GuiMarket Specification Using the Unified Modeling Language

AbstractGuiMarket is an e-Marketplace of health care, social care services developed as a pilot project in a Northern Portuguese Municipality, with the main objective of improving the well-being of elderly people and people with special needs staying at home, or their caregivers. This paper makes a brief introduction of this platform, explains its overall implementation and operation using an IDEF0 (Integration DEFinition) diagram, and presents the specification of the main services of the e-Marketplace using UML (Unified Modeling Language)

Virtue without pleasure?: Aristotle and the joy of a noble life

How it is possible for Aristotle to say that the virtuoiis man finds the greatest pleasures I In this article I try to show a reasonable link between virtue and pleasure, ground· ed on the notion of peifect activity, which in the case of human beings is an activity according to virtue. The virtuoiis person can contemplate his own noble life and find joy in his good actions, and pleasure appears in this contemplation, which is a perfect activity

Quons Restricted to the Antisymmetric Subspace: Formalism and Applications

In this work we develop a formalism to treat quons restricted to the antisymmetric part of their many-body space. A model in which a system of identical quons interact through a pairing force is then solved within this restriction and the differences between our solution and the usual fermionic model solution are then presented and discussed in detail. Possible connections to physical systems are also considered.Comment: 12 pages, 3 figure

Modifier Genes as Therapeutics: The Nuclear Hormone Receptor Rev Erb Alpha (Nr1d1) Rescues Nr2e3 Associated Retinal Disease

Nuclear hormone receptors play a major role in many important biological processes. Most nuclear hormone receptors are ubiquitously expressed and regulate processes such as metabolism, circadian function, and development. They function in these processes to maintain homeostasis through modulation of transcriptional gene networks. In this study we evaluate the effectiveness of a nuclear hormone receptor gene to modulate retinal degeneration and restore the integrity of the retina. Currently, there are no effective treatment options for retinal degenerative diseases leading to progressive and irreversible blindness. In this study we demonstrate that the nuclear hormone receptor gene Nr1d1 (Rev-Erba) rescues Nr2e3- associated retinal degeneration in the rd7 mouse, which lacks a functional Nr2e3 gene. Mutations in human NR2E3 are associated with several retinal degenerations including enhanced S cone syndrome and retinitis pigmentosa. The rd7 mouse, lacking Nr2e3, exhibits an increase in S cones and slow, progressive retinal degeneration. A traditional genetic mapping approach previously identified candidate modifier loci. Here, we demonstrate that in vivo delivery of the candidate modifier gene, Nr1d1 rescues Nr2e3 associated retinal degeneration. We observed clinical, histological, functional, and molecular restoration of the rd7 retina. Furthermore, we demonstrate that the mechanism of rescue at the molecular and functional level is through the re-regulation of key genes within the Nr2e3-directed transcriptional network. Together, these findings reveal the potency of nuclear receptors as modulators of disease and specifically of NR1D1 as a novel therapeutic for retinal degenerations

Simulation in Information Systems: Potential of the vulnerability theory

Systems simulation has been widely used in the last decades in order to analyze the impact of different scenarios in several areas, and its application to information systems in no exception. Analyzing information systems through simulation models is simultaneously much more affordable; it is required a smaller amount of resources and it is less disruptive with the real system. Since information systems are becoming a cornerstone for our society, a failure in these systems can have a huge impact. The theory of vulnerability identifies failures in which small damage can have disproportionate impact consequences in terms of the functionality of the whole system. This paper discusses the use of the theory of vulnerability in information system simulation

Role of magnetic anisotropy on the magnetic properties of Ni nanoclusters embedded in a ZnO matrix

We have investigated the magnetic properties of Ni nanoaggregates produced by ion implantation in ZnO single crystals. Several deviations from classical models usually adopted to describe the magnetic properties of nanoparticle systems were found. The strain between host and Ni nanoaggregates induces a magnetic anisotropy with a preferred direction. We show that these anisotropy effects can be misinterpreted as a ferromagnetic or antiferromagnetic coupling among the nanoaggregates similar to that of an oriented, interacting nanocrystal ensemble

Temperature and Polarization Patterns in Anisotropic Cosmologies

We study the coherent temperature and polarization patterns produced in homogeneous but anisotropic cosmological models. We show results for all Bianchi types with a Friedman-Robertson-Walker limit (i.e. Types I, V, VII$_{0}$, VII$_{h}$ and IX) to illustrate the range of possible behaviour. We discuss the role of spatial curvature, shear and rotation in the geodesic equations for each model and establish some basic results concerning the symmetries of the patterns produced. We also give examples of the time-evolution of these patterns in terms of the Stokes parameters $I$, $Q$ and $U$.Comment: 24 pages, 7 Figures, submitted to JCAP. Revised version: numerous references added, text rewritten, and errors corrected

Statefinder Parameter for Varying G in Three Fluid System

In this work, we have considered variable G in flat FRW universe filled with the mixture of dark energy, dark matter and radiation. If there is no interaction between the three fluids, the deceleration parameter and statefinder parameters have been calculated in terms of dimensionless density parameters which can be fixed by observational data. Also the interaction between three fluids has been analyzed due to constant $G$. The statefinder parameters also calculated in two cases: pressure is constant and pressure is variable.Comment: 5 pages, Accepted for publication in "Astrophysics and Space Science

t→bWt \to b W in NonCommutative Standard Model

We study the top quark decay to b quark and W boson in the NonCommutative Standard Model (NCSM). The lowest contribution to the decay comes from the terms quadratic in the matrix describing the noncommutative (NC) effects while the linear term is seen to identically vanish because of symmetry. The NC effects are found to be significant only for low values of the NC characteristic scale.Comment: 11 page Latex file containing 2 eps figures (redrawn). More discussion included. To appear in PR