Down regulation of miR-143 is related with tumor size, lymph node metastasis and HPV16 infection in cervical squamous cancer

The HIV epidemic, which started with a handful of cases in the early 80s, very quickly became a worldwide epidemic. It has since then killed millions; devastating lives and destroying economies. Zimbabwe has one of the worst HIV epidemics in the world with within country variations. This study investigates successive 2005 and 2010-11 Demographic and Health Surveys (ZDHS) from Zimbabwe. a random representative sample of 30,000 men aged 15-59 and women aged 15 to 49 was selected in both surveys. HIV prevalence are mapped in a flexible, coherent regression framework using a geo-additive semi-parametric mixed model and produce HIV indicators (prevalence maps) at the sub-national regional level, an administrative level relevant for policy design, planning and decisions. It was found that there is substantial regional variation, not only in the burden of HIV, but also in the risk factors. This therefore requires varying responses/policies at the regional level to ensure that the often diverse needs of populations across a country are met and incorporated into planning the HIV response. The use of geographically referenced data in the successive ZDHS provides crucial new insights into the spatial characteristics of the HIV epidemic in Zimbabwe. It especially highlights the HIV heterogeneity across Zimbabwe. There is substantial regional variation, not only in the burden of HIV, but also in the risk factors

Bis(diethyl­enetriamine)­cobalt(III) hexa­chloridoindate(III)

The title compound, [Co(C4H13N3)2][InCl6], was synthesized under hydro­thermal conditions. In the cation, the Co—N bond lengths lie in the range 1.967 (2)–1.9684 (15) Å. In the anion, the InIII atom is coordinated by six Cl atoms resulting in a slightly distorted octa­hedral geometry. Both metal atoms are located on special positions of site symmetry 2/m. Furthermore, one Cl atom and one N atom are located on a mirror plane. N—H⋯Cl hydrogen bonds between cations and anions consolidate the crystal packing

\u3cem\u3eIn Situ\u3c/em\u3e Activated Co\u3csub\u3e3–x\u3c/sub\u3eNi\u3csub\u3ex\u3c/sub\u3eO\u3csub\u3e4\u3c/sub\u3e as a Highly Active and Ultrastable Electrocatalyst for Hydrogen Generation

The spinel Co3O4 has emerged as a promising alternative to noble-metal-based electrocatalysts for electrochemical water electrolysis in alkaline medium. However, pure Co3O4, despite having high activity in anodic water oxidation, remains inactive toward the hydrogen evolution reaction (HER). Here, a Ni-doped Co3O4(Co3–xNixO4) prepared by a simple method exhibits favorable HER activity and stability (\u3e300 h, whether in 1 M KOH or the realistic 30 wt % KOH solution) after in situ electrochemical activation, outperforming almost all of the oxide-based electrocatalysts. More importantly, using the combination of in situ Raman spectroscopy and multiple high-resolution electron microscopy techniques, it is identified that the surface of Co3–xNixO4 crystals is reduced into intertwined CoyNi1–yO nanoparticles with highly exposed {110} reactive planes. Density functional theory calculations further prove that the Ni-doped CoO component in CoyNi1–yO plays a major role during the alkaline HER, because the introduction of Ni atoms into Co–O octahedra can optimize the electrical conductivity and tailor the adsorption/desorption free energies of Had and OHad intermediates

The characteristics of soil salinization effects on nitrogen mineralization and nitrification in upland fields

The influence of soil salinization on nitrogen (N) transformation is largely unknown, which impedes the reasonable management of N in saline fields. A comprehensive meta-analysis was thus conducted to evaluate the effects of salinity and relative soil physicochemical properties on net N mineralization and nitrification in upland soils. Results showed that effects of salinity on the net-N mineralization rate (Min) and nitrification rate (Nit) changed with the salinity level and incubation time. Generally, the inhibitory effect of salt on Min and Nit decreased gradually with incubation time. At 14–16 days of soil incubation, significant stimulatory effects on Min were observed in middle-level (ECe: 12–16 dS m-1) and high-level (ECe >16 dS m-1) saline soils, and on Nit in low-level (ECe: 4–12 dS m-1) saline soils. Regression analysis revealed that the effects of soil organic carbon (SOC), total N (TN), C/N, pH, and clay content on Min and Nit were closely related to salinity levels. Nit at 5–7 days of soil incubation first enhanced and then decreased with C/N increase, and the threshold value was 34.7. The effect of pH on Nit changed with salinity levels, and shifted from stimulation to inhibition with increasing pH. Min at 5–7 days of soil incubation in middle-level group first increased with increasing pH, and decreased when pH was higher than 8.1. Salinization deeply affected soil properties, which further influenced N turnover via alteration of the availability of substrates and microbial biomass and activities. Our findings suggest that the influence of salinity on soil N turnover closely related with salinity level, and salinity level should be considered fully when optimizing N management in saline upland fields

Unveiling the additive-assisted oriented growth of perovskite crystallite for high performance light-emitting diodes.

Solution-processed metal halide perovskites have been recognized as one of the most promising semiconductors, with applications in light-emitting diodes (LEDs), solar cells and lasers. Various additives have been widely used in perovskite precursor solutions, aiming to improve the formed perovskite film quality through passivating defects and controlling the crystallinity. The additive's role of defect passivation has been intensively investigated, while a deep understanding of how additives influence the crystallization process of perovskites is lacking. Here, we reveal a general additive-assisted crystal formation pathway for FAPbI3 perovskite with vertical orientation, by tracking the chemical interaction in the precursor solution and crystallographic evolution during the film formation process. The resulting understanding motivates us to use a new additive with multi-functional groups, 2-(2-(2-Aminoethoxy)ethoxy)acetic acid, which can facilitate the orientated growth of perovskite and passivate defects, leading to perovskite layer with high crystallinity and low defect density and thereby record-high performance NIR perovskite LEDs (~800 nm emission peak, a peak external quantum efficiency of 22.2% with enhanced stability)

Biomarkers associated with functional improvement after stroke rehabilitation: a systematic review and meta-analysis of randomized controlled trials

ObjectiveThis study aims to identify blood and cerebrospinal fluid biomarkers that are correlated to the functional improvement of stroke patients after rehabilitation therapy, and provide ideas for the treatment and evaluation of stroke patients.MethodsThe PubMed, Web of Science, and Embase databases were searched for articles published in the English language, from inception to December 8, 2022.ResultsA total of 9,810 independent records generated 50 high-quality randomized controlled trials on 119 biomarkers. Among these records, 37 articles were included for the meta-analysis (with a total of 2,567 stroke patients), and 101 peripheral blood and cerebrospinal fluid biomarkers were included for the qualitative analysis. The quantitative analysis results revealed a moderate quality evidence that stroke rehabilitation significantly increased the level of brain-derived neurotrophic factor (BDNF) in serum. Furthermore, the low-quality evidence revealed that stroke rehabilitation significantly increased the concentration of serum noradrenaline (NE), peripheral blood superoxide dismutase (SOD), peripheral blood albumin (ALB), peripheral blood hemoglobin (HB), and peripheral blood catalase (CAT), but significantly decreased the concentration of serum endothelin (ET) and glutamate. In addition, the changes in concentration of these biomarkers were associated with significant improvements in post-stroke function. The serum BNDF suggests that this can be used as a biomarker for non-invasive brain stimulation (NIBS) therapy, and to predict the improvement of stroke patients.ConclusionThe concentration of serum BNDF, NE, ET and glutamate, and peripheral blood SOD, ALB, HB and CAT may suggest the function improvement of stroke patients

Ultrasensitive binder-free glucose sensors based on the pyrolysis of in situ grown Cu MOF

A non-enzymatic glucose sensor based on carbon/Cu composite materials was developed by the in-situ growth and subsequent pyrolysis of metal-organic frameworks (MOFs) on Cu foam. After pyrolysis, SEM, HRTEM and STEM-EELS were employed to clarify the hierarchical Cu@porous carbon electrode. It is found that the Cu nanoparticles are uniformly embedded in the carbon matrix, carbon matrix in close contact with the pyrolized carbon sheets. The electrocatalytic activity of the Cu@porous carbon matrix electrode for glucose sensing was explored by cyclic voltammetry (CV) and chronoamperometry. The resulting Cu@porous carbon matrix electrode displays ultrahigh sensitivity (10.1 mA cm⁻² mM⁻¹), low detection limit (0.6 μM), short response time (less than 2 s) and good stability, indicating that the developed electrode is a promising glucose sensor

Strain-based tunable optical microresonator with an in-fiber rectangular air bubble

We demonstrate a strain-based fully tunable, near-lossless, whispering gallery mode (WGM) resonator made of an in-fiber rectangular air bubble, which is fabricated by splicing two segments of standard single-mode fibers. Such a resonator, with a 39 μm order radius and 1 μm order wall thickness, contributes to a high quality factor exceeding 106. The tuning in resonant wavelength is achieved by applying tensile strain to the resonator, and the voltage-tuning rate of the WGM resonance peaks is about 31.96 pm/V (strain-tuning rate ∼14.12 pm∕με), and the corresponding tuning accuracy is better than 0.03 pm. Since the tensile strain applied on the resonator can reach 1000 με, the achievable total tunable bandwidth of ∼14.12 nm is more than two times that of its azimuthal free spectral range

On the Conformation of Dimeric Acceptors and Their Polymer Solar Cells with Efficiency over 18 %

The determination of molecular conformations of oligomeric acceptors (OAs) and their impact on molecular packing are crucial for understanding the photovoltaic performance of their resulting polymer solar cells (PSCs) but have not been well studied yet. Herein, we synthesized two dimeric acceptor materials, DIBP3F-Se and DIBP3F-S, which bridged two segments of Y6-derivatives by selenophene and thiophene, respectively. Theoretical simulation and experimental 1D and 2D NMR spectroscopic studies prove that both dimers exhibit O-shaped conformations other than S- or U-shaped counter-ones. Notably, this O-shaped conformation is likely governed by a distinctive “conformational lock” mechanism, arising from the intensified intramolecular π–π interactions among their two terminal groups within the dimers. PSCs based on DIBP3F-Se deliver a maximum efficiency of 18.09 %, outperforming DIBP3F-S-based cells (16.11 %) and ranking among the highest efficiencies for OA-based PSCs. This work demonstrates a facile method to obtain OA conformations and highlights the potential of dimeric acceptors for high-performance PSCs