
<b>Methods</b>: Two hundred patients had undergone surgery for node-negative colorectal cancer between 1997 and 2004. Specimens were scored with Jassâ and Klintrupâs criteria for peritumoural infiltrate. Pathological data were taken from the reports at that time.
<b>Results</b>: Low-grade inflammatory infiltrate assessed using Klintrupâs criteria was an independent prognostic factor in node-negative disease. In patients with a low-risk Petersen Index (n = 179), low-grade infiltrate carried a threefold increased risk of cancer death. Low-grade infiltrate was related to increasing T stage and an infiltrating margin.
<b>Conclusion</b>: Assessment of inflammatory infiltrate using Klintrupâs criteria provides independent prognostic information on node-negative colorectal cancer. A high-grade local inflammatory response may represent effective host immune responses impeding tumour growth
Application of an Equilibrium Vaporization Model to the Ablation of Chondritic and Achondritic Meteoroids
We modeled equilibrium vaporization of chondritic and achondritic materials
using the MAGMA code. We calculated both instantaneous and integrated element
abundances of Na, Mg, Ca, Al, Fe, Si, Ti, and K in chondritic and achondritic
meteors. Our results are qualitatively consistent with observations of meteor
spectra.Comment: 8 pages, 4 figures; in press, Earth, Moon, and Planets, Meteoroids
2004 conference proceeding
Vacuum replicas in QCD
The properties of the vacuum are addressed in the two- and four-dimensional
quark models for QCD. It is demonstrated that the two-dimensional QCD ('t Hooft
model) possesses only one possible vacuum state - the solution to the mass-gap
equation, which provides spontaneous breaking of the chiral symmetry (SBCS). On
the contrary, the four-dimensional theory with confinement modeled by the
linear potential supplied by the Coulomb OGE interaction, not only has the
chirally-noninvariant ground vacuum state, but it possesses an excited vacuum
replica, which also exhibits SBCS and can realize as a metastable intermediate
state of hadronic systems. We discuss the influence of the latter on physical
observables as well as on the possibility to probe the vacuum background fields
in QCD.Comment: RevTeX4, 26 pages, 8 EPS figures, extended references, corrected some
typos, to appear in Phys.Rev.
Qualitative Evaluation of Web-Based Digital Intervention to Prevent and Reduce Excessive Alcohol Use and Harm Among Young People Aged 14-15 Years: A "Think-Aloud" Study
This is the final version. Available on open access from JMIR Publications via the DOI in this recordBACKGROUND: In the United Kingdom, despite some downward trends in alcohol use among young people, over one-fifth of young people reported excessive alcohol use in the past month, which is associated with short- and long-term harm to health. Digital interventions to reduce alcohol use, such as websites, among young people present an appealing and cost-effective mode of intervention that can be integrated into the education system. However, relatively few school-based digital alcohol-focused interventions have been developed and evaluated for young people in the United Kingdom. OBJECTIVE: This study aims to develop a novel web-based intervention, Rethink Alcohol, to prevent and reduce excessive alcohol use and related harm among young people aged between 14 and 15 years, and explore the views of young people, teachers, and youth workers in relation to the content, design, and usability of the intervention. METHODS: Intervention development followed the person-based approach, using theories of social norms and social influence. Qualitative "Think-Aloud" interviews, either one-to-one or paired, were conducted while participants perused and worked through the web-based intervention, talking aloud. Participants included 20 young people (12 female, 8 male), 5 youth workers (4 female, 1 male), 3 teachers (2 male, 1 female), and 1 (male) clinical professional, recruited via youth groups and professional networks. Interviews were audio recorded, transcribed verbatim, and analyzed thematically. RESULTS: The prototype web-based intervention included normative feedback, information, a quiz, interactive activities, and scenarios. On a rating scale of impressions from poor (1) to excellent (5), participants gave an average score of 3.6/5. A total of 5 themes were identified: content, credibility of the website, making the website easy to understand, design and navigation, and suitability for the audience. These themes reflected views that the content was interesting, credible, informative, and embodied a neutral and nonjudgmental tone, but stronger messaging was needed regarding social pressures and short-term risks regarding safety and risk behavior alongside clarity around pathways of risk; credibility and trustworthiness of information were critical features, determined in part, by the professionalism of design and referencing of sources of information provided; and messages should be succinct and come to life through design and interactive features. CONCLUSIONS: Together, the data illustrated the importance and challenge of communicating nuanced alcohol-focused public health messages to young people in concise, clear, nonjudgmental, and appealing ways. Young people report interest in clear, credible, neutral, and interactive messages regarding social pressures and short-term risks of alcohol use via a web-based intervention. There is scope for optimization and feasibility testing of the Rethink Alcohol intervention
A common behavior of thermoelectric layered cobaltites: incommensurate spin density wave states in [CaCoCuO][CoO] and [CaCoO][CoO]
Magnetism of a misfit layered cobaltite
[CaCoCuO][CoO] ( 0.62, RS
denotes a rocksalt-type block) was investigated by a positive muon spin
rotation and relaxation (SR) experiment. A transition to an
incommensurate ({\sf IC}) spin density wave ({\sf SDW}) state was found below
180 K (= ); and a clear oscillation due to a static
internal magnetic field was observed below 140 K (= ). Furthermore,
an anisotropic behavior of the zero-field SR experiment indicated that
the {\sf IC-SDW} propagates in the - plane, with oscillating moments
directed along the c axis. These results were quite similar to those for the
related compound [CaCoO][CoO], {\sl i.e.},
CaCoO. Since the {\sf IC-SDW} field in
[CaCoCuO][CoO] was approximately
same to those in pure and doped [CaCoO][CoO], it
was concluded that the {\sf IC-SDW} exist in the [CoO] planes.Comment: 15 pages, 6 figures. accepted for publication in J. Phys.: Condens.
Matte
Long-lived photoexcited states in polydiacetylenes with different molecular and supramolecular organization
With the aim of determining the importance of the molecular and supramolecular organization on the excited states of polydiacetylenes, we have studied the photoinduced absorption spectra of the red form of poly[1,6-bis(3,6-didodecyl-N-carbazolyl)-2,4-hexadiyne] (polyDCHD-S) and the results compared with those of the blue form of the same polymer. An interpretation of the data is given in terms of both the conjugation length and the interbackbone separation also in relation to the photoinduced absorption spectra of both blue and red forms of poly[1,6-bis(N-carbazolyl)-2,4-hexadiyne] (polyDCHD), which does not carry the alkyl substituents on the carbazolyl side groups. Information on the above properties is derived from the analysis of the absorption and Raman spectra of this class of polydiacetylenes
New Limits on Coupling of Fundamental Constants to Gravity Using Sr Optical Lattice Clocks
The - clock transition frequency
in neutral Sr has been measured relative to the Cs
standard by three independent laboratories in Boulder, Paris, and Tokyo over
the last three years. The agreement on the level makes
the best agreed-upon optical atomic frequency. We combine
periodic variations in the Sr clock frequency with Hg and
H-maser data to test Local Position Invariance by obtaining the strongest
limits to date on gravitational-coupling coefficients for the fine-structure
constant , electron-proton mass ratio and light quark mass.
Furthermore, after Hg, Yb and H, we add Sr as
the fourth optical atomic clock species to enhance constraints on yearly drifts
of and .Comment: Published version. 4 pages, 4 figure
Sr lattice clock at 1x10^{-16} fractional uncertainty by remote optical evaluation with a Ca clock
Optical atomic clocks promise timekeeping at the highest precision and
accuracy, owing to their high operating frequencies. Rigorous evaluations of
these clocks require direct comparisons between them. We have realized a
high-performance remote comparison of optical clocks over km-scale urban
distances, a key step for development, dissemination, and application of these
optical standards. Through this remote comparison and a proper design of
lattice-confined neutral atoms for clock operation, we evaluate the uncertainty
of a strontium (Sr) optical lattice clock at the 1x10-16 fractional level,
surpassing the best current evaluations of cesium (Cs) primary standards. We
also report on the observation of density-dependent effects in the
spin-polarized fermionic sample and discuss the current limiting effect of
blackbody radiation-induced frequency shifts.Comment: To be published in Science, 200
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