LRP2 mediates folate uptake in the developing neural tube

The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2) is a multifunctional cell surface receptor expressed in the embryonic neuroepithelium. Loss of LRP2 in the developing murine central nervous system (CNS) causes impaired closure of the rostral neural tube at embryonic stage (E) 9.0. Similar neural tube defects (NTDs) have previously been attributed to impaired folate metabolism in mice. We therefore asked whether LRP2 might be required for delivery of folate to neuroepithelial cells during neurulation. Uptake assays in whole embryo cultures showed that LRP2 deficient neuroepithelial cells are unable to mediate uptake of folate bound to soluble folate receptor 1 (sFOLR1). Consequently, folate concentrations are significantly reduced in Lrp2(-/-) embryos compared to control littermates. Moreover, the folic acid dependent gene Alx3 is significantly down regulated in Lrp2 mutants. In conclusion, we show that LRP2 is essential for cellular folate uptake in the developing neural tube, a crucial step for proper neural tube closure

Geology of the Nevado Coropuna volcanic complex

The Nevado Coropuna volcanic complex (NCVC), located in the northernmost CAVZ (15°3’ S, 72º39’ W), includes several edifices, aligned WNW-ESE above Neogene ignimbrites. Adjacent composite volcanoes include the Late Pliocene, eroded Sunjillpa to the WNW and the glacially eroded, 0.6-0.25 Ma-old Cunciacha to the ESE. Located on the west flank of the Western Cordillera, the asymmetric volcanic complex shows stubby lava flows overlying the NE, 4500 m-high plateau, contrasting with long, inverted lava flows and debris-avalanche deposits filling deep valleys draining the steep SW flanks. The central, highest NCVC is a cluster of five, aligned lava domes reaching 6160 and 6330 masl. The dome cluster and its voluminous lava flows overlie an old stratovolcano with inverted lava flows dated at 1.02 Ma. The 0.4 Ma-old base of dome cluster is overlain by lower lava flows c. 270 - 254 ka, middle lava flows c. 118 - 108 ka, and the uppermost lava domes 70 – 60 ka. A high-spatial resolution DEM shows six vents on the domes and one collapse scar open to the south. NCVC has grown atop a caldera as shown by AMS data collected on Early Quaternary ignimbrites dipping away west, south and east of NCVC, and by abnormal contacts with both adjacent volcanoes to the WNW and the ESE. All lavas show two major compositional fields of high-K andesites and dacites (SiO2 57-67%wt). Harker diagrams and trace elements suggest AFC magmatic processes. Although CNVC tephra and PDC deposits represent a small volume, we observed Late Glacial Plinian fallout are scattered and Holocene ashfall layers are associated with three lava flows, the youngest being 1700 to 2400 yr old. The Nevado Coropuna ice cap c. 44.1 km2 is arguably the largest in the world tropical belt

Chromosome studies on the silky anteater Cyclopes Didactylus L. (Myrmecophagidae: Xenarthra, Edentata)

The karyotype of the silky anteater Cyclopes didactylus, the smallest of the anteaters is described. A notable difference in karyotypes exists between C. didactylus (2n = 64) and the other species of the family Myrmecophagidae. Both fusion/fission as well as other mechanisms are probably involved in the reduction of the chromosome number of 64 chromosome in Cyclopes to 60 and 54 in Tamandua and Myrmecophaga, respectively. © 1985 Taylor & Francis Group, LLC

Electromagnetic Response of Layered Superconductors with Broken Lattice Inversion Symmetry

We investigate the macroscopic effects of charge density waves (CDW) and superconductivity in layered superconducting systems with broken lattice inversion symmetry (allowing for piezoelectricity) such as two dimensional (2D) transition metal dichalcogenides (TMD). We work with the low temperature time dependent Ginzburg-Landau theory and study the coupling of lattice distortions and low energy CDW collective modes to the superconducting order parameter in the presence of electromagnetic fields. We show that superconductivity and piezoelectricity can coexist in these singular metals. Furthermore, our study indicates the nature of the quantum phase transition between a commensurate CDW phase and the stripe phase that has been observed as a function of applied pressure.Comment: 9 pages, 1 figure. Final version. Accepted in Phys.Rev.

Vegetación espontánea como reservorio de sírfidos en agroecosistemas de frutilla, Tucumán, Argentina

PosterEl cultivo de frutilla es afectado principalmente por arañuelas, trips y pulgones (Dughetti et al., 2017; Cingolani & Greco, 2018), siendo su control principalmente dependiente de agroquímicos.EEA FamailláFil: Maza, N. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Renganeschi, M.F. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Funes, Claudia Fernanda. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; ArgentinaFil: Avila, Ana Lucía. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Avila, Ana Lucía. MAPEA; ArgentinaFil: Paz, R.M. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Cabrera, C. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Kirschbaum, Daniel Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; ArgentinaFil: Kirschbaum, Daniel Santiago. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentin

The Milky Way Bulge: Observed properties and a comparison to external galaxies

The Milky Way bulge offers a unique opportunity to investigate in detail the role that different processes such as dynamical instabilities, hierarchical merging, and dissipational collapse may have played in the history of the Galaxy formation and evolution based on its resolved stellar population properties. Large observation programmes and surveys of the bulge are providing for the first time a look into the global view of the Milky Way bulge that can be compared with the bulges of other galaxies, and be used as a template for detailed comparison with models. The Milky Way has been shown to have a box/peanut (B/P) bulge and recent evidence seems to suggest the presence of an additional spheroidal component. In this review we summarise the global chemical abundances, kinematics and structural properties that allow us to disentangle these multiple components and provide constraints to understand their origin. The investigation of both detailed and global properties of the bulge now provide us with the opportunity to characterise the bulge as observed in models, and to place the mixed component bulge scenario in the general context of external galaxies. When writing this review, we considered the perspectives of researchers working with the Milky Way and researchers working with external galaxies. It is an attempt to approach both communities for a fruitful exchange of ideas.Comment: Review article to appear in "Galactic Bulges", Editors: Laurikainen E., Peletier R., Gadotti D., Springer Publishing. 36 pages, 10 figure

Exclusion limits on the WIMP-nucleon cross-section from the Cryogenic Dark Matter Search

The Cryogenic Dark Matter Search (CDMS) employs low-temperature Ge and Si detectors to search for Weakly Interacting Massive Particles (WIMPs) via their elastic-scattering interactions with nuclei while discriminating against interactions of background particles. For recoil energies above 10 keV, events due to background photons are rejected with >99.9% efficiency, and surface events are rejected with >95% efficiency. The estimate of the background due to neutrons is based primarily on the observation of multiple-scatter events that should all be neutrons. Data selection is determined primarily by examining calibration data and vetoed events. Resulting efficiencies should be accurate to about 10%. Results of CDMS data from 1998 and 1999 with a relaxed fiducial-volume cut (resulting in 15.8 kg-days exposure on Ge) are consistent with an earlier analysis with a more restrictive fiducial-volume cut. Twenty-three WIMP candidate events are observed, but these events are consistent with a background from neutrons in all ways tested. Resulting limits on the spin-independent WIMP-nucleon elastic-scattering cross-section exclude unexplored parameter space for WIMPs with masses between 10-70 GeV c^{-2}. These limits border, but do not exclude, parameter space allowed by supersymmetry models and accelerator constraints. Results are compatible with some regions reported as allowed at 3-sigma by the annual-modulation measurement of the DAMA collaboration. However, under the assumptions of standard WIMP interactions and a standard halo, the results are incompatible with the DAMA most likely value at >99.9% CL, and are incompatible with the model-independent annual-modulation signal of DAMA at 99.99% CL in the asymptotic limit.Comment: 40 pages, 49 figures (4 in color), submitted to Phys. Rev. D; v.2:clarified conclusions, added content and references based on referee's and readers' comments; v.3: clarified introductory sections, added figure based on referee's comment

The ALHAMBRA survey: evolution of galaxy clustering since z ~ 1

We study the clustering of galaxies as function of luminosity and redshift in the range 0.35 < z < 1.25 using data from the Advanced Large Homogeneous Area Medium-Band Redshift Astronomical (ALHAMBRA) survey. The ALHAMBRA data used in this work cover 2.38 deg2 in seven independent fields, after applying a detailed angular selection mask, with accurate photometric redshifts, σz ≲ 0.014(1 + z), down to IAB < 24. Given the depth of the survey, we select samples in B-band luminosity down to Lth ≃ 0.16L* at z = 0.9. We measure the real-space clustering using the projected correlation function, accounting for photometric redshifts uncertainties. We infer the galaxy bias, and study its evolution with luminosity. We study the effect of sample variance, and confirm earlier results that the Cosmic Evolution Survey (COSMOS) and European Large Area ISO Survey North 1 (ELAIS-N1) fields are dominated by the presence of large structures. For the intermediate and bright samples, Lmed ≳ 0.6L*, we obtain a strong dependence of bias on luminosity, in agreement with previous results at similar redshift. We are able to extend this study to fainter luminosities, where we obtain an almost flat relation, similar to that observed at low redshift. Regarding the evolution of bias with redshift, our results suggest that the different galaxy populations studied reside in haloes covering a range in mass between log10[Mh/( h−1 M⊙)] ≳ 11.5 for samples with Lmed ≃ 0.3L* and log10[Mh/( h−1 M⊙)] ≳ 13.0 for samples with Lmed ≃ 2L*, with typical occupation numbers in the range of ∼1–3 galaxies per halo