Fate of topological states in incommensurate generalized Aubry-Andr\'e models

We study one-dimensional optical lattices described by generalized Aubry-Andr\'e models that include both commensurate and incommensurate modulations of the hopping amplitude. This brings together two interesting features of this class of systems: Anderson localization and the existence of topological edge states. We follow changes of the single-particle energy spectrum induced by variations of the system parameters, with focus on the survival of topological states in the localized regime.Comment: 5 pages, 5 figure

Finite-size effects in Anderson localization of one-dimensional Bose-Einstein condensates

We investigate the disorder-induced localization transition in Bose-Einstein condensates for the Anderson and Aubry-Andre models in the non-interacting limit using exact diagonalization. We show that, in addition to the standard superfluid fraction, other tools such as the entanglement and fidelity can provide clear signatures of the transition. Interestingly, the fidelity exhibits good sensitivity even for small lattices. Effects of the system size on these quantities are analyzed in detail, including the determination of a finite-size-scaling law for the critical disorder strength in the case of the Anderson model.Comment: 15 pages, 7 figure

investigation of particle dynamics and classification mechanism in a spiral jet mill through computational fluid dynamics and discrete element methods

Abstract Predicting the outcome of jet-milling based on the knowledge of process parameters and starting material properties is a task still far from being accomplished. Given the technical difficulties in measuring thermodynamics, flow properties and particle statistics directly in the mills, modelling and simulations constitute alternative tools to gain insight in the process physics and many papers have been recently published on the subject. An ideal predictive simulation tool should combine the correct description of non-isothermal, compressible, high Mach number fluid flow, the correct particle-fluid and particle-particle interactions and the correct fracture mechanics of particle upon collisions but it is not currently available. In this paper we present our coupled CFD-DEM simulation results; while comparing them with the recent modelling and experimental works we will review the current understating of the jet-mill physics and particle classification. Subsequently we analyze the missing elements and the bottlenecks currently limiting the simulation technique as well as the possible ways to circumvent them towards a quantitative, predictive simulation of jet-milling

Conditioning of hiPSC-derived cardiomyocytes using surface topography obtained with high throughput technology

Surface functionalization of polymers aims to introduce novel properties that favor bioactive responses. We have investigated the possibility of surface functionalization of polyethylene terephthalate (PET) sheets by the combination of laser ablation with hot embossing and the application of such techniques in the field of stem cell research. We investigated the response of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to topography in the low micrometer range. HiPSC-CMs are expected to offer new therapeutic tools for myocardial replacement or regeneration after an infarct or other causes of cardiac tissue loss. However, hiPSC-CMs are phenotypically immature compared to myocytes in the adult myocardium, hampering their clinical application. We aimed to develop and test a high-throughput technique for surface structuring that would improve hiPSC-CMs structural maturation. We used laser ablation with a ps-laser source in combination with nanoimprint lithography to fabricate large areas of homogeneous micron- to submicron line-like pattern with a spatial period of 3 µm on the PET surface. We evaluated cell morphology, alignment, sarcomeric myofibrils assembly, and calcium transients to evaluate phenotypic changes associated with culturing hiPSC-CMs on functionalized PET. Surface functionalization through hot embossing was able to generate, at low cost, low micrometer features on the PET surface that influenced the hiPSC-CMs phenotype, suggesting improved structural and functional maturation. This technique may be relevant for high-throughput technologies that require conditioning of hiPSC-CMs and may be useful for the production of these cells for drug screening and disease modeling applications with lower costs.Fil: Cortella, Lucas R. X.. Universidade de Sao Paulo; BrasilFil: Cestari, Idágene A.. Universidade de Sao Paulo; BrasilFil: Lahuerta, Ricardo D.. Universidade de Sao Paulo; BrasilFil: Arana, Matheus C.. Universidade de Sao Paulo; BrasilFil: Soldera, Marcos Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; ArgentinaFil: Rank, Andreas. Technische Universität Dresden; AlemaniaFil: Lasagni, Andrés F.. Technische Universität Dresden; AlemaniaFil: Cestari, Ismar N.. Universidade de Sao Paulo; Brasi

Long-lasting positive effects of collaborative remembering on false assents to misleading questions

Previous studies showed that collaborative remembering can reduce false memories through a process of mutual error checking, although conclusions were limited by the nature of the memory tasks (very few errors). The present experiments extend these findings to eyewitness memory by using a paradigm designed to increase the frequency of memory errors. Collaborative and nominal pairs viewed a video-clip illustrating a bank robbery, provided an immediate free recall, were forced to confabulate answers to false-event questions, and, after a short- (1 h: Experiment 1) or a long-term delay (1 week: Experiment 2), were administered a yes/no recognition task in which the misleading statements either matched the questions presented in the confabulation phase (answered questions) or not (control questions). Collaborative pairs recalled fewer correct details in the immediate free recall task, replicating the negative effects of collaborative inhibition. Most importantly, in the final recognition test, collaborative pairs were less likely to provide false assents to misleading statements, regardless of whether they had provided a response to the related false-event questions 1 h or 1 week earlier. Our results suggest that collaboration can increase the eyewitnesses' tendency to check the accuracy of others' responses and reject false memories through discussion

Vari aspetti del nulla assoluto nelle filosofie di Nishida e Tanabe

This paper deals with the conception of Absolute Nothingness (zettai mu), one of the pivotal terms in Japanese contemporary philosophy. This idea is generally considered as the philosophical version of the Buddhist notion of Śūnyatā (emptiness). In the thinking of Nishida Kitarō and Tanabe Hajime, two leading philosophers of the so called Kyōto School, Absolute Nothingness becomes the fundamental tool to build a dialectics which is meant to overcome Hegelian system

Critical exponents of the disorder-driven superfluid-insulator transition in one-dimensional Bose-Einstein condensates

We investigate the nature of the superfluid-insulator quantum phase transition driven by disorder for non-interacting ultracold atoms on one-dimensional lattices. We consider two different cases: Anderson-type disorder, with local energies randomly distributed, and pseudo-disorder due to a potential incommensurate with the lattice, which is usually called the Aubry-Andr\'e model. A scaling analysis of numerical data for the superfluid fraction for different lattice sizes allows us to determine quantum critical exponents characterizing the disorder-driven superfluid-insulator transition. We also briefly discuss the effect of interactions close to the non-interacting quantum critical point of the Aubry-Andr\'e model.Comment: 5 pages, 4 figure

First report about saxitoxins in freshwater fish Hoplias malabaricus through trophic exposure.

Cyanobacterial waterblooms, such as the saxitoxin (STX) producer Cylindrospermopsis raciborskii, have been a worldwide concern in environmental health. However, the bioaccumulation of this neurotoxin in the trophic chain is not completely known. The aim of the present work was to evaluate STX bioaccumulation through chemical analyses and the toxic and trophic effects using biomarkers in the tropical freshwater fish Hoplias malabaricus. They were fed once every five days with Astyanax sp. before being subjected to intraperitoneal inoculation with STX extract (0.08 mg/100 g) obtained by lysis of toxic C. raciborskii strain (T3). After 20 days the brain was collected for acetylcholinesterase (AChE), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione (GSH), lipoperoxidation (LPO), protein carbonylation (PCO), and comet assay analysis. The muscle was collected for STX chemical analysis. The activities of SOD and concentrations of PCO and LPO increased. The CAT, GST, and GPx activities decreased. Genotoxicity was observed in the experimental group. STX was not detected in muscle samples. Thus, an oxidative stress was observed in the brain, leading to the damage of lipids, proteins, and DNA. The mechanism of action of the neurotoxin in this subchronic exposure suggests an apoptotic cellular process

Hematologic and hepatic responses of the freshwater fish Hoplias malabaricus after saxitoxin exposure.

The bioaccumulation of saxitoxins (STX) in the trophic chain, mainly in freshwater, are not completely known. This work aimed to elucidate the effects of STX on Hoplias malabaricus through trophic bioassay. The fish were fed once every five days with Astyanax sp. before being subjected to an intraperitoneal inoculation with the lysate of Cylindrospermopsis raciborskii culture containing 97% STX and 3% by neosaxitoxin and gonyautoxin during 20 days. The animal?s liver was assessed using biomarkers as activities of superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPx), and concentrations of reduced glutathione (GSH) and lipoperoxidation (LPO) and protein carbonylation (PCO). In the blood was analyzed the genotoxic and hematological parameters. The hepatosomatic index and the relative condition factor did not show a significant difference between the exposed and control groups. The values of mean corpuscular hemoglobin concentration and mean corpuscular hemoglobin increased in the STX group. The hepatic tissue from both groups exhibited a typical pattern that have been already described for most teleost fish. The results suggested the generation of reactive oxygen species, with increased activity of GPx and concentrations of LPO and GSH; whereas the specific activity of SOD decreased. However, no changes were observed in the CAT, PCO, and DNA damage. Although the STX effects are known as neurotoxic, this cyanotoxin caused liver biochemical alterations that can be considered ecologically relevant