1,330 research outputs found
Polyhedral monocarbaborane chemistry. Carboxylic acid derivatives of the [closo-2-CB9H10](-) anion
Reaction of B10H14 with para-(OHC)C6H4(COOH) in aqueous KOH gives the [nido-6-CB9H11-6-(C6H4-para-COOH)](-) anion I which upon cluster closure with iodine in alkali solution gives the [closo-2-CB9H9-2-(C6H4-para-COOH)](-) anion 2; an analogous procedure with B10H14 and glyoxalic acid OHCCOOH gives the [closo-2-CB9H9-2-(COOH)](-) anion 4 via the [arachno-6-CB9H13-6-(COOH)](-) anion 3
Exact strip postbuckling analysis of composite plates under compression and shear
Stiffened wing and fuselage panels often have a postbuckling reserve of strength, enabling them to carry loads far in excess of their critical buckling loads. Therefore allowing for postbuckling in design can reduce their weight, hence reducing fuel consumption and environmental impact. The present paper extends the postbuckling analysis in the exact strip software VICONOPT to more accurately reflect the skewed mode shapes arising from shear load and anisotropy. Such mode shapes are represented by a series of sinusoidal responses with different half-wavelengths which are coupled together using Lagrangian multipliers to enforce the boundary conditions. In postbuckling analysis the in-plane deflections involve responses with additional half-wavelengths which are absent from the out-of-plane deflection series. Numerical results are presented and compared with finite element analysis for validation. The present analysis gives close results compared to the finite element and finite strip methods and saves computational time significantly
Recommended from our members
Inter- and intra-specimen variability masks reliable temperature control on shell Mg/Ca ratios in laboratory and field cultured Mytilus edulis and Pecten maximus (bivalvia).
yesThe Mg/Ca ratios of biogenic calcite is commonly
seen as a valuable palaeo-proxy for reconstructing
past ocean temperatures. The temperature dependence of
Mg/Ca ratios in bivalve calcite has been the subject of contradictory
observations. The palaeoceanographic use of a
geochemical proxy is dependent on initial, rigorous calibration
and validation of relationships between the proxy
and the ambient environmental variable to be reconstructed.
Shell Mg/Ca ratio data are reported for the calcite of two bivalve
species, Mytilus edulis (common mussel) and Pecten
maximus (king scallop), which were grown in laboratory
culturing experiments at controlled and constant aquarium
seawater temperatures over a range from 10 to 20 C.
Furthermore, Mg/Ca ratio data of laboratory- and fieldgrown
M. edulis specimens were compared. Only a weak,
albeit significant, shell Mg/Ca ratio¿temperature relationship
was observed in the two bivalve species: M. edulis
(r2=0.37, p<0.001 for laboratory-cultured specimens and
r2=0.50, p<0.001 for field-cultured specimens) and P. maximus
(r2=0.21, p<0.001 for laboratory-cultured specimens
only). In the two species, shell Mg/Ca ratios were not found
to be controlled by shell growth rate or salinity. The Mg/Ca
ratios in the shells exhibited a large degree of variability
among and within species and individuals. The results suggest
that the use of bivalve calcite Mg/Ca ratios as a temperature
proxy is limited, at least in the species studied to
date. Such limitations are most likely due to the presence
of physiological effects on Mg incorporation in bivalve calcite.
The utilization is further limited by the great variability
both within and among shells of the same species that were
precipitated under the same ambient condition
Multiobjective Algorithms Hybridization to Optimize Broadcasting Parameters in Mobile Ad-Hoc Networks
Proceeding of: 10th InternationalWork-Conference
on Artificial Neural Networks, IWANN 2009
Salamanca, Spain, June 10-12, 2009The aim os this paper is to study the hybridization of two multi-objective algorithms in the context of a real problem, the MANETs problem. The algorithms studied are Particle Swarm Optimization (MOPSO) and a new multiobjective algorithm based in the combination of NSGA-II with Evolution Strategies (ESN). This work analyzes the improvement produced by hybridization over the Pareto’s fronts compared with the non-hybridized algorithms. The purpose of this work is to validate how hybridization of two evolutionary algorithms of different families may help to solve certain problems together in the context of MANETs problem. The hybridization used for this work consists on a sequential execution of the two algorithms and using the final population of the first algorithm as initial population of the second one.This article has been financed by the Spanish founded research MEC projects OPLINK::UC3M, Ref:TIN2005-08818- C04-02 and MSTAR::UC3M, Ref:TIN2008-06491-C04-03.Publicad
Impact of vertical mixing on sea surface pCO2 in temperate seasonally stratified shelf seas
A key parameter in determining the exchange of CO2 across the ocean-atmosphere interface is the sea surface partial pressure of carbon dioxide (pCO2). Temperate seasonally stratified shelf seas represent a significant sink for atmospheric CO2. Here an analytical model is used to quantify the impact of vertical mixing across the seasonal thermocline on pCO2. The model includes the impacts of the resultant dissolved inorganic carbon, heat, salt, and alkalinity fluxes on the solubility of CO2 and the effect of the inorganic carbon sink created by the primary production fuelled by the flux of limiting nutrient. The results indicate that diapycnal mixing drives a modest but continuous change in pCO2 of order 1–10 µatm d−1. In quantifying the individual impacts of the fluxes of the different parameters, we find that the impact of the fluxes of DIC and nitrate fluxes dominate. In consequence, both the direction and magnitude of the change in pCO2 are strongly dependent on the C:N uptake ratio in primary production. While the smaller impacts of the heat and salt fluxes tend to compensate for each other at midshelf locations, the heat flux dominates close to the shelf break. The analysis highlights the importance of the accurate parameterization of the C:N uptake ratio, the surface-mixed layer depth, and the TKE dissipation rate within the seasonal thermocline in models to be used to predict the air-sea exchange of carbon dioxide in these regimes. The results implicate storms as key periods of pCO2 perturbation
Postbuckled stability of panels with torsional buckling
The panel analysis and optimization code VICONOPT, based on exact strip theory, is
utilized to investigate the postbuckling stability of a stiffened aerospace panel in a torsional
buckled state. The paper shows that the postbuckling characteristics of a panel buckling in
a torsional mode has similarity to the postbuckling behavior of a panel with a skin initiated
mode and a panel initiated mode. The postbuckled stiffness of the torsional mode is similar
to the skin mode in terms of load versus end shortening and is similar to the panel
postbuckling behavior in terms of load versus out-of-plane deflection. If the panel has
stiffeners of more than one size then there are multiple torsional modes. For panel design it
is suggested that small stiffener buckling, i.e., in a torsional mode, can have postbuckling
stability with regard to the growth of the out-of-plane deflection. If the large stiffeners
initiate the buckling then there is no postbuckling reserve of strength. This has implications
for design of such panels as mass could be saved if allowance is made for small stiffener
buckling in the optimization process
The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation
Objective—The activation of nuclear factor-kB (NF-kB) is a crucial step in the arterial wall’s response to injury. The
identification and characterization of the NF-kB essential modulator– binding domain (NBD) peptide, which can block
the activation of the IkB kinase complex, have provided an opportunity to selectively abrogate the inflammation-induced
activation of NF-kB. The aim of the present study was to evaluate the effect of the NBD peptide on neointimal
formation.<br></br>
Methods and Results—In the rat carotid artery balloon angioplasty model, local treatment with the NBD peptide (300
microg/site) significantly reduced the number of proliferating cells at day 7 (by 40%; P<0.01) and reduced injury-induced neointimal formation (by 50%; P<0.001) at day 14. These effects were associated with a significant reduction of NF-kB activation and monocyte chemotactic protein-1 expression in the carotid arteries of rats treated with the peptide. In addition, the NBD peptide (0.01 to 1 micromol/L) reduced rat smooth muscle cell proliferation, migration, and invasion in
vitro. Similar results were observed in apolipoprotein E-/-, mice in which the NBD peptide (150 microg/site) reduced wire-induced neointimal formation at day 28 (by 47%; P<0.01).<br></br>
Conclusion—The NBD peptide reduces neointimal formation and smooth muscle cell proliferation/migration, both effects
associated with the inhibition of NF-kB activation
Brain rhythms define distinct interaction networks with differential dependence on anatomy
Cognitive functions are subserved by rhythmic neuronal synchronization across widely distributed brain areas. In 105 area pairs, we investigated functional connectivity (FC) through coherence, power correlation, and Granger causality (GC) in the theta, beta, high-beta, and gamma rhythms. Between rhythms, spatial FC patterns were largely independent. Thus, the rhythms defined distinct interaction networks. Importantly, networks of coherence and GC were not explained by the spatial distributions of the strengths of the rhythms. Those networks, particularly the GC networks, contained clear modules, with typically one dominant rhythm per module. To understand how this distinctiveness and modularity arises on a common anatomical backbone, we correlated, across 91 area pairs, the metrics of functional interaction with those of anatomical projection strength. Anatomy was primarily related to coherence and GC, with the largest effect sizes for GC. The correlation differed markedly between rhythms, being less pronounced for the beta and strongest for the gamma rhythm
Haploidentical Stem Cell Transplants in Children With Acute Lymphoblastic Leukemia in First or Second Remission
- …