Implant treatment in patients with osteoporosis

Osteoporosis is very common, particularly in post-menopausal women and is characterized by a decrease in bone mass and strength. Osteoporosis also affects the jawbone and it is considered a potential contraindication to placement of dental implants. The present paper reviews the literature regarding the effect of osteoporosis on osseointegration of implants. Experimental models have shown that osteoporosis affects the process of osseointegration, which can be reversed by treatment. However, studies in subjects with osteoporosis have shown no differences in survival of the implants compared to healthy individuals. Therefore, osteoporosis cannot be considered a contraindication for implant placement. Oral bisphosphonates are the most commonly used pharmacological agents in the treatment of osteoporosis. Although there have been cases of osteonecrosis of the jaw in patients treated with bisphosphonates, they are very rare and it is more usually associated with intravenous bisphosphonates in patients with neoplasms or other serious diseases. Nevertheless, patients treated with bisphosphonates must be informed in writing about the possibility of this complication and must give informed consent. Ceasing to use bisphosphonates before implant placement does not seem to be necessary

A first approach for an evidence-based in vitro digestion method to adjust pancreatic enzyme replacement therapy in cystic fibrosis

[EN] Background Patients with cystic fibrosis have to take enzymatic supplements to allow for food digestion. However, an evidence-based method to adjust Pancreatic Enzyme Replacement Therapy (PERT) is inexistent, and lipid content of meals is used as a rough criterion. Objective In this study, an in vitro digestion model was set up to determine the theoretical optimal dose (TOD) of enzymatic supplement for a selection of foods, which is the dose that allows for maximum lipolysis extent. Methods A static in vitro digestion model was applied to simulate digestion of eight foods covering a wide range of lipid contents. First, the dose of the enzymatic supplement was fixed at 2000 lipase units per gram of fat (LU/g fat) using intestinal pH and bile salt concentration as variables. Second, intestinal pH and bile salt concentrations were fixed and the variable was the dose of the enzymatic supplement. Lipolysis extent was determined by measuring the free fatty acids released from initial triglycerides content of foods after digestion. Results in terms of percentage of lipolysis extent were fitted into a linear-mixed segmented model and the deducted equations were used to predict the TOD to reach 90% of lipolysis in every food. In addition, the effect of intestinal pH and bile salt concentration were investigated. Results The predictive equations obtained for the assessed foods showed that lipolysis was not only dependent on the dose of the enzyme supplement or the lipid content. Moreover, intestinal pH and bile salt concentration had significant effects on lipolysis. Therefore an evidence-based model can be developed taking into account these variables. Conclusions Depending on food characteristics, a specific TOD should be assigned to achieve an optimal digestion extent. This work represents a first step towards an evidence-based method for PERT dosing, which will be applied in an in vivo setting to validate its efficacy.This work was fully funded by the European Union and the Horizon 2020 Research and Innovation Framework Programme (PHC-26-2014 call Self management of health and disease: citizen engagement and mHealth) under grant number 643806.Calvo-Lerma, J.; Fornes-Ferrer, V.; Peinado Pardo, I.; Heredia Gutiérrez, AB.; Ribes-Koninckx C.; Andrés Grau, AM. (2019). A first approach for an evidence-based in vitro digestion method to adjust pancreatic enzyme replacement therapy in cystic fibrosis. PLoS ONE. 14(2):1-14. https://doi.org/10.1371/journal.pone.0212459S114142Lesmes, U., & McClements, D. J. (2012). Controlling lipid digestibility: Response of lipid droplets coated by β-lactoglobulin-dextran Maillard conjugates to simulated gastrointestinal conditions. Food Hydrocolloids, 26(1), 221-230. doi:10.1016/j.foodhyd.2011.05.011Humbert, L., Rainteau, D., Tuvignon, N., Wolf, C., Seksik, P., Laugier, R., & Carrière, F. (2018). Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients. Journal of Lipid Research, 59(11), 2202-2213. doi:10.1194/jlr.m084830Lamothe, S., Azimy, N., Bazinet, L., Couillard, C., & Britten, M. (2014). Interaction of green tea polyphenols with dairy matrices in a simulated gastrointestinal environment. Food Funct., 5(10), 2621-2631. doi:10.1039/c4fo00203bMuggeo, V. & Muggeo, V. M. R. Segmented mixed models with random changepoints in R Working paper (2016)

Color changes in beef meat during pan cooking: kinetics, modeling and application to predict turn over time

The kinetics of heat-induced color changes in beef meat was determined and implemented in a numerical model for doublesided pan cooking of steak. The CIELab color space was used to obtain the lightness (coordinate L∗ ) and the reddish tone (coordinate a∗ ) of the cooked meat. L∗ was the CIELab coordinate that contributed the most to the change in the absolute color. Two response surfaces were found to describe the evolution with time and temperature of both color coordinates, L∗ and a∗ . The model results were successfully verified with experimental data of the two coordinates along the thickness of the meat for three degrees of cooking. The Root-Mean-Squared Errors (RMSE) for coordinate L∗ were 5.17 (very rare), 2.02 (medium rare) and 3.83 (done), and for coordinate a∗ 1.44 (very rare), 1.26 (medium rare) and 0.89 (done). The applicability of the model for practical cooking purposes was illustrated by determining the optimum turn over time to achieve a similar color profile on both sides of the meat. The turn over time depended on the desired degrees of cooking, and were comprised between one-half and two-thirds of the final cooking time, increasing from very rare cooking degree to done cooking degree

Modeling domestic pancake cooking incorporating the rheological properties of the batter. Application to seven batter recipes

A 2D axisymmetric model for coupled transient heat and mass transfer was developed to simulate pancake cooking on a domestic induction hob. Unlike previous models, the current model considers a variable thermal contact conductance resulting from the crust formation at the bottom of the batter. It aims to take into account the heat transfer phenomena between the pan surface and the batter influenced by the physicochemical changes that the batter undergoes during the cooking process. To quantify the variation of the heat flow that this change in the structure of the batter involves, a normalized relationship between batter viscosity and the temperature was introduced in the model. The performance of seven cereal and legume flour-based batters was evaluated in an experimental setup. The proposed model is capable of adequately predicting the weight loss and the average surface temperature of the batter using parameters related with the rheological properties of the batter and its composition

RUNA: el repositorio institucional del Sistema Público de Salud de Galicia

The objective of this work is to analyze the characteristics of RUNA, the institutional repository of the Public Health System of Galicia. RUNA is considered as a unique information point, which brings together intellectual, educational and administrative production as well as certain clinical documentation generated by the professionals of the Galician health system

RUNA: el repositorio institucional del Sistema Público de Salud de Galicia

The objective of this work is to analyze the characteristics of RUNA, the institutional repository of the Public Health System of Galicia. RUNA is considered as a unique information point, which brings together intellectual, educational and administrative production as well as certain clinical documentation generated by the professionals of the Galician health system

Open access availability of the Galician Health Service (SERGAS) scientific production between 2014 and 2019

Introducci?n: Se estudia la disponibilidad en acceso abierto de la producci?n cient?fica del personal del Servicio Gallego de Salud (Sergas) de los a?os 2014 a 2019, su evoluci?n a trav?s de las distintas v?as de acceso y qu? volumen se podr?a depositar en el repositorio institucional. Metodolog?a: A partir de una exportaci?n de Sophos, la herramienta que mide la producci?n cient?fica del Sergas, se analiza el conjunto de publicaciones en las que participa al menos un autor con filiaci?n institucional del Sergas. Se utilizaron las APIs de Unpaywall, DOAJ y la funci?n Find Full Text de EndNote para determinar si el art?culo ten?a una versi?n de texto completo disponible. Resultados: La producci?n cient?fica del Sergas de 2014 a 2019, excluidas las comunicaciones a congresos, asciende a 7.792 art?culos de los cuales el 44.10% de pueden clasificar como de acceso abierto real (dorado, bronce o h?brido), el 51.16% est?n publicados en revistas que permiten el auto-archivo y solo un 4.75% no admiten acceso abierto o no ofrecen informaci?n sobre su pol?tica de acceso. Estos art?culos se publicaron en 1.695 revistas diferentes, de las cuales 409 siguen el modelo de acceso abierto dorado. Conclusiones: El 95% de los art?culos revisados pueden estar disponibles para el usuario final por alguna de las v?as de acceso abierto y podr?an ser depositados en el repositorio institucional.Introduction: This paper studies the open access availability to the Galician Health Service (SERGAS) staff?s scientific production between 2014 and 2019, its evolution through the different open access routes and the volumen of publications that could be deposited in the institutional repository. Methodology: Based on an export from Sophos, (the tool that measures the scientific production of the SERGAS), this paper analizes the set of publications in which at least one author with SERGAS institutional affiliation. The APIs of Unpaywall, DOAJ and the Find Full Text function of EndNote were used to determine whether the article had a full-text version available. Results: The SERGAS scientific production between 2014 and 2019, excluding conference contributions, amounts to 7,792 articles. 44.10% of those articles can be classified as real open access (gold, bronze or hybrid), 51.16% are published in journals that allow self-archiving and only 4.75% do not support open access or do not provide information on their access policy. These articles were published in 1,695 different journals, 409 of wich follow the gold open access model. Conclusions: 95% of the articles reviewed would be available to the end user through one of the open access routes and could be deposited in the institutional repository

Spontaneous generation of infectious prion disease in transgenic mice

We generated transgenic mice expressing bovine cellular prion protein (PrP(C)) with a leucine substitution at codon 113 (113L). This protein is homologous to human protein with mutation 102L, and its genetic link with Gerstmann-Sträussler-Scheinker syndrome has been established. This mutation in bovine PrP(C) causes a fully penetrant, lethal, spongiform encephalopathy. This genetic disease was transmitted by intracerebral inoculation of brain homogenate from ill mice expressing mutant bovine PrP to mice expressing wild-type bovine PrP, which indicated de novo generation of infectious prions. Our findings demonstrate that a single amino acid change in the PrP(C) sequence can induce spontaneous generation of an infectious prion disease that differs from all others identified in hosts expressing the same PrP(C) sequence. These observations support the view that a variety of infectious prion strains might spontaneously emerge in hosts displaying random genetic PrP(C) mutations

Ser o no ser y estar o no estar en Internet.

Objective: To reflect the situation of the websites of the hospital libraries in Spain in 2003. Material and methods: The websites of the hospital libraries have been located through C-17 directory, various hospital directories and searching Google, Altavista and Alltheweb. It has been applied the questionnaire of evaluation of websites with pondered punctuation by Lluís Codina. Visibility indicators have been obtained as well as accessibility according TAW. Results: From the C-17 catalogue have been retrieved 176 hospital libraries, of which 13 have a website; we added to these other 19 websites found through other directories and search engines. Of those 32 websites, 2 were not active; the remaining 30 were analyzed. Five of them passed the Codina's test of level I. In the TAW priority level 1, the problems detected automatically oscillated between 0 and 77. Conclusions: The results show the low number of hospital libraries with websites on the internet. The websites quality should be improved following the recommendations of the checkup lists to evaluate digital resources on the internet. The scarce visibility of these webs, hinders greatly its localization. On the other hand, the low accessibility rate of these webs blocks their visualization to handicapped people

An innovative tool for intraoperative electron beam radiotherapy simulation and planning: description and initial evaluation by radiation oncologists

The lack of specific treatment planning tools limits the spread of Intraoperative Electron Radiation Therapy. An innovative simulation and planning tool is presented. Applicator positioning, isodose curves, and doseevolume histograms can be estimated for previously segmented regions to treat/protect. Evaluation by three radiation oncologists on 15 patients showed high parameter agreement in nine cases, demonstrating the possibilities in cases involving different anatomical locations, and identifying the importance of specialized surgical input in the preplanning process.Supported by grants PI08/90473, IPT 300000 2010 3, ARTEMIS S2009/DPI 1802(CAM), TEC2010 21619 C04 01, PI09/90568, ERD Funds.Publicad