204 research outputs found
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Assessing the Utility of Restaurant Descriptors and Typologies for Advancing the Body of Knowledge in Restaurant Management
The study begins with a review of existing typologies in the restaurant management literature. Segment labels from three typologies are used as keywords to collect 251 empirical studies from nine relevant academic journals serving the restaurant management discipline. Content analysis of titles, abstracts, and methodology sections reveals inconsistent use of existing typologies and limited use of effective restaurant descriptors. Recommendations are offered to optimize the use of restaurant descriptors so that the content of empirical studies may be more effectively accessed, digested, and compared across, thereby enhancing the communication of advances in the restaurant management body of knowledge
Evolutionary Computing Approach to Optimize Superframe Scheduling on Industrial Wireless Sensor Networks
There has been a paradigm shift in the industrial wireless sensor domain
caused by the Internet of Things (IoT). IoT is a thriving technology leading
the way in short range and fixed wireless sensing. One of the issues in
Industrial Wireless Sensor Network-IWSN is finding the optimal solution for
minimizing the defect time in superframe scheduling. This paper proposes a
method using the evolutionary algorithms approach namely particle swarm
optimization (PSO), Orthogonal Learning PSO, genetic algorithms (GA) and
modified GA for optimizing the scheduling of superframe. We have also evaluated
a contemporary method, deadline monotonic scheduling on the ISA 100.11a. By
using this standard as a case study, the presented simulations are
object-oriented based, with numerous variations in the number of timeslots and
wireless sensor nodes. The simulation results show that the use of GA and
modified GA can provide better performance for idle and missed deadlines. A
comprehensive and detailed performance evaluation is given in the paper
Altered Env conformational dynamics as a mechanism of resistance to peptide‑triazole HIV‑1 inactivators.
Background: We previously developed drug-like peptide triazoles (PTs) that target HIV-1 Envelope (Env) gp120,
potently inhibit viral entry, and irreversibly inactivate virions. Here, we investigated potential mechanisms of viral
escape from this promising class of HIV-1 entry inhibitors.
Results: HIV-1 resistance to cyclic (AAR029b) and linear (KR13) PTs was obtained by dose escalation in viral passaging
experiments. High-level resistance for both inhibitors developed slowly (relative to escape from gp41-targeted
C-peptide inhibitor C37) by acquiring mutations in gp120 both within (Val255) and distant to (Ser143) the putative PT
binding site. The similarity in the resistance profiles for AAR029b and KR13 suggests that the shared IXW pharmacophore
provided the primary pressure for HIV-1 escape. In single-round infectivity studies employing recombinant virus,
V255I/S143N double escape mutants reduced PT antiviral potency by 150- to 3900-fold. Curiously, the combined
mutations had a much smaller impact on PT binding affinity for monomeric gp120 (four to ninefold). This binding
disruption was entirely due to the V255I mutation, which generated few steric clashes with PT in molecular docking.
However, this minor effect on PT affinity belied large, offsetting changes to association enthalpy and entropy. The
escape mutations had negligible effect on CD4 binding and utilization during entry, but significantly altered both
binding thermodynamics and inhibitory potency of the conformationally-specific, anti-CD4i antibody 17b. Moreover,
the escape mutations substantially decreased gp120 shedding induced by either soluble CD4 or AAR029b.
Conclusions: Together, the data suggest that the escape mutations significantly modified the energetic landscape of
Env’s prefusogenic state, altering conformational dynamics to hinder PT-induced irreversible inactivation of Env. This
work therein reveals a unique mode of virus escape for HIV-1, namely, resistance by altering the intrinsic conformational
dynamics of the Env trimerpost-print4093 K
Uso de simulador para el análisis de filtros de compatibilidad electromagnética
La complejidad de los sistemas electrónicos ha aumentado con los años. Los simuladores es una herramienta que permite a los ingenieros analizar las distintas configuraciones y condiciones de trabajo de dichos sistemas, reduciendo costos y tiempos de desarrollo. Por lo tanto, su uso es una competencia de importancia en la formación de ingenieros en electrónica. Con esta idea en mente se planteó la formación de un grupo de investigación para estudiar los softwares de simulación para la cátedra de Tecnología Electrónica, en particular, y otras materias de la carrera de Ingeniería en Electrónica, en general.
El presente trabajo explica el uso de software de simulación para el análisis de un filtro de Compatibilidad Electromagnética, elemento fundamental en muchos sistemas electrónicos.
La elección de este análisis se debe a que el filtro está constituido por componentes pasivos (resistencias, capacitores, inductores), los cuales son estudiados la cátedra de Tecnología Electrónica.
A continuación, se realizará una introducción.
Se seguirá con un análisis de los simuladores investigados y su selección. Luego se detallan las simulaciones planteadas para el análisis de los filtros, se comentarán los resultados obtenidos y finalmente se expondrán las conclusiones.Red de Universidades con Carreras en Informátic
Automated Defect Detection For Masonry Arch Bridges
The condition of masonry arch bridges is predominantly monitored with manual visual inspection. This process has been found to be subjective, relying on an inspection engineer’s interpretation of the condition of the structure. This paper initially presents a workflow that has been developed that can be used by a future automated bridge monitoring system to determine underlying faults in a bridge and suggest appropriate remedial action based on a set of detectable symptoms. This workflow has been used to identify the main classes of defects that an automated visual detection system for masonry should be capable of detecting.
Subsequently, a convolutional neural network is used to classify these identified defect classes from images of masonry. As the mortar joints in the masonry are more distinctive than the defects being sought, their effect on the performance of an automated defect classifier is investigated. Compared to classifying all the regions of the masonry with a single classifier, it is found that where the mortar and brick regions have been classified separately, defect and defect free areas of the masonry have been predicted both with more confidence and with better accuracy
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Early 21st century cyclone climatology: a 3D perspective. Basic characterization
Extratropical cyclones are a relevant feature in the climate at middle and high latitudes. Despite their relevance, most of studies typically focus on cyclones identified at a single atmospheric level and on events close to the surface. This paper provides a new perspective on the Southern Hemisphere cyclone events based on the multilevel cyclone tracking algorithm STACKER. The algorithm, using relative vorticity, detects the raw tracks at single levels and objectively combine them to provide the 3D events and their evolutionary timeline. As result, 3D cyclone climatology, based on ECMWF Reanalysis ERA-I data from 12 pressure levels in the troposphere and lowermost stratosphere is presented. To the best of our knowledge this is the first analysis carried out throughout the troposphere and the lowermost extratropical/subpolar stratosphere in order to give a comprehensive picture of the cyclone events as physical entities throughout their lifetime. Cyclone properties analysed are track densities, translational velocity, vorticity and lifetimes. For the subtropical and extrattropical SH, results support many previous ideas about cyclone characteristics, but new insights are also obtained. A total of 58231 multilevel cyclone events lasting at least 2 days were detected, with vertical structures spanning two or more levels. This means an average of 303 cyclone events of all types per month, between 2001 and 2017, disregarding seasonality. Results shows that the lowermost level of cyclones are most frequently detected at 925 and 700 hPa, Considering that cyclonic systems can be grouped into families, results per month on average, show that shallow systems are the most frequent events with approximately 248 systems detected, followed by 43 intermediates and 11 deep events. Shallow and deep systems have a large percentage of events with genesis at 925 and 700hPa. Density statistics show that shallow events are present at all latitude ranges mostly poleward 30ºS with high and medium intensities, while intermediate ones are mostly restricted to mid-latitudes and deep events are mostly confined to sub-polar and polar latitudes. Cyclones over Antarctica seems to be mostly intermediates and deeps, with longer lifetimes and lower velocities
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Equatorial Kelvin waves as revealed by EOS Microwave Limb Sounder observations and European Centre for Medium-Range Weather Forecasts analyses: Evidence for slow Kelvin waves of zonal wave number 3
[1] Temperature and ozone observations from the Microwave Limb Sounder (MLS) on the EOS Aura satellite are used to study equatorial wave activity in the autumn of 2005. In contrast to previous observations for the same season in other years, the temperature anomalies in the middle and lower tropical stratosphere are found to be characterized by a strong wave-like eastward progression with zonal wave number equal to 3. Extended empirical orthogonal function (EOF) analysis reveals that the wave 3 components detected in the temperature anomalies correspond to a slow Kelvin wave with a period of 8 days and a phase speed of 19 m/s. Fluctuations associated with this Kelvin wave mode are also apparent in ozone profiles. Moreover, as expected by linear theory, the ozone fluctuations observed in the lower stratosphere are in phase with the temperature perturbations, and peak around 20–30 hPa where the mean ozone mixing ratios have the steepest vertical gradient. A search for other Kelvin wave modes has also been made using both the MLS observations and the analyses from one experiment where MLS ozone profiles are assimilated into the European Centre for Medium-Range Weather Forecasts (ECMWF) data assimilation system via a 6-hourly 3D var scheme. Our results show that the characteristics of the wave activity detected in the ECMWF temperature and ozone analyses are in good agreement with MLS data
Methods of assessing human health vulnerability and public health adaptation to climate change
The Impact of Entrepreneurship Education in Higher Education: A Systematic Review and Research Agenda
Using a teaching model framework, we systematically review empirical evidence on the impact of entrepreneurship education (EE) in higher education on a range of entrepreneurial outcomes, analyzing 159 published articles from 2004 to 2016. The teaching model framework allows us for the first time to start rigorously examining relationships between pedagogical methods and specific outcomes. Reconfirming past reviews and meta-analyses, we find that EE impact research still predominantly focuses on short-term and subjective outcome measures and tends to severely underdescribe the actual pedagogies being tested. Moreover, we use our review to provide an up-to-date and empirically rooted call for less obvious, yet greatly promising, new or underemphasized directions for future research on the impact of university-based entrepreneurship education. This includes, for example, the use of novel impact indicators related to emotion and mind-set, focus on the impact indicators related to the intention-to-behavior transition, and exploring the reasons for some contradictory findings in impact studies including person-, context-, and pedagogical model-specific moderator
Placental growth factor may predict increased left ventricular mass index in patients with mild to moderate chronic kidney disease – a prospective observational study
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