361 research outputs found
Object-based modelling of avulsion-generated sandbody distributions and connectivity in a fluvial reservoir analogue of low to moderate net-to-gross ratio
Canalization of the evolutionary trajectory of the human influenza virus
Since its emergence in 1968, influenza A (H3N2) has evolved extensively in
genotype and antigenic phenotype. Antigenic evolution occurs in the context of
a two-dimensional 'antigenic map', while genetic evolution shows a
characteristic ladder-like genealogical tree. Here, we use a large-scale
individual-based model to show that evolution in a Euclidean antigenic space
provides a remarkable correspondence between model behavior and the
epidemiological, antigenic, genealogical and geographic patterns observed in
influenza virus. We find that evolution away from existing human immunity
results in rapid population turnover in the influenza virus and that this
population turnover occurs primarily along a single antigenic axis. Thus,
selective dynamics induce a canalized evolutionary trajectory, in which the
evolutionary fate of the influenza population is surprisingly repeatable and
hence, in theory, predictable.Comment: 29 pages, 5 figures, 10 supporting figure
Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes.
Language development builds upon a complex network of interacting subservient systems. It therefore follows that variations in, and subclinical disruptions of, these systems may have secondary effects on emergent language. In this paper, we consider the relationship between genetic variants, hearing, auditory processing and language development. We employ whole genome sequencing in a discovery family to target association and gene x environment interaction analyses in two large population cohorts; the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK10K. These investigations indicate that USH2A variants are associated with altered low-frequency sound perception which, in turn, increases the risk of developmental language disorder. We further show that Ush2a heterozygote mice have low-level hearing impairments, persistent higher-order acoustic processing deficits and altered vocalizations. These findings provide new insights into the complexity of genetic mechanisms serving language development and disorders and the relationships between developmental auditory and neural systems
How do you say ‘hello’? Personality impressions from brief novel voices
On hearing a novel voice, listeners readily form personality impressions of that speaker. Accurate or not, these impressions are known to affect subsequent interactions; yet the underlying psychological and acoustical bases remain poorly understood. Furthermore, hitherto studies have focussed on extended speech as opposed to analysing the instantaneous impressions we obtain from first experience. In this paper, through a mass online rating experiment, 320 participants rated 64 sub-second vocal utterances of the word ‘hello’ on one of 10 personality traits. We show that: (1) personality judgements of brief utterances from unfamiliar speakers are consistent across listeners; (2) a two-dimensional ‘social voice space’ with axes mapping Valence (Trust, Likeability) and Dominance, each driven by differing combinations of vocal acoustics, adequately summarises ratings in both male and female voices; and (3) a positive combination of Valence and Dominance results in increased perceived male vocal Attractiveness, whereas perceived female vocal Attractiveness is largely controlled by increasing Valence. Results are discussed in relation to the rapid evaluation of personality and, in turn, the intent of others, as being driven by survival mechanisms via approach or avoidance behaviours. These findings provide empirical bases for predicting personality impressions from acoustical analyses of short utterances and for generating desired personality impressions in artificial voices
Auxin pretreatment promotes regeneration of sugarcane (Saccharum spp. hybrids) midrib segment explants
We have developed a new, simple,
quick and genotype-independent method for direct
regeneration of sugarcane using novel midrib
segment explants. Our protocol involves two
steps: the pretreatment of starting material on MS
(Murashige and Skoog (1962) Physiol Plant
15:473–497) medium containing 3.0 mg/l 2,4-
dichlorophenoxyacetic acid (2,4-D) for 8 days
under continuous dark and subsequent transfer of
the explants to MS medium augmented with
0.1 mg/l benzyladenine (BA) and 0.1 mg/l naphthaleneacetic
acid (NAA) under light-dark conditions.
On the regeneration medium, numerous
globular structures appeared from the explants
and subsequently differentiated into shoots.
Regenerated shoots attained 2–5 cm height
within 30 days of culture initiation and readily
rooted on MS basal medium. Hardened plants
were successfully established in the greenhouse.
The regulation of sugarcane morphogenesis by
auxin pretreatment is discussed
Comparison of the protein-coding genomes of three deep-sea, sulfur-oxidising bacteria: “Candidatus Ruthia magnifica”, “Candidatus Vesicomyosocius okutanii” and Thiomicrospira crunogena
Abstract Objective “ Candidatus Ruthia magnifica”, “Candidatus Vesicomyosocius okutanii” and Thiomicrospira crunogena are all sulfur-oxidising bacteria found in deep-sea vent environments. Recent research suggests that the two symbiotic organisms, “Candidatus R. magnifica” and “Candidatus V. okutanii”, may share common ancestry with the autonomously living species T. crunogena. We used comparative genomics to examine the genome-wide protein-coding content of all three species to explore their similarities. In particular, we used the OrthoMCL algorithm to sort proteins into groups of putative orthologs on the basis of sequence similarity. Results The OrthoMCL inflation parameter was tuned using biological criteria. Using the tuned value, OrthoMCL delimited 1070 protein groups. 63.5% of these groups contained one protein from each species. Two groups contained duplicate protein copies from all three species. 123 groups were unique to T. crunogena and ten groups included multiple copies of T. crunogena proteins but only single copies from the other species. “Candidatus R. magnifica” had one unique group, and had multiple copies in one group where the other species had a single copy. There were no groups unique to “Candidatus V. okutanii”, and no groups in which there were multiple “Candidatus V. okutanii” proteins but only single proteins from the other species. Results align with previous suggestions that all three species share a common ancestor. However this is not definitive evidence to make taxonomic conclusions and the possibility of horizontal gene transfer was not investigated. Methodologically, the tuning of the OrthoMCL inflation parameter using biological criteria provides further methods to refine the OrthoMCL procedure
Zebra finches and Dutch adults exhibit the same cue weighting bias in vowel perception
Vocal tract resonances, called formants, are the most important parameters in human speech production and perception. They encode linguistic meaning and have been shown to be perceived by a wide range of species. Songbirds are also sensitive to different formant patterns in human speech. They can categorize words differing only in their vowels based on the formant patterns independent of speaker identity in a way comparable to humans. These results indicate that speech perception mechanisms are more similar between songbirds and humans than realized before. One of the major questions regarding formant perception concerns the weighting of different formants in the speech signal (“acoustic cue weighting”) and whether this process is unique to humans. Using an operant Go/NoGo design, we trained zebra finches to discriminate syllables, whose vowels differed in their first three formants. When subsequently tested with novel vowels, similar in either their first formant or their second and third formants to the familiar vowels, similarity in the higher formants was weighted much more strongly than similarity in the lower formant. Thus, zebra finches indeed exhibit a cue weighting bias. Interestingly, we also found that Dutch speakers when tested with the same paradigm exhibit the same cue weighting bias. This, together with earlier findings, supports the hypothesis that human speech evolution might have exploited general properties of the vertebrate auditory system
Syncope as a health risk for soldiers - influence of medical history and clinical findings on the sensitivity of head-up tilt table testing
- …