Feocromocitoma canino: reporte de un caso

This paper reports a case of pheochromocytoma in a 20-year old mongrel breed dog female submitted to a consultation at the Small Animal Vet Hospital “Dr. Santiago Reyes Amaya” in Bucaramanga. Patient had clinical neurological symptoms (seizure episodes and ataxia), among other symptoms. Clinical examination found a patient with severe symptoms of pain, tachypnea, tachycardia, tetraparesis, nystagmus, anterior-and-posterior limb proprioception loss, impaired mental status, hyper-reflexia, and abdominal pain. The neurological examination of cranial nerves I-III-V-VII-XI resulted in abnormality, cephalic and cervical inclination towards left side. A hematological examination was performed, including complete blood count and blood biochemistry (liver and renal profile), and also skull radiographies, but everything was normal. After reporting neurological status with a medical report of poor prognosis, and taking into account the patient’s general condition and age, owner decided to perform euthanasia. So patient was available to the clinic with the owner permission to perform autopsy for academic purposes. The goal of this paper is review general aspects of canine pheochromocytoma, reporting a case.Este artículo reporta un caso clínico de feocromocitoma en un paciente canino hembra, de raza criolla con 20 años de edad, que se presentó a consulta en la clínica veterinaria de pequeños animales “Dr. Santiago Reyes Amaya” de Bucaramanga. La paciente presentaba un cuadro clínico con sintomatología nerviosa (episodios convulsivos y ataxia), entre otros síntomas. Al examen clínico se encontró una paciente con fuertes manifestaciones de dolor, taquipnea, taquicardia, tetraparesia, nistagmos, pérdida de propiocepción tanto en miembros anteriores como posteriores, alteración de su estado mental, hiperreflexia, dolor abdominal. En la evaluación neurológica de los pares craneales I-III-V-VII-XI, se encontró anormalidad, inclinación cefálica y cervical hacia lateral izquierdo. Se realizó análisis hematológico, incluyendo hemograma y bioquímica sanguínea (perfil hepático y renal), encontrándose todos dentro de los parámetros normales, así como también radiografías de cráneo.El propietario, después de recibir el informe del estado neurológico de paciente con un parte médico de pronóstico reservado, y teniendo en cuenta la condición general del paciente y su edad (20 años), decide realizar la eutanasia. El paciente es dejado a disposición de la clínica con autorización para la realización de necropsia con fines académicos. El objetivo principal de este artículo es abordar los aspectos generales sobre el feocromocitoma canino, reportando un caso clínico

Sustainable supply chain design under correlated uncertainty in energy and carbon prices

This paper aims to provide an improvement in the modeling of supply chain designs by incorporating correlated uncertainty among multiple parameters, resulting in a more resilient design. A new methodology to generate forecasts for historically correlated time series, regardless of their underlying probability distributions, is presented and applied to generate scenarios for energy and carbon prices, which historically proved to be correlated. These scenarios are then used in a stochastic computation to obtain a three-echelon supply chain design in Europe maximizing the economic performance. The emissions were monetarized through the incorporation of the European Union cap-and-trade emissions trading system into the model. The social impact of the supply chain network is measured in terms of the direct, indirect and induced jobs it creates, which are proportional to the economic performance. By combining the developed methodology with data mining algorithms, a reduction in the number of required scenarios by more than 90% was achieved. The numerical case study moreover shows that the stochastic design ensures an average reduction of emissions by more than 3 ktons compared to the use of a deterministic approach. In comparison, the computation of a stochastic supply chain design without parameter correlation takes 5 times longer.The authors gratefully acknowledge financial support to the Conselleria de Innovacion, Universidades, Ciencia y Sociedad Digital of the Generalitat Valenciana, Spain, under project PROMETEO/2020/064 and project PID2021-124139NB-C21

Design of a Cooperative Sustainable Three-Echelon Supply Chain under Uncertainty in CO2 Allowance

Driven by the growing concern regarding greenhouse gas emissions, in this work, we provide a robust stochastic model for the design of a cooperative supply chain (SC) under uncertainty in CO2 allowance prices from the European Union Emissions Trading System (EU ETS). During the last years, CO2 allowance prices have undergone unexpected changes, having strong impact on the design and management of optimal SC. The consideration of uncertainty in the allowance prices has therefore become more important. We use an autoregressive integrated moving average (ARIMA) model to predict future allowance prices. A full discretization of the underlying probability space leads to a number of scenarios far too large to be handled, so we compare two approaches to reduce the number of scenarios to a feasible maximum, the ScenRed algorithm and K-means clustering. The obtained results are compared with a deterministic approach that is widely studied in the literature, showing an increase in the benefits and a reduction of emissions.The authors gratefully acknowledge financial support to the Conselleria de Innovacion, Universidades, Ciencia y Sociedad Digital of the Generalitat Valenciana, Spain, under project PROMETEO/2020/064

Tri-Criterion Model for Constructing Low-Carbon Mutual Fund Portfolios: A Preference-Based Multi-Objective Genetic Algorithm Approach

[EN] Sustainable finance, which integrates environmental, social and governance criteria on financial decisions rests on the fact that money should be used for good purposes. Thus, the financial sector is also expected to play a more important role to decarbonise the global economy. To align financial flows with a pathway towards a low-carbon economy, investors should be able to integrate into their financial decisions additional criteria beyond return and risk to manage climate risk. We propose a tri-criterion portfolio selection model to extend the classical Markowitz's mean-variance approach to include investor's preferences on the portfolio carbon risk exposure as an additional criterion. To approximate the 3D Pareto front we apply an efficient multi-objective genetic algorithm called ev-MOGA which is based on the concept of epsilon-dominance. Furthermore, we introduce a-posteriori approach to incorporate the investor's preferences into the solution process regarding their climate-change related preferences measured by the carbon risk exposure and their loss-adverse attitude. We test the performance of the proposed algorithm in a cross-section of European socially responsible investments open-end funds to assess the extent to which climate-related risk could be embedded in the portfolio according to the investor's preferences.Hilario Caballero, A.; Garcia-Bernabeu, A.; Salcedo-Romero-De-Ávila, J.; Vercher, M. (2020). Tri-Criterion Model for Constructing Low-Carbon Mutual Fund Portfolios: A Preference-Based Multi-Objective Genetic Algorithm Approach. International Journal of Environmental research and Public Health. 17(17):1-15. https://doi.org/10.3390/ijerph17176324S1151717Morningstar Low Carbon Designationhttps://bit.ly/2SfAFUAKrueger, P., Sautner, Z., & Starks, L. T. (2020). 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Markowitz-based portfolio selection with minimum transaction lots, cardinality constraints and regarding sector capitalization using genetic algorithm. Expert Systems with Applications, 36(3), 5058-5063. doi:10.1016/j.eswa.2008.06.007Anagnostopoulos, K. P., & Mamanis, G. (2011). The mean–variance cardinality constrained portfolio optimization problem: An experimental evaluation of five multiobjective evolutionary algorithms. Expert Systems with Applications. doi:10.1016/j.eswa.2011.04.233Woodside-Oriakhi, M., Lucas, C., & Beasley, J. E. (2011). Heuristic algorithms for the cardinality constrained efficient frontier. European Journal of Operational Research, 213(3), 538-550. doi:10.1016/j.ejor.2011.03.030Meghwani, S. S., & Thakur, M. (2017). Multi-criteria algorithms for portfolio optimization under practical constraints. Swarm and Evolutionary Computation, 37, 104-125. doi:10.1016/j.swevo.2017.06.005Liagkouras, K., & Metaxiotis, K. (2016). A new efficiently encoded multiobjective algorithm for the solution of the cardinality constrained portfolio optimization problem. Annals of Operations Research, 267(1-2), 281-319. doi:10.1007/s10479-016-2377-zMetaxiotis, K., & Liagkouras, K. (2012). Multiobjective Evolutionary Algorithms for Portfolio Management: A comprehensive literature review. Expert Systems with Applications, 39(14), 11685-11698. doi:10.1016/j.eswa.2012.04.053Silva, Y. L. T. V., Herthel, A. B., & Subramanian, A. (2019). A multi-objective evolutionary algorithm for a class of mean-variance portfolio selection problems. Expert Systems with Applications, 133, 225-241. doi:10.1016/j.eswa.2019.05.018Chang, T.-J., Yang, S.-C., & Chang, K.-J. (2009). Portfolio optimization problems in different risk measures using genetic algorithm. Expert Systems with Applications, 36(7), 10529-10537. doi:10.1016/j.eswa.2009.02.062Liagkouras, K. (2019). A new three-dimensional encoding multiobjective evolutionary algorithm with application to the portfolio optimization problem. Knowledge-Based Systems, 163, 186-203. doi:10.1016/j.knosys.2018.08.025Kaucic, M., Moradi, M., & Mirzazadeh, M. (2019). Portfolio optimization by improved NSGA-II and SPEA 2 based on different risk measures. Financial Innovation, 5(1). doi:10.1186/s40854-019-0140-6Babaei, S., Sepehri, M. M., & Babaei, E. (2015). Multi-objective portfolio optimization considering the dependence structure of asset returns. European Journal of Operational Research, 244(2), 525-539. doi:10.1016/j.ejor.2015.01.025Ruiz, A. B., Saborido, R., Bermúdez, J. D., Luque, M., & Vercher, E. (2019). Preference-based evolutionary multi-objective optimization for portfolio selection: a new credibilistic model under investor preferences. Journal of Global Optimization, 76(2), 295-315. doi:10.1007/s10898-019-00782-1Anagnostopoulos, K. P., & Mamanis, G. (2010). A portfolio optimization model with three objectives and discrete variables. Computers & Operations Research, 37(7), 1285-1297. doi:10.1016/j.cor.2009.09.009Hu, Y., Chen, H., He, M., Sun, L., Liu, R., & Shen, H. (2019). Multi-Swarm Multi-Objective Optimizer Based on p-Optimality Criteria for Multi-Objective Portfolio Management. Mathematical Problems in Engineering, 2019, 1-22. doi:10.1155/2019/8418369Rangel-González, J. A., Fraire, H., Solís, J. F., Cruz-Reyes, L., Gomez-Santillan, C., Rangel-Valdez, N., & Carpio-Valadez, J. M. (2020). Fuzzy Multi-objective Particle Swarm Optimization Solving the Three-Objective Portfolio Optimization Problem. International Journal of Fuzzy Systems, 22(8), 2760-2768. doi:10.1007/s40815-020-00928-4Garcia-Bernabeu, A., Salcedo, J. V., Hilario, A., Pla-Santamaria, D., & Herrero, J. M. (2019). Computing the Mean-Variance-Sustainability Nondominated Surface by ev-MOGA. 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BIBO stabilisation of continuous time takagi sugeno systems under persistent perturbations and input saturation

[EN] This paper presents a novel approach to the design of fuzzy state feedback controllers for continuous-time non-linear systems with input saturation under persistent perturbations. It is assumed that all the states of the Takagi¿Sugeno (TS) fuzzy model representing a non-linear system are measurable. Such controllers achieve bounded input bounded output (BIBO) stabilisation in closed loop based on the computation of inescapable ellipsoids. These ellipsoids are computed with linear matrix inequalities (LMIs) that guarantee stabilisation with input saturation and persistent perturbations. In particular, two kinds of inescapable ellipsoids are computed when solving a multiobjective optimization problem: the maximum volume inescapable ellipsoids contained inside the validity domain of the TS fuzzy model and the smallest inescapable ellipsoids which guarantee a minimum *-norm (upper bound of the 1-norm) of the perturbed system. For every initial point contained in the maximum volume ellipsoid, the closed loop will enter the minimum *-norm ellipsoid after a finite time, and it will remain inside afterwards. Consequently, the designed controllers have a large domain of validity and ensure a small value for the 1-norm of closed loop.The authors wish to thank the Editor-in-Chief and the anonymous reviewers for their valuable comments and suggestions. This work has been funded by Ministerio de Economia y Competitividad (Spain) through the research project DPI2015-71443-R and by Generalitat Valenciana (Valencia, Spain) through the research project GV/2017/029.Salcedo-Romero-De-Ávila, J.; Martínez Iranzo, MA.; Garcia-Nieto, S.; Hilario Caballero, A. (2018). BIBO stabilisation of continuous time takagi sugeno systems under persistent perturbations and input saturation. International Journal of Applied Mathematics and Computer Science (Online). 28(3):457-472. https://doi.org/10.2478/amcs-2018-0035S45747228

T-S Fuzzy Bibo Stabilisation of Non-Linear Systems Under Persistent Perturbations Using Fuzzy Lyapunov Functions and Non-PDC Control Laws

[EN] This paper develops an innovative approach for designing non-parallel distributed fuzzy controllers for continuous-time non-linear systems under persistent perturbations. Non-linear systems are represented using Takagi-Sugeno fuzzy models. These non-PDC controllers guarantee bounded input bounded output stabilisation in closed-loop throughout the computation of generalised inescapable ellipsoids. These controllers are computed with linear matrix inequalities using fuzzy Lyapunov functions and integral delayed Lyapunov functions. LMI conditions developed in this paper provide non-PDC controllers with a minimum *-norm (upper bound of the 1-norm) for the T-S fuzzy system under persistent perturbations. The results presented in this paper can be classified into two categories: local methods based on fuzzy Lyapunov functions with guaranteed bounds on the first derivatives of membership functions and global methods based on integral-delayed Lyapunov functions which are independent of the first derivatives of membership functions. The benefits of the proposed results are shown through some illustrative examples.This work has been funded by Ministerio de Economia y Competitividad, Spain (research project RTI2018-096904-B-I00) and Conselleria de Educacion, Cultura y Deporte-Generalitat Valenciana, Spain (research project AICO/2019/055).Salcedo-Romero-De-Ávila, J.; Martínez Iranzo, MA.; Garcia-Nieto, S.; Hilario Caballero, A. (2020). T-S Fuzzy Bibo Stabilisation of Non-Linear Systems Under Persistent Perturbations Using Fuzzy Lyapunov Functions and Non-PDC Control Laws. International Journal of Applied Mathematics and Computer Science (Online). 30(3):529-550. https://doi.org/10.34768/amcs-2020-0039S52955030

Systematic Tools for the Conceptual Design of Inherently Safer Chemical Processes

Society is continuously facing challenges for safer chemical plants design, which is usually driven by economic criteria during the early steps of the design process, relegating safety concerns to the latest stages. This paper highlights the synergy of merging Process System Engineering tools with inherent safety principles. First, we design a superstructure that comprises several alternatives for streams, equipment, and process conditions, which exhibit different performance of economic and inherently safer indicators, the total annualized cost, and the Dow’s Fire and Explosion Index, respectively. The solution to this multiobjective problem is given by a Pareto set of solutions that indicates the existing trade-off between both objectives. The capabilities of the proposed framework are illustrated through two case studies, which solutions provide valuable insights into the design problem and are intended to guide decision-makers toward the adoption of inherently safer process alternatives.The authors acknowledge financial support from “Proyectos de l+D para grupos de investigación emergentes GV/2016/005” (Conselleria d’Educació, Investigació, Cultura i Esport, GENERALITAT VALENCIANA) and from the Spanish “Ministerio de Economía, Industria y Competitividad” (CTQ2016-77968-C3-02-P, AEI/FEDER, UE)

Water Management in Shale Gas: A Perspective from the Cooperative Games Theory

This project has received funding from the European Union's Horizon 2020 Research and Innovation Program under grant agreement No. 640979

Shale Water Desalination: Multistage membrane distillation considering different configurations and heat integration

This work introduces a simultaneous synthesis of membrane distillation systems with heat exchanger networks (HENs) for desalinating shale gas flowback and produce water. The direct contact and vacuum membrane configurations are the best options for desalination. Moreover, multistage membrane distillation systems usually have higher efficiencies than single-stages processes. For this reason, two different mathematical models for synthetizing multistage direct contact membrane distillation (MSDCMD) and multistage vacuum membrane distillation (MSVMD) are developed and optimized to achieve zero liquid discharge (ZLD) conditions. To this aim, brine discharges are considered to be near to the salt saturation conditions. The multi-stage superstructures are implemented in GAMS and optimized by SBB solver. The mathematical model is formulated via generalized disjunctive programming (GDP) and mixed-integer nonlinear programming (MINLP), to minimize the total annualized cost.This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No. 640979