Factors related with the university degree selection in Spanish public university system. An structural equation model analysis

The final publication is available at Springer via http://dx.doi.org/10.1007/s11135-014-0008-9Students take into account different factors in their choice of university studies and college. Some are global, as the quality of the degree (ratio available places/firstchoice places in, cut-off grade, etc.), and others are subjective factors (e.g.: my friends are also taking this degree). In this work we present a partial multivariate model that takes into account the weight of the different variables shown by different works linked to this decision. We have studied three samples (n = 372 from the Universidad Pablo de Olavide; n = 2,244 from the Universitat Politécnica de Valencia, and n = 543 from the Universitat de Barcelona) from several degrees in the 2010 2011 and 2011 2012 academic years, all of them new students, coming from high school, and who had choosen these universities as first choice. The global effect shows that the structural model fits reasonably well in the three universities studied. Similarly, university and specialty models show different intensity effects, and we found that, in the case of Universitat Politécnica de Valencia (UPV) and Universitat de Barcelona (UB), they show higher intensity than in Universidad Pablo de Olavide (UPO). This makes us think that in most urban universities with a clear and regular offer of degrees (engineering in the case of UPV, and Health and Social Sciences in the case of UB), personal and social factors are more important than in the case of universities, as is the case of UPO, with an offer and dimension not yet completely defined.Guàrdia Olmos, J.; Peró Cebollero, M.; Hervás Jorge, A.; Capilla Lladró, R.; Soriano Jiménez, PP.; Porras Yañez, M. (2014). Factors related with the university degree selection in Spanish public university system. An structural equation model analysis. Quality and Quantity. March(2014):1-19. doi:10.1007/s11135-014-0008-9S119March2014Baker, S., Brown, B.: Images of excellence: constructions of institutional prestige and reflections in the university choice process. Br. J. Sociol. Educ. 28(3), 377–391 (2007)Browne, M.W., Cudeck, R.: Alternative ways of assessing model fit. Sociol. Methods Res. 21, 230–258 (1992)Capilla, R.: Análisis estratégico de los estudios TIC en la Universidad Politécnica de Valencia. Tesis Doctoral no Publicada. Valencia: Universitat Politécnica de Valéncia. (2009). http://riunet.upv.es/handle/10251/5767 . Retrieved 11 Mar 2014Ford, D.Y.: The underrepresentation of minority students in gifted education: problems and promises in recruitment and retention. J. Spec. Educ. 31(1), 4–14 (2008)Guàrdia, J., Peró, M., Hervás, A., Capilla, R., Soriano, P.P., Porras, M.: Factores asociados con la decisión de cursar estudios universitarios de Psicología. Una aproximación mediante modelos de ecuaciones estructurales. Anuario de Psicologia 42(1), 87–104 (2012)Guerra, C., & Rueda, E.M.: Estudio longitudinal de los jóvenes en el tránsito de la enseñza secundaria a la universidad: orientación, expectativas, toma de decisiones y acogida de los nuevos estudiantes en la universidad. Dirección General de Universidades. Estudios y Análisis (2005)Hu, L., Bentler, P.M.: Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Struct. Equ. Model. 6, 1–55 (1999)Huang, Sh, Fang, N.: Predicting student academic performance in an enginnering dynamics course: a comparison for four types of predictive mathematical models. Comput. Educ. 61, 133–145 (2013)Leppel, K., Williams, M.L., Waldauer, C.: The impact of parental occupation and socioeconomic status on choice of college major. J. Fam. Econ. Issues 22(4), 373–394 (2001)Maringe, F.: University and course choice Implications for positioning, recruitment and marketing. Int. J. Educ. Manage. 20(6), 466–479 (2006)Muñiz, J.: Utilización de los test. En J. Muñiz, A.M. Fidalgo, E. García-Cueto, R. Martínez y R. Moreno (Eds.). Análisis de los ítems, (pp. 133–172). Madrid: La Muralla, S.A (2005)Murphy, P.E., McGarrity, R.A.: Marketing universities: a survey of student recruitment activities. Coll. Univ. 53(3), 249–261 (1978)Ory, D.T., Mokhtarian, P.L.: The impact of non-normality, sample size and estimation technique on goodness-of-fit measures in structural equation modeling: evidence from ten empirical models of travel behavior. Qual. Q. 44(3), 427–445 (2010)Palomo, J., Dunson, D.B., Bollen, K.: Bayesian structural equation modeling. In: Lee, S.Y. (ed.) Handbook of Latent Variable and Related Models, pp. 163–179. Elsevier, New York (2007)Perna, L.W., Titus, M.A.: Understanding differences in the choice of college attended: the role of state public policies. Rev. High. Educ. 27(4), 501–525 (2004)Poon, W.Y., Lee, S.Y.: A Distribution Free Approach for Analysis of Two-level Structural Equation Model. Elsevier, New York (1994)Price, I., Matzdorf, F., Smith, L., Agahi, H.: The impact of facilities on student choice of university. Facilities 21(10), 212–222 (2003)Raymond, S.: Predicting academic succes of first-year engineering students from standardized test scores and psychological variables. Int. J. Eng. Educ. 17(1), 75–80 (2001)Turner, C.S.V., Thompson, J.R.: Socializing women doctoral students: minority and majority experiences. Rev. High. Educ. 6, 232–241 (1993)Veenstra, C.P., Dey, E.L., Herrin, G.D.: Is modeling of freshman engineering succes different from modeling of non-engineering succes? J. Eng. Educ. 97, 467–479 (2008)Yurtseven, T.: How does the image of engineering affect student recruitment and retention? A perspective from the USA. Glob. J. Eng. Educ. 6(2), 267 (2002

Localisation of RNAs into the germ plasm of vitellogenic xenopus oocytes

We have studied the localisation of mRNAs in full-grown Xenopus laevis oocytes by injecting fluorescent RNAs, followed by confocal microscopy of the oocyte cortex. Concentrating on RNA encoding the Xenopus Nanos homologue, nanos1 (formerly Xcat2), we find that it consistently localised into aggregated germ plasm ribonucleoprotein (RNP) particles, independently of cytoskeletal integrity. This implies that a diffusion/entrapment-mediated mechanism is active, as previously reported for previtellogenic oocytes. Sometimes this was accompanied by localisation into scattered particles of the “late”, Vg1/VegT pathway; occasionally only late pathway localisation was seen. The Xpat RNA behaved in an identical fashion and for neither RNA was the localisation changed by any culture conditions tested. The identity of the labelled RNP aggregates as definitive germ plasm was confirmed by their inclusion of abundant mitochondria and co-localisation with the germ plasm protein Hermes. Further, the nanos1/Hermes RNP particles are interspersed with those containing the germ plasm protein Xpat. These aggregates may be followed into the germ plasm of unfertilized eggs, but with a notable reduction in its quantity, both in terms of injected molecules and endogenous structures. Our results conflict with previous reports that there is no RNA localisation in large oocytes, and that during mid-oogenesis even germ plasm RNAs localise exclusively by the late pathway. We find that in mid oogenesis nanos1 RNA also localises to germ plasm but also by the late pathway. Late pathway RNAs, Vg1 and VegT, also may localise into germ plasm. Our results support the view that mechanistically the two modes of localisation are extremely similar, and that in an injection experiment RNAs might utilise either pathway, the distinction in fates being very subtle and subject to variation. We discuss these results in relation to their biological significance and the results of others

Discovery and functional characterisation of a luqin-type neuropeptide signalling system in a deuterostome

The results presented in this paper have not been published previously in whole or in part. The work reported in this paper was supported by grants from the BBSRC awarded to M.R.E (BB/M001644/1) and J.H.S. (BB/M001032/1). L.A.Y.G is supported by a PhD studentship awarded by the Mexican Council of Science and Technology (CONACyT studentship no. 418612) and Queen Mary University of London. We are grateful to Philipp Bauknecht and Gáspár Jékely (Max Planck Institute for Developmental Biology, Tübingen, Germany) for providing the Gα16 plasmid and the CHO-G5A cells, which were originally generated by Baubet et al. (Proc Natl Acad Sci USA 97:7260–7265). We are also grateful to Phil Edwards for his help with collecting starfish, Paul Fletcher for maintaining our seawater aquarium and Maria Eugenia Guerra for creating the silhouettes of animals used in Figure 7

A novel blood-based biomarker for detection of autism spectrum disorders

Autism spectrum disorders (ASD) are classified as neurological developmental disorders. Several studies have been carried out to find a candidate biomarker linked to the development of these disorders, but up to date no reliable biomarker is available. Mass spectrometry techniques have been used for protein profiling of blood plasma of children with such disorders in order to identify proteins/peptides that may be used as biomarkers for detection of the disorders. Three differentially expressed peptides with mass–charge (m/z) values of 2020±1, 1864±1 and 1978±1 Da in the heparin plasma of children with ASD that were significantly changed as compared with the peptide pattern of the non-ASD control group are reported here. This novel set of biomarkers allows for a reliable blood-based diagnostic tool that may be used in diagnosis and potentially, in prognosis of ASD

The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo

<p>Abstract</p> <p>Background</p> <p>Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unknown. To investigate the role of the normal breast microenvironment on breast cancer cell tumorigenicity, we examined whether extracellular matrix molecules (ECM) derived from premenopausal African-American (AA) or Caucasian-American (CAU) breast tissue would affect the tumorigenicity of cancer cells <it>in vitro </it>and <it>in vivo</it>. We chose these two populations because of the well documented predisposition of AA women to develop aggressive, highly metastatic breast cancer compared to CAU women.</p> <p>Methods</p> <p>The effects of primary breast fibroblasts on tumorigenicity were analyzed via real-time PCR arrays and mouse xenograft models. Whole breast ECM was isolated, analyzed via zymography, and its effects on breast cancer cell aggressiveness were tested <it>in vitro </it>via soft agar and invasion assays, and <it>in vivo </it>via xenograft models. Breast ECM and hormone metabolites were analyzed via mass spectrometry.</p> <p>Results</p> <p>Mouse mammary glands humanized with premenopausal CAU fibroblasts and injected with primary breast cancer cells developed significantly larger tumors compared to AA humanized glands. Examination of 164 ECM molecules and cytokines from CAU-derived fibroblasts demonstrated a differentially regulated set of ECM proteins and increased cytokine expression. Whole breast ECM was isolated; invasion and soft agar assays demonstrated that estrogen receptor (ER)^-, progesterone receptor (PR)/PR^-cells were significantly more aggressive when in contact with AA ECM, as were ER⁺/PR⁺cells with CAU ECM. Using zymography, protease activity was comparatively upregulated in CAU ECM. In xenograft models, CAU ECM significantly increased the tumorigenicity of ER⁺/PR⁺cells and enhanced metastases. Mass spectrometry analysis of ECM proteins showed that only 1,759 of approximately 8,000 identified were in common. In the AA dataset, proteins associated with breast cancer were primarily related to tumorigenesis/neoplasia, while CAU unique proteins were involved with growth/metastasis. Using a novel mass spectrometry method, 17 biologically active hormones were measured; estradiol, estriol and 2-methoxyestrone were significantly higher in CAU breast tissue.</p> <p>Conclusions</p> <p>This study details normal premenopausal breast tissue composition, delineates potential mechanisms for breast cancer development, and provides data for further investigation into the role of the microenvironment in cancer disparities.</p

Mitochondrial Disease in Autism Spectrum Disorder Patients: A Cohort Analysis

Previous reports indicate an association between autism spectrum disorders (ASD) and disorders of mitochondrial oxidative phosphorylation. One study suggested that children with both diagnoses are clinically indistinguishable from children with idiopathic autism. There are, however, no detailed analyses of the clinical and laboratory findings in a large cohort of these children. Therefore, we undertook a comprehensive review of patients with ASD and a mitochondrial disorder.We reviewed medical records of 25 patients with a primary diagnosis of ASD by DSM-IV-TR criteria, later determined to have enzyme- or mutation-defined mitochondrial electron transport chain (ETC) dysfunction. Twenty-four of 25 patients had one or more major clinical abnormalities uncommon in idiopathic autism. Twenty-one patients had histories of significant non-neurological medical problems. Nineteen patients exhibited constitutional symptoms, especially excessive fatigability. Fifteen patients had abnormal neurological findings. Unusual developmental phenotypes included marked delay in early gross motor milestones (32%) and unusual patterns of regression (40%). Levels of blood lactate, plasma alanine, and serum ALT and/or AST were increased at least once in 76%, 36%, and 52% of patients, respectively. The most common ETC disorders were deficiencies of complex I (64%) and complex III (20%). Two patients had rare mtDNA mutations of likely pathogenicity.Although all patients' initial diagnosis was idiopathic autism, careful clinical and biochemical assessment identified clinical findings that differentiated them from children with idiopathic autism. These and prior data suggest a disturbance of mitochondrial energy production as an underlying pathophysiological mechanism in a subset of individuals with autism

What can health inequalities researchers learn from an intersectionality perspective?:Understanding social dynamics with an inter-categorical approach

The concept of intersectionality was developed by social scientists seeking to analyse the multiple interacting influences of social location, identity and historical oppression. Despite broad take-up elsewhere, its application in public health remains underdeveloped. We consider how health inequalities research in the United Kingdom has predominantly taken class and later socioeconomic position as its key axis in a manner that tends to overlook other crucial dimensions. We especially focus on international research on ethnicity, gender and caste to argue that an intersectional perspective is relevant for health inequalities research because it compels researchers to move beyond (but not ignore) class and socioeconomic position in analysing the structural determinants of health. Drawing on these theoretical developments, we argue for an inter-categorical conceptualisation of social location that recognises differentiation without reifying social groupings – thus encouraging researchers to focus on social dynamics rather than social categories, recognising that experiences of advantage and disadvantage reflect the exercise of power across social institutions. Such an understanding may help address the historic tendency of health inequalities research to privilege methodological issues and consider different axes of inequality in isolation from one another, encouraging researchers to move beyond micro-level behaviours to consider the structural drivers of inequalities

Effects of 2-methoxyestradiol administration in mouse models purported to show signs of preeclampsia and fetal growth restriction

Plasma concentration of 2-methoxyestradiol (2-ME) and placental expression of catechol-O-methyltransferase(COMT) are elevated in normal pregnancy, but reduced in women with preeclampsia (PE). Women with PE and fetal growth restriction (FGR)exhibit decreased utero-placental blood flow. Catechol-O-methyltransferase knockout mice (COMT-/-) and female CBA/J mice mated with male DBA/2 mice (CBA/J × DBA/2)show many signs of PE during pregnancy and deliver growth-restricted pups. 2-ME is known to induce significant vasorelaxation of uterine arteries from pregnant mice. We hypothesized that 2-ME administration during pregnancy will lead to an increase in uterine artery blood flow velocity in COMT-/- and CBA/J × DBA/2 mice and therefore ameliorate PE-like signs and rescue fetal growth in these animal models. Pregnant COMT-/- and their controls (C57BL/6),and CBA/J × DBA/2 and their controls (CBA/J × BALB/c),were injected subcutaneously daily with 10 ng of 2-ME or vehicle (olive oil) from gestational day (GD) 12.5 to 17.5. There was no significant effect of genotype/strain or treatment on maternal blood pressure, uterine artery blood flow velocity or fetal growth. A perturbed phenotype only occurred in the COMT-/- mice in regard to umbilical artery flow velocity, proteinuria and 2-ME levels. Administration of 2-ME led to normalization ofumbilical artery blood flow velocity and proteinuria in COMT-/- mice. The utility of 2-ME in cases of PE and FGR needs to be further explored in PE models that exhibit more severe disease phenotypes