515 research outputs found
Exploring the Decision Making Processes of Early Career Strength and Conditioning Coaches
The role of Strength and Conditioning coaches within sporting environments is growing in importance and more attention is being directed towards acknowledging the characteristics and decision making processes of these coaches. To date, most of the research has been with experienced coaches thus created a need to better understand those coaches at the early stages of their career. The present study utilised Applied Cognitive Task Analysis to elicit knowledge from eight strength and conditioning coaches with less than three years full time experience. Methods applied identified that less experienced strength and conditioning coaches operate in predominately stable conditions and feel comfortable delivering within this stability. Interviews revealed early career coaches to prioritise movement qualities and rely on previously acquired theoretical knowledge to make predetermined decisions on training content and responses within environments. A final theme generated demonstrated that connections with athletes were important for coaches to feel confident within their role. Implications for future coach development materials exploring the use of metacognition and its associated components of planning, monitoring and evaluation discussed
Hadron mass corrections in semi-inclusive deep inelastic scattering
We derive mass corrections for semi-inclusive deep inelastic scattering of
leptons from nucleons using a collinear factorization framework which
incorporates the initial state mass of the target nucleon and the final state
mass of the produced hadron. The formalism is constructed specifically to
ensure that physical kinematic thresholds for the semi-inclusive process are
explicitly respected. A systematic study of the kinematic dependencies of the
mass corrections to semi-inclusive cross sections reveals that these are even
larger than for inclusive structure functions, especially at very small and
very large hadron momentum fractions. The hadron mass corrections compete with
the experimental uncertainties at kinematics typical of current facilities, and
will be important to efforts at extracting parton distributions or
fragmentation functions from semi-inclusive processes at intermediate energies.Comment: 22 pages, 6 figures; expanded discussion of kinematics and new
scaling variable; appendix comparing collinear frames included; version to
appear in JHE
Setting the stage for individualized therapy in hemophilia: what role can pharmacokinetics play?
Replacement therapy with clotting factor concentrates (CFC) is the mainstay of treatment in hemophilia. Its widespread application has led to a dramatic decrease in morbidity and mortality in patients, with concomitant improvement of quality of life. However, dosing is challenging and costs are high. This review discusses benefits and limitations of pharmacokinetic (PK)-guided dosing of replacement therapy as an alternative for current dosing regimens. Dosing of CFC is now primarily based on body weight and based on its in vivo recovery (IVR). Benefits of PK-guided dosing include individualization of treatment with better targeting, more flexible blood sampling, increased insight into association of coagulation factor levels and bleeding, and potential overall lowering of overall costs. Limitations include a slight burden for the patient, and availability of closely collaborating, experienced clinical pharmacologists
Weak multiplicativity for random quantum channels
It is known that random quantum channels exhibit significant violations of
multiplicativity of maximum output p-norms for any p>1. In this work, we show
that a weaker variant of multiplicativity nevertheless holds for these
channels. For any constant p>1, given a random quantum channel N (i.e. a
channel whose Stinespring representation corresponds to a random subspace S),
we show that with high probability the maximum output p-norm of n copies of N
decays exponentially with n. The proof is based on relaxing the maximum output
infinity-norm of N to the operator norm of the partial transpose of the
projector onto S, then calculating upper bounds on this quantity using ideas
from random matrix theory.Comment: 21 pages; v2: corrections and additional remark
Treatment regimens and outcomes in severe and moderate haemophilia A in the UK: The THUNDER study
Introduction: The THUNDER study provides an analysis of treatment patterns and outcomes in UK patients with severe or moderate haemophilia A (SHA/MHA) in 2015.
Methods: Patients with SHA or MHA registered with the UK National Haemophilia Database (NHD) were segregated by severity, inhibitor status and age. Haemophilia joint health score (HJHS) was derived from NHD records and treatment regimen and annualized bleed/joint‐bleed rate (ABR/AJBR) from Haemtrack (HT) in HT‐compliant patients.
Results: We report 1810 patients with SHA and 864 with MHA. Prophylaxis was used in 94.9% (n = 130/137) of HT‐compliant children <12 years with SHA, falling to 74.1% (n = 123/166) aged ≥40 years. Median ABR increased with age (1.0, IQR 0.0‐5.0, <12 years; 3.0 IQR, 1.0‐8.0, ≥40 years). Inhibitors were present in 159 (8.8%) SHA and 34 (3.9%) MHA. Median ABR increased from 2.0 (<12 years) to 21.(≥40 years) in SHA inhibitor patients using prophylaxis. Prophylaxis was used by 68.8% of HT‐compliant MHA patients (n = 106) (median FVIII baseline 0.01 IU/mL) associated with a median (IQR) ABR of 3.0 (1.0‐7.0). Median HJHS (n = 453) increased with age in SHA and MHA. Median (IQR) HJHS was higher in SHA inhibitor (17.0, 0.0‐64.5) than non‐ or past inhibitor patients (7.0, 0.0‐23.0).
Conclusions: Increasing ABR with age persists despite current prophylaxis regimens.SHA and MHA had similar ABR/AJBR and HJHS, leading to a suspicion that a subgroup of MHA may be relatively undertreated. More intensive prophylaxis may improve outcomes, but this requires further study
Next-to-leading Corrections to the Higgs Boson Transverse Momentum Spectrum in Gluon Fusion
We present a fully analytic calculation of the Higgs boson transverse
momentum and rapidity distributions, for nonzero Higgs , at
next-to-leading order in the infinite-top-mass approximation. We separate the
cross section into a part that contains the dominant soft, virtual, collinear,
and small--enhanced contributions, and the remainder, which is
organized by the contributions due to different parton helicities. We use this
cross section to investigate analytically the small- limit and compare
with the expectation from the resummation of large logarithms of the type
. We also compute numerically the cross section at moderate
where a fixed-order calculation is reliable. We find a -factor
that varies from , and a reduction in the scale dependence, as
compared to leading order. Our analysis suggests that the contribution of
current parton distributions to the total uncertainty on this cross section at
the LHC is probably less than that due to uncalculated higher orders.Comment: 40 pages, 10 figures, JHEP style (minor changes, added reference
Anisotropic optical properties of single-crystal GdBa2Cu3O7-delta
The optical spectrum of reduced-T(c) GdBa2Cu3O7-delta has been measured for polarizations parallel and perpendicular to the ab plane. The sample was an oxygen-deficient single crystal with a large face containing the c axis. The polarized reflectance from this face was measured from 20-300 K in the spectral region from 30-3000 cm-1, with 300 K data to 30 000 cm-1. Kramers-Kronig analysis was used to determine the spectral dependence of the ab and the c components of the dielectric tensor. The optical properties are strongly anisotropic. The ab-plane response resembles that of other reduced-T(c) materials whereas the c axis, in contrast, shows only the presence of several phonons. There is a complete absence of charge carrier response along c above and below T(c). This observation allows us to set an upper limit to the free-carrier spectral weight for transport perpendicular to the CuO2 planes
Theoretical and experimental analysis of the vacuum pressure in a vacuum glazing after extreme thermal cycling
The UKIDSS Galactic Plane Survey
'The definitive version is available at www.blackwell-synergy.com .' Copyright Blackwell Publishing DOI: 10.1111/j.1365-2966.2008.13924.xThe UKIDSS Galactic Plane Survey (GPS) is one of the five near-infrared Public Legacy Surveys that are being undertaken by the UKIDSS consortium, using the Wide Field Camera on the United Kingdom Infrared TelescopePeer reviewe
Phase-Field Approach for Faceted Solidification
We extend the phase-field approach to model the solidification of faceted
materials. Our approach consists of using an approximate gamma-plot with
rounded cusps that can approach arbitrarily closely the true gamma-plot with
sharp cusps that correspond to faceted orientations. The phase-field equations
are solved in the thin-interface limit with local equilibrium at the
solid-liquid interface [A. Karma and W.-J. Rappel, Phys. Rev. E53, R3017
(1996)]. The convergence of our approach is first demonstrated for equilibrium
shapes. The growth of faceted needle crystals in an undercooled melt is then
studied as a function of undercooling and the cusp amplitude delta for a
gamma-plot of the form 1+delta(|sin(theta)|+|cos(theta)|). The phase-field
results are consistent with the scaling law "Lambda inversely proportional to
the square root of V" observed experimentally, where Lambda is the facet length
and V is the growth rate. In addition, the variation of V and Lambda with delta
is found to be reasonably well predicted by an approximate sharp-interface
analytical theory that includes capillary effects and assumes circular and
parabolic forms for the front and trailing rough parts of the needle crystal,
respectively.Comment: 1O pages, 2 tables, 17 figure
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