15 research outputs found

    Notas para uma Contextualização do Cinema Moçambicano

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    The present text intends to deal with three different moments of the route travelled by Mozambican cinema, placing them in its historical context and in its the subjective environment, trying to provide scholars with further information for a deeper understanding of the options that were made and the projects conceived.El presente texto pretende abordar tres momentos distintos del recorrido del cine mozambiqueño, buscando situarles en el contexto histórico y en el clima subjetivo en que se insirieron, con la intención de ofrecer a los estudiosos otros datos para una mejor comprensión de las elecciones tomadas y de los proyectos trazados.O presente texto pretende abordar três momentos distintos do percurso do cinema moçambicano, procurando situá-los no contexto histórico e no clima subjetivo em que se inseriram, de forma a fornecer aos estudiosos outros dados para uma melhor compreensão das opções feitas e dos projetos traçados

    A experiência revolucionária moçambicana

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    A revista Germinal convidou o professor José Luís de Oliveira Cabaço para partilhar com nossas leitoras e nossos leitores suas reflexões acadêmicas sobre a empresa colonial na África assim como suas experiências na Frente de Libertação de Moçambique (Frelimo). Sua tese, intitulada Moçambique: identidades, colonialismo e libertação, foi premiada pela Associação Nacional de Pós-graduação e Pesquisa em Ciências Sociais (Anpocs) e publicada em 2009 pela Editora Unesp. Hoje é docente emérito da Universidade Técnica de Moçambique e tem importantes análises sobre o tema divulgadas em livros e artigos. O Comitê editorial, formado por Jaqueline Botelho (UFF), Márcia Lemos (Uesb) e Muniz Ferreira (UFRRJ) agradece ao professor o aceite do convite e sua valiosa contribuição ao responder com generosidade e rigor analítico às questões apresentadas

    RAB3A Regulates Melanin Exocytosis and Transfer Induced by Keratinocyte-Conditioned Medium

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    Funding: We would like to thank our group for the critical reading of the manuscript and the NMS microscopy and cell culture facilities, as well as José Belo’s group, for the kind gift of mouse embryonic fibroblasts. This study was supported by Fundação para a Ciência e a Tecnologia (Portugal) through grant PTDC/BIA-CEL/29765/2017 and PhD fellowships to LCC, MVN, LBL and AF (2020.08812.BD, PD/BD/137442/2018, SFRH/BD/131938/2017 and PD/BD/ 135506/2018, respectively). This work was developed with the support from the research infrastructure PPBI-POCI-01-0145-FEDER-022122, cofinanced by Fundação para a Cieˆncia e a Tecnologia (Portugal) and Lisboa2020, under the PORTUGAL2020 agreement (European Regional Development Fund). This article was supported by the LYSOCIL project, which has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement number 811087. This work was also supported by iNOVA4Health e UIDB/04462/2020 and UIDP/04462/2020 and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (Portugal).Skin pigmentation is imparted by melanin and is crucial for photoprotection against UVR. Melanin is synthesized and packaged into melanosomes within melanocytes and is then transferred to keratinocytes (KCs). Although the molecular players involved in melanogenesis have been extensively studied, those underlying melanin transfer remain unclear. Previously, our group proposed that coupled exocytosis/phagocytosis is the predominant mechanism of melanin transfer in human skin and showed an essential role for RAB11B and the exocyst tethering complex in this process. In this study, we show that soluble factors present in KC-conditioned medium stimulate melanin exocytosis from melanocytes and transfer to KCs. Moreover, we found that these factors are released by differentiated KCs but not by basal layer KCs. Furthermore, we found that RAB3A regulates melanin exocytosis and transfer stimulated by KC-conditioned medium. Indeed, KC-conditioned medium enhances the recruitment of RAB3A to melanosomes in melanocyte dendrites. Therefore, our results suggest the existence of two distinct routes of melanin exocytosis: a basal route controlled by RAB11B and a RAB3A-dependent route, stimulated by KC-conditioned medium. Thus, this study provides evidence that soluble factors released by differentiated KCs control skin pigmentation by promoting the accumulation of RAB3A-positive melanosomes in melanocyte dendrites and their release and subsequent transfer to KCs.publishersversionpublishe

    Grupo de Trabalho de Arqueobotânica e Zooarqueologia : resultados da primeira reunião

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    Resultados da primeira reunião geral de investigadores das áreas científicas da Arqueobotânica e Zooarqueologia a trabalhar em Portugal, realizada em Outubro de 2014, no Museu Nacional de Arqueologia (Lisboa). Identificando um conjunto de dificuldades comuns às duas disciplinas, os presentes decidiram criar um grupo de trabalho informal para fomentar o diálogo profissional e com as instituições universitárias, a tutela (administração central e regional), as empresas e a comunidade arqueológica em geral.Results of the first general meeting of researchers in the fields of Archaeobotany and Zooarchaeology working in Portugal, which took place in October 2014 at the National Museum of Archaeology in Lisbon. Having identified a set of difficulties in common, participants at the meeting decided to set up an informal work group to encourage dialogue among professionals and with universities, central and regional authorities, companies and the archaeological community at large

    Globalização ou recolonização?

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    The capitalist offensive for world hegemony that intensified after the fall of the Berlin Wall has strong analogies with the first great globalization of capital. The structure and methodologies of the reorganization of the world economy underway on the African continent, under the ideological coverage of globalization and the non-existence of alternatives, are analyzed in a way compared to the phase of capital expansion that marked the history of humanity a little more of a century and a half, and that led to colonialism.A ofensiva capitalista pela hegemonia mundial que se intensificou após a queda do muro de Berlim tem fortes analogias com a primeira grande mundialização do capital. A estrutura e as metodologias da reorganização da economia-mundo em curso no continente africano, sob a cobertura ideológica da globalização e da inexistência de alternativas, são analisadas de forma comparada com a fase de expansão do capital  que marcou a História da humanidade há pouco mais de um século e meio, e que conduziu ao colonialismo
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