Air quality in Buenos Aires Province, Argentina

Studies of different gaseous contaminants and particulate matter were made in several cities of the Buenos Aires Province in Argentina. These cities have noticeable differences in relation to the number of inhabitants, vehicular density, industrial activities, etc. They are La Plata, Bahía Blanca, Mar del Plata, Pergamino and San Nicolás, among other towns. In each city, continuous monitoring equipment with electrochemical sensor technology was installed, in order to determine the NOx, CO, HC, SO2 and O3 concentration. The particulate matter samples were picked up using high volume equipment and daily concentrations corresponding to total suspended solids (PM) were determined by a gravimetric method. The particles were characterized by optical microscopy, scanning electron microscopy (SEM) and electron diffraction analysis X-ray (EDAX). The results obtained showed a direct relationship between the type and quantity of the present particles and the general characteristics of the towns. The present study is part of the research project "Study of the Air Quality in Buenos Aires Province", financially supported by the National Agency of Scientific and Technological Promotion, Argentina.Facultad de Ciencias ExactasCentro de Investigación y Desarrollo en Ciencias Aplicada

Air quality in Buenos Aires Province, Argentina

Studies of different gaseous contaminants and particulate matter were made in several cities of the Buenos Aires Province in Argentina. These cities have noticeable differences in relation to the number of inhabitants, vehicular density, industrial activities, etc. They are La Plata, Bahía Blanca, Mar del Plata, Pergamino and San Nicolás, among other towns. In each city, continuous monitoring equipment with electrochemical sensor technology was installed, in order to determine the NOx, CO, HC, SO2 and O3 concentration. The particulate matter samples were picked up using high volume equipment and daily concentrations corresponding to total suspended solids (PM) were determined by a gravimetric method. The particles were characterized by optical microscopy, scanning electron microscopy (SEM) and electron diffraction analysis X-ray (EDAX). The results obtained showed a direct relationship between the type and quantity of the present particles and the general characteristics of the towns. The present study is part of the research project "Study of the Air Quality in Buenos Aires Province", financially supported by the National Agency of Scientific and Technological Promotion, Argentina.Facultad de Ciencias ExactasCentro de Investigación y Desarrollo en Ciencias Aplicada

Blood–brain barrier impairment in patients living with hiv: Predictors and associated biomarkers

Despite the substantial changes resulting from the introduction of combination antiretroviral therapy (cART), the prevalence of HIV-associated neurocognitive disorders (HAND) remains substantial. Blood–brain barrier impairment (BBBi) is a frequent feature in people living with HIV (PLWH) and it may persist despite effective antiretroviral treatment. A cross-sectional study was performed in PLWH who underwent lumbar puncture for clinical reasons or research protocols and several cerebrospinal fluid biomarkers were studied. BBBi was defined as cerebrospinal fluid-to-serum albumin ratio (CSAR) >6.5 (<40 years) or >8 (>40 years). We included 464 participants: 147 cART-naïve and 317 on cART. Male sex was prevalent in both groups (72.1% and 72.2% respectively); median age was 44 (38–52) years in naïve and 49 (43–57) years in treated subjects. BBBi was observed in 35.4% naïve and in 22.7% treated participants; the use of integrase inhibitors was associated with a lower prevalence (18.3 vs. 30.9%, p = 0.050). At multivariate binary logistic regression (including age and sex) nadir CD4 cell count (p = 0.034), presence of central nervous system (CNS) opportunistic infections (p = 0.024) and cerebrospinal fluid (CSF) HIV RNA (p = 0.002) in naïve participants and male sex (p = 0.021), a history of CNS opportunistic infections (p = 0.001) and CSF HIV RNA (p = 0.034) in treated patients were independently associated with BBBi. CSF cells and neopterin were significantly higher in participants with BBBi. BBBi was prevalent in naïve and treated PLWH and it was associated with CSF HIV RNA and neopterin. Systemic control of viral replication seems to be essential for BBB integrity while sex and treatment influence need further studies

Niveles de contaminación de aire: relación con distintos factores

Se realizaron estudios de diferentes contaminantes gaseosos y material particulado en varias ciudades de la Provincia de Buenos Aires, Argentina. Estas ciudades tienen diferencias notables respecto del número de habitantes, la densidad vehicular, la actividad industrial, etc. Ellas son La Plata, Bahía Blanca, Mar del Plata, Pergamino, San Nicolás, entre otras. En cada ciudad, se instaló un equipo de monitoreo continuo con tecnología de sensores electroquímicos para determinar NOx, CO, HC, SO2 y O3. Las muestras del material particulado total para su análisis fisicoquímico fueron recogidas usando un equipo de alto volumen, y las concentraciones diarias de PM10 fueron determinadas por analizador de tecnología láser. Las partículas fueron caracterizadas por microscopías óptica y electrónica de barrido, y análisis por difracción electrónica de Rayos X. Los resultados obtenidos mostraron una relación directa entre el tipo y la cantidad de las partículas presentes y las características generales de las ciudades

Air quality in Buenos Aires Province, Argentina

Studies of different gaseous contaminants and particulate matter were made in several cities of the Buenos Aires Province in Argentina. These cities have noticeable differences in relation to the number of inhabitants, vehicular density, industrial activities, etc. They are La Plata, Bahía Blanca, Mar del Plata, Pergamino and San Nicolás, among other towns. In each city, continuous monitoring equipment with electrochemical sensor technology was installed, in order to determine the NOx, CO, HC, SO2 and O3 concentration. The particulate matter samples were picked up using high volume equipment and daily concentrations corresponding to total suspended solids (PM) were determined by a gravimetric method. The particles were characterized by optical microscopy, scanning electron microscopy (SEM) and electron diffraction analysis X-ray (EDAX). The results obtained showed a direct relationship between the type and quantity of the present particles and the general characteristics of the towns. The present study is part of the research project "Study of the Air Quality in Buenos Aires Province", financially supported by the National Agency of Scientific and Technological Promotion, Argentina.Facultad de Ciencias ExactasCentro de Investigación y Desarrollo en Ciencias Aplicada

A importância do Plano Nacional de Fertilizantes para o futuro do agronegócio e do Brasil.

Carta da Agricultura

Seroprevalence of five neglected parasitic diseases among immigrants accessing five infectious and tropical diseases units in Italy: a cross-sectional study.

: This multicentre cross-sectional study aims to estimate the prevalence of five neglected tropical diseases (Chagas disease, filariasis, schistosomiasis, strongyloidiasis, toxocariasis) among immigrants accessing health care facilities in five Italian cities (Bologna, Brescia, Florence, Rome, Verona). : Individuals underwent a different set of serological tests, according to country of origin and presence of eosinophilia. Seropositive patients were treated and further followed up. : A total of 930 adult immigrants were enrolled: 477 men (51.3%), 445 women (47.9%), 8 transgender (0.8%); median age was 37.81 years (range 18-80). Most of them were coming from the African continent (405/930, 43.5%), the rest from East Europe, South America and Asia. A portion of 9.6% (89/930) were diagnosed with at least one of the infections under study. Seroprevalence of each specific infection varied from 3.9% (7/180) for Chagas diseases to 9.7% (11/113) for toxocariasis. Seropositive people were more likely to be 35 to 40 years-old male and to come from South East Asia, Sub-Saharan Africa or South America. : The results of our study confirm that neglected tropical diseases represent a substantial health problem among immigrants and highlight the need for addressing this emerging public health issue.<br/

Phase Ib study of NGR–hTNF, a selective vascular targeting agent, administered at low doses in combination with doxorubicin to patients with advanced solid tumours

Contains fulltext : 81937timmer-bonte.pdf (publisher's version ) (Closed access)BACKGROUND: Asparagine-glycine-arginine-human tumour necrosis factor (NGR-hTNF) is a vascular targeting agent exploiting a tumour-homing peptide (NGR) that selectively binds to aminopeptidase N/CD13, overexpressed on tumour blood vessels. Significant preclinical synergy was shown between low doses of NGR-TNF and doxorubicin. METHODS: The primary aim of this phase I trial was to verify the safety of low-dose NGR-hTNF combined with doxorubicin in treating refractory/resistant solid tumours. Secondary objectives included pharmacokinetics (PKs), pharmacodynamics, and clinical activity. In all 15 patients received NGR-hTNF (0.2-0.4-0.8-1.6 microg m(-2)) and doxorubicin (60-75 mg m(-2)), both given intravenously every 3 weeks. RESULTS: No dose-limiting toxicity occurred and the combination was well tolerated. Around two cases of neutropenic fevers, lasting 2 days, and two cases of cardiac ejection-fraction drops, one asymptomatic and the other symptomatic, were registered. Only 11% of the adverse events were related to NGR-hTNF and were short-lasting and mild-to-moderate in severity. There was no apparent PK interaction and the shedding of soluble TNF-receptors did not increase to 0.8 microg m(-2). One partial response (7%), at dose level 0.8 microg m(-2), and 10 stable diseases (66%), lasting for a median duration of 5.6 months, were observed. CONCLUSIONS: NGR-hTNF plus doxorubicin was administered safely and showed promising activity in patients pre-treated with anthracyclines. The dose level of 0.8 microg m(-2) NGR-hTNF plus doxorubicin 75 mg m(-2) was selected for phase II development

Extended follow-up and impact of high-risk prognostic factors from the phase 3 RESONATE(TM) study in patients with previously treated CLL/SLL.

In the phase 3 RESONATE(TM) study, ibrutinib demonstrated superior progression-free survival (PFS), overall survival (OS), and overall response rate (ORR) compared with ofatumumab in relapsed/refractory CLL patients with high-risk prognostic factors. We report updated results from RESONATE in these traditionally chemotherapy resistant high-risk genomic subgroups at a median follow-up of 19 months. Mutations were detected by Foundation One Heme Panel. Baseline mutations in the ibrutinib arm included TP53 (51%), SF3B1 (31%), NOTCH1 (28%), ATM (19%), and BIRC3 (14%). Median PFS was not reached, with 74% of patients randomized to ibrutinib alive and progression-free at 24 months. The improved efficacy of ibrutinib vs. ofatumumab continues in all prognostic subgroups including del17p and del11q. No significant difference within the ibrutinib arm was observed for PFS across most genomic subtypes, although a subset carrying both TP53 mutation and del17p had reduced PFS compared to patients with neither abnormality. Reduced PFS or OS was not evident in patients with only del17p. PFS was significantly better for ibrutinib-treated patients in second-line vs. later lines of therapy. The robust clinical activity of ibrutinib continues to show ongoing efficacy and acceptable safety consistent with prior reports, independent of various known high-risk mutations

Programmed Death-1 and Its Ligand Are Novel Immunotolerant Molecules Expressed on Leukemic B Cells in Chronic Lymphocytic Leukemia

Programmed death-1 (PD-1) is an immunoreceptor predominantly expressed on exhausted T cells, which through an interaction with its ligand (PD-L1), controls peripheral tolerance by limiting effector functions of T lymphocytes. qRT-PCR for PD-1, PD-L1 and their splicing forms as well as flow cytometric assessment of surface expression was performed in a cohort of 58 chronic lymphocytic leukemia (CLL) patients. In functional studies, we assessed the influence of the proliferative response of leukemic B-cells induced by IL-4 and CD40L on PD-1 transcripts and expression on the protein level. The median level of PD-1, but not PD-L1, transcripts in CLL patients was higher in comparison to healthy volunteers (HVs, n = 43, p = 0.0057). We confirmed the presence of PD-1 and PD-L1 on the CLL cell surface, and found the expression of PD-1, but not PD-L1, to be higher among CLL patients in comparison to HVs (47.2% vs. 14.8%, p<0.0001). The Kaplan-Meier curves for the time to progression and overall survival in groups with high and low surface expression of PD-1 and PD-L1 revealed no prognostic value in CLL patients. After stimulation with IL-4 and CD40L, protein expression of PD-1 was significantly increased in samples that responded and up-regulated CD38. PD-1, which is aberrantly expressed both at mRNA and cell surface levels in CLL cells might represent a novel immunotolerant molecule involved in the pathomechanism of the disease, and could provide a novel target for future therapies