La verdad acrisolada [Texto impreso] : dissertacion apologetica theologico-mistico dogmatica sobre el sentido mas genuino, y usual de estas voces, "consumada mortificacion o purgacion" ...

Prelim. fechados en 1753Sign.: *3, 2*8, A-V

From farmers to bioengineers: Sowing genes, harvesting molecules

Twenty-first-century agriculture faces major challenges that urgently need to be answered. In the last decade, new breeding technologies have been developed that can help meet these challenges. These technologies are not only more accurate and efficient, but are also simpler and more accessible, which will facilitate the progressive democratisation of agricultural biotechnology. In this text we discuss future agricultural development in terms of technological democratisation and regulatory relaxation. In this scenario one would expect an increase in the diversity of cultivated varieties and species, the strong development of biofactory crops and, in the long term, the emergence of increasingly fit «smart» crops

Devoto septenario en memoria de los siete principales gozos de Maria Santissima que... como Madre del Remedio y Patrona de Albayda...

Fecha de la aprobación, 1756, también según Palau,39579Sign.: A25Front. xil., representando a la Patrona de la Villa de Albayd

Efecto de la selección por ganancia media diaria durante el engorde sobre el crecimiento prenatal y postnatal en conejo

[ES] La vitrificación es una técnica de conservación de embriones, que hace posible la evaluación del efecto de la selección genética en la ganancia media diaria de peso, comparando poblaciones de la misma línea que se encuentran separadas en el tiempo, mediante la reconstitución de poblaciones. El objetivo de este estudio es reconstituir dos poblaciones de la línea Rosa de la Granja de Mejora Genética de la UPV, seleccionada por velocidad de crecimiento: una población control, de la cual se vitrificaron embriones de 72 horas en el año 1999 cuando se encontraba en la generación 25 y una población actual con embriones vitrificados también a 72 horas en 2014 encontrándose en la generación 36. Para ello se transferirán los embriones de cada una de las dos generaciones a 25 hembras de la línea Amarilla por tener estas mejores aptitudes maternales. Con esto se pretende obtener al menos quince orígenes vía macho de cada población para garantizar una baja consanguinidad en los posteriores cruces. A partir de los diez días de gestación, se realizarán ecografías cada dos días para llevar un seguimiento del crecimiento intrauterino de los fetos. A los catorce días se realizará una endoscopia para ver el número de implantados y posibles regresiones. Finalmente, los gazapos nacidos serán identificados con chips electrónicos para el seguimiento semanal de ganancia de peso individual.[EN] From a long time ago, selection has been a tool used by the humanity to obtain offspring with interesting features from a productive point of view, including both animal and vegetable species. Currently, there are breeding programs of many species that use different selection methods to preserve the best individuals, in order to reproduce them and to be able to improve the lines. Due to the high genetic value that individuals achieve after years of selection and the possibility of its loss which could suppose a delay, banks of genetic material were established. In these banks, embryos are vitrified and stored in liquid nitrogen to -196OC. Therefore, this work has been carried out in order to evaluate the current vitrified embryos and those vitrified and stored 15 years ago from a rabbit line selected by daily average gain in the fattening period, of the Genetic Progress Unit in the UPV. In this work a total of 534 embryos were used, from two different generations of R line (18 and 36). From these 534, 301 were used as control (generation 36) and the 233 remaining as problem (generation 18). The results obtained showed that there were no significant differences in the post native growth up to the weaning, since both generations showed parallel and practically superposed growth curves. Nevertheless, there were significant differences in the prenatal growth, being the fetuses from the generation 36 longer than the generation 18. There were also differences in the time of storage of the embryos, since those from 18 generation, vitrified in 1999 showed less availability than those from generation 36, vitrified in 2014 and therefore a less cryopreservation efficiency. The above mentioned was favored by the loss of two straws that exploded during the warming procedure.Estarlich Calatayud, V. (2015). Efecto de la selección por ganancia media diaria durante el engorde sobre el crecimiento prenatal y postnatal en conejo. http://hdl.handle.net/10251/54197.TFG

Estudio anatómico-histológico de las flores del endemismo Lamottea diania (Asteraceae) y de los efectos del ozono troposférico sobre su desarrollo.

"Estudio anatómico-histológico de las flores del endemismo Lamottea diania (Asteraceae) y de los efectos del ozono troposférico sobre su desarrollo". Lilloa 53 (2). Plantas del endemismo Lamottea diania se expusieron en cámaras OTC (Open Top Chambers) a aire ambiente filtrado y a aire ambiente no filtrado más 30 ppb de ozono para observar el efecto de este contaminante sobre el desarrollo de sus flores, particularmente sobre su androceo. Hemos comprobado, mediante estudios de microscopía óptica y electrónica, que el ozono afecta el proceso de desarrollo y maduración de los estambres y del polen. Las anteras se ven afectadas, en unos casos al abortar algunos estambres en su desarrollo y, en otros, impidiéndose el desarrollo correcto de los sacos polínicos en el interior de las mismas. Asimismo, el ozono impide la formación correcta del polen encontrando numerosos granos de polen sin desarrollar o desarrollados y madurados de forma anómala en el interior de los sacos polínicos. Los resultados indican que el ozono es el responsable del desarrollo anormal del androceo y del polen en plantas de L. diania. Anatomical and histological study of endemism flowers of Lamottea diania (Asteraceae) and the effects of tropospheric ozone on their development'. Lilloa 53 (2). Plants of endemism Lamottea diania were exposed in cameras OTC (Open Top Chambers) to filtered ambient air and ambient air unfiltered over 30 ppb ozone to observe the effect of this pollutant on the development of its flowers, particularly on its androecium. We have found, through studies of optical and electron microscopy, that ozone affects the process of development and maturation of stamens and pollen. The anthers are affected, in some cases by aborting some stamens in their development and in other, prevented the proper development of the pollen sacs within them. In addition, ozone prevents proper formationand maturation of pollen found many undeveloped pollen grains or developed abnormally inside the pollen sacs. Results indicate that ozone was responsible for the abnormal development of androecium and pollen in L. diania

La pobreza de Cervantes : discurso

Velada literaria dedicada por el Instituto de 2ª Enseñanza de Valencia con motivo del tercer Aniversario de la aparición del Quijot

On the generalized logistic random differential equation: Theoretical analysis and numerical simulations with real-world data

Based on the previous literature about the random logistic and Gompertz models, the aim of this paper is to extend the investigations to the generalized logistic differential equation in the random setting. First, this is done by rigorously constructing its solution in two different ways, namely, the sample-path approach and the mean-square calculus. Secondly, the probability density function at each time instant is derived in two ways: by applying the random variable transformation technique and by solving the associated Liouville’s partial differential equation. It is also proved that both the stochastic solution and its density function converge, under specific conditions, to the corresponding solution and density function of the logistic and Gompertz models, respectively. The investigation finishes showing some examples, where a number of computational techniques are combined to construct reliable approximations of the probability density of the stochastic solution. In particular, we show, step-by-step, how our findings can be applied to a real-world problem

Simulación CFD del comportamiento mecánico de las Unidades de Detección del telescopio submarino de neutrinos KM3NeT

[ES] KM3NeT (www.km3net.org) será el detector de neutrinos submarino más grande del mundo. Se compone por Unidades de Detección, consistentes en líneas verticales de 18 Módulos Ópticos de Detección erguidas por flotabilidad. Su base está anclada al lecho marino pero el resto de la línea se encuentra en constante movimiento a causa de las corrientes marinas. Es necesario monitorizar la posición de cada Módulo para poder reconstruir latrayectoria del neutrino detectado. Mediante CFD (Computational Fluid Dynamics) se pretende estudiar en detalle cómo se distribuyen las fuerzas y momentos infringidos por las corrientes dependiendo de su velocidad y dirección a lo largo de la línea. Dichas simulaciones ayudarán a comprender el comportamiento de ésta y a mejorar los modelos matemáticos usados por el Modelo Mecánico de reconstrucción actual. Las simulaciones se realizarán mediante el software ingenieril SimScale que, además de su potencial, es el primero que permite simular todo desde la nube.[EN] KM3NeT (www.km3net.org) aims to be the biggest submarine neutrino detector. Is made up of Detection Units that are vertical lines with 18 Detection Optical Modules straightened by buoyancy. The line base is anchored to the seabed but the rest of it is in constant movement due to sea currents. This justifies the position monitoring of each Module so that when a neutrino is detected, the track of the particle can be reconstructed. Through CFD (Computational Fluid Dynamics) simulations, forces and moments infringed by sea currents, depending on their velocity and direction, will be studied. The simulations will help to understand the line behaviour and therefore enhance the mathematical models used by the Mechanical Model reconstruction. The software chosen to work with is SimScale, innovative software with big potential and first allowing to make the entire simulation process on the web.[CA] KM3NeT (www.km3net.org) serà el detector de neutrins submarí més gran del món. Es compon per Unitats de Detecció, les quals estan formades per línies verticals amb 18 Mòduls Òptics de Detecció mantingudes en vertical per la seua flotabilitat. La seua base està ancorada al fons marí, però la resta de la línia es troba en constant moviment a causa dels corrents marins. És necessari monitorar la posició de cada Mòdul per poder reconstruir la trajectòria del neutrí detectat. Mitjançant CFD (Computational Fluid Dynamics) es pretén estudiar en detall com es distribueixen les forces i moments infringits pels corrents depenent de la seua velocitat i direcció al llarg de la línia. Les simulacions ajudaran a comprendre el comportament d’aquesta i a millorar els models matemàtics utilitzats pel Model Mecànic de reconstrucció actual. Les simulacions es realitzaran mitjançant el software ingenieril SimScale que, a més del seu potencial, és el primer que permet simular-ho tot en línia.González Calatayud, JV. (2021). Simulación CFD del comportamiento mecánico de las Unidades de Detección del telescopio submarino de neutrinos KM3NeT. Universitat Politècnica de València. http://hdl.handle.net/10251/173704TFG

DNA assembly standards: Setting the low-level programming code for plant biotechnology

[EN] Synthetic Biology is defined as the application of engineering principles to biology. It aims to increase the speed, ease and predictability with which desirable changes and novel traits can be conferred to living cells. The initial steps in this process aim to simplify the encoding of new instructions in DNA by establishing low-level programming languages for biology. Together with advances in the laboratory that allow multiple DNA molecules to be efficiently assembled together into a desired order in a single step, this approach has simplified the design and assembly of multigene constructs and has even facilitated the automated construction of synthetic chromosomes. These advances and technologies are now being applied to plants, for which there are a growing number of software and wetware tools for the design, construction and delivery of DNA molecules and for the engineering of endogenous genes. Here we review the efforts of the past decade that have established synthetic biology workflows and tools for plants and discuss the constraints and bottlenecks of this emerging field.Marta Vazquez-Vilar is funded by Wageningen University & Research. Diego Orzaez is funded by the Spanish Ministry of Economy and Competitiveness [grant number BIO2016-78601-R]. Nicola Patron is funded by the UK Biotechnological and Biological Sciences Research Council (BBSRC) and Engineering and Physics Research Council (EPSRC)Synthetic Biology for Growth programme [OpenPlant Synthetic Biology Research Centre, grant number BB/L0I4130/1], and by the Earlham DNA Foundry [grant number BB/CCG1720/1].Vázquez-Vilar, M.; Orzáez Calatayud, DV.; Patron, N. (2018). DNA assembly standards: Setting the low-level programming code for plant biotechnology. Plant Science. 273:33-41. https://doi.org/10.1016/j.plantsci.2018.02.024S334127

Twin axial vortices generated by Fibonacci lenses

Optical vortex beams, generated by Diffractive Optical Elements (DOEs), are capable of creating optical traps and other multifunctional micromanipulators for very specific tasks in the microscopic scale. Using the Fibonacci sequence, we have discovered a new family of DOEs that inherently behave as bifocal vortex lenses, and where the ratio of the two focal distances approaches the golden mean. The disctintive optical properties of these Fibonacci vortex lenses are experimentally demonstrated. We believe that the versatility and potential scalability of these lenses may allow for new applications in micro and nanophotonics.We acknowledge the financial support from Ministerio de Economia y Competitividad (grant FIS2011-23175), Generalitat Valenciana (grant PROMETEO2009-077), and Universitat Politecnica de Valencia (SP20120569), Spain. L.R. acknowledges a fellowship of "Fundacion CajaMurcia", Spain.Calatayud Calatayud, A.; Ferrando Martín, V.; Remón Martín, L.; WALTER DANIEL FURLAN; Monsoriu Serra, JA. (2013). Twin axial vortices generated by Fibonacci lenses. Optics Express. 21(8):10234-10239. https://doi.org/10.1364/OE.21.010234S1023410239218Sakdinawat, A., & Liu, Y. (2007). Soft-x-ray microscopy using spiral zone plates. Optics Letters, 32(18), 2635. doi:10.1364/ol.32.002635Siemion, A., Siemion, A., Makowski, M., Suszek, J., Bomba, J., Czerwiński, A., … Sypek, M. (2012). Diffractive paper lens for terahertz optics. Optics Letters, 37(20), 4320. doi:10.1364/ol.37.004320Saavedra, G., Furlan, W. D., & Monsoriu, J. A. (2003). Fractal zone plates. Optics Letters, 28(12), 971. doi:10.1364/ol.28.000971Davis, J. A., Sigarlaki, S. P., Craven, J. M., & Calvo, M. L. (2006). Fourier series analysis of fractal lenses: theory and experiments with a liquid-crystal display. Applied Optics, 45(6), 1187. doi:10.1364/ao.45.001187Furlan, W. D., Saavedra, G., & Monsoriu, J. A. (2007). White-light imaging with fractal zone plates. Optics Letters, 32(15), 2109. doi:10.1364/ol.32.002109Roux, F. S. (2004). Distribution of angular momentum and vortex morphology in optical beams. Optics Communications, 242(1-3), 45-55. doi:10.1016/j.optcom.2004.08.006Gbur, G., & Visser, T. D. (2006). Phase singularities and coherence vortices in linear optical systems. Optics Communications, 259(2), 428-435. doi:10.1016/j.optcom.2005.08.074Bishop, A. I., Nieminen, T. A., Heckenberg, N. R., & Rubinsztein-Dunlop, H. (2003). Optical application and measurement of torque on microparticles of isotropic nonabsorbing material. Physical Review A, 68(3). doi:10.1103/physreva.68.033802Ladavac, K., & Grier, D. G. (2004). Microoptomechanical pumps assembled and driven by holographic optical vortex arrays. Optics Express, 12(6), 1144. doi:10.1364/opex.12.001144Lee, W. M., Yuan, X.-C., & Cheong, W. C. (2004). Optical vortex beam shaping by use of highly efficient irregular spiral phase plates for optical micromanipulation. Optics Letters, 29(15), 1796. doi:10.1364/ol.29.001796Tao, S. H., Yuan, X.-C., Lin, J., & Burge, R. E. (2006). Sequence of focused optical vortices generated by a spiral fractal zone plate. Applied Physics Letters, 89(3), 031105. doi:10.1063/1.2226995Furlan, W. D., Giménez, F., Calatayud, A., & Monsoriu, J. A. (2009). Devil’s vortex-lenses. Optics Express, 17(24), 21891. doi:10.1364/oe.17.021891Maciá, E. (2012). Exploiting aperiodic designs in nanophotonic devices. Reports on Progress in Physics, 75(3), 036502. doi:10.1088/0034-4885/75/3/036502Sah, Y., & Ranganath, G. . (1995). Optical diffraction in some Fibonacci structures. Optics Communications, 114(1-2), 18-24. doi:10.1016/0030-4018(94)00600-yGedzelman, S. D., & Vollmer, M. (2011). Crepuscular rays: laboratory experiments and simulations. Applied Optics, 50(28), F142. doi:10.1364/ao.50.00f142Swartzlander, G. A. (2001). Peering into darkness with a vortex spatial filter. Optics Letters, 26(8), 497. doi:10.1364/ol.26.000497Curtis, J. E., & Grier, D. G. (2003). Structure of Optical Vortices. Physical Review Letters, 90(13). doi:10.1103/physrevlett.90.133901Calatayud, A., Rodrigo, J. A., Remón, L., Furlan, W. D., Cristóbal, G., & Monsoriu, J. A. (2012). Experimental generation and characterization of Devil’s vortex-lenses. Applied Physics B, 106(4), 915-919. doi:10.1007/s00340-012-4913-