A preconditioning for the spectral solution of incompressible variable-density flows

In the present study, the efficiency of preconditioners for solving linear systems associated with the discretized variable-density incompressible Navier-Stokes equations with semiimplicit second-order accuracy in time and spectral accuracy in space is investigated. The method, in which the inverse operator for the constant-density flow system acts as preconditioner, is implemented for three iterative solvers: the General Minimal Residual, the Conjugate Gradient and the Richardson Minimal Residual. We discuss the method, first, in the context of the one-dimensional flow case where a top-hat like profile for the density is used. Numerical evidence shows that the convergence is significantly improved due to the notable decrease in the condition number of the operators. Most importantly, we then validate the robustness and convergence properties of the method on two more realistic problems: the two-dimensional Rayleigh-Taylor instability problem and the three-dimensional variable-density swirling jet

Space–time dynamics of optimal wavepackets for streaks in a channel entrance flow

The laminar–turbulent transition of a plane channel entrance flow is revisited using global linear optimization analyses and direct numerical simulations. The investigated case corresponds to uniform upstream velocity conditions and a moderate value of Reynolds number so that the two-dimensional developing flow is linearly stable under the parallel flow assumption. However, the boundary layers in the entry zone are capable of supporting the development of streaks, which may experience secondary instability and evolve to turbulence. In this study, global optimal linear perturbations are computed and studied in the nonlinear regime for different values of streak amplitude and optimization time. These optimal perturbations take the form of wavepackets having either varicose or sinuous symmetry. It is shown that, for short optimization times, varicose wavepackets grow through a combination of Orr and lift-up effects, whereas for longer target times, both sinuous and varicose wavepackets exhibit an instability mechanism driven by the presence of inflection points in the streaky flow. In addition, while the optimal varicose modes obtained for short optimization times are localized near the inlet, where the base flow is strongly three-dimensional, when the target time is increased, the sinuous and varicose optimal modes are displaced farther downstream, in the nearly parallel streaky flow. Finally, the optimal wavepackets are found to lead to turbulence for sufficiently high initial amplitudes. It is noticed that the resulting turbulent flows have the same wall-shear stress, whether the wavepackets have been obtained for short or for long time optimization

Magnetic characterization of isolated candidate vertebrate magnetoreceptor cells

Over the past 50 y, behavioral experiments have produced a large body of evidence for the existence of a magnetic sense in a wide range of animals. However, the underlying sensory physiology remains poorly understood due to the elusiveness of the magnetosensory structures. Here we present an effective method for isolating and characterizing potential magnetite-based magnetoreceptor cells. In essence, a rotating magnetic field is employed to visually identify, within a dissociated tissue preparation, cells that contain magnetic material by their rotational behavior. As a tissue of choice, we selected trout olfactory epithelium that has been previously suggested to host candidate magnetoreceptor cells. We were able to reproducibly detect magnetic cells and to determine their magnetic dipole moment. The obtained values (4 to 100 fAm^2) greatly exceed previous estimates (0.5 fAm^2). The magnetism of the cells is due to a μm-sized intracellular structure of iron-rich crystals, most likely single-domain magnetite. In confocal reflectance imaging, these produce bright reflective spots close to the cell membrane. The magnetic inclusions are found to be firmly coupled to the cell membrane, enabling a direct transduction of mechanical stress produced by magnetic torque acting on the cellular dipole in situ. Our results show that the magnetically identified cells clearly meet the physical requirements for a magnetoreceptor capable of rapidly detecting small changes in the external magnetic field. This would also explain interference of ac powerline magnetic fields with magnetoreception, as reported in cattle

Co‐developing guidance for conservation: An example for seabirds in the North‐East Atlantic in the face of climate change impacts

Conservation guidance—an authoritative source of information and recommendations explicitly supporting decision-making and action regarding nature conservation—represents an important tool to communicate evidence-based advice to conservation actors. Given the rapidly increasing pressure that climate change poses to biodiversity, producing accessible, well-informed guidance on how to best manage the impacts and risks of changing climatic conditions is particularly urgent. Guidance documents should ideally be produced with multistage input from stakeholders who are likely to use and implement such advice; however, this step can be complicated and costly, and remains largely unformalized. Moreover, there is currently little direct evidence synthesized for actions that specifically target climate change and guidance remains largely absent. Here, we introduce a process for co-developing guidance for species conservation in the face of climate change, using seabirds in the North-East Atlantic as a case study. Specifically, we collated evidence on climate change vulnerability and possible conservation actions using literature synthesis, stakeholder surveys, and ecological modeling. This evidence base was then discussed, refined, and expanded using structured stakeholder workshops. We summarize the knowledge gained through stakeholder engagement and provide recommendations for future international efforts to co-produce conservation guidance for managing wildlife, in the context of a rapidly changing climate.info:eu-repo/semantics/publishedVersio

Topological insights in polynuclear Ni/Na coordination clusters derived from a schiff base ligand

This article presents the syntheses, crystal structures, topological features and magnetic properties of two NiII/NaI coordination clusters (CCs) formulated [NiII3Na(L1)3(HL1 (MeOH)2] (1) and [NiII6Na(L1)5(CO3)(MeO (MeOH)3(H2O)3]·4(MeOH) 2(H2O) [2 4(MeOH) 2(H2O)] where H2L1 is the semi rigid Schiff base ligand (E)-2-(2-hydroxy-3 methoxybenzylideneamino)-phenol). Compound 1 possesses a rare NiII3NaI cubane (3M4-1) topology and compound 2 is the first example in polynuclear Ni/Na chemistry that exhibits a 2,3,4M7-1 topology

Progress Report on Target Development

The present document is the D08 deliverable report of work package 1 (Target Development) from the MEGAPIE TEST project of the 5th European Framework Program. Deliverable D08 is the progress report on the activities performed within WP 1. The due date of this deliverable was the 5th month after the start of the EU project. This coincided with a technical status meeting of the MEGAPIE Initiative, that was held in March 2002 in Bologna (Italy). The content of the present document reflects the status of the MEGAPIE target development at that stage. It gives an overview of the Target Design, the related Design Support activities and the progress of the work done for the safety assessment and licensing of the target

Achieving coherence between the Marine Strategy Framework Directive and the Maritime Spatial Planning Directive

Alignment and coordination of the Marine Strategy Framework Directive (MSFD) with other key policies is considered indispensable to accomplish its objectives. To ensure that economic activities do not generate unsustainable pressures in the marine environment, it is imperative to streamline the MSFD with the Maritime Spatial Planning Directive (MSPD), the policy regulating the spatial dimension of maritime activities and their planning. To investigate the coherence between the MSFD and MSPD, an analysis was performed in the framework of MEDREGION project (11.0661/2018/794286/SUB/ENV.C2) on the conceptual relations of the two processes. The needs and challenges encountered by MSFD Competent Authorities (CAs) in the implementation of the Directives were considered, while the Programmes of Measures (PoMs) established by Mediterranean Member States (MSs) for selected MSFD Descriptors were analysed to see whether measures can contribute to the integration of the two Directives. The MSPD implementation considers the MSFD provisions, however, there are still challenges and gaps for an effective integration. Herein, recommendations are made to face these challenges and facilitate the alignment of the two Directives. Moreover, the analysis of the MSFD PoMs shows that the MSFD identifies, directly or indirectly, human activities related to Maritime Spatial Planning (MSP) sectors and addresses them with specific measures. Therefore, MSFD PoMs constitute a concrete basis for the planning of the marine space, thus, bridging the two Directives, avoiding conflicts and facilitating synergies.The research leading to these results has received funding from the European Commission Directorate General for the Environment under grant agreement n° 11.0661/2018/794286/SUB/ENV.C2 – MEDREGION project (Support Mediterranean Member States towards implementation of the MSFD New GES Decision and programmes of measures and contribute to regional/subregional cooperation).Peer reviewe

Multi-omics signatures of the human early life exposome

Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations (https://helixomics.isglobal.org/) will serve to guide future investigation into the biological imprints of the early life exposome

Labor-Market Performance in the OECD: An Assessment of Recent Evidence

In this paper we assess the evolution of labor-market performance in the Organisation for Economic Co-operation and Development (OECD) over the last decade. We provide a survey of the literature dealing with labor-market performance in the OECD, finding that, while this literature tends to conclude that institutions are a key part of the story, the survey's results appear far less robust and uniform than is commonly believed. We then assess the robustness of the claims made in the most recent (2005) OECD followup study within a very similar cross-country setup, and highlight the impact of unobserved heterogeneity and outliers on the policy estimates. We find that in recent OECD cross-country data, changes in labor-market performance are consistently (and inversely) linked to its lagged level. Structural changes are also important: changes in the share of construction employees are very significant, even in the presence of various kinds of policy change indicators. As far as the latter are concerned, some consistent role seems to emerge only for active labor-market policies and (to a lesser extent) unemployment benefit reforms