9 research outputs found

    Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

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    Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

    Policy Challenges for Professional Higher Education in Central and South-Eastern Europe

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    PROCSEE is a policy-oriented project, aimed at strengthening the provision of professional higher education, by strengthening the policy-work conducted by umbrella organizations representing professional higher education institutions in Central and South-Eastern in Europe. Working together over three years, the project intends to: identify the main challenges facing PHE in the region, propose policy solutions to address those challenges in the short-to-midterm, through a mixture of good-practice identification and stakeholder consultation, bring together the main actors in PHE in each participating country, so as to build implementation roadmaps for the identified policy solutions. The result of the first year of activities of the project, this document outlines the main challenges facing professional higher education in the CSEE region, with the aim of highlighting potential areas for reform in the next project phases. (DIPF/Orig.

    Modelling a stakeholder community via a social platform: The case of TELeurope.eu

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    Past attempts at creating stakeholder networks for specific fields of research or industrial sectors have shown to be a resource-consuming and time-consuming process, which requires continuous monitoring and political efforts, as well as the trial-and-error deployment of technological tools. Still, these networks are thought to be an efficient and essential communication instrument for addressing challenges and building capacities. The EU FP7 STELLAR Network of Excellence has the mission of establishing a network for Technology Enhanced Learning (TEL) stakeholders, and has decided to do so via an online social community called TELeurope. In this paper we provide an overview of some relevant experience in establishing collaborative networks in the fields of business sciences, learning networks and communities of practice and reflect on our experience thus far with TELeurope

    Bioturbation functional roles associated with mangrove development in French Guiana, South America

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    Assessing the Energy-Efficiency Gap

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