Neural-network selection of high-redshift radio quasars, and the luminosity function at z~4

We obtain a sample of 87 radio-loud QSOs in the redshift range 3.6<z<4.4 by cross-correlating sources in the FIRST radio survey S{1.4GHz} > 1 mJy with star-like objects having r <20.2 in SDSS Data Release 7. Of these 87 QSOs, 80 are spectroscopically classified in previous work (mainly SDSS), and form the training set for a search for additional such sources. We apply our selection to 2,916 FIRST-DR7 pairs and find 15 likely candidates. Seven of these are confirmed as high-redshift quasars, bringing the total to 87. The candidates were selected using a neural-network, which yields 97% completeness (fraction of actual high-z QSOs selected as such) and an efficiency (fraction of candidates which are high-z QSOs) in the range of 47 to 60%. We use this sample to estimate the binned optical luminosity function of radio-loud QSOs at $z\sim 4$, and also the LF of the total QSO population and its comoving density. Our results suggest that the radio-loud fraction (RLF) at high z is similar to that at low-z and that other authors may be underestimating the fraction at high-z. Finally, we determine the slope of the optical luminosity function and obtain results consistent with previous studies of radio-loud QSOs and of the whole population of QSOs. The evolution of the luminosity function with redshift was for many years interpreted as a flattening of the bright end slope, but has recently been re-interpreted as strong evolution of the break luminosity for high-z QSOs, and our results, for the radio-loud population, are consistent with this.Comment: 20 pages. Accepted for publication in MNRAS on 3 March 201

Partial purification and MALDI-TOF MS analysis of UN1, a tumor antigen membrane glycoprotein.

UN1 is a membrane glycoprotein that is expressed in immature human thymocytes, a subpopulation of peripheral T lymphocytes, the HPB acute lymphoblastic leukemia (ALL) T-cell line and fetal thymus. We previously reported the isolation of a monoclonal antibody (UN1 mAb) recognizing the UN1 protein that was classified as "unclustered" at the 5th and 6th International Workshop and Conference on Human Leukocyte Differentiation Antigens. UN1 was highly expressed in breast cancer tissues and was undetected in non-proliferative lesions and in normal breast tissues, indicating a role for UN1 in the development of a tumorigenic phenotype of breast cancer cells. In this study, we report a partial purification of the UN1 protein from HPB-ALL T cells by anion-exchange chromatography followed by immunoprecipitation with the UN1 mAb and MALDI-TOF MS analysis. This analysis should assist in identifying the amino acid sequence of UN

Optimization of the Efficiency in a Syngas Powered Si Engine Through Numerical Studies Related to the Geometry of the Combustion Chamber

The combustion process occurring in an alternative Spark Ignition (SI) engine powered with bio-syngas from biomass gasification was previously studied by authors through the development of two different numerical models: a 0-1D model developed in the GT-Suite® environment, aimed at gaining a first look upon the main features of the heat release by the syngas and engine performances; a 3D Computational Fluid Dynamics (CFD) model developed within the AVL FireTM software reproducing the engine combustion cycle within a Reynolds Averaged Navier Stokes (RANS) schematization and employing a detailed chemical reaction mechanism to highlight the interaction between the fluid dynamics and the kinetics of the specific biofuel oxidation chain. The numerical results were validated with respect to experimental measurements in a baseline condition, where the presence of a relatively high amount of CO in the exhaust gases was noticed as related to an engine low combustion efficiency, mainly due to the peripheral spark plug position that determines the persistence of residual gases on the opposite side of the combustion chamber wall. The proposed work presents a numerical analysis made through the developed models on the effects of proper changes in the spark plug position. A multi-objective optimization problem is conducted also by varying the Start of Spark (SOS) and the mixture air-to-fuel ratio with the aim of reducing the engine environmental impact without affecting its performances. A centrally mounted spark, along with a correct calibration of the SOS and mixture ratio, allows a reduction of more than 90% of CO emission with respect to the baseline condition without penalizing the engine brake power and efficienc

941 Myocardial viability predicts reverse remodelling after cardiac resynchronization therapy (CRT): a 2D strain echocardiography (2DSE) study

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Platelet aggregation is affected by nitrosothiols in patients with chronic hepatitis: in vivo and in vitro studies

AIM: To investigate the relationship among the number of platelets and plasma levels of S-nitrosothiols (S-NO), nitrite, total non-protein SH (NPSH), glutathione (GSH), cysteine (CYS), malondialdehyde (MDA), 4-hydroxininenal (4HNE), tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-6 in patients with chronic hepatitis C (CH). METHODS: In vitro the aggregation of platelets derived from controls and CH patients was evaluated before and after the addition of adenosine diphosphate (ADP) and collagen, both in basal conditions and after incubation with nitrosoglutathione (GSNO). RESULTS: In vivo, S-NO plasma levels increased significantly in CH patients and they were significantly directly correlated with platelet numbers. Patients with platelet counts 150000/microL. In vitro, the ADP and collagen aggregation time was increased in platelets from patients and not from controls; in addition, platelets from CH patients but not from controls also showed a latency time after exposure to collagen

The bisphenol a induced oxidative stress in non-alcoholic fatty liver disease male patients: A clinical strategy to antagonize the progression of the disease

Introduction: Bisphenol A (BPA) exposure has been correlated to non-alcoholic fatty liver disease (NAFLD) development and progression. We investigated, in a clinical model, the effects of the administration of 303 mg of silybin phospholipids complex, 10 μg of vitamin D, and 15 mg of vitamin E (RealSIL, 100D, IBI-Lorenzini, Aprilia, Italy) in male NAFLD patients exposed to BPA on metabolic, hormonal, and oxidative stress-related parameters. Methods: We enrolled 32 male patients with histologic diagnosis of NAFLD and treated them with Realsil 100D twice a day for six months. We performed at baseline clinical, biochemical, and food consumption assessments as well as the evaluation of physical exercise, thiobarbituric acid reactive substances (TBARS), plasmatic and urinary BPA and estrogen levels. The results obtained were compared with those of healthy control subjects and, in the NAFLD group, between baseline and the end of treatment. Results: A direct proportionality between TBARS levels and BPA exposure was shown (p &lt; 0.0001). The therapy determined a reduction of TBARS levels (p = 0.011), an improvement of alanine aminotransferase, aspartate aminotransferase, insulinemia, homeostatic model assessment insulin resistance, C reactive protein, tumor necrosis factor alpha (p &lt; 0.05), an increase of conjugated BPA urine amount, and a reduction of its free form (p &lt; 0.0001; p = 0.0002). Moreover, the therapy caused an increase of plasmatic levels of the native form of estrogens (p = 0.03). Conclusions: We highlighted the potential role of BPA in estrogen oxidation and oxidative stress in NAFLD patients. The use of Realsil 100D could contribute to fast BPA detoxification and to improve cellular antioxidant power, defending the integrity of biological estrogen-dependent pathways

Implementation of the new multichannel X-mode edge density profile reflectometer for the ICRF antenna on ASDEX Upgrade

A new multichannel frequency modulated continuous-wave reflectometry diagnostic has been successfully installed and commissioned on ASDEX Upgrade to measure the plasma edge electron density profile evolution in front of the Ion Cyclotron Range of Frequencies (ICRF) antenna. The design of the new three-strap ICRF antenna integrates ten pairs (sending and receiving) of microwave reflectometry antennas. The multichannel reflectometer can use three of these to measure the edge electron density profiles up to 2 x 10(19) m(-3), at different poloidal locations, allowing the direct study of the local plasma layers in front of the ICRF antenna. ICRF power coupling, operational effects, and poloidal variations of the plasma density profile can be consistently studied for the first time. In this work the diagnostic hardware architecture is described and the obtained density profile measurements were used to track outer radial plasma position and plasma shape

Progress and verification of DTT ICRF antenna simulation using COMSOL

In this paper we present the extension of a full-wave FEM model (COMSOL®+MATLAB®) - initially developed to compute the electromagnetic field in presence of the anisotropic inhomogeneous plasma of the Electron Cyclotron Resonance Ion Sources (ECRISs) [1] – to the Ion Cyclotron Range of Frequency (ICRF). The model - based on the full non-uniform dielectric tensor in "cold plasma" approximation - has been employed to study antenna geometries of increasing complexity. Various antenna types have been analyzed, starting from single flat strap up to the two straps of an antenna option considered for the Divertor Tokamak Test facility (DTT) [2]. The results have been compared, cross-checked and validated with a simpler COMSOL-based tool [3] and with the TOPICA code [4]