Accidental Father-to-Son HIV-1 Transmission During the Seroconversion Period

A 4-year-old child born to an HIV-1 seronegative mother was diagnosed with HIV-1, the main risk factor being transmission from the child's father who was seroconverting at the time of the child's birth. In the context of a forensic investigation, we aimed to identify the source of infection of the child and date of the transmission event. Samples were collected from the father and child at two time points about 4 years after the child's birth. Partial segments of three HIV-1 genes (gag, pol, and env) were sequenced and maximum likelihood (ML) and Bayesian methods were used to determine direction and estimate date of transmission. Neutralizing antibodies were determined using a single cycle assay. Bayesian trees displayed a paraphyletic-monophyletic topology in all three genomic regions, with the father's host label at the root, which is consistent with father-to-son transmission. ML trees found similar topologies in gag and pol and a monophyletic-monophyletic topology in env. Analysis of the time of the most recent common ancestor of each HIV-1 gene population indicated that the child was infected shortly after the father. Consistent with the infection history, both father and son developed broad and potent HIV-specific neutralizing antibody responses. In conclusion, the direction of transmission implicated the father as the source of transmission. Transmission occurred during the seroconversion period when the father was unaware of the infection and was likely accidental. This case shows how genetic, phylogenetic, and serological data can contribute for the forensic investigation of HIV transmission.info:eu-repo/semantics/publishedVersio

Galaxy Counts, Sizes, Colours and Redshifts in the Hubble Deep Field

We compare the galaxy evolution models of Bruzual & Charlot (1993) with the faint galaxy count, size and colour data from the Hubble and Herschel Deep Fields (Metcalfe et al 1996). For qo=0.05, we find that models where the SFR increases exponentially out to z>2 are consistent with all of the observational data. For qo=0.5, such models require an extra population of galaxies which are only seen at high redshift and then rapidly fade or disappear. We find that, whatever the cosmology, the redshift of the faint blue galaxies and hence the epoch of galaxy formation is likely to lie at z>2. We find no implied peak in the SFR at z=1 and we suggest that the reasons for this contradiction with the results of Madau et al (1996) include differences in faint galaxy photometry, in the treatment of spiral dust and in the local galaxy count normalisation.Comment: 8 pages, 5 eps figures, needs paspconf.st

Extractive method optimization for Ligustrum lucidum yhat leads to a better free radical scavenging activity

info:eu-repo/semantics/publishedVersio

Critical phenomena of thick branes in warped spacetimes

We have investigated the effects of a generic bulk first-order phase transition on thick Minkowski branes in warped geometries. As occurs in Euclidean space, when the system is brought near the phase transition an interface separating two ordered phases splits into two interfaces with a disordered phase in between. A remarkable and distinctive feature is that the critical temperature of the phase transition is lowered due to pure geometrical effects. We have studied a variety of critical exponents and the evolution of the transverse-traceless sector of the metric fluctuations.Comment: revtex4, 4 pages, 4 figures, some comments added, typos corrected, published in PR

String Gas Cosmology

We present a critical review and summary of String Gas Cosmology. We include a pedagogical derivation of the effective action starting from string theory, emphasizing the necessary approximations that must be invoked. Working in the effective theory, we demonstrate that at late-times it is not possible to stabilize the extra dimensions by a gas of massive string winding modes. We then consider additional string gases that contain so-called enhanced symmetry states. These string gases are very heavy initially, but drive the moduli to locations that minimize the energy and pressure of the gas. We consider both classical and quantum gas dynamics, where in the former the validity of the theory is questionable and some fine-tuning is required, but in the latter we find a consistent and promising stabilization mechanism that is valid at late-times. In addition, we find that string gases provide a framework to explore dark matter, presenting alternatives to $\Lambda$CDM as recently considered by Gubser and Peebles. We also discuss quantum trapping with string gases as a method for including dynamics on the string landscape.Comment: 55 pages, 1 figure, minor corrections, version to appear in Reviews of Modern Physic

Stochastic semiclassical fluctuations in Minkowski spacetime

The semiclassical Einstein-Langevin equations which describe the dynamics of stochastic perturbations of the metric induced by quantum stress-energy fluctuations of matter fields in a given state are considered on the background of the ground state of semiclassical gravity, namely, Minkowski spacetime and a scalar field in its vacuum state. The relevant equations are explicitly derived for massless and massive fields arbitrarily coupled to the curvature. In doing so, some semiclassical results, such as the expectation value of the stress-energy tensor to linear order in the metric perturbations and particle creation effects, are obtained. We then solve the equations and compute the two-point correlation functions for the linearized Einstein tensor and for the metric perturbations. In the conformal field case, explicit results are obtained. These results hint that gravitational fluctuations in stochastic semiclassical gravity have a ``non-perturbative'' behavior in some characteristic correlation lengths.Comment: 28 pages, RevTeX, no figure

String windings in the early universe

We study string dynamics in the early universe. Our motivation is the proposal of Brandenberger and Vafa, that string winding modes may play a key role in decompactifying three spatial dimensions. We model the universe as a homogeneous but anisotropic 9-torus filled with a gas of excited strings. We adopt initial conditions which fix the dilaton and the volume of the torus, but otherwise assume all states are equally likely. We study the evolution of the system both analytically and numerically to determine the late-time behavior. We find that, although dynamical evolution can indeed lead to three large spatial dimensions, such an outcome is not statistically favored.Comment: 26 pages, LaTeX, 4 eps figure

Management of Iatrogenic Urorectal Fistulae in Men with Pelvic Cancer

INTRODUCTION: Urorectal fistula (URF) is a devastating complication of pelvic cancer treatments and a surgical challenge for the reconstructive surgeon. We report a series of male patients with URF resulting from pelvic cancer treatments, specifically prostate (PCa), bladder (BCa), and rectal cancer (RCa), and explore the differences and impact on outcomes between purely surgical and non-surgical treatment modalities. METHODS: Between October 2008 and June 2015, 15 male patients, aged 59-78 years (mean 67), with URF induced by pelvic cancer treatments were identified in our institutions. Patients with a history of diverticulitis, inflammatory bowel disease, or other benign conditions were excluded. We reviewed the patients' medical records for symptoms, diagnostic tests performed, type and etiology of the fistula, type of surgical reconstruction, followup, and outcomes. RESULTS: Fourteen patients underwent surgical reconstruction. One patient developed metastatic disease before URF repair and, therefore, was excluded from this study. Mean followup (FU) was 32.7 months (14-79). All patients received diverting colostomy and temporary urinary diversion. An exclusively transperineal approach was used in nine (64.3%) patients and a combined abdominoperineal in five (35.7%). Overall successful URF closure was achieved in 12 (85.7%) patients, nine (64.3%) of whom at the first reconstructive attempt, two (14.3%) after two attempts (in our institution), and one (7.1%) after three attempts (two of which elsewhere). An interposition flap was used in seven (50%) patients. Surgical reconstruction failed ultimately in two (14.3%) patients who still have a colostomy and do not wish any further reconstruction. CONCLUSIONS: Our study has several limitations, including its retrospective nature and the heterogeneity of our small patient cohort. Nonetheless, although surgical reconstruction of URF may be extremely difficult and complex in the non-surgical/energy ablation patients, its successful reconstruction is possible in most through a transperineal, or a more aggressive abdominoperineal, approach with tissue interposition in selected patients.info:eu-repo/semantics/publishedVersio