204 research outputs found

    Evolutionary Computing Approach to Optimize Superframe Scheduling on Industrial Wireless Sensor Networks

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    There has been a paradigm shift in the industrial wireless sensor domain caused by the Internet of Things (IoT). IoT is a thriving technology leading the way in short range and fixed wireless sensing. One of the issues in Industrial Wireless Sensor Network-IWSN is finding the optimal solution for minimizing the defect time in superframe scheduling. This paper proposes a method using the evolutionary algorithms approach namely particle swarm optimization (PSO), Orthogonal Learning PSO, genetic algorithms (GA) and modified GA for optimizing the scheduling of superframe. We have also evaluated a contemporary method, deadline monotonic scheduling on the ISA 100.11a. By using this standard as a case study, the presented simulations are object-oriented based, with numerous variations in the number of timeslots and wireless sensor nodes. The simulation results show that the use of GA and modified GA can provide better performance for idle and missed deadlines. A comprehensive and detailed performance evaluation is given in the paper

    Altered Env conformational dynamics as a mechanism of resistance to peptide‑triazole HIV‑1 inactivators.

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    Background: We previously developed drug-like peptide triazoles (PTs) that target HIV-1 Envelope (Env) gp120, potently inhibit viral entry, and irreversibly inactivate virions. Here, we investigated potential mechanisms of viral escape from this promising class of HIV-1 entry inhibitors. Results: HIV-1 resistance to cyclic (AAR029b) and linear (KR13) PTs was obtained by dose escalation in viral passaging experiments. High-level resistance for both inhibitors developed slowly (relative to escape from gp41-targeted C-peptide inhibitor C37) by acquiring mutations in gp120 both within (Val255) and distant to (Ser143) the putative PT binding site. The similarity in the resistance profiles for AAR029b and KR13 suggests that the shared IXW pharmacophore provided the primary pressure for HIV-1 escape. In single-round infectivity studies employing recombinant virus, V255I/S143N double escape mutants reduced PT antiviral potency by 150- to 3900-fold. Curiously, the combined mutations had a much smaller impact on PT binding affinity for monomeric gp120 (four to ninefold). This binding disruption was entirely due to the V255I mutation, which generated few steric clashes with PT in molecular docking. However, this minor effect on PT affinity belied large, offsetting changes to association enthalpy and entropy. The escape mutations had negligible effect on CD4 binding and utilization during entry, but significantly altered both binding thermodynamics and inhibitory potency of the conformationally-specific, anti-CD4i antibody 17b. Moreover, the escape mutations substantially decreased gp120 shedding induced by either soluble CD4 or AAR029b. Conclusions: Together, the data suggest that the escape mutations significantly modified the energetic landscape of Env’s prefusogenic state, altering conformational dynamics to hinder PT-induced irreversible inactivation of Env. This work therein reveals a unique mode of virus escape for HIV-1, namely, resistance by altering the intrinsic conformational dynamics of the Env trimerpost-print4093 K

    Uso de simulador para el análisis de filtros de compatibilidad electromagnética

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    La complejidad de los sistemas electrónicos ha aumentado con los años. Los simuladores es una herramienta que permite a los ingenieros analizar las distintas configuraciones y condiciones de trabajo de dichos sistemas, reduciendo costos y tiempos de desarrollo. Por lo tanto, su uso es una competencia de importancia en la formación de ingenieros en electrónica. Con esta idea en mente se planteó la formación de un grupo de investigación para estudiar los softwares de simulación para la cátedra de Tecnología Electrónica, en particular, y otras materias de la carrera de Ingeniería en Electrónica, en general. El presente trabajo explica el uso de software de simulación para el análisis de un filtro de Compatibilidad Electromagnética, elemento fundamental en muchos sistemas electrónicos. La elección de este análisis se debe a que el filtro está constituido por componentes pasivos (resistencias, capacitores, inductores), los cuales son estudiados la cátedra de Tecnología Electrónica. A continuación, se realizará una introducción. Se seguirá con un análisis de los simuladores investigados y su selección. Luego se detallan las simulaciones planteadas para el análisis de los filtros, se comentarán los resultados obtenidos y finalmente se expondrán las conclusiones.Red de Universidades con Carreras en Informátic

    Automated Defect Detection For Masonry Arch Bridges

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    The condition of masonry arch bridges is predominantly monitored with manual visual inspection. This process has been found to be subjective, relying on an inspection engineer’s interpretation of the condition of the structure. This paper initially presents a workflow that has been developed that can be used by a future automated bridge monitoring system to determine underlying faults in a bridge and suggest appropriate remedial action based on a set of detectable symptoms. This workflow has been used to identify the main classes of defects that an automated visual detection system for masonry should be capable of detecting. Subsequently, a convolutional neural network is used to classify these identified defect classes from images of masonry. As the mortar joints in the masonry are more distinctive than the defects being sought, their effect on the performance of an automated defect classifier is investigated. Compared to classifying all the regions of the masonry with a single classifier, it is found that where the mortar and brick regions have been classified separately, defect and defect free areas of the masonry have been predicted both with more confidence and with better accuracy

    The Impact of Entrepreneurship Education in Higher Education: A Systematic Review and Research Agenda

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    Using a teaching model framework, we systematically review empirical evidence on the impact of entrepreneurship education (EE) in higher education on a range of entrepreneurial outcomes, analyzing 159 published articles from 2004 to 2016. The teaching model framework allows us for the first time to start rigorously examining relationships between pedagogical methods and specific outcomes. Reconfirming past reviews and meta-analyses, we find that EE impact research still predominantly focuses on short-term and subjective outcome measures and tends to severely underdescribe the actual pedagogies being tested. Moreover, we use our review to provide an up-to-date and empirically rooted call for less obvious, yet greatly promising, new or underemphasized directions for future research on the impact of university-based entrepreneurship education. This includes, for example, the use of novel impact indicators related to emotion and mind-set, focus on the impact indicators related to the intention-to-behavior transition, and exploring the reasons for some contradictory findings in impact studies including person-, context-, and pedagogical model-specific moderator
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