EU-Rent car rentals specification

EU-Rent is a widely known case study being promoted as a basis for demonstration of product capabilities. However, no in-depth case analysis neither specification has been developed. Therefore, it was considered interesting, useful and even necessary to develop a complete study of the case, which would lead to its whole specification. On the other hand, it was considered a good opportunity to test the application of some proposals, such as alternate mechanisms to define integrity constraints and derivation rules, as well as an alternative approach to model events.Postprint (published version

Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance.

Phthalate diesters have been shown to be developmental and reproductive toxicants in animal studies. A recent epidemiologic study showed certain phthalates to be significantly associated with reduced anogenital distance in human male infants, the first evidence of subtle developmental effects in human male infants exposed prenatally to phthalates. We used two previously published methods to estimate the daily phthalate exposures for the four phthalates whose urinary metabolites were statistically significantly associated with developmental effects in the 214 mother-infant pairs [di-n-butyl phthalate (DnBP) , diethyl phthalate (DEP) , butylbenzyl phthalate (BBzP) , diisobutyl phthalate (DiBP) ] and for another important phthalate [di-2-ethylhexyl phthalate (DEHP) ]. We estimated the median and 95th percentile of daily exposures to DBP to be 0.99 and 2.68 microg/kg/day, respectively ; for DEP, 6.64 and 112.3 microg/kg/day ; for BBzP, 0.50 and 2.47 microg/kg/day ; and for DEHP, 1.32 and 9.32 microg/kg/day. The U.S. Environmental Protection Agency (EPA) reference doses for these chemicals are 100 (DBP) , 800 (DEP) , 200 (BBzP) , and 20 (DEHP) microg/kg/day. The median and 95th percentile exposure estimates for the phthalates associated with reduced anogenital distance in the study population are substantially lower than current U.S. EPA reference doses for these chemicals and could be informative to any updates of the hazard assessments and risk assessments for these chemicals

Entre el llenguatge i la realitat: vint anys de poesia catalana

Between 1970 and 1990, Catalan poetry experienced a significant increase in new authors and works, that followed in succession the already established authors like Espriu, Foix, Estellés, Vinyoli and Martí ï Pol, amongst others. Here the fundamental characteristics of these new authors and their poetry are analized. A characterization of the most remarkable poets is also studied

Production of selenium-enriched yeast (Kluyveromyces marxianus) biomass in a whey-based culture medium

Two important aspects of agriculture intensification are the reduction in the concentration of specific soil minerals that affects livestock production and the increase of agricultural by-products, which produce environmental pollution. In this regard, whey - a cheese by-product-often is considered a wasted-product. Due to its lactose concentration, (4.5%), when whey is discarded without treatment generates a high Biological Oxygen Demand (BOD) and a high Chemical Oxygen Demand (COD). Taking into account these two issues, we developed a whey-based culture medium to produce selenium-enriched Kluyveromyces biomass. Then, we evaluated the effect of its supplementation on calves blood selenium concentration. Kluyveromyces marxianus DSM 11954 and Kluyveromyces lactis DSM 3795 strains were used in this study. Different culture media were prepared using whey as a main component and supplemented with peptone, yeast extract, (NH4)2SO4 and K2HPO4 as appropriate. In the selected whey culture medium, three sodium selenite concentrations between 10-30 μg/mL were tested to produce selenium-enriched biomass. After that, a scaled up to 5 L stirred-tank bioreactor was carried out to increase final yeast biomass levels. Finally, dietary supplementation experiments with selenium-enriched yeast were conducted to increase selenium content in calves. K. marxianus DSM 11954 showed a better growth performance than K. lactis DSM 3795 in a medium composed by whey, (NH4)2SO4 5 g/L, K2HPO4 1 g/L (pH 6.5) so, this strain was chosen to continue the experiments. The results showed that sodium selenite addition at 20 μg/mL was adequate to generate selenium-enriched biomass. Our study demonstrated that whey is an optimal and economical culture medium to produce selenium-enriched- yeast biomass. Also, we proved that 10 days of yeast-biomass supplementation raised blood-selenium level in calves.Fil: Gurdo, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Calafat, Mario Jose. Universidad Nacional de La Pampa. Facultad de Agronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Noseda, Diego Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Gigli, Isabel. Universidad Nacional de La Pampa. Facultad de Agronomía; Argentin

Esport i massa òssia (II). Característiques de l'exercici físic que condicionen el modelatge i el remodelatge ossis

L'exercici físic és un dels factors que condicionen el modelatge i el remodelatge ossi. En l'os, l'estímul més important es produeix quan les càrregues, inherents a l'exercici físic, excedeixen les habituals i tenen una distribució inusual; aleshores és més important la intensitat que no la durada d'aquestes. L'exercici físic que sembla que té més potencial osteogènic és el que inclou salts no estereotipats, en trajectòries diferents. L'activitat física de baix impacte, que implica escassa sobrecàrrega mecànica, no sembla que tingui cap avantatge. Així doncs, les disciplines esportives que inclouen activitats d'impacte vertical, en les quals cal suportar el pes del cos, són més favorables per a la massa òssia que no pas aquelles en què no hi ha impacte, com la natació. Aquests beneficis seran específics de les àrees especialment implicades en l'exercici, ja que la resposta de l'os a la càrrega mecànica acostuma de ser local i no generalitzada