297 research outputs found

    Profits and balance sheet developments at U.S. commercial banks in 2006

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    The U.S. commercial banking industry continued to be quite profitable in 2006, and industry assets grew considerably. The strength in profitability and growth of bank balance sheets last year reflected favorable U.S. financial market conditions and the generally solid economic expansion. Industry return on equity advanced from its 2005 level, and the return on assets edged up to match its highest annual level in recent decades. Profitability was supported by brisk growth in non-interest income and generally strong asset quality; the flattening of the yield curve and competitive pressures, however, further weighed on net interest margins.Bank profits ; Banks and banking, American

    Repräsentation durch institutionalisierte Gegenmacht: Unabhängige Beratungsstellen für Erwerbslose im Rechtskreis des SGB II

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    Der neue Populismus gilt als Sprachrohr der soge-nannten ‚Abgehängten’ beschäftigungspolitischer Umbrüche. Eine Ursache ist die mangelhafte Repräsen-tation der Interessen dieser Menschen, die von den Parteien der politischen Mitte bis in die arbeitsmarkt-orientierte Grundsicherung nach SGB II reicht. Inner-halb des SGB II-Rechtskreises könnte diese Lücke zum Beispiel durch unabhängige Erwerbslosenberatungs-stellen als arbeitsmarktpolitische Akteure im Sinne institutionalisierter Gegenmacht geschlossen werden

    The Living Together Arrangement: Social Work and the Lost Client

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    A recent research study suggests that persons living together outside of marriage do not view social work services as a potential source of help for problems brought into the living together arrangement, those common to all intimate long-range dyadic relationships or those directly related to choice of lifestyle. A multi-faceted approach is suggested which would aim at reaching this potential client group in a climate which will neither stigmatize or judge the alternate lifestyle or the persons who practice it

    Statistical significance - meaningful or not

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    An environmental assessment of the Charleston Ocean Dredged Material Disposal Site and surrounding areas : physical and biological conditions after completion of the Charleston Harbor Deepening Project

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    A monitoring program of the physical and biological condition of bottom habitats within and surrounding the Charleston Ocean Dredged Material Disposal Site was completed after the conclusion of disposal activities associated with the 1999-2002 Charleston Harbor Deepening Project. Approximately 20-25 million cubic yards of inner harbor and entrance channel materials were placed at the ODMDS as part of the project. Findings presented here include analyses of sediment characteristics, sediment contaminants, and benthic assemblages in the disposal zone, inner boundary zone, and outer boundary zone

    The Effectiveness of Support and Rehabilitation Services for Women Offenders

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    There is a large body of research evidence suggesting that support, rehabilitation, and supervision programs can help offenders to reduce recidivism. However, the effectiveness of these services is dependent upon the extent to which the workers who deliver them comply with "what works" principles and practices. Because most of this research has been conducted with men, this study focused on the extent to which these principles and practices apply to women. In particular, the study examined services offered to a group of women in prison in Victoria, Australia, and following their release to the community; and the relationship between these women's views about the services, recidivism, and the characteristics of the services. Results were generally consistent with earlier research. The women favoured services that are delivered by workers who are reliable, holistic, collaborative, who understand the women's perspective, and that focus on strengths. They did not support services that challenged the women, focused on their offences, or on the things they did badly

    Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production

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    Despite recent therapeutic advancements, multiple myeloma (MM) remains incurable and new therapies are needed, especially for the treatment of elderly and relapsed/refractory patients. We have screened a panel of 100 off-patent licensed oral drugs for anti-myeloma activity and identified niclosamide, an anti-helminthic. Niclosamide, at clinically achievable non-toxic concentrations, killed MM cell lines and primary MM cells as efficiently as or better than standard chemotherapy and existing anti-myeloma drugs individually or in combinations, with little impact on normal donor cells. Cell death was associated with markers of both apoptosis and autophagy. Importantly, niclosamide rapidly reduced free light chain (FLC) production by MM cell lines and primary MM. FLCs are a major cause of renal impairment in MM patients and light chain amyloid and FLC reduction is associated with reversal of tissue damage. Our data indicate that niclosamides anti-MM activity was mediated through the mitochondria with rapid loss of mitochondrial membrane potential, uncoupling of oxidative phosphorylation and production of mitochondrial superoxide. Niclosamide also modulated the nuclear factor-κB and STAT3 pathways in MM cells. In conclusion, our data indicate that MM cells can be selectively targeted using niclosamide while also reducing FLC secretion. Importantly, niclosamide is widely used at these concentrations with minimal toxicity
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