La inversión en España

El trabajo trata de profundizar en los rasgos fundamentales del comportamiento de la inversion de la economia española. El estudio se ocupa de una variable fundamental como es la inversion, ya que, por un lado, determina en gran medida las posibilidades de crecimiento de largo plazo de la economia y, por otro, sus oscilaciones condicionan de manera decisiva las fluctuaciones de la produccion y del empleo. Por tanto, el conocimiento de su evolucion y determinante permitira diseñar politicas economicas que ayuden al crecimiento y a estabilizar las fluctuaciones economicas. El trabajo realiza un analisis descriptivo, seguido de diversas estimaciones agregadas de la inversion productiva privada, que permite conocer los principales factores explicativos y conjeturar la respuesta de esta variable ante posibles perturbaciones economicas. La segunda parte utiliza la informacion individual de un grupo de empresas no financieras y trata de cuantificar la influencia sobre la inversion de la estructura financiera. (aeg) (fcf) (igc) (jvl) (mac

Experimentos de contrôle do Phytophthora infestans nas condições de Pelotas e São Lourenço do Sul, no Rio Grande do Sul

The Plant Pathology and Horticulture Sections of the IPEAS, in collaboration with the IRI, have carried out eight experiments for comparison of fungicides in the control of Phytophthora infestans (Mont.) De Bary, the agent of the mildew of potato (Solanum tuberosum L.). The tests were made during the period from 1965 to 1967. All of the fungicides tested showed capacity for the control of the disease, even when a small number of applications were made. It was not possible to analyze statistically the combined data of production from all the experiments. Nevertheless, the phytopathological observations made during the course of the work made clear that there was a slight superiority of the fungicides Manzate D, Dithane M-45 and Miltox as compared with the other fungicides. Thus, it was demonstrated that the efficiency of presently available fungicides is adequate for use in chemical prophylactic treatment, however, it is conditioned by other factors that are described in the text and in previous research work.As Seções de Fitopatologia e de Horticultura do Instituto de Pesquisas e Experimentação Agropecuárias do Sul, em colaboração com o IRI, realizaram oito experimentas de competição entre fungicidas, no período de 1965 a 1967, visando controlar o Phytophthora infestans (Mont.) De Bary, agente do míldio da batata (Solanum tuberosum, L.). Todos os fungicidas testados demonstraram capacidade de contrôle da moléstia, mesmo com pequeno número de pulverizações. Não foi possível analisar estatisticamente os dados de produção do conjunto de experimentos. Entretanto, as observações fitopatológicas, efetuadas no transcurso dos trabalhos, deixaram transparecer uma leve superioridade dos fungicidas Manzate D, Dithane M-45 e Miltox, sôbre os demais. Desta forma, ficou demonstrado não constituir problema o tratamento químico profilático do míldio da batata, no que concerne à eficiência de fungicidas. A viabilidade dos tratamentos, entretanto, fica condicionada a outros fatôres, relacionados no texto e em trabalhos anteriores

E-Comunicando: desafios na implementação de uma conferência com emissão streaming

A Internet e várias aplicações web são usadas virtualmente em todos os domínios das atividades humanas. A preparação de conferências é um dos exemplos onde a internet é amplamente utilizada para divulgação das informações sobre um evento futuro (através de e-mail e websites), Registo do participantes e submissão e armazenamento de documentos associados ao evento. No âmbito da 1ª Convenção Nacional do Ensino a Distância , o Instituto Politécnico do Porto, propôs-se organizar este evento de forma integrada – presencial e online. Resultando a experiência acumulada da Unidade de e-Learning e Inovação Pedagógica, e com o expertise de técnicos especializados, a C convenção foi realizada no dia 6 de Maio de 2019, envolvendo com cerca de meia centena de participantes online a a distância, e cerca de 30% dos oradores estiveram a distância . Com este paper pretendemos partilhar experiência e conhecimento, focando-nos nos aspetos organizacionais, comunicacionais, tecnológicos , legais e financeiros associados a um evento desta natureza.info:eu-repo/semantics/publishedVersio

Adjuvant dabrafenib and trametinib for patients with resected BRAF-mutated melanoma: DESCRIBE-AD real-world retrospective observational study

BRAF and MEK inhibitor, dabrafenib plus trametinib, adjuvant therapy is effective for high-risk resected melanoma patients with BRAF-V600 mutations. However, real-world evidence is limited. We aimed to determine the feasibility of this therapy in routine clinical practice. DESCRIBE-AD, a retrospective observational study, collected real-world data from 25 hospitals in Spain. Histologically confirmed and resected BRAF-mutated melanoma patients aged & GE;18 years who were previously treated with dabrafenib plus trametinib adjuvant therapy, were included. The primary objectives were treatment discontinuation rate and time to discontinuation. The secondary objectives included safety and efficacy. From October 2020 to March 2021, 65 patients were included. Dabrafenib and trametinib discontinuation rate due to treatment-related adverse events (TRAEs) of any grade was 9%. Other reasons for discontinuation included patients' decisions (6%), physician decisions (6%), unrelated adverse events (3%), disease progression (5%), and others (5%). The median time to treatment discontinuation was 9 months [95% confidence interval (CI), 5-11]. G3-4 TRAEs occurred in 21.5% of patients, the most common being pyrexia (3%), asthenia (3%), and diarrhoea (3%). Unscheduled hospitalisations and clinical tests occurred in 6 and 22% of patients, respectively. After 20-month median follow-up (95% CI, 18-22), 9% of patients had exitus due to disease progression, with a 12-month relapse-free survival and overall survival rates of 95.3% and 100%, respectively. Dabrafenib and trametinib adjuvant therapy proved effective for melanoma patients in a real-world setting, with a manageable toxicity profile. Toxicity frequencies were low leading to low incidence of unscheduled medical visits, tests, and treatment discontinuations

Os primórdios da organização do espaço territorial e da vila cearense: algumas notas

This paper presents, in outline, the action taken by economic agents, representatives of the Church and the Portuguese State in organizing the space of the Captaincy of Ceará in the eighteenth century. The Portuguese State founded towns in strategic locations for better capitalization of the cattle breeder economy, where first settled sesmeiros and the Church. There was no reason or justification of geopolitical nature that demanded technical and financial investments by the Portuguese in the full adequacy of the local conditions to Portuguese urban guidelines. In the face of the late occupation, the article also discusses the late cartographic representation as expressing the lack of interests of the Portuguese administration in relation to a fuller understanding of the region

SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry

Background The Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 ( GRAVID ).Methods The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect of melanoma treatment and tumor stage on the risk of COVID-19 complications. These are the final data of the register, including cases from February 2020 to September 2021.Results One hundred-fifty cases were registered. Median age was 68 years (range 6-95), 61 (40%) patients were females, and 63 (42%) patients had stage IV. Thirty-nine (26%) were on treatment with immunotherapy, and 17 (11%) with BRAF-MEK inhibitors. COVID-19 was resolved in 119 cases, including 85 (57%) patients cured, 15 (10%) that died due to melanoma, and 20 (13%) that died due to COVID-19. Only age over 60 years, cardiovascular disorders, and diabetes mellitus increased the risk of death due to COVID-19, but not advanced melanoma stage nor melanoma systemic therapies. Three waves have been covered by the register: February-May 2020, August-November 2020, and December 2020-April 2021. The first wave had the highest number of registered cases and COVID-19 mortality.Conclusion Tumor stage or melanoma treatments are non-significant prognostic factors for COVID-19 mortality. During the pandemic in Spain there was a downward trend in the number of patients registered across the waves, as well as in the severity of the infection

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

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