Competencias digitales y resiliencia en profesores de nivel inicial, Juliaca, 2022

El presente trabajo responde al objetivo de determinar el nivel de relación entre las competencias digitales y la resiliencia de los profesores de nivel inicial, Juliaca, 2022 y con objetivos específicos de determinar el nivel de relación entre las dimensiones (Información y alfabetización informacional, comunicación y colaboración, creación de contenidos, seguridad y resolución de problemas) de las competencias digitales y la resiliencia. Se utilizaron dos cuestionarios diseñados para la población de estudio los cuales fueron validados por expertos como también una validación de confiabilidad de alfa de Cronbach, así mismo la muestra fue de 118 profesores de instituciones educativas de nivel inicial escolarizadas de la ciudad de Juliaca que laboraron en el año académico 2022. De las conclusiones resultantes del presente estudio se destaca la correlación directa positiva media que se tienen entre ambas variables con un coeficiente de correlación de 0.513 y coeficientes de correlación de 0.413; 0.435; 0.525; 0.377 y 0.420 respectivamente por cada dimensión

Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation

Block copolymer dispersions that form gels at body temperature and that additionally are able to reduce a gold salt to nanoparticles (AuNPs) directly in the final formulation under mild conditions were designed as hybrid depots for photothermal therapy. The in situ gelling systems may retain AuNPs in the application zone for a long time so that localized elevations of temperature can be achieved each time the zone is irradiated. To carry out the work, dispersions were prepared covering a wide range of poloxamine Tetronic 1307:gold salt molar ratios in NaCl media (also varying from pure water to hypertonic solution). Even at copolymer concentrations well above the critical micelle concentration, the reducing power of the copolymer was maintained, and AuNPs were formed in few hours without extra additives. Varying the copolymer and NaCl concentrations allowed a fine tuning of nanoparticles’ shape from spherical to triangular nanoplates, which determined that the surface plasmon resonance showed a maximum intensity at 540 nm or at 1000 nm, respectively. The information gathered on the effects of (i) the poloxamine concentration on AuNPs’ size and shape under isotonic conditions, (ii) the AuNPs on the temperature-induced gelling transition, and (iii) the gel properties on the photothermal responsiveness of the AuNPs during successive irradiation cycles may help the rational design of one-pot gels with built-in temperature and light responsiveness.This research was funded by MINECO (SAF2017-83118-R; MAT2016-80266-R), Agencia Estatal de Investigación (AEI) Spain, Xunta de Galicia (Grupo de Referencia Competitiva ED431C 2016/008; Agrupación Estratégica en Materiales-AEMAT ED431E 2018/08), and FEDER (Spain). S.C.-M. acknowledges a Xunta de Galicia predoctoral grantS

Recent insights in magnetic hyperthermia: From the “hot-spot” effect for local delivery to combined magneto-photo-thermia using magneto-plasmonic hybrids

International audienceMagnetic hyperthermia which exploits the heat generated by magnetic nanoparticles (MNPs) when exposed to an alternative magnetic field (AMF) is now in clinical trials for the treatment of cancers. However, this thermal therapy requires a high amount of MNPs in the tumor to be efficient. On the contrary the hot spot local effect refers to the use of specific temperature profile at the vicinity of nanoparticles for heating with minor to no long-range effect. This magneto-thermal effect can be exploited as a relevant external stimulus to temporally and spatially trigger drug release.In this review, we focus on recent advances in magnetic hyperthermia. Indirect experimental proofs of the local temperature increase are first discussed leading to a good estimation of the temperature at the surface (from 0.5 to 6 nm) of superparamagnetic NPs. Then we highlight recent studies illustrating the hot-spot effect for drug- release. Finally, we present another recent strategy to enhance the efficacity of thermal treatment by combining photothermal therapy with magnetic hyperthermia mediated by magneto-plasmonic nanoplatforms

Lectura de contexto y abordaje psicosocial desde los enfoques narrativos Cartagena.

Lectura de contexto y abordaje psicosocial desde los enfoques narrativos Cartagena.El conflicto armado que ha sufrido el país en las últimas seis décadas ha afectado la sociedad civil, la institucionalidad y la población en general. El impacto del conflicto en Colombia, como en todos los países donde ocurren este tipo de guerras, afectando a la sociedad. El proceso de la guerra han producido muchos efectos adversos en la población en genral de diferente manera, no solo en la salud mental y el bienestar sino en la estructura y el tejido social de un país, más cuándo los afectados son los niños, niñas y adolescentes. El presente trabajo fue realizado bajo emergentes psicosociales, los impactos que quedaron en la memoria de cada una de las víctimas, proponer acciones de apoyo en trabajo colaborativo en caso Pandurí, establecer estrategias psicosociales con los pobladores.The armed conflict that the country has suffered in the last six decades has affected civil society, institutions and the population in general. The impact of the conflict in Colombia, as in all countries where this type of war occurs, affecting society. The war process has produced many adverse effects on the general population in different ways, not only in mental health and well-being, but also in the structure and social fabric of a country, especially when children and children are affected. teenagers. the present work was carried out under psychosocial emergencies, the impacts that remained in the memory of each one of the victims, propose support actions in collaborative work in Pandurí case, establish psychosocial strategies with the inhabitants

Praxis in laboratories for research and production in arts: background and possibilities of institutional development

En el marco del Taller de Tesis de Investigación en la orientación de Teoría y Crítica de la carrera de Artes Audiovisuales de la Facultad de Artes (FDA) de la Universidad de La Plata (UNLP), nos proponemos llevar adelante un proceso de tesis colectiva, de investigación y producción teórica a partir del análisis de producciones regionales en relación con las artes audiovisuales.1 Este trabajo forma parte de esta realización colaborativa. Desde esta perspectiva, el presente proyecto de investigación pretende describir y analizar los aspectos metodológicos desarrollados en torno a los laboratorios de investigación y producción en artes, haciendo énfasis en la problemática sobre el lugar de la praxis y el desarrollo de conocimientos y saberes dentro del campo artístico desde la noción de trabajo colectivo. Su abordaje está pensado particularmente en vínculo con las instituciones académicas y educativas, por lo que su recorte espacio-temporal está alojado en el último plan vigente (2008) de la licenciatura en Artes Audiovisuales, perteneciente a la FDA de la UNLP.Understanding the laboratory as a workplace where knowledge is built, this paper intends to describe and analyze the operation of research and production laboratories in arts developed around the cinematographic careers of the Argentine Republic in general and in the faculty of Arts, from the National University of La Plata (UNLP), in particular. Faced with the problem of a vacancy in relation to the development of these spaces in institutional frameworks, its main objective is to conduct an exploration and establish a descriptive-analytical bridge with the state of the art in the period developed around the last current plan (2008) of the Audiovisual Arts career of the FDA-UNLP. Finally, its results are expected to foster research development from a notion of praxis, which will return to the artistic community in general and to our discipline in particular, its place as fields of construction and production of knowledge.Facultad de Arte

Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation

Block copolymer dispersions that form gels at body temperature and that additionally are able to reduce a gold salt to nanoparticles (AuNPs) directly in the final formulation under mild conditions were designed as hybrid depots for photothermal therapy. The in situ gelling systems may retain AuNPs in the application zone for a long time so that localized elevations of temperature can be achieved each time the zone is irradiated. To carry out the work, dispersions were prepared covering a wide range of poloxamine Tetronic 1307:gold salt molar ratios in NaCl media (also varying from pure water to hypertonic solution). Even at copolymer concentrations well above the critical micelle concentration, the reducing power of the copolymer was maintained, and AuNPs were formed in few hours without extra additives. Varying the copolymer and NaCl concentrations allowed a fine tuning of nanoparticles’ shape from spherical to triangular nanoplates, which determined that the surface plasmon resonance showed a maximum intensity at 540 nm or at 1000 nm, respectively. The information gathered on the effects of (i) the poloxamine concentration on AuNPs’ size and shape under isotonic conditions, (ii) the AuNPs on the temperature-induced gelling transition, and (iii) the gel properties on the photothermal responsiveness of the AuNPs during successive irradiation cycles may help the rational design of one-pot gels with built-in temperature and light responsiveness

Iron Oxide Nanoflowers @ CuS Hybrids for Cancer Tri-Therapy: Interplay of Photothermal Therapy, Magnetic Hyperthermia and Photodynamic Therapy

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Intracellular Biodegradation of Ag Nanoparticles, Storage in Ferritin, and Protection by a Au Shell for Enhanced Photothermal Therapy

International audienceDespite their highly efficient plasmonic properties, gold nanoparticles are currently preferred to silver nanoparticles for biomedical applications such as photothermal therapy due to their high chemical stability in the biological environment. To confer protection while preserving their plasmonic properties, we allied the advantages of both materials and produced hybrid nanoparticles made of an anisotropic silver nanoplate core coated with a frame of gold. The efficiency of these hybrid nanoparticles (Ag@AuNPs) in photothermia was compared to monometallic silver nanoplates (AgNPs) or gold nanostars (AuNPs). The structural and functional properties of AuNPs, AgNPs, and Ag@AuNPs were investigated in environments of increasing complexity, in water suspensions, in cells, and in tumors in vivo. While AgNPs showed the greatest heating efficiency in suspension (followed by Ag@AuNPs and AuNPs), this trend was reversed intracellularly within a tissue-mimetic model. In this setup, AgNPs failed to provide consistent photothermal conversion over time, due to structural damage induced by the intracellular environment. Remarkably, the degraded Ag was found to be stored within the iron-storage ferritin protein. By contrast, the Au shell provided the Ag@AuNPs with total Ag biopersistence. As a result, photothermal therapy was successful with Ag@AuNPs in vivo in a mouse tumor model, providing the ultimate proof on Au shell's capability to shield the Ag core from the harsh biological environment and preserve its excellent heating properties