4,318 research outputs found
A three-dimensional simulation of transition and early turbulence in a time-developing mixing layer
The physics of the transition and early turbulence regimes in the time developing mixing layer was investigated. The sensitivity of the mixing layer to the disturbance field of the initial condition is considered. The growth of the momentum thickness, the mean velocity profile, the turbulence kinetic energy, the Reynolds stresses, the anisotropy tensor, and particle track pictures of computations are all examined in an effort to better understand the physics of these regimes. The amplitude, spectrum shape, and random phases of the initial disturbance field were varied. A scheme of generating discrete orthogonal function expansions on some nonuniform grids was developed. All cases address the early or near field of the mixing layer. The most significant result shows that the secondary instability of the mixing layer is produced by spanwise variations in the straining field of the primary vortex structures
Perspectives for designing a new healthcare environment ; what person-environment factors do future users think are important?
Proton transport and torque generation in rotary biomotors
We analyze the dynamics of rotary biomotors within a simple
nano-electromechanical model, consisting of a stator part and a ring-shaped
rotor having twelve proton-binding sites. This model is closely related to the
membrane-embedded F motor of adenosine triphosphate (ATP) synthase, which
converts the energy of the transmembrane electrochemical gradient of protons
into mechanical motion of the rotor. It is shown that the Coulomb coupling
between the negative charge of the empty rotor site and the positive stator
charge, located near the periplasmic proton-conducting channel (proton source),
plays a dominant role in the torque-generating process. When approaching the
source outlet, the rotor site has a proton energy level higher than the energy
level of the site, located near the cytoplasmic channel (proton drain). In the
first stage of this torque-generating process, the energy of the
electrochemical potential is converted into potential energy of the
proton-binding sites on the rotor. Afterwards, the tangential component of the
Coulomb force produces a mechanical torque. We demonstrate that, at low
temperatures, the loaded motor works in the shuttling regime where the energy
of the electrochemical potential is consumed without producing any
unidirectional rotation. The motor switches to the torque-generating regime at
high temperatures, when the Brownian ratchet mechanism turns on. In the
presence of a significant external torque, created by ATP hydrolysis, the
system operates as a proton pump, which translocates protons against the
transmembrane potential gradient. Here we focus on the F motor, even though
our analysis is applicable to the bacterial flagellar motor.Comment: 24 pages, 5 figure
A study of major coding techniques for digital communication Final report
Coding techniques for digital communication channel
Fluctuating Hall resistance defeats the quantized Hall insulator
Using the Chalker-Coddington network model as a drastically simplified, but
universal model of integer quantum Hall physics, we investigate the
plateau-to-insulator transition at strong magnetic field by means of a
real-space renormalization approach. Our results suggest that for a fully
quantum coherent situation, the quantized Hall insulator with R_H approx. h/e^2
is observed up to R_L ~25 h/e^2 when studying the most probable value of the
distribution function P(R_H). Upon further increasing R_L ->\infty the Hall
insulator with diverging Hall resistance R_H \propto R_L^kappa is seen. The
crossover between these two regimes depends on the precise nature of the
averaging procedure.Comment: major revision, discussion of averaging improved; 8 pages, 7 figures;
accepted for publication in EP
Playing with the future: social irrealism and the politics of aesthetics
In this paper we wish to explore the political possibilities of video games. Numerous scholars now take seriously the place of popular culture in the remaking of our geographies, but video games still lag behind. For us, this tendency reflects a general response to them as imaginary spaces that are separate from everyday life and 'real' politics. It is this disconnect between abstraction and lived experience that we complicate by defining play as an event of what Brian Massumi calls lived abstraction. We wish to short-circuit the barriers that prevent the aesthetic resonating with the political and argue that through their enactment, video games can animate fantastical futures that require the player to make, and reflect upon, profound ethical decisions that can be antagonistic to prevailing political imaginations. We refer to this as social irrealism to demonstrate that reality can be understood through the impossible and the imagined
Total synthesis of (±)-aspidospermidine, (±)-aspidofractinine, (±)-limaspermidine, and (±)-vincadifformine via a cascade and common intermediate strategy
D.L.C. thanks EPSRC and GSK for a Ph.D. studentship.A concise strategy for the total synthesis of several Aspidosperma alkaloids is reported. A Suzuki–Miyaura cross-coupling provides access to a 2-vinyl indole that undergoes a Diels–Alder cascade reaction with butyn-2-one to deliver a pyrroloindoline intermediate. This undergoes cascade amidation, reduction, skeletal rearrangement, and intramolecular Michael addition to provide a common intermediate containing the full framework of the Aspidosperma alkaloids. The utility of this intermediate is shown in the synthesis of four different natural products.Publisher PDFPeer reviewe
The Politics of Commerce : The Congress of Chambers of Commerce of the Empire, 1886-1914
Peer reviewedPublisher PD
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