DR9.3 Final report of the JRRM and ASM activities

Deliverable del projecte europeu NEWCOM++This deliverable provides the final report with the summary of the activities carried out in NEWCOM++ WPR9, with a particular focus on those obtained during the last year. They address on the one hand RRM and JRRM strategies in heterogeneous scenarios and, on the other hand, spectrum management and opportunistic spectrum access to achieve an efficient spectrum usage. Main outcomes of the workpackage as well as integration indicators are also summarised.Postprint (published version

D11.2 Consolidated results on the performance limits of wireless communications

Deliverable D11.2 del projecte europeu NEWCOM#The report presents the Intermediate Results of N# JRAs on Performance Limits of Wireless Communications and highlights the fundamental issues that have been investigated by the WP1.1. The report illustrates the Joint Research Activities (JRAs) already identified during the first year of the project which are currently ongoing. For each activity there is a description, an illustration of the adherence and relevance with the identified fundamental open issues, a short presentation of the preliminary results, and a roadmap for the joint research work in the next year. Appendices for each JRA give technical details on the scientific activity in each JRA.Peer ReviewedPreprin

VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad

Acta de congresoLa conmemoración de los cien años de la Reforma Universitaria de 1918 se presentó como una ocasión propicia para debatir el rol de la historia, la teoría y la crítica en la formación y en la práctica profesional de diseñadores, arquitectos y urbanistas. En ese marco el VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad constituyó un espacio de intercambio y reflexión cuya realización ha sido posible gracias a la colaboración entre Facultades de Arquitectura, Urbanismo y Diseño de la Universidad Nacional y la Facultad de Arquitectura de la Universidad Católica de Córdoba, contando además con la activa participación de mayoría de las Facultades, Centros e Institutos de Historia de la Arquitectura del país y la región. Orientado en su convocatoria tanto a docentes como a estudiantes de Arquitectura y Diseño Industrial de todos los niveles de la FAUD-UNC promovió el debate de ideas a partir de experiencias concretas en instancias tales como mesas temáticas de carácter interdisciplinario, que adoptaron la modalidad de presentación de ponencias, entre otras actividades. En el ámbito de VIII Encuentro, desarrollado en la sede Ciudad Universitaria de Córdoba, se desplegaron numerosas posiciones sobre la enseñanza, la investigación y la formación en historia, teoría y crítica del diseño, la arquitectura y la ciudad; sumándose el aporte realizado a través de sus respectivas conferencias de Ana Clarisa Agüero, Bibiana Cicutti, Fernando Aliata y Alberto Petrina. El conjunto de ponencias que se publican en este Repositorio de la UNC son el resultado de dos intensas jornadas de exposiciones, cuyos contenidos han posibilitado actualizar viejos dilemas y promover nuevos debates. El evento recibió el apoyo de las autoridades de la FAUD-UNC, en especial de la Secretaría de Investigación y de la Biblioteca de nuestra casa, como así también de la Facultad de Arquitectura de la UCC; va para todos ellos un especial agradecimiento

Evaluation of the antiviral activity of an aqueous extract from Solidago virgaurea against Herpes simplex virus type 2

Herpes simplex virus type 2 (HSV-2) is widely distributed through the human population, infecting more than 500 million people globally [1]. Although typically causing mild diseases this virus may be responsible for severe infections, mainly in immunocompromised patients. Currently, there is a number of systemic antiviral agents against herpesvirus, the most commonly used being acyclovir and related drugs. However, long term treatments with these drugs may result in the development of resistance, especially in immunocompromised patients, which leads to a continuous search for new and better therapeutic alternatives [2]. According to the World Health Organization plants are the best sources for obtaining a wide variety of drugs [3]. So, in the last decades many pharmacological and chemical studies have focused on medicinal plants to the discovery of new natural antiviral compounds.Financial support: CESAM (UID/AMB/50017), Centro de Química e Bioquimica (UID/MULTI/00612/2013) and FCT/MEC through national funds and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020.N/

Utilización de internet como vía de información médica para el paciente sometido a radioterapia: revisión y presentación de un proyecto de estudio

Recientemente, las publicaciones populares y profesionales relacionadas con los cuidados de la salud han comenzado a expresar su interés acerca de Internet como recurso para obtener información medica y apoyo psicológico para aquellas personas diagnosticadas de diversas enfermedades. El presente articulo es una revisión sobre el impacto que la información obtenida a través de Internet ocasiona en el paciente sometido a radioterapia y la posible utilidad de las nuevas vías de información para proporcionar cuidados clínicos de soporte más individualizados. Presentamos un proyecto de estudio para evaluar la influencia de la información medica en Internet en el paciente y en el equipo asistencial.Recently, both popular and professional publications about health care have begun to express enthusiasm for the Internet as a source of medical information and possibly of psychological support for those with serious illnesses. We review here the published studies that analyze the impact of Internet information on patients receiving radiation therapy. A research project is under development in order to investigate how users evaluate the information they find in Internet and the possible influence of this information in their psicological status, quality of life, and relation with the clinical staff

DR9.3 Final report of the JRRM and ASM activities

Deliverable del projecte europeu NEWCOM++This deliverable provides the final report with the summary of the activities carried out in NEWCOM++ WPR9, with a particular focus on those obtained during the last year. They address on the one hand RRM and JRRM strategies in heterogeneous scenarios and, on the other hand, spectrum management and opportunistic spectrum access to achieve an efficient spectrum usage. Main outcomes of the workpackage as well as integration indicators are also summarised

Target Dissemination Level: PU Status of the Document:

This addendum summarises the discussions that happened after the release of version 1.0 of the D.C.1 Deliverable. Thus, it clarifies the motivation and vision of OConS, highlights the key design principles, defines the networking concepts used, and presents the main building blocks. Moreover, it specifies a revised focus of the OConS work around two use-cases centred on the SAIL flash crowd scenario (rather than four as specified in D.A.1): OConS for CloNe – “Mobile access and data centre interconnect”, and OConS for NetInf – “Mobile and Multi-P for information-centric networking”. The experimentation and prototyping activities will be closely aligned with this refocused work. Disclaimer: This document has been produced in the context of the SAIL Project. The research leading to these results has received funding from the European Community's Seventh Framework Programme ([FP7/2010-2013] [FP7/2010-2013]) under grant agreement n ° 257448 All information in this document is provided "as is " and no guarantee or warranty is given that the information is fit for any particular purpose. The user thereof uses the information at its sole risk and liability. For the avoidance of all doubts, the European Commission has no liability in respect of this document, which is merel

Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma

Approximately 20% of head and neck squamous cell carcinomas (HNSCC) exhibit reduced methylation on lysine 36 of histone H3 (H3K36me) due to mutations in histone methylase NSD1 or a lysine-to-methionine mutation in histone H3 (H3K36M). Whether such alterations of H3K36me can be exploited for therapeutic interventions is still unknown. Here, we show that HNSCC models expressing H3K36M can be divided into two groups: those that display aberrant accumulation of H3K27me3 and those that maintain steady levels of H3K27me3. The first group shows decreased proliferation, genome instability, and increased sensitivity to genotoxic agents, such as PARP1/2 inhibitors. In contrast, the H3K36M HNSCC models with steady H3K27me3 levels do not exhibit these characteristics unless H3K27me3 levels are elevated, either by DNA hypomethylating agents or by inhibiting the H3K27me3 demethylases KDM6A/B. Mechanistically, we found that H3K36M reduces H3K36me by directly impeding the activities of the histone methyltransferase NSD3 and the histone demethylase LSD2. Notably, we found that aberrant H3K27me3 levels induced by H3K36M expression is not a bona fide epigenetic mark in HNSCC since it requires continuous expression of H3K36M to be inherited. Moreover, increased sensitivity of H3K36M HNSCC models to PARP1/2 inhibitors solely depends on the increased H3K27me3 levels. Indeed, aberrantly high H3K27me3 levels decrease BRCA1 and FANCD2-dependent DNA repair, resulting in higher sensitivity to DNA breaks and replication stress. Finally, in support of our in vitro findings, a PARP1/2 inhibitor alone reduce tumor burden in a H3K36M HNSCC xenograft model with elevated H3K27me3, whereas in a H3K36M HNSCC xenograft model with consistent H3K27me3 levels, a combination of PARP1/2 inhibitors and agents that upregulate H3K27me3 proves to be successful. In conclusion, our findings underscore a delicate balance between H3K36 and H3K27 methylation, essential for maintaining genome stability. This equilibrium presents promising therapeutic opportunities for patients with H3K36me-deficient tumors

D11.2 Consolidated results on the performance limits of wireless communications

Deliverable D11.2 del projecte europeu NEWCOM#The report presents the Intermediate Results of N# JRAs on Performance Limits of Wireless Communications and highlights the fundamental issues that have been investigated by the WP1.1. The report illustrates the Joint Research Activities (JRAs) already identified during the first year of the project which are currently ongoing. For each activity there is a description, an illustration of the adherence and relevance with the identified fundamental open issues, a short presentation of the preliminary results, and a roadmap for the joint research work in the next year. Appendices for each JRA give technical details on the scientific activity in each JRA.Peer Reviewe