ISO LWS Spectra of T Tauri and Herbig AeBe stars

We present an analysis of ISO-LWS spectra of eight T Tauri and Herbig AeBe young stellar objects. Some of the objects are in the embedded phase of star-formation, whereas others have cleared their environs but are still surrounded by a circumstellar disk. Fine-structure lines of [OI] and [CII] are most likely excited by far-ultraviolet photons in the circumstellar environment rather than high-velocity outflows, based on comparisons of observed line strengths with predictions of photon-dominated and shock chemistry models. A subset of our stars and their ISO spectra are adequately explained by models constructed by Chiang & Goldreich (1997) and Chiang et al. (2001) of isolated, passively heated, flared circumstellar disks. For these sources, the bulk of the LWS flux at wavelengths longward of 55 µm arises from the disk interior which is heated diffusively by reprocessed radiation from the disk surface. At 45 µm, water ice emission bands appear in spectra of two of the coolest stars, and are thought to arise from icy grains irradiated by central starlight in optically thin disk surface layers

GPR30 is necessary for estradiol-induced desensitization of 5- HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus

Estrogen therapy used in combination with selective serotonin reuptake inhibitor (SSRI) treatment improves SSRI efficacy for the treatment of mood disorders. Desensitization of serotonin 1A (5-HT1A) receptors, which takes one to two weeks to develop in animals, is necessary for SSRI therapeutic efficacy. Estradiol modifies 5-HT1A receptor signaling and induces a partial desensitization in the paraventricular nucleus (PVN) of the rat within two days, but the mechanisms underlying this effect are currently unknown. The purpose of this study was to identify the estrogen receptor necessary for estradiol-induced 5-HT1A receptor desensitization. We previously showed that estrogen receptor β is not necessary for 5-HT1A receptor desensitization and that selective activation of estrogen receptor GPR30 mimics the effects of estradiol in rat PVN. Here, we used a recombinant adenovirus containing GPR30 siRNAs to decrease GPR30 expression in the PVN. Reduction of GPR30 prevented estradiol-induced desensitization of 5-HT1A receptor as measured by hormonal responses to the selective 5-HT1A receptor agonist, (+)8-OH-DPAT. To determine the possible mechanisms underlying these effects, we investigated protein and mRNA levels of 5-HT1A receptor signaling components including 5-HT1A receptor, Gαz, and RGSz1. We found that two days of estradiol increased protein and mRNA expression of RGSz1, and decreased 5-HT1A receptor protein but increased 5-HT1A mRNA; GPR30 knockdown prevented the estradiol-induced changes in 5-HT1A receptor protein in the PVN. Taken together, these data demonstrate that GPR30 is necessary for estradiol-induced changes in the 5-HT1A receptor signaling pathway and desensitization of 5-HT1A receptor signaling

Pavement Evaluation of the Concrete Tie-bars and Dowel Baskets on Irvin Cobb Drive, US 60, McCracken County, KY

A 1500 Mhz. ground coupled, ground penetrating radar antenna was used to identify both the horizontal alignment and the vertical displacement of the concrete tie-bars and the transverse joint dowel bar assembles on a Portland-Cement-Concrete-Pavement (PCCP) on US 60 in McCracken County, KY. Approximately 5 lanes miles of PCCP were evaluated using the 1500 Mhz. ground coupled antenna. Results indicate that only one transverse dowel basket out of an approximate total of 1,760 were within 4.17 inches of the pavement surface. Seven transverse dowel baskets were misaligned four inches or greater from the location of the sawed joint. These areas represent 0.45 percent of the total transverse joints on the project. The ground penetrating radar results also indicated there were no areas along the longitudinal joint where the tie-bars were either too close to the pavement surface or missing

VistaClara: an expression browser plug-in for Cytoscape

Summary: VistaClara is a plug-in for Cytoscape which provides a more flexible means to visualize gene and protein expression within a network context. An extended attribute browser is provided in the form of a graphical and interactive permutation matrix that resembles the heat map displays popular in gene-expression analysis. This extended browser permits a variety of display options and interactions not currently available in Cytoscape

Cover Crops for Utah

This fact sheet provides the current state of knowledge on cover crop management for Utah based on USU research and local grower experience

Influence of Harvest Date on Seed Yield and Quality in Forage Kochia

Forage kochia (Bassia prostrata) is used for rangeland reclamation and livestock and wildlife forage, but limited research has been conducted on its seed production. Therefore, this research evaluated the effect of harvest date on seed weight, germination, and seed yield of forage kochia subspecies virescens and grisea. Seed was harvested from individual plants for 3 years during October, November, and December. October harvest had the lightest 100-seed weights, with the November harvest slightly heavier than December, for most accessions. Cultivar Snowstorm and breeding line Sahsel, both subsp. grisea, had the greatest 100-seed weights in November, 155 and 143 mg, respectively, whereas, cv. Immigrant (subsp. virescens), the standard for forage kochia, ranked among the least for 100-seed weight. For most accessions, germination was lowest from the October harvest (11%–43%), with greater germination with November and December harvested seeds (43%–64%). Viable seed yields were greatest in November with the exception of two accessions, which peaked in October, indicating earlier maturity. Results indicate that forage kochia usually reaches optimum seed maturity by early November, after plants are exposed to freezing temperatures; however, earlier maturing accessions exist in both subspecies virescens and grisea

Estradiol induces partial desensitization of serotonin 1A receptor signaling in the paraventricular nucleus of the hypothalamus and alters expression and interaction of RGSZ1and Gαz

Hyperactivity of hypothalamic-pituitary mediated hormone responses, such as to stimulation with a serotonin 1A (5-HT1A) receptor agonist, are a feature of depression which are normalized with clinical improvement during drug therapy. We previously reported that SSRIs induce desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the hypothalamus (PVN) while estradiol benzoate (EB) produces a more rapid, partial desensitization. In the current study, time-course and dose-response experiments demonstrated that two once daily doses of EB is the minimum needed to induce the desensitization response as indicated by 5-HT1A receptor-stimulated release of oxytocin and that 10 μg/kg/day EB produces the maximal response, a partial desensitization of approximately 40%. The effects of two once daily injections of 10 μg/kg/day EB on Gαz and RGSZ1 proteins were examined as components of the 5-HT1A receptor signaling system, which mediates the release of oxytocin and adrenocorticotropin hormone. RGSZ1 appears to be a major target for EB-mediated responses in the 5-HT1A receptor signaling system. A 55 kD membrane-associate RGSZ1 protein was greatly increased in the PVN and rest of the hypothalamus and moderately increased in the dorsal hippocampus and amygdala after EB treatment as well as after an acute dose of a 5-HT1A receptor agonist. These results suggest that EB is a candidate for adjuvant therapy with SSRIs to hasten the therapeutic response and that RGSZ1 is a major target of EB therapy which could be explored as a target for novel therapeutic approaches for the treatment of depression

GREAT [CII] and CO observations of the BD+40{\deg}4124 region

The BD+40\degree4124 region was observed with high angular and spectral resolution with the German heterodyne instrument GREAT in CO J = 13 \rightarrow 12 and [CII] on SOFIA. These observations show that the [CII] emission is very strong in the reflection nebula surrounding the young Herbig Ae/Be star BD+40\degree4124. A strip map over the nebula shows that the [CII] emission approximately coincides with the optical nebulosity. The strongest [CII] emission is centered on the B2 star and a deep spectrum shows that it has faint wings, which suggests that the ionized gas is expanding. We also see faint CO J = 13 \rightarrow 12 at the position of BD+40\degree4124, which suggests that the star may still be surrounded by an accretion disk.We also detected [CII] emission and strong CO J = 13 \rightarrow 12 toward V1318 Cyg. Here the [CII] emission is fainter than in BD+40\degree4124 and appears to come from the outflow, since it shows red and blue wings with very little emission at the systemic velocity, where the CO emission is quite strong. It therefore appears that in the broad ISO beam the [CII] emission was dominated by the reflection nebula surrounding BD+40\degree4124, while the high J CO lines originated from the adjacent younger and more deeply embedded binary system V1318 Cyg