Synthesis of novel epibatidine-related derivatives through 1,3-dipolar cycloaddition of pyridinenitrile oxides

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An improved encapsulation protocol for regrowth and conservation of four ornamental species

The encapsulation technology, initially developed for clonal propagation through the production of synthetic seeds with somatic embryos, is currently proposed for use with non-embryogenic explants, such as buds and nodal segments (unipolar propagules). In the present study, the encapsulation procedure and its effect on shoot regeneration were evaluated. Apical buds isolated from shoot cultures of four ornamental species (Photinia × fraseri Dress., Polygala myrtifolia L., Metrosideros excelsa Soland. ex Gaertn., and Rosa) were encapsulated in 3% sodium alginate. Effects of complexation time, sucrose concentration, and storage temperature on the regrowth ability of propagules were assessed. With the appropriate combination of sucrose concentration and polymerization time, the encapsulated explants proved to have a better regrowth (80–100%) after sowing than the naked ones. In addition, medium-term storage of Metrosideros encapsulated explants promoted a high level of regrowth (74%) after 4 months in the dark at 10°C; while polygala beads were preserved up to 8 months regardless of storage temperatures. Potential current applications of encapsulation technology and the future use of beads in vivo conditions are also discussed

La suggestione e il suo ruolo nella clinica tra passato, presente e futuro

Neuroscience has offered confirmation that perception of reality does not correspond to reality. The mind is a very effective tool of falsification, because it builds "virtual scenarios" so persuasive that they are interpreted by human beings for "reality". It has been known since ancient times that words have power over reality and philosophical disciplines have often dealt with the relationship between language and reality. Suggestion is based on a particular form of communication, traditionally used in care, that includes a set of techniques for manipulating expectations and perceptions. In many human activities the suggestion reached a high level of complexity and has been widely applied; main areas are advertising, economic choice and political vote. For over a century, however, medicine, in search of scientific foundations, has neglected the role of suggestion in the clinical field. The authors illustrate some historical paths of suggestion in medical context and an overview of its presence, sometimes not recognized and not studied, in various areas of the current clinic practice.Da tempo si è iniziato a dubitare che il rapporto con la realtà sia oggettivo e unicamente centrato su aspetti logico-razionali. Le neuroscienze hanno offerto conferme al fatto che la percezione della realtà non corrisponda alla realtà. La mente è uno strumento di falsificazione molto efficace, perché costruisce “scenari virtuali” così persuasivi da essere scambiati dagli esseri umani per “realtà”. È noto fin dall’antichità che le parole hanno potere sulla realtà e le discipline filosofiche si sono occupate spesso del rapporto tra linguaggio e realtà. La suggestione può essere intesa come una particolare forma di comunicazione, tradizionalmente impiegata nella cura, che comprende un insieme di tecniche per manipolare aspettative e percezioni. In molte attività umane il tema della suggestione ha raggiunto un alto livello di elaborazione ed è stato diffusamente applicato; tra questi ambiti ricordiamo quello pubblicitario, della scelta economica e del voto politico. Da oltre un secolo la medicina, alla ricerca di fondamenti scientifici, ha però trascurato il ruolo della suggestione nei processi di cura. Gli autori illustrano alcuni percorsi storici della suggestione nella cura e una panoramica della sua presenza, talvolta non riconosciuta e non studiata, in vari ambiti della clinica attuale

Synthesis of 5-substituted 7,9-dihydro-8H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-8-ones as anticonvulsant agents

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Mechanical Prevention of Distal Embolization During Primary Angioplasty

Background— Effective myocardial reperfusion after primary percutaneous coronary intervention (PCI) may be limited by distal embolization. We tested the safety, feasibility, and efficacy of the FilterWire-Ex (FW), a distal embolic protection device, as an adjunct to primary PCI. Methods and Results— Fifty-three consecutive patients undergoing primary PCI with FW protection were compared with a matched control group treated by primary PCI alone. Successful FW positioning was obtained in 47 patients (89%) without complications. Histological analysis of the content of the last 13 filters showed multiple embolic debris in all cases. FW use was associated with lower postinterventional corrected TIMI frame count (22±14 versus 31±19; P =0.005) and higher occurrence of grade 3 myocardial blush (66% versus 36%; P =0.006) and early ST-segment elevation resolution (80% versus 54%; P= 0.006). At multivariate analysis, FW use was the only independent predictor of early ST-segment elevation resolution and of grade 3 myocardial blush. FW patients showed lower peak creatine kinase-MB release (236±172 versus 333±219 ng/mL; P =0.013) and greater improvement at 30 days in left ventricular wall motion score index (−0.30±0.19 versus −0.18±0.26; P= 0.008) and ejection fraction (+7±4% versus +4±7%; P =0.012). Conclusions— FW use during primary PCI is feasible and safe. Distal embolization prevention appears to exert a beneficial effect on markers of myocardial reperfusion and on left ventricular function improvement at 30 days

apeNEXT: A multi-TFlops Computer for Simulations in Lattice Gauge Theory

We present the APE (Array Processor Experiment) project for the development of dedicated parallel computers for numerical simulations in lattice gauge theories. While APEmille is a production machine in today's physics simulations at various sites in Europe, a new machine, apeNEXT, is currently being developed to provide multi-Tflops computing performance. Like previous APE machines, the new supercomputer is largely custom designed and specifically optimized for simulations of Lattice QCD.Comment: Poster at the XXIII Physics in Collisions Conference (PIC03), Zeuthen, Germany, June 2003, 3 pages, Latex. PSN FRAP15. Replaced for adding forgotten autho

The apeNEXT project (Status report)

We present the current status of the apeNEXT project. Aim of this project is the development of the next generation of APE machines which will provide multi-teraflop computing power. Like previous machines, apeNEXT is based on a custom designed processor, which is specifically optimized for simulating QCD. We discuss the machine design, report on benchmarks, and give an overview on the status of the software development.Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics (CHEP03), La Jolla, Ca, USA, March 2003, 8 pages, LaTeX, 12 eps figures. PSN THIT00

Status of the apeNEXT project

We present the current status of the apeNEXT project. Aim of this project is the development of the next generation of APE machines which will provide multi-teraflop computing power. Like previous machines, apeNEXT is based on a custom designed processor, which is specifically optimized for simulating QCD. We discuss the machine design, report on benchmarks, and give an overview on the status of the software development

The Impact of Adherence to Screening Guidelines and of Diabetes Clinics Referral on Morbidity and Mortality in Diabetes

Despite the heightened awareness of diabetes as a major health problem, evidence on the impact of assistance and organizational factors, as well as of adherence to recommended care guidelines, on morbidity and mortality in diabetes is scanty. We identified diabetic residents in Torino, Italy, as of 1st January 2002, using multiple independent data sources. We collected data on several laboratory tests and specialist medical examinations to compare primary versus specialty care management of diabetes and the fulfillment of a quality-of-care indicator based on existing screening guidelines (GCI). Then, we performed regression analyses to identify associations of these factors with mortality and cardiovascular morbidity over a 4 year- follow-up. Patients with the lowest degree of quality of care (i.e. only cared for by primary care and with no fulfillment of GCI) had worse RRs for all-cause (1.72 [95% CI 1.57–1.89]), cardiovascular (1.74 [95% CI 1.50–2.01]) and cancer (1.35 [95% CI 1.14–1.61]) mortality, compared with those with the highest quality of care. They also showed increased RRs for incidence of major cardiovascular events up to 2.03 (95% CI 1.26–3.28) for lower extremity amputations. Receiving specialist care itself increased survival, but was far more effective when combined with the fulfillment of GCI. Throughout the whole set of analysis, implementation of guidelines emerged as a strong modifier of prognosis. We conclude that management of diabetic patients with a pathway based on both primary and specialist care is associated with a favorable impact on all-cause mortality and CV incidence, provided that guidelines are implemented

Digital Health Europe (DHE) Twinning on Severe Asthma—Kick-off Meeting Report

info:eu-repo/semantics/publishedVersio