Constraints on Supersymmetric Theories from μ→e,γ\mu\to e,\gamma

In the absence of any additional assumption it is natural to conjecture that sizeable flavour-mixing mass entries, $\Delta m^2$, may appear in the mass matrices of the scalars of the MSSM, i.e. $\Delta m^2\sim O(m^2)$. This flavour violation can still be reconciled with the experiment if the gaugino mass, $M_{1/2}$, is large enough, leading to a {\em gaugino dominance} framework (i.e. $M_{1/2}^2\gg m^2$), which permits a remarkably model--independent analysis. We study this possibility focussing our attention on the $\mu\rightarrow e,\gamma$ decay. In this way we obtain very strong and general constraints, in particular \frac{M_{1/2}^2}{\Delta m}\simgt 34\ {\rm TeV}. On the other hand, we show that our analysis and results remain valid for values of $m^2$ much larger than $\Delta m^2$, namely for \frac{\Delta m^2}{m^2}\simgt \frac{m^2} {10\ {\rm TeV^2}}, thus extending enormously their scope of application. Finally, we discuss the implications for superstring scenarios.Comment: 12 pages, Latex, 5 figures as uuencoded compressed postscript files, uses psfig.st

Model for a Universe described by a non-minimally coupled scalar field and interacting dark matter

In this work it is investigated the evolution of a Universe where a scalar field, non-minimally coupled to space-time curvature, plays the role of quintessence and drives the Universe to a present accelerated expansion. A non-relativistic dark matter constituent that interacts directly with dark energy is also considered, where the dark matter particle mass is assumed to be proportional to the value of the scalar field. Two models for dark matter pressure are considered: the usual one, pressureless, and another that comes from a thermodynamic theory and relates the pressure with the coupling between the scalar field and the curvature scalar. Although the model has a strong dependence on the initial conditions, it is shown that the mixture consisted of dark components plus baryonic matter and radiation can reproduce the expected red-shift behavior of the deceleration parameter, density parameters and luminosity distance.Comment: 11 pages and 6 figures. To appear in GR

Anomalous U(1) D-term Contribution in Type I String Models

We study the $D$-term contribution for anomalous U(1) symmetries in type I string models and derive general formula for the $D$-term contribution, assuming that the dominant source of SUSY breaking is given by $F$-terms of the dilaton, (overall) moduli or twisted moduli fields. On the basis of the formula, we also point out that there are several different features from the case in heterotic string models. The differences originate from the different forms of K\"ahler potential between twisted moduli fields in type I string models and the dilaton field in heterotic string models.Comment: 16 pages, latex, no figur

Late-time cosmology in (phantom) scalar-tensor theory: dark energy and the cosmic speed-up

We consider late-time cosmology in a (phantom) scalar-tensor theory with an exponential potential, as a dark energy model with equation of state parameter close to -1 (a bit above or below this value). Scalar (and also other kinds of) matter can be easily taken into account. An exact spatially-flat FRW cosmology is constructed for such theory, which admits (eternal or transient) acceleration phases for the current universe, in correspondence with observational results. Some remarks on the possible origin of the phantom, starting from a more fundamental theory, are also made. It is shown that quantum gravity effects may prevent (or, at least, delay or soften) the cosmic doomsday catastrophe associated with the phantom, i.e. the otherwise unavoidable finite-time future singularity (Big Rip). A novel dark energy model (higher-derivative scalar-tensor theory) is introduced and it is shown to admit an effective phantom/quintessence description with a transient acceleration phase. In this case, gravity favors that an initially insignificant portion of dark energy becomes dominant over the standard matter/radiation components in the evolution process.Comment: LaTeX file, 48 pages, discussion of Big Rip is enlarged, a reference is adde

Cosmology With Non-Minimally Coupled K-Field

We consider non-minimally coupled (with gravity) scalar field with non-canonical kinetic energy. The form of the kinetic term is of Dirac-Born-Infeld (DBI) form.We study the early evolution of the universe when it is sourced only by the k-field, as well as late time evolution when both the matter and k-field are present. For the k-field, we have considered constant potential as well as potential inspired from Boundary String Field Theory (B-SFT). We show that it is possible to have inflationary solution in early time as well as late time accelerating phase. The solutions also exhibit attractor property in a sense that it does not depend on the initial conditions for a certain values of the parameters.Comment: 10 pages, Revtex style, 14 eps figures, to appear in General Relativity and Gravitatio

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation

The b--->s{\gamma} constraint in effective supergravities from string theory

We study the constraints from the $b{\rightarrow}s{\gamma}$ decay in the parameter space of effective supergravities from orbifold string theory and with minimal supesymmetric particle content. Both the general dilaton-dominated universal scenario as well as a non-universal scenario for the soft terms are investigated. It is found that the recently reported CLEO upper and lower bounds constrain the parameter space of the models under scrutiny. In particular we find constraints on the values of the parameter $\tan{\beta}$ and the gluino masses. In this class of string scenarios the negative sign of the Higgs mixing parameter $\mu$, is phenomenologically preferred.Comment: LaTeX 11 pages, figures uuencoded included in a separate file, some typos have been corrected,1 figure adde

Low-Energy Effective Lagrangian from Non-Minimal Supergravity with Unified Gauge Symmetry

From general supergravity theory with unified gauge symmetry, we obtain the low-energy effective Lagrangian by taking the flat limit and integrating out the superheavy fields in model-independent manner. The scalar potential possesses some excellent features. Some light fields classified by using supersymmetric fermion mass, in general, would get intermediate masses at the tree level after the supersymmetry is broken. We show that the stability of weak scale can be guaranteed under some conditions. There exist extra non-universal contributions to soft supersymmetry breaking terms which can give an impact on phenomenological study.Comment: 37 pages, Figures not include