Assessment of the scientific evidence of the potential use of açaí (Euterpe oleracea, Mart.) in clinical outcomes: analysis with focus on antioxidant and anti-inflammatory action

The açaí berry (Euterpe oleracea, Mart.), fruit native to the Amazon region and explored mainly in the region of Pará, gained importance in recent years due to potential health benefits, associated with its phytochemical composition and antioxidant capacity, related to its high content of flavonoids. Among these, anthocyanins are responsible for the anti-inflammatory and antioxidant capacity of this fruit. Experimental studies show that due to its composition, the acai berry has antioxidant activity related to its ability to reduce the reactive oxygen species (ROS) and its potential to inhibit cyclooxygenase 2 (COX-2). Another benefit studied is the analysis of their effectiveness in the anti-inflammatory process, being observed inhibition of araquedônico acid-derived mediators, suggesting that the fruit can act in the chronic inflammatory process. Also it was possible to observe that the fruit may have anti-inflammatory effects in healthy patients. Thus, the supplementation of diets with use of acai berry could attenuate inflammation process and oxidative stress, today with more consistent evidence derived primarily from in vitro studies. However, there is still need for further studies to prove the action of this fruit in the mechanisms involved in these processes, isolation of specific compounds and determining their optimal dosage

Feasibility Study on the Use of Cold Premixed Asphalt in Coari - AM

As road transport is the predominant type of transport for the traffic of people, vehicles and cargo, it is extremely important to ensure the quality of the country\u27s road pavement. Good pavement ensures comfort, safety and economy to road users. There are several types of coatings to be used depending on the project, the traffic demand of the road to be paved and others. Thus, the main objective of this research is to show the feasibility of using cold premixed asphalt in the city of Coari, municipality of the interior of Amazonas. For this, an investigation was conducted in bibliographies, in order to support the study. A budget based on DNIT unit cost compositions was made to compare the costs required to apply this asphalt mix with hot-machined concrete, as this is the most commonly used for pavement construction. Checking the advantages and disadvantages of its use to evaluate its application in the municipality in question. As the cold premix showed to meet most of the requirements for good paving, having a better cost-benefit ratio, it was found that it can be used on low and medium traffic roads, bringing several positive aspects in operational issues. and economical

Avaliação de imóvel paradigma em múltiplos terrenos urbanos de Caxambu, sul de Minas Gerais

As incorporadoras e construtoras, independentemente da região, trabalham com a escolha de um terreno onde irão desenvolver seus empreendimentos. O que difere os terrenos ideais para construir um empreendimento são as variáveis, particulares para cada imóvel, sendo que estas impactam diretamente no valor de avaliação dos imóveis. Portanto, o objetivo deste estudo é identificar entre os três terrenos estudados qual apresenta o maior retorno do investimento imobiliário utilizando variáveis que apresentem impacto no valor final de avaliação deste imóvel a ser construído, como se pronto estivesse, ou seja, um imóvel paradigma. A pesquisa dá início na identificação de variáveis que terão suas significâncias testadas por meio da inferência estatística, adotando o método comparativo direto de dados de mercado de acordo com a NBR 14653 (ABNT, 2011) avaliação de bens. Os dados da pesquisa são da cidade de Caxambu, localizada no sul de Minas Gerais, coletados em imobiliárias locais. Obtidos os 30 dados, todos foram tratados e 3 foram descartados, verificando a significância dos outros 27 dados utilizados na elaboração do modelo de regressão linear para avaliação do imóvel paradigma. Os resultados encontrados indicam que as variáveis que mostraram coerência com a hipótese inicial, assim como significância no valor do imóvel paradigma, são: área do terreno, área da construção, frente do imóvel, topografia e zoneamento do imóvel. As variáveis possuir equipamentos, posição na quadra, vagas de garagem, distância à praça central e padrão construtivo foram estudadas e não apresentaram relevância no modelo inferencial ou não atenderam à hipótese inicial. O terreno melhor avaliado apresentou resultado financeiro para execução do imóvel paradigma proposto de R$20.342,17 e R$ 34.043,18 acima dos outros dois terrenos estudados. O trabalho atinge o Grau II de Fundamentação e Grau III de Precisão de acordo com a NBR 14653 (ABNT, 2011). Conclui-se que é crucial o estudo de um modelo estatístico adotando variáveis significativas para avaliar o imóvel paradigma a fim de se aumentar a lucratividade do empreendimento.Developers and construction companies, regardless of the region, work with the choice of land where they will develop their projects. What differentiates the ideal land to build a venture is the variables, particular to each property, and these directly impact the valuation value of the properties. Therefore, the objective of this study is to identify, among the three lands studied, which one has the highest return on real estate investment using variables that have an impact on the final valuation value of this property to be built, as if it were ready, that is, a paradigm property. The research begins with the identification of variables that will have their significance tested through statistical inference, adopting the direct comparative method of market data in accordance with NBR 14653 (ABNT, 2011) asset valuation. The research data are from the city of Caxambu, located in the south of Minas Gerais, collected in local real estate agencies. After obtaining the 30 data, all were treated and 3 were discarded, verifying the significance of the other 27 data used in the elaboration of the linear regression model to evaluate the immovable paradigm. The results found indicate that the variables that showed consistency with the initial hypothesis, as well as significance in the value of the paradigm property, are: land area, construction area, front of the property, topography and zoning of the property. The variables having equipment, position on the court, parking spaces, distance from the central square and construction standard were studied and did not show relevance in the inferential model or did not meet the initial hypothesis. The best evaluated land presented a financial result for the execution of the proposed paradigm property of R$20,342.17 and R$ 34,043.18 above the other two lands studied. The work reaches Grade II of Grounds and Grade III of Precision according to NBR 14653 (ABNT, 2011). It is concluded that it is crucial to study a statistical model adopting significant variables to evaluate the paradigm property in order to increase the profitability of the enterprise

Elements that influence knowledge sharing in the university-industry-government collaboration Case studies in Brazil

Purpose – The purpose of this paper is to determine the factors for an academic research project in electrical engineering to become relevant. Design/methodology/approach – As a conceptual basis, a few theories of entrepreneurial university and triple helix were correlated, seeking to determine the main critical factors and the successful criteria of an academic research project. The research was conducted through four cases of electric engineering that succeed in generating social and economic impact. Findings – When analyzing the available bibliography, it is clear that the connection among the companies, the market and the research that happens at the university is very important. Not only that, but also, according to the results, this is the key to generating revenue and impact on society. In addition, operational policies and competent leaders promoting this impact inside the universities are extremely important. Originality/value – The topic was selected because of the reduced number of articles related to the identification and analyses of the main aspects that make an academic research project relevant to the society. Furthermore, the paper is significant because it analyzes the main factors that help develop a better society and country through academic research

Extramammary Paget’s disease affecting the external auditory canal: a case report

INTRODUCTION: Extramammary Paget’s disease is a rare histological type of intraepithelial adenocarcinoma that mainly affects apocrine sweat gland-rich areas. Predilection sites include the anogenital region and, less commonly, the axillae. These tumors rarely occur in non-apocrine regions. The aim of this case report is to describe a case of extramammary Paget’s disease in the external auditory canal with extensive temporal bone involvement and skull base invasion. CASE PRESENTATION: A 40-year-old Caucasian man presented with a progressively growing, vegetating lesion localized in his right-hand external auditory canal. He had peripheral facial nerve paralysis and complete ipsilateral hearing loss. An incisional biopsy suggested extramammary Paget’s disease, and the immunohistochemical analysis confirmed the diagnosis. The tumor was considered inoperable because of the extensive skull base involvement, and he was referred for palliative radiotherapy. CONCLUSION: We report here the third case of extramammary Paget’s disease affecting the external auditory canal to be described in the literature. In all the three cases, the prognosis was unfavorable despite treatment

A relação entre a constituição do liberalismo político e as desigualdades sociais e econômicas em John Rawls : a questão do direito a um mínimo social e do princípio da diferença como direitos constitucionais

Tese (doutorado)—Universidade de Brasília, Faculdade de Direito, Programa de Pós-Graduação em Direito, 2015.Trata-se de tese de doutorado em direito, estado e constituição. Faz uma relação entre filosofia e direito constitucional. Tem como objetivo geral estudar como uma constituição se relaciona com normas relevantes que estruturam a divisão dos ônus e dos bônus da cooperação social no pensamento de John Rawls. Tem como objetivos específicos: apresentar a teoria da justiça como equidade; descrever a constituição da justiça como equidade; analisar a constituição do liberalismo político; apresentar o princípio da diferença e analisar o direito a um mínimo social como um direito inerente à constituição. O problema consiste em saber por que o princípio da diferença não é uma parte integrante dos elementos constitucionais essenciais do liberalismo político descrito por Rawls ao passo que o direito a um mínimo social é parte integrante desses elementos. A hipótese é a de que o princípio da diferença e o direito a um mínimo social possam ser considerados como elementos constitucionais essenciais do liberalismo político descrito por Rawls. Essa hipótese parece não ter sido suficientemente testada até o momento e as justificativas que a sustentam também parecem não serem suficientemente claras diante do contexto mais amplo das obras do autor. Emprega como técnica de pesquisa a documentação indireta, isto é, a documentação feita por meio da pesquisa documental (fontes primárias) e da pesquisa bibliográfica (fontes secundárias), com ênfase dada à pesquisa documental. Em função do objeto estudado, as fontes escritas por Rawls são consideradas fontes primárias, ao passo que as fontes escritas pelos autores a respeito de Rawls e as demais fontes são consideradas fontes secundárias. Em razão da preocupação com a preservação da complexidade do processo de interpretação, não há emprego de métodos heurísticos. A metodologia empregada é a argumentação. Desse modo, o teste da hipótese de trabalho foi feito por meio de dois critérios: (1) o critério da vinculação entre o direito a um mínimo social e o princípio da diferença e (2) o critério de essencialidade, correspondente aos critérios da distinção entre princípios que abrangem direitos e liberdades fundamentais e princípios concernentes às desigualdades sociais e econômicas. Com base nas descrições da constituição da teoria original da justiça como equidade e da constituição do liberalismo político descrito por Rawls, compreende-se por que os critérios da urgência, da verificação, da concordância e da diferença entre os papéis da estrutura básica não permitem a inclusão do princípio da diferença como elemento constitucional essencial do liberalismo político. Ainda com base nessas descrições, compreende-se por que o critério de vinculação entre o direito a um mínimo social e o princípio da diferença mantém a plausibilidade de o princípio da diferença ser aceito por uma sociedade politicamente liberal como uma questão fundamental da razão pública, mas não como um elemento constitucional essencial do liberalismo político. A hipótese de trabalho se confirma em parte. Em termos práticos, a confirmação parcial da hipótese significa a possiblidade de qualquer pessoa solicitar e receber do estado a remuneração correspondente ao mínimo social com fundamento constitucional, observado o critério de razoabilidade do valor estabelecido e observado o direito de imigração nos casos aplicáveis, independentemente de o direito a um mínimo social constar por escrito na constituição.It is a doctoral thesis in law, state, and constitution. It makes a relationship between philosophy and constitutional law. This doctoral thesis has as a general aim studying how a constitution is related to relevant norms framing the sharing of burdens and benefits of social cooperation in the thought of John Rawls. It has as particular aims introducing the theory of justice as fairness, describing the constitution in justice as fairness, analyzing the constitution in political liberalism, presenting the difference principle, and analyzing the right to a social minimum as a right inherent to the constitution. The problem is to know the reason why the difference principle is not a constitutional essential of political liberalism as described by Rawls, whilst the right to a social minimum is such an essential. The hypothesis is that the difference principle and the right to a social minimum can both be taken as constitutional essentials of political liberalism as described by Rawls. This hypothesis seem having been tested enough so far and the justifications holding it seem either not clear enough against the wider context of the authors’ works. It makes use as a research technique the indirect documentation, that is, the documentation made by documental research (primary sources) and by bibliographic research (secondary sources), with emphasis on documental research. Taking into consideration the subject matter, the sources written by Rawls are taken as primary sources, whilst the sources written by other authors on Rawls are taken as secondary sources. Due to the concern in preserving the complexity of the interpretation process, there is no use of heuristic methods. The methodology employed is argumentation. In this way, the test of the hypothesis was made by means of two criteria: (1) the criterion of the attachment between the right of a social minimum and the difference principle, and (2) the essentiality criterion, corresponding to the criteria of the distinction between the principles related to the basic rights and liberties and the principles related to the social and economic inequalities. Based on the account of the constitution in the original theory of justice as fairness and on the account of the constitution in political liberalism as described by Rawls, one understands why the criterions of urgency, of verifiability, of agreement, and of the difference between the roles of the basic structure do not allow the inclusion of the difference principle as a constitutional essential of political liberalism. Still based on these accounts, one understands why the criterion of the attachment between the right of a social minimum and the difference principle keeps the plausibility of the difference principle being accepted by a politically liberal society as a basic matter of public reason, but not as a constitutional essential of political liberalism. The hypothesis is in part confirmed. In practical terms, the partial confirmation of the hypothesis means the possibility of any person ask and receive from the state the revenue corresponding to the social minimum with constitutional ground, in accordance with the criterion of reasonableness of the established value and in accordance with the right of immigration in due cases, in spite of the right of a social minimum being written in the constitution

Panorama legal das moedas virtuais : natureza jurídica, projetos de regulamentação e a responsabilidade civil das exchanges

Trabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Faculdade de Direito, 2019.Este estudo se propõe a examinar a natureza jurídica das moedas virtuais visando a determinação das formas de proteção de seus usuários, tendo em vista a emergência de tais moedas como forma de redução de custos na intermediação financeira e sua crescente mercantilização como ativos de investimento. Com base nas funções das moedas virtuais, o bitcoin e outras criptomoedas ainda têm natureza jurídica indeterminada. Juridicamente, não podem ser consideradas moedas, mas suas aplicações criam relações contratuais entre os usuários e os intermediários. Definida a natureza jurídica das moedas virtuais, o estudo busca determinar a responsabilidade civil das empresas que operam como “casas de câmbio”, as exchanges, visando a análise das possíveis responsabilizações sobre a má administração das “chaves” e possíveis perdas de valores. Por fim, tem como objeto um breve retrato do panorama regulatório mundial desses criptoativos.This study proposes to examine the legal nature of virtual currencies in order to determine the ways of protecting their users, in view of the emergence of such currencies as a way of reducing costs in financial intermediation and their increasing commercialization as investment assets. Based on the functions of virtual currencies, bitcoin and other crypto-coins are of indeterminate legal nature. Legally, they can’t be considered currencies, but their applications create contractual relations between users and intermediaries. Defining the legal nature of virtual currencies, the study seeks to determine the civil liability of companies operating as "exchange houses", the exchanges, aiming at the analysis of possible accountability on the mismanagement of the "keys" and possible losses of values. Finally, it has as object a brief picture of the world regulatory panorama of these cryptoactive ones

National culture and innovation: a multidimensional analysis

Purpose – This study aims to examine the relationships between the different national culture dimensionspresented by Hofstede and innovation data by country to analyze which characteristics of national culturedimensions contribute to the country becoming more innovative.Design/methodology/approach – The study is characterized as descriptive and quantitative, usingmultiple linear regression equations as data analysis technique. To carry out the analysis, this study made useof secondary data from Hofstede’s national culture database, data on innovation indicators from the GlobalInnovation Index and population data from the World Bank database. The analysis comprises data from 2015to 2018.Findings – National culture affects innovation rates positively. The most favorable situation to boostinnovation is when there is a low distance from power, high individualism, femininity characteristics, lowaversion to uncertainty, long-term orientation and a higher level of indulgence.Originality/value – The temporal analysis comprises a wider list of countries from all continents, whichhad not been considered in previous studies

Empreendedorismo no Brasil: resultados das políticas públicas para pequenos negócios / Entrepreneurship in Brazil: results of public policies for small businesses

O presente estudo analisou as políticas públicas que visam simplificar e favorecer o empreendedorismo dos pequenos negócios no Brasil, editadas entre os anos 1984 a 2019, e seus impactos formais, através do cruzamento de dados dos principais indicadores socioeconômicos do período. A busca foi por compreender o real impacto dessas políticas públicas através da identificação dos resultados gerados; propor possíveis novas estratégias para melhorar desenvolvimento socioeconômico brasileiro e por fim situar o ambiente pátrio ante as práticas contemporâneas de desenvolvimento socioeconômico por meio do empreendedorismo. Constatou-se que, apesar de se notar avanços na estruturação legal e institucional, o Brasil ainda tem muito a fazer no que tange ao fomento ao empreendedorismo.