Lucky imaging speckle statistics applied to halo suppression

In ground based astronomy, the Lucky Imaging (LI) technique consists of selecting the best quality pictures among those that have been taken with a short exposure time to freeze the atmosphere distortions. Although it has different advantages, the peak intensity of a star is always surrounded by speckled light which, once averaged, provides the halo. The halo can make it difficult to detect faint companions immersed in it. In this paper, we take advantage of the speckle statistics to remove the halo and so to make more effective current detection techniques. Theoretical predictions are confirmed using experimental LI data. Finally, a photometry algorithm is also proposed.Funding by Ministerio de Economía y Competitividad, project AYA2016-78773-C2-1-P

Super-Gaussian apodization in ground based telescopes for high contrast coronagraph imaging

We introduce the use of Super-Gaussian apodizing functions in the telescope pupil plane and/or the coronagraph Lyot plane to improve the imaging contrast in ground-based coronagraphs. We describe the properties of the Super-Gaussian function, we estimate its second-order moment in the pupil and Fourier planes and we check it as an apodizing function. We then use Super-Gaussian function to apodize the telescope pupil, the coronagraph Lyot plane or both of them. The result is that a proper apodizing masks combination can reduce the exoplanet detection distance up to a 45% with respect to the classic Lyot coronagraph, for moderately aberrated wavefronts. Compared to the prolate spheroidal function the Super-Gaussian apodizing function allows the planet light up to 3 times brighter. An extra help to increase the extinction rate is to perform a frame selection (Lucky Imaging technique). We show that a selection of the 10% best frames will reduce up to a 20% the detection angular distance when using the classic Lyot coronagraph but that the reduction is only around the 5% when using an apodized coronagraph

Quaternary adaptive optics

We present a new Point Diffraction Interferometer (PDI). Binary adaptive optics (BAO) and Quaternary Adaptive Optics (QAO) can be performed with the help of this PDI as a wavefront sensor. The PDI interferogram, once binarized, is used in two consecutive steps to produce a quaternary mask with phase values 0, π/2, π and 3π/2. The addition of the quaternary mask compensates for the aberrated wavefront and allows us to reach a Strehl ratio of about 0.81. We have verified through computer simulations that the use of QAO depends on the number of actuators of the compensating device to achieve effective compensation. The technique was successfully validated through an experiment.Ministerio de Economía y Competitividad (MINECO) (AYA2016-78773-C2-1-P)

El videoCD, un formato a medida del profesor.

El VideoCD es un formato de disco compacto poco conocido, que permite almacenar imágenes fijas, vídeo y audio estéreo de excelente calidad. Este formato nos permite, tras un proceso sencillo, realizar nuestros propios "vídeos interactivos", en un soporte cómodo, fiable y barato. Puede ser reproducido en cualquier aula de prácticas que disponga de ordenadores con unidad lectora de CD-ROM, convirtiéndose por tanto en un formato práctico a medida del profesor, el cuál puede sacarle mayor rendimiento educativo del obtenido hasta ahora.VideoCD is a practically unheard Compact Disc Format, which allows one to hold fixed images, video and stereo audio with a high quality. This format lets, after a simple process, make our own interactive-video, in a practical, cheap and secure way. In order to be played in a classroom with PC´s fitted with a CD-ROM reader. This way, it becomes in a good format, for the teacher, who could improve the educational obtained results so far

Coronagraphs adapted to atmosphere conditions

In this paper we show new ways to improve the performance of ground-based coronagraphy. We introduce adaptive coronagraphic masks whose profile is a binary version of the instantaneous atmospherically degraded star image. We also propose the hyper-Gaussian profile masks obtained by averaging adaptive masks. In addition, adaptive Lyot stops and hyper-Gaussian Lyot stops are analyzed. Computer simulations show that all these masks outperform the circular hard-edged mask and that a proper mask and stop combination significantly reduces the angular separation at which a faint companion can be detected

Experimental validation of Lyot stop apodization in ground-based coronagraphy

ABSTRACT We show that the use of apodizing functions at the coronagraph Lyot plane may be useful for improving the image contrast of ground-based coronagraphs. An experimental set-up consisting of a tip–tilt mirror, a coronagraph and a low-noiseEMCCDcamerawas implemented at theWilliam Herschel Telescope. Images were taken in the I band, which meant that the D/r0 value was around 10. Experimental results confirm that, for moderately aberrated wavefronts, our instrument works as theoretically expected, and that the contrast value attained is high enough to provide direct detection of faint companions.This research was supported by the Ministerio de Economía y Competitividad under project FIS2012-31079 and the Fundación Séneca of Murcia under projects 15419/PI/10 and 15345/PI/10

Covariance of lucky images: Performance analysis

The covariance of ground-based lucky images is a robust and easy-to-use algorithm that allows us to detect faint companions surrounding a host star. In this paper, we analyse the relevance of the number of processed frames, the frames' quality, the atmosphere conditions and the detection noise on the companion detectability. This analysis has been carried out using both experimental and computer-simulated imaging data. Although the technique allows us the detection of faint companions, the camera detection noise and the use of a limited number of frames reduce the minimum detectable companion intensity to around 1000 times fainter than that of the host star when placed at an angular distance corresponding to the few first Airy rings. The reachable contrast could be even larger when detecting companions with the assistance of an adaptive optics system.This research was supported by the Ministerio de Economía y Competitividad under project FIS2012-31079. We would like to thank the technical staff of the Calar Alto Observatory in Spain for all its help with the observations

Applied diagnostics in liver cancer. Efficient combinations of sorafenib with targeted inhibitors blocking AKT/mTOR

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. There is increasing interest in developing specific markers to serve as predictors of response to sorafenib and to guide targeted therapy. Using a sequencing platform designed to study somatic mutations in a selection of 112 genes (HepatoExome), we aimed to characterize lesions from HCC patients and cell lines, and to use the data to study the biological and mechanistic effects of case-specific targeted therapies used alone or in combination with sorafenib. We characterized 331 HCC cases in silico and 32 paired samples obtained prospectively from primary tumors of HCC patients. Each case was analyzed in a time compatible with the requirements of the clinic (within 15 days). In 53% of the discovery cohort cases, we detected unique mutational signatures, with up to 34% of them carrying mutated genes with the potential to guide therapy. In a panel of HCC cell lines, each characterized by a specific mutational signature, sorafenib elicited heterogeneous mechanistic and biological responses, whereas targeted therapy provoked the robust inhibition of cell proliferation and DNA synthesis along with the blockage of AKT/mTOR signaling. The combination of sorafenib with targeted therapies exhibited synergistic anti-HCC biological activity concomitantly with highly effective inhibition of MAPK and AKT/mTOR signaling. Thus, somatic mutations may lead to identify case-specific mechanisms of disease in HCC lesions arising from multiple etiologies. Moreover, targeted therapies guided by molecular characterization, used alone or in combination with sorafenib, can effectively block important HCC disease mechanisms.FUNDING: Grants from ISCIII, co-financed by the European Union (FEDER) (PI16/00156), Ramón and Cajal research program from MINECO (RYC-2013-14097) and FUNDACIÓN LUCHAMOS POR LA VIDA to JPV. Grants from ISCIII (RD06/0020/0107-RD012/0036/0060) to MAP. Grant from ISCIII (Ref. PIE15/00079) to JC & JPV. NGD is a recipient of a UC-IDIVAL pre-doctoral fellow. I.V. was also supported by the Ramón and Cajal research program

The E-ELT first light spectrograph HARMONI: capabilities and modes

Trabajo presentado en SPIE Astronomical Telescopes, celebrado en San Diego (California), del 26 de junio al 1 de julio de 2016HARMONI is the E-ELT's first light visible and near-infrared integral field spectrograph. It will provide four different spatial scales, ranging from coarse spaxels of 60 × 30 mas best suited for seeing limited observations, to 4 mas spaxels that Nyquist sample the diffraction limited point spread function of the E-ELT at near-infrared wavelengths. Each spaxel scale may be combined with eleven spectral settings, that provide a range of spectral resolving powers (R 3500, 7500 and 20000) and instantaneous wavelength coverage spanning the 0.5 - 2.4 ¿m wavelength range of the instrument. In autumn 2015, the HARMONI project started the Preliminary Design Phase, following signature of the contract to design, build, test and commission the instrument, signed between the European Southern Observatory and the UK Science and Technology Facilities Council. Crucially, the contract also includes the preliminary design of the HARMONI Laser Tomographic Adaptive Optics system. The instrument's technical specifications were finalized in the period leading up to contract signature. In this paper, we report on the first activity carried out during preliminary design, defining the baseline architecture for the system, and the trade-off studies leading up to the choice of baseline

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies