1,551 research outputs found
Induced Parity-Breaking Term at Finite Chemical Potential and Temparature
We exactly calculated the parity-odd term of the effective action induced by
the fermions in 2+1 dimensions at finite chemical potential and finite
temperature. It shows that gauge invariance is still respected. A more gerneral
class of background configurations is considered. The knowledge of the reduced
1+1 determinant is required in order to draw exact conclusions about the gauge
invariance of the parity-odd term in this latter case.Comment: 8 pages, LATEX, no figure
Ixekizumab Citrate-Free Formulation : Results from Two Clinical Trials
Introduction: Subcutaneous (SC) injection is a common route of drug administration; however, injection site pain (ISP) might create a negative patient experience. We evaluated ISP, bioequivalence, and overall safety of the citrate-free (CF) formulation of ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin-17A. Methods: Two phase 1, single-blind studies were conducted in healthy participants. The crossover study A (NCT03848403) evaluated pain intensity on injection as measured by visual analog scale of pain (VAS) scores. Subjects (N = 70) were randomized 1:1:1 at the beginning to three possible treatment sequences and received a 1 mL SC injection of the three formulations sequentially in the abdomen on days 1, 8, and 15, respectively. A mixed-effects repeated measures analysis model was used to analyze VAS score by time post-injection. Study B (NCT04259346) evaluated the bioequivalence of a single 80 mg dose of CF formulation compared to the original commercial formulation. Subjects (N = 245) were randomized 1:1 to either commercial or CF formulation and received a single SC injection into the abdomen, arm, or thigh. Results: Primary endpoint was achieved in both studies. In study A, least-squares mean (LSM) difference of VAS scores immediately post injection between commercial (n = 61) and CF formulation (n = 63) was − 21.7 (p < 0.0001), indicating a lower degree of pain associated with CF formulation. In study B, bioequivalence of the CF formulation was established as 90% CIs for the ratio of geometric LSM AUC, AUC, and C between treatments were contained within the prespecified limits of 0.8 and 1.25. Except for less ISP in the CF formulation, overall safety profile was comparable. Conclusion: Ixekizumab CF formulation proved to be bioequivalent, was associated with less ISP, and had no other notable differences in the safety profile compared to the original commercial formulation. Trail Registration: ClinicalTrials.gov identifier NCT03848403, NCT04259346
A liquid helium target system for a measurement of parity violation in neutron spin rotation
A liquid helium target system was designed and built to perform a precision
measurement of the parity-violating neutron spin rotation in helium due to the
nucleon-nucleon weak interaction. The measurement employed a beam of low energy
neutrons that passed through a crossed neutron polarizer--analyzer pair with
the liquid helium target system located between them. Changes between the
target states generated differences in the beam transmission through the
polarizer--analyzer pair. The amount of parity-violating spin rotation was
determined from the measured beam transmission asymmetries. The expected
parity-violating spin rotation of order rad placed severe constraints
on the target design. In particular, isolation of the parity-odd component of
the spin rotation from a much larger background rotation caused by magnetic
fields required that a nonmagnetic cryostat and target system be supported
inside the magnetic shielding, while allowing nonmagnetic motion of liquid
helium between separated target chambers. This paper provides a detailed
description of the design, function, and performance of the liquid helium
target system.Comment: V2: 29 pages, 14 figues, submitted to Nucl. Instrum. Meth. B. Revised
to address reviewer comment
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis. While inflammatory cytokines, including interleukin (IL)-6, are elevated in IPF, the molecular mechanisms that underlie this disease are incompletely understood, although the development of fibrosis is believed to depend on canonical transforming growth factor (TGF)-β signalling. We examined bleomycin-induced inflammation and fibrosis in mice carrying a mutation in the shared IL-6 family receptor gp130. Using genetic complementation, we directly correlate the extent of IL-6-mediated, excessive Stat3 activity with inflammatory infiltrates in the lung and the severity of fibrosis in corresponding gp130757F mice. The extent of fibrosis was attenuated in B lymphocyte-deficient gp130757F;µMT−/− compound mutant mice, but fibrosis still occurred in their Smad3−/− counterparts consistent with the capacity of excessive Stat3 activity to induce collagen 1α1 gene transcription independently of canonical TGF-β/Smad3 signalling. These findings are of therapeutic relevance, since we confirmed abundant STAT3 activation in fibrotic lungs from IPF patients and showed that genetic reduction of Stat3 protected mice from bleomycin-induced lung fibrosis
Study of and from and Decays
We use the decay modes and to
study the scalar mesons and within perturbative QCD
framework. For , we perform our calculation in two
scenarios of the scalar meson spectrum. The results indicate that scenario II
is more favored by experimental data than scenario I. The important
contribution from annihilation diagrams can enhance the branching ratios about
50% in scenario I, and about 30% in scenario II. The predicted branching ratio
of in scenario I is also less favored by the experiments.
The direct CP asymmetries in are small, which are
consistent with the present experiments.Comment: More references are added. Published Versio
Andreev Reflection in Ferromagnet/Superconductor/Ferromagnet Double Junction Systems
We present a theory of Andreev reflection in a
ferromagnet/superconductor/ferromagnet double junction system. The spin
polarized quasiparticles penetrate to the superconductor in the range of
penetration depth from the interface by the Andreev reflection. When the
thickness of the superconductor is comparable to or smaller than the
penetration depth, the spin polarized quasiparticles pass through the
superconductor and therefore the electric current depends on the relative
orientation of magnetizations of the ferromagnets. The dependences of the
magnetoresistance on the thickness of the superconductor, temperature, the
exchange field of the ferromagnets and the height of the interfacial barriers
are analyzed. Our theory explains recent experimental results well.Comment: 8 pages, 9 figures, submitted to Phys. Rev.
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Tomonaga–Luttinger liquid behavior and spinon confinement in YbAlO 3
Low dimensional quantum magnets are interesting because of the emerging collective behavior arising from strong quantum fluctuations. The one-dimensional (1D) S = 1/2 Heisenberg antiferromagnet is a paradigmatic example, whose low-energy excitations, known as spinons, carry fractional spin S = 1/2. These fractional modes can be reconfined by the application of a staggered magnetic field. Even though considerable progress has been made in the theoretical understanding of such magnets, experimental realizations of this low-dimensional physics are relatively rare. This is particularly true for rare-earth-based magnets because of the large effective spin anisotropy induced by the combination of strong spin–orbit coupling and crystal field splitting. Here, we demonstrate that the rare-earth perovskite YbAlO3 provides a realization of a quantum spin S = 1/2 chain material exhibiting both quantum critical Tomonaga–Luttinger liquid behavior and spinon confinement–deconfinement transitions in different regions of magnetic field–temperature phase diagram
Measurements of the observed cross sections for exclusive light hadrons containing at , 3.650 and 3.6648 GeV
By analyzing the data sets of 17.3, 6.5 and 1.0 pb taken,
respectively, at , 3.650 and 3.6648 GeV with the BES-II
detector at the BEPC collider, we measure the observed cross sections for
, , ,
and at the three energy
points. Based on these cross sections we set the upper limits on the observed
cross sections and the branching fractions for decay into these
final states at 90% C.L..Comment: 7 pages, 2 figure
Partial wave analysis of J/\psi \to \gamma \phi \phi
Using events collected in the BESII detector, the
radiative decay is
studied. The invariant mass distribution exhibits a near-threshold
enhancement that peaks around 2.24 GeV/.
A partial wave analysis shows that the structure is dominated by a
state () with a mass of
GeV/ and a width of GeV/. The
product branching fraction is: .Comment: 11 pages, 4 figures. corrected proof for journa
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