69 research outputs found

    Influence of music on driver psychology and safety-relevant behaviours: a multi-study inductive content analysis

    Get PDF
    Supplemental data for this article is available online at https://doi.org/10.1080/1463922X.2021.2009933 .Copyright © 2021 The Author(s). Underpinned by pragmatism and symbolic interactionism, an inductive content analysis was conducted to assess driving experiences under a variety of music conditions. Many quantitative studies have addressed the effects of music on drivers, but there has been a conspicuous dearth of qualitative research to provide a more nuanced understanding of music-related phenomena. Data collection took place over three simulated driving studies, each with different tasks/participants (Study 1 – n = 34, Study 2 – n = 46, and Study 3 – n = 27). The inductive content analysis was conducted by two members of the research team and a peer debriefing was conducted by a third. Findings show that music can have a range of affective, behavioural and cognitive effects (both positive and negative), that are moderated by the driving environment (i.e. urban vs. highway) and aspects of the musical stimulus (i.e. inclusion/non-inclusion of lyrics, loudness and tempo). Participants were mindful of the implications of in-vehicle music vis-à-vis the safety–performance–pleasure trade-off. The analysis suggested a perceived beneficial effect of music and consequent contribution to driving style/safety-related performance. Younger drivers’ apparent reliance on music as a means by which to regulate their emotion highlights an education need in terms of optimising selections.UKRI Economic and Social Research Council grant (ES/R005559/1); Direct Line Group (UK)

    Psychological and psychophysiological effects of music intensity and lyrics on simulated urban driving

    Get PDF
    © 2021 The Authors. The main aim of this study was to investigate the effect of musical characteristics (i.e., presence of lyrics and loudness) in the context of simulated urban driving. Previous work has seldom isolated musical characteristics and examined these both singularly and interactively. We investigated the potentially distracting effects of processing lyrics through exposing young drivers to the same piece of music with/without lyrics and at different sound intensities (60 dBA [soft] and 75 dBA [loud]) using a counterbalanced, within-subjects design (N = 34; Mage = 22.2 years, SD = 2.0 years). Six simulator conditions were included that comprised low-intensity music with/without lyrics, high-intensity music with/without lyrics, plus two controls – ambient in-car noise and spoken lyrics. Between-subjects variables of driving style (defensive vs. assertive) and sex (women vs. men) were explored. A key finding was that the no lyrics/soft condition yielded lower affective arousal scores when compared to the other music conditions. There was no main effect of condition for HRV data (SDNN and RMSSD). Exploratory analyses showed that, for assertive drivers, NASA-TLX Performance scores were lower in the no lyrics/soft condition compared to the lyrics/loud condition. Moreover, women exhibited higher mean heart rate than men in the presence of lyrics. Although some differences emerged in subjective outcomes, these were not replicated in HRV, which was used as an objective index of emotionality. Drivers should consider the use of soft, non-lyrical music to optimise their affective state during urban driving.UKRI Economic and Social Research Council grant (ES/R005559/ 1); Direct Line Group (UK)

    GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain.

    Get PDF
    Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in EV assembly and secretion. We observe high levels of GAPDH binding to the outer surface of EVs via a phosphatidylserine binding motif (G58), which promotes extensive EV clustering. Further studies in a Drosophila EV biogenesis model reveal that GAPDH is required for the normal generation of intraluminal vesicles in endosomal compartments, and promotes vesicle clustering. Fusion of the GAPDH-derived G58 peptide to dsRNA-binding motifs enables highly efficient loading of small interfering RNA (siRNA) onto the EV surface. Such vesicles efficiently deliver siRNA to multiple anatomical regions of the brain in a Huntington's disease mouse model after systemic injection, resulting in silencing of the huntingtin gene in different regions of the brain

    Effects of music on arousal during imagery in elite shooters: A pilot study

    Get PDF
    © 2017 Kuan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Beneficial effects of music on several performance-related aspects of sport have been reported, but the processes involved are not well understood. The purpose of the present study was to investigate effects of relaxing and arousing classical music on physiological indicators and subjective perceptions of arousal during imagery of a sport task. First, appropriate music excerpts were selected. Then, 12 skilled shooters performed shooting imagery while listening to the three preselected music excerpts in randomized order. Participants' galvanic skin response, peripheral temperature, and electromyography were monitored during music played concurrently with imagery. Subjective music ratings and physiological measures showed, as hypothesized, that unfamiliar relaxing music was the most relaxing and unfamiliar arousing music was the most arousing. Researchers should examine the impact of unfamiliar relaxing and arousing music played during imagery on subsequent performance in diverse sports. Practitioners can apply unfamiliar relaxing and arousing music with imagery to manipulate arousal level.This present study was support by the Fundamental Research Grant Scheme, Ministry of Higher Education, Ministry of Education, Malaysia (FRGS/1/2014/SS02/USM/03/1)

    Mental health of female foreign spouses in transnational marriages in southern Taiwan

    Get PDF
    <p>Abstract</p> <p>Background</p> <p>The aim of this study was to investigate the mental health status, and the risk factors associated with mild psychiatric disorders, of female foreign spouses (from Vietnam, Indonesia, and mainland China) in southern Taiwan, and to understand the mental health needs of these women.</p> <p>Methods</p> <p>One hundred and twenty nine participants were willing to participate in this study. All participants fulfilled all questionnaires which included demographic information, the Chinese Health Questionnaire (CHQ), the Eysenck Personality Questionnaire (EPQ), and the Mental Health Care Needs Questionnaire (MHCNQ).</p> <p>Results</p> <p>By multiple linear regression, neuroticism characteristics (p = 0.000), the dimension of knowledge of the level of their own psychological disturbance (p = 0.001), dimension of friends assistance (p = 0.033), and dimension of religion comfort (p = 0.041) in mental health care needs could be used to predict possible mild psychiatric disorders. Furthermore, SEM model showed that Indonesian or Vietnamese spouses have more likely degree in mental health care needs (β = -0.24, <it>p </it>= 0.003), compared with Chinese ones. A higher level of neuroticism was associated with a greater likelihood of mild psychiatric disorder (β = 0.54, <it>p </it>< 0.001), and of mental health care needs (β = 0.21, <it>p </it>= 0.013). A higher degree of mental health care needs was related to a greater likelihood of mild psychiatric disorder (β = 0.14, <it>p </it>= 0.05).</p> <p>Conclusion</p> <p>In conclusion, we have obtained a better understanding of the mental health status of female foreign spouses in transnational marriages, who face many difficulties. Indonesian or Vietnamese spouses tend to more likely degree in mental health care needs than Chinese spouses, and then indirectly influenced their mental health status. Some individuals with a neurotic personality are exposed to high risk and might suffer from mild psychiatric symptoms. The needs for psychological counseling and religion therapy were the first priority for these women, particularly the Indonesian and Vietnamese spouses. From these findings, we have a better understanding of how to assist these female foreign spouses in future.</p

    The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia

    Get PDF
    Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with p-values of 10−7 or lower. These studies have been performed primarily in cigarette smokers, raising the possibility that the observed associations could be related to tobacco use, lung carcinogenesis, or both. Since most women in Asia do not smoke, we conducted a genome-wide association study of lung adenocarcinoma in never-smoking females (584 cases, 585 controls) among Han Chinese in Taiwan and found that the most significant association was for rs2736100 on chromosome 5p15.33 (p = 1.30×10−11). This finding was independently replicated in seven studies from East Asia totaling 1,164 lung adenocarcinomas and 1,736 controls (p = 5.38×10−11). A pooled analysis achieved genome-wide significance for rs2736100. This SNP marker localizes to the CLPTM1L-TERT locus on chromosome 5p15.33 (p = 2.60×10−20, allelic risk = 1.54, 95% Confidence Interval (CI) 1.41–1.68). Risks for heterozygote and homozygote carriers of the minor allele were 1.62 (95% CI; 1.40–1.87), and 2.35 (95% CI: 1.95–2.83), respectively. In summary, our results show that genetic variation in the CLPTM1L-TERT locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma

    ICAR: endoscopic skull‐base surgery

    Get PDF
    n/

    On Multipoint Numerical Interpolation

    No full text
    corecore