Advanced onboard storage concepts for natural gas-fueled automotive vehicles

The evaluation of several advanced concepts for storing natural gas at reduced pressure is presented. The advanced concepts include adsorption on high surface area carbon, adsorption in high porosity zeolite, storage in clathration compounds, and storage by dissolution in liquid solvents. High surface area carbons with high packing density are the best low pressure storage mediums. A simple mathematical model is used to compare adsorption storage on a state of the art carbon with compression storage. The model indicates that a vehicle using adsorption storage of natural gas at 3.6 MPa will have 36 percent of the range, on the EPA city cycle, of a vehicle operating on a compression storage system having the same physical size and a peak storage pressure of 21 MPa. Preliminary experiments and current literature suggest that the storage capacity of state of the art carbons could be improved by as much as 50 percent, and that adsorption systems having a capacity equal to compression storage at 14 MPa are possible without exceeding a maximum pressure of 3.6 MPa

Human papilloma virus genotype distribution and risk factor analysis amongst reproductive aged women in urban Gambia

Purpose. Cervical cancer is the most frequently diagnosed female cancer in The Gambia, representing approximately 30% of cases. In 2014, the quadrivalent human papilloma virus (HPV) vaccine was introduced, which offers protection against HPV genotypes 6, 11, 16 and 18. To evaluate the potential effectiveness of this vaccine, genotype distribution and risk factor analysis were assessed. Methodology. Endocervical samples (n=232) were collected from women aged 20-49 years residing in urban Gambia. A questionnaire was administered to capture socio-demographic and cervical cancer risk factors. HPV detection and genotyping was performed by PCR amplification of the L1 major capsid gene and analysis of sequenced PCR products. Results/ Key Findings. The prevalence of HPV was 12% (28/232) and the high risk (HR) genotype HPV 52 (5/28) was the most prevalent genotype. HR-HPV sequences had high identity (≥ 90 %) to isolates which originated from America, Europe and Asia but not from Africa. Half (14/28) of participants were co-infected with Ureaplasma urealyticum/parvum, which increases the risk of progression to cervical cancer. Female genital mutilation and the use of hormone contraception for >5 years were identified as potential risk factors for HPV infection. Ethnicity-associated differences were also noted; participants of the Fula ethnic group had a higher prevalence of HR-HPV infection (31.3%) compared to the Mandinka (18.8%) and Wollof (12.5%) groups. Conclusion. These data may have a significant public health impact as the HPV quadrivalent vaccine may be of limited value if the circulating non-HPV 16/18 HR-genotypes are responsible for cytological abnormalities of the cervix

NON-DARCY FLOW EVALUATION OF UNCONSOLIDATED POROUS MEDIA IN A CLOSED LOOP PERMEAMETER

A new closed loop permeameter was implemented in this work to study the fluid flow through two different unconsolidated porous media. An apparent permeability, similar to that proposed by Barree and Conway, was described in this work in terms of the absolute permeability combined with a new fluid property description, the inertial contribution factor that accounts for the domain of viscous and inertial forces. Such approach discriminate those properties of the rock as intrinsic permeability from those related to the fluid as the inertial contribution factor. The apparent permeability equation of Barree and Conway was applied to different intervals of the experimental data in which it was possible to obtain the Forchheimer coefficients as well as the inertial contribution factors according to each interval. Two different types of unconsolidated porous media materials were utilized in the new Closed Loop Permeameter, sand (1-2 mm) and glass spheres (3.96 mm). The equation of Barree and Conway provided a great agreement fitting the experimental data in a wide non-Darcy Reynolds number range. It was observed an increase in the Forchheimer coefficient and decrease in the apparent permeability with the flow rate increase. The results indicate a correlation between the permeability and the inertial effects in the non-Darcy turbulent regions in which the porous media materials with low permeability values are probably more subjected to flow losses due to the inertial effects

NUTRIÇÃO ARTIFICIAL NO DOENTE CRÍTICO

Introdução: O suporte nutricional tem papel importan- te no tratamento dos doentes internados em Unidades de Cuidados Intensivos (UCI). O objetivo deste trabalho foi avaliar a carga calórica fornecida aos doentes críticos, con- siderando o impacto da carga calórica “secundária” (não nutricional) e a teoria da “Subnutrição permissiva”. Obje- tivos: Avaliar a carga calórica fornecida aos doentes inter- nados em Unidades de Cuidados Intensivos. Material e métodos: Estudo transversal analítico realizado em 6 dife- rentes Unidades de Cuidados Intensivos em doentes inter- nados mais de 5 dias. Resultados: 153 doentes, idade 58,18 ± 18,47 anos, sendo do foro médico (22,88%), cirúrgico (21,56%), neurocirúrgico (28,76%) e trauma (26,80%). Internados durante 14,54 ± 9,05 dias, com SOFA de 6,95 ± 3.23 e IMC de 24,57 ± 3,84. A mortalidade foi de 32,03%. Foram fornecidos 12,3 ± 8,4 kcal/kg/dia, com evolução gradativa nos 10 primeiros dias. A carga calórica secundária decresceu, apresentando impacto no valor calórico global somente até ao 2o dia de internamento. Os doentes do foro médico atingiram mais precocemente os objetivos nutricio- nais. A carga calórica secundária teve maior impacto nos pacientes cirúrgicos. Numa fase imediata e intermediária os doentes receberam um aporte calórico significativamente superior ao modelo de Wilmore, enquanto que na fase final o aporte foi significativamente inferior. Discussão: A sub- nutrição encontrada revelou-se diferente do conceito de subnutrição permissiva de Wilmore, provavelmente devido à desvalorização do peso, do bom estado nutricional na admissão, ou à própria gravidade desses doentes, colocan- do a terapia nutricional em segundo plano. Conclusão: Este estudo vem realçar a dificuldade que existe em fornecer um suporte nutricional adequado aos doentes internados em Unidades de Cuidados Intensivos

Building SO(10) models from F-theory

We revisit local F-theory SO(10) and SU(5) GUTs and analyze their properties within the framework of the maximal underlying E_8 symmetry in the elliptic fibration. We consider the symmetry enhancements along the intersections of seven-branes with the GUT surface and study in detail the embedding of the abelian factors undergoing monodromies in the covering gauge groups. We combine flux data from the successive breaking of SO(10) to SU(5) gauge symmetry and subsequently to the Standard Model one, and further constrain the parameters determining the models' particle spectra. In order to eliminate dangerous baryon number violating operators we propose ways to construct matter parity like symmetries from intrinsic geometric origin. We study implementations of the resulting constrained scenario in specific examples obtained for a variety of monodromies.Comment: 53 page

Scalar geometry and masses in Calabi-Yau string models

We study the geometry of the scalar manifolds emerging in the no-scale sector of Kahler moduli and matter fields in generic Calabi-Yau string compactifications, and describe its implications on scalar masses. We consider both heterotic and orientifold models and compare their characteristics. We start from a general formula for the Kahler potential as a function of the topological compactification data and study the structure of the curvature tensor. We then determine the conditions for the space to be symmetric and show that whenever this is the case the heterotic and the orientifold models give the same scalar manifold. We finally study the structure of scalar masses in this type of geometries, assuming that a generic superpotential triggers spontaneous supersymmetry breaking. We show in particular that their behavior crucially depends on the parameters controlling the departure of the geometry from the coset situation. We first investigate the average sGoldstino mass in the hidden sector and its sign, and study the implications on vacuum metastability and the mass of the lightest scalar. We next examine the soft scalar masses in the visible sector and their flavor structure, and study the possibility of realizing a mild form of sequestering relying on a global symmetry.Comment: 36 pages, no figure

Non-perturbative Vacuum Destabilization and D-brane Dynamics

We analyze the process of string vacuum destabilization due to instanton induced superpotential couplings which depend linearly on charged fields. These non-perturbative instabilities result in potentials for the D-brane moduli and lead to processes of D-brane recombination, motion and partial moduli stabilization at the non-perturbative vacuum. By using techniques of D-brane instanton calculus, we explicitly compute this scalar potential in toroidal orbifold compactifications with magnetized D-branes by summing over the possible discrete instanton configurations. We illustrate explicitly the resulting dynamics in globally consistent models. These instabilities can have phenomenological applications to breaking hidden sector gauge groups, open string moduli stabilization and supersymmetry breaking. Our results suggest that breaking supersymmetry by Polonyi-like models in string theory is more difficult than expected.Comment: 61 pages, 6 figures, 5 tables; Minor corrections, version published in JHE

In silico identification of a candidate synthetic peptide (Tsgf1(18-43)) to monitor human exposure to tsetse flies in West Africa

Background: The analysis of humoral responses directed against the saliva of blood-sucking arthropods was shown to provide epidemiological biomarkers of human exposure to vector-borne diseases. However, the use of whole saliva as antigen presents several limitations such as problems of mass production, reproducibility and specificity. The aim of this study was to design a specific biomarker of exposure to tsetse flies based on the in silico analysis of three Glossina salivary proteins (Ada, Ag5 and Tsgf1) previously shown to be specifically recognized by plasma from exposed individuals. Methodology/Principal Findings: Synthetic peptides were designed by combining several linear epitope prediction methods and Blast analysis. The most specific peptides were then tested by indirect ELISA on a bank of 160 plasma samples from tsetse infested areas and tsetse free areas. Anti-Tsgf1(18-43) specific IgG levels were low in all three control populations (from rural Africa, urban Africa and Europe) and were significantly higher (p < 0.0001) in the two populations exposed to tsetse flies (Guinean HAT foci, and South West Burkina Faso). A positive correlation was also found between Anti-Tsgf1(18-43) IgG levels and the risk of being infected by Trypanosoma brucei gambiense in the sleeping sickness foci of Guinea. Conclusion/Significance: The Tsgf1(18-43) peptide is a suitable and promising candidate to develop a standardize immunoassay allowing large scale monitoring of human exposure to tsetse flies in West Africa. This could provide a new surveillance indicator for tsetse control interventions by HAT control programs

Wavefunctions and the Point of E8 in F-theory

In F-theory GUTs interactions between fields are typically localised at points of enhanced symmetry in the internal dimensions implying that the coefficient of the associated operator can be studied using a local wavefunctions overlap calculation. Some F-theory SU(5) GUT theories may exhibit a maximum symmetry enhancement at a point to E8, and in this case all the operators of the theory can be associated to the same point. We take initial steps towards the study of operators in such theories. We calculate wavefunctions and their overlaps around a general point of enhancement and establish constraints on the local form of the fluxes. We then apply the general results to a simple model at a point of E8 enhancement and calculate some example operators such as Yukawa couplings and dimension-five couplings that can lead to proton decay.Comment: 46 page