The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: design and multicenter pilot study

Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join

The Earth: Plasma Sources, Losses, and Transport Processes

This paper reviews the state of knowledge concerning the source of magnetospheric plasma at Earth. Source of plasma, its acceleration and transport throughout the system, its consequences on system dynamics, and its loss are all discussed. Both observational and modeling advances since the last time this subject was covered in detail (Hultqvist et al., Magnetospheric Plasma Sources and Losses, 1999) are addressed

Highly-parallelized simulation of a pixelated LArTPC on a GPU

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype

Observations of the warm plasma cloak and an explanation of its formation in the magnetosphere

International audiencePrevious studies of the magnetospheric plasma populations have concentrated on the low-energy (1 eV) plasma of the plasmasphere, the more energetic (1-100 keV) plasma of the plasma sheet and ring current, and the high-energy (approximately MeV) plasma of the radiation belts. A compilation of satellite measurements over the past 30 years augmented by recent observations from the Polar-TIDE instrument has revealed a new perspective on a plasma population in the middle magnetosphere. This population consists of ions with energies of a few eV to greater than several hundred eV which display a characteristic bidirectional field-aligned pitch angle distribution. Measurements from the ATS, ISEE, SCATHA, DE, and POLAR satellites establish the characteristics of this “warm plasma cloak” of particles that is draped over the nightside region of the plasmasphere and is blown into the morning and early afternoon dayside sector by the sunward convective wind in the magnetosphere. The satellite observations combined with the predictions of an ion trajectory model are used to describe the formation and dynamics of the warm plasma cloak

A case study of plasma structure in the dusk sector associated with enhanced magnetospheric convection

In a case study from June 8–9, 1982, data from ground whistler stations Siple and Halley, Antarctica, located at L ∼4.3 and spaced by ∼2 hours in MLT, and from satellites DE 1 and GEOS 2, have provided confirming evidence that the bulge region of the magnetosphere can exhibit an abrupt westward “edge,” as reported earlier from whistlers. The present data and previous MHD modeling work suggest that this distinctive feature develops during periods of steady or declining substorm activity, when dense plasma previously carried sunward under the influence of enhanced convection activity begins to rotate with the Earth at angular velocities that decrease with increasing L value and becomes spirallike in form. For the first time, whistler data have been used to identify a narrow dense plasma feature, separated from the main plasmasphere and extending sunward into the late afternoon sector at L values near the outer observed limits of the main plasmasphere bulge. The westward edge of the main bulge, found by both whistler stations to be at ∼1800 MLT, appeared to be quasi-stationary in Sun-Earth coordinates during the prevailing conditions of gradually declining geomagnetic agitation. It is possible that outlying dense plasma features such as the one observed develop as part of the process leading to the occurrence of the more readily detectable abrupt westward edge of the bulge. It was not possible in this case to determine the extent to which the outlying feature was smoothly attached to or isolated from the main bulge region

An examination of the process and magnitude of ionospheric plasma supply to the magnetosphere.

The contribution of ionospheric plasma to the Earth’s magnetosphere has beenrecognized for more than 3 decades. The magnitude of this contribution has become moreevident over that same time period with the observed magnitude of the low-energyionospheric supply increasing as the measurement techniques improved. Estimates basedon Dynamics Explorer measurements in the mid-1980s suggested that the ionosphericplasma supply is sufficient to populate the plasmasphere, plasma trough, plasma sheet, andmagnetotail lobes. Recent measurements from the Thermal Ion Dynamics Experiment onthe Polar spacecraft have been used in conjunction with an ion trajectory model toreexamine the process and magnitude of the ionospheric supply of magnetosphericplasma. These measurements reveal the energy, pitch angle, and flux characteristics of theupward flowing polar wind over broad regions of the high-latitude ionosphere. Onboardmeasurement of spacecraft potential is found to be a fundamental element ininterpreting the measured ion outflow. Newly derived polar wind fluxes are determined tobe near 6.0 107 ions cm2 s1 at 5000 km altitude during local winter and magneticallyquiet conditions. Using the measured ionospheric source characteristics incombination with the trajectory code reveals the nature of the ionospheric/magnetospherefilling process and shows that the ionospheric source is sufficient to supply the observeddensities and energies of the plasma sheet and magnetotail lobes. Many of theionospheric particles are further transformed to ring current energies and locations aftercirculation through the plasma sheet. This measurement/calculation approach is ableto show which regions of the high-latitude ionosphere are important for plasma sheet/ringcurrent filling. The ionospheric sources used in the calculations include thedominant polar wind, the cleft ion fountain, and the auroral zone