451 research outputs found
Hypercalcemic crisis associated with primary hyperparathyroidism during pregnancy
Primary hyperparathyroidism is a rare occurrence in pregnancy with significant risks to the mother and the foetus, witch is related to the level of serum calcium. A 41-year-old women, gravida 2, para 1, presented at 22 weeks gestation with nausea, vomiting and mild cognitive dysfunction associated with hypercalcemic crisis. The hypercalcemia was observed to be related to parathyroid hyperplasia that was surgically removed. Complete resolution of her symptomatology and hypercalcemia occurred postoperatively. The pregnancy was complicated with transient hypertension. A small for gestational age healthy male infant was delivered at term with no neonatal complications related with this pathology
Transmutations and spectral parameter power series in eigenvalue problems
We give an overview of recent developments in Sturm-Liouville theory
concerning operators of transmutation (transformation) and spectral parameter
power series (SPPS). The possibility to write down the dispersion
(characteristic) equations corresponding to a variety of spectral problems
related to Sturm-Liouville equations in an analytic form is an attractive
feature of the SPPS method. It is based on a computation of certain systems of
recursive integrals. Considered as families of functions these systems are
complete in the -space and result to be the images of the nonnegative
integer powers of the independent variable under the action of a corresponding
transmutation operator. This recently revealed property of the Delsarte
transmutations opens the way to apply the transmutation operator even when its
integral kernel is unknown and gives the possibility to obtain further
interesting properties concerning the Darboux transformed Schr\"{o}dinger
operators.
We introduce the systems of recursive integrals and the SPPS approach,
explain some of its applications to spectral problems with numerical
illustrations, give the definition and basic properties of transmutation
operators, introduce a parametrized family of transmutation operators, study
their mapping properties and construct the transmutation operators for Darboux
transformed Schr\"{o}dinger operators.Comment: 30 pages, 4 figures. arXiv admin note: text overlap with
arXiv:1111.444
HFE gene polymorphism defined by sequence based typing of the Brazilian population and a standardized nomenclature for HFE allele sequences
The HFE molecule controls iron uptake from gut, and defects in the molecule have been associated with iron overload, particularly in hereditary hemochromatosis. The HFE gene including both coding and boundary intronic regions were sequenced in 304 Brazilian individuals, encompassing healthy individuals and patients exhibiting hereditary or acquired iron overload. Six sites of variation were detected: i) H63D Câ>âG in exon 2, ii) IVS2 (+4) Tâ>âC in intron 2, iii) a Câ>âG transversion in intron 3, iv) C282Y Gâ>âA in exon 4, v) IVS4 (-44) Tâ>âC in intron 4, and vi) a new Guanine deletion (Gâ>âdel) in intron 5, which were used for haplotype inference. Nine HFE alleles were detected and six of these were officially named on the basis of the HLA Nomenclature, defined by the WHO Nomenclature Committee for Factors of the HLA System, and published via the IPD-IMGT/HLA website. Four alleles, HFE*001, 002, 003 and 004 exhibited variation within their exon sequences
Biomedical word sense disambiguation with word embeddings
There is a growing need for automatic extraction of information and knowledge from the increasing amount of biomedical and clinical data produced, namely in textual form. Natural language processing comes in this direction, helping in tasks such as information extraction and information retrieval. Word sense disambiguation is an important part of this process, being responsible for assigning the proper concept to an ambiguous term.
In this paper, we present results from machine learning and knowledge-based algorithms applied to biomedical word sense disambiguation. For the supervised machine learning algorithms we used word embeddings, calculated from the full MEDLINE literature database, as global features and compare the results to the use of local unigram and bigram features.
For the knowledge-based method we represented the textual definitions of biomedical concepts from the UMLS database as word embedding vectors, and combined this with concept associations derived from the MeSH term co-occurrences.
Both the machine learning and the knowledge-based results indicate that word embeddings are informative and improve the biomedical word disambiguation accuracy. Applied to the reference MSH WSD data set, our knowledge-based approach achieves 85.1% disambiguation accuracy, which is higher than some previously proposed approaches that do not use machine-learning strategies.publishe
Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space
Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202
Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space
Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202
Excellent outcomes of laparoscopic esophagomyotomy for achalasia in patients older than 60Â years of age
The effectiveness of an esophagomyotomy for dysphagia in elderly patients with achalasia has been questioned. This study was designed to provide an answer.
A total of 162 consecutive patients with achalasia who had a laparoscopic myotomy and Dor fundoplication and who were available for follow-up interview were divided by age: <60Â years (range, 14â59; 118 patients), and â„60Â years (range, 60â93; 44 patients). Primary outcome measures were severity of dysphagia, regurgitation, heartburn, and chest pain before and after the operation as assessed on a four-point Likert scale, and the need for postoperative dilatation or revisional surgery.
Follow-up averaged 64Â months. Older patients had less dysphagia (mean score 3.6 vs. 3.9; PÂ <Â 0.01) and less chest pain (1.0 vs. 1.8; PÂ <Â 0.01). Regurgitation (3.0 vs. 3.2; PÂ =Â not significant (NS)) and heartburn (1.6 vs. 2.0, PÂ =Â NS) were similar. Older patients were no different in degree of esophageal dilation, manometric findings, number of previous pneumatic dilatations, or previous botulinum toxin therapy. None of the older patients had previously had an esophagomyotomy, whereas 14% of younger patients had (PÂ <Â 0.01).
After laparoscopic myotomy, older patients had better relief of dysphagia (mean score 1.0 vs 1.6; PÂ <Â 0.01), less heartburn (0.8 vs. 1.1; PÂ =Â 0.03), and less chest pain (0.2 vs. 0.8, PÂ <Â 0.01). Complication rates were similar. Older patients did not require more postoperative dilatations (22 patients vs. 10 patients; PÂ =Â 0.7) or revisional surgery for recurrent or persistent symptoms (3 vs. 1 patients; PÂ =Â 0.6). Satisfaction scores did not differ, and more than 90% of patients in both groups said in retrospect they would have undergone the procedure if they had known beforehand how it would turn out.
This retrospective review with long follow-up supports laparoscopic esophagomyotomy as first-line therapy in older patients with achalasia. They appeared to benefit even more than younger patients
Tratamento do cĂąncer de laringe: revisĂŁo da literatura publicada nos Ășltimos dez anos
- âŠ