Atención psicológica pre- y pospandemia en la clínica universitaria del CPA-UAM

The general objective of this research is to analyze the impact that the coronavirus pandemic has had on the psychological health of people in treatment at the CPA-UAM university clinic (omitted for blind review). Pre- and post-pandemic data of people who visited the center between 2016 and 2021 are compared, both for regular treatment (N = 535, 448 pre-COVID, 87 post-COVID) and for free telephone assistance during confinement and de-escalation (N = 73 people, 98 telephone calls). The treatments were based on the cognitive-behavioral approach. A notable increase in demand for treatment for anxiety-related problems was found as of the arrival of the pandemic, as well as in the severity of these cases. Anxiety was also the main demand for telephone assistance during confinement, although there was an increase in specific demands, such as grief and fear of contagion. No differences were found in any other aspect of the treatments, except in the number of demands for online care after the pandemic. It is essential to adapt both therapies and therapists' training to the new post-pandemic reality and guarantee quality psychological treatment for the population.El objetivo general de la presente investigación es analizar el impacto que la pandemia por coronavirus ha tenido en la salud psicológica de las personas atendidas en la clínica universitaria del CPA-UAM. Se comparan los datos pre- y post-pandemia de las personas que acudieron al centro entre 2016 y 2021, tanto para tratamiento regular (N= 535, 448 pre-COVID, 87 post-COVID), como para atención telefónica gratuita durante el confinamiento y la desescalada (N= 73 personas, 98 llamadas). Los tratamientos tuvieron un enfoque cognitivo-conductual.  Se encontró un aumento notable de demanda de tratamiento por problemas de ansiedad a partir de la llegada de la pandemia, y también de la gravedad que presentaban esos casos. También la ansiedad fue la principal demanda de atención telefónica durante el confinamiento, aunque hubo un incremento de demandas específicas, como duelo y miedo al contagio. No se encontraron diferencias en ningún otro aspecto de los tratamientos, excepto en el número de demandas de atención en lína a partir de la pandemia. Es imprescindible adaptar las terapias y la formación de los terapeutas a la nueva realidad post-pandemia y garantizar servicios de atención psicológica de calidad para la población

Two different strategies to enhance osseointegration in porous titanium: Inorganic thermo-chemical treatment versus organic coating by peptide adsorption

In this study, highly-interconnected porous titanium implants were produced by powder sintering with different porous diameters and open interconnectivity. The actual foams were produced using high cost technologies: Chemical Vapor Deposition (CVD), Physical Vapor Deposition (PVD), and spark plasma sintering, and the porosity and/or interconnection was not optimized. The aim was to generate a bioactive surface on foams using two different strategies, based on inorganic thermo-chemical treatment and organic coating by peptide adsorption, to enhance osseointegration. Porosity was produced using NaCl as a space holder and polyethyleneglicol as a binder phase. Static and fatigue tests were performed in order to determine mechanical behaviors. Surface bioactivation was performed using a thermo-chemical treatment or by chemical adsorption with peptides. Osteoblast-like cells were cultured and cytotoxicity was measured. Bioactivated scaffolds and a control were implanted in the tibiae of rabbits. Histomorphometric evaluation was performed at 4 weeks after implantation. Interconnected porosity was 53% with an average diameter of 210 µm and an elastic modulus of around 1 GPa with good mechanical properties. The samples presented cell survival values close to 100% of viability. Newly formed bone was observed inside macropores, through interconnected porosity, and on the implant surface. Successful bone colonization of inner structure (40%) suggested good osteoconductive capability of the implant. Bioactivated foams showed better results than non-treated ones, suggesting both bioactivation strategies induce osteointegration capability.Postprint (published version

Proyecto de Intervención destinado a acompañantes de personas dependientes en centros residenciales. "Tu Dependencia. Mi dependencia".

Se trata de un proyecto de intervención destinado a mejorar la calidad de vida y mantener la autonomía de las personas acompañantes de dependientes en centros residenciales. Para ello, se han utilizado técnicas como la entrevista, tanto a profesionales como a usuarios, y la observación para dar respuesta a los objetivos planteados, los cuales van relacionados con las consecuencias y los efectos de la entrada de una persona autónoma, en un centro residencial, cumpliendo la función de acompañante. El análisis de la información ha permitido conocer la adaptación y los problemas principales relacionados con dicha población

Proyecto de Intervención destinado a acompañantes de personas dependientes en centros residenciales. "Tu Dependencia. Mi dependencia".

Se trata de un proyecto de intervención destinado a mejorar la calidad de vida y mantener la autonomía de las personas acompañantes de dependientes en centros residenciales. Para ello, se han utilizado técnicas como la entrevista, tanto a profesionales como a usuarios, y la observación para dar respuesta a los objetivos planteados, los cuales van relacionados con las consecuencias y los efectos de la entrada de una persona autónoma, en un centro residencial, cumpliendo la función de acompañante. El análisis de la información ha permitido conocer la adaptación y los problemas principales relacionados con dicha población

Proyecto de Intervención destinado a acompañantes de personas dependientes en centros residenciales. "Tu Dependencia. Mi dependencia".

Se trata de un proyecto de intervención destinado a mejorar la calidad de vida y mantener la autonomía de las personas acompañantes de dependientes en centros residenciales. Para ello, se han utilizado técnicas como la entrevista, tanto a profesionales como a usuarios, y la observación para dar respuesta a los objetivos planteados, los cuales van relacionados con las consecuencias y los efectos de la entrada de una persona autónoma, en un centro residencial, cumpliendo la función de acompañante. El análisis de la información ha permitido conocer la adaptación y los problemas principales relacionados con dicha población

Clínica jurídica, una forma de aprendizaje-servicio para la protección de Derechos humanos

[spa] El artículo explica los primeros pasos dados en el desarrollo del proyecto "Clínica jurídica: una forma de aprendizaje-servicio para la protección de derechos humanos" en la Universidad de Valladolid, cuyo principal objetivo consiste en la formación de juristas socialmente comprometidos.[eng] The paper explains the first steps given on the development of the Project “Clínica jurídica: una forma de aprendizaje-servicio para la protección de derechos humanos“ at the University of Valladolid which main aim would be a social engaged lawyers training

Estudi ATDOM-O2 : Fase I. Estan formades les professionals d'infermeria d'atenció primària en oxigenoteràpia crònica domiciliària?

L'oxigenoteràpia crònica domiciliària (OCD) és l'ús terapèutic de l'oxigen per reduir el dèficit d'oxigenació de la sang. L'objectiu del tractament amb OCD és corregir la hipoxèmia per evitar la hipòxia tissular i millorar la supervivència i la qualitat de vida dels pacients amb insuficiència respiratòria crònica demostrada

Zoonotic "Enterocytozoon bieneusi" genotypes in free-ranging and farmed wild ungulates in Spain

Microsporidia comprises a diverse group of obligate, intracellular, and spore-forming parasites that infect a wide range of animals. Among them, Enterocytozoon bieneusi is the most frequently reported species in humans and other mammals and birds. Data on the epidemiology of E. bieneusi in wildlife are limited. Hence, E. bieneusi was investigated in eight wild ungulate species present in Spain (genera Ammotragus, Capra, Capreolus, Cervus, Dama, Ovis, Rupicapra, and Sus) by molecular methods. Faecal samples were collected from free-ranging (n = 1058) and farmed (n = 324) wild ungulates from five Spanish bioregions. The parasite was detected only in red deer (10.4%, 68/653) and wild boar (0.8%, 3/359). Enterocytozoon bieneusi infections were more common in farmed (19.4%, 63/324) than in wild (1.5%, 5/329) red deer. A total of 11 genotypes were identified in red deer, eight known (BEB6, BEB17, EbCar2, HLJD-V, MWC_d1, S5, Type IV, and Wildboar3) and three novel (DeerSpEb1, DeerSpEb2, and DeerSpEb3) genotypes. Mixed genotype infections were detected in 15.9% of farmed red deer. Two genotypes were identified in wild boar, a known (Wildboar3) and a novel (WildboarSpEb1) genotypes. All genotypes identified belonged to E. bieneusi zoonotic Groups 1 and 2. This study provides the most comprehensive epidemiological study of E. bieneusi in Spanish ungulates to date, representing the first evidence of the parasite in wild red deer populations worldwide. Spanish wild boars and red deer are reservoir of zoonotic genotypes of E. bieneusi and might play an underestimated role in the transmission of this microsporidian species to humans and other animal

Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA

The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. In this study, we present a novel DNA-based next-generation sequencing (NGS) methodology for KD ABL1 mutation detection and monitoring with a 1.0E−4 sensitivity. This approach was validated with a well-stablished RNA-based nested NGS method. The correlation of both techniques for the quantification of ABL1 mutations was high (Pearson r = 0.858, p < 0.001), offering DNA-DeepNGS a sensitivity of 92% and specificity of 82%. The clinical impact was studied in a cohort of 129 patients (n = 67 for CML and n = 62 for B-ALL patients). A total of 162 samples (n = 86 CML and n = 76 B-ALL) were studied. Of them, 27 out of 86 harbored mutations (6 in warning and 21 in failure) for CML, and 13 out of 76 (2 diagnostic and 11 relapse samples) did in B-ALL patients. In addition, in four cases were detected mutation despite BCR::ABL1 < 1%. In conclusion, we were able to detect KD ABL1 mutations with a 1.0E−4 sensitivity by NGS using DNA as starting material even in patients with low levels of disease.Tis project was funded in part by CRIS CANCER FOUNDATION