Evaluation of a PET Prototype Using LYSO:Ce Monolithic Detector Block

We have analyzed the performance of a PET demonstrator formed by two sectors of four monolithic detector blocks placed face-to-face. Both front-end and read-out electronics have been evaluated by means of coincidence measurements using a rotating 22Na source placed at the center of the sectors in order to emulate the behavior of a complete full ring. A continuous training method based on neural network (NN) algorithms has been carried out to determine the entrance points over the surface of the detectors. Reconstructed images from 1 MBq 22Na point source and 22Na Derenzo phantom have been obtained using both filtered back projection (FBP) analytic methods and the OSEM 3D iterative algorithm available in the STIR software package [1]. Preliminary data on image reconstruction from a 22Na point source with Ø = 0.25 mm show spatial resolutions from 1.7 to 2.1 mm FWHM in the transverse plane. The results confirm the viability of this design for the development of a full-ring brain PET scanner compatible with magnetic resonance imaging for human studies

LanderPick, a Remote Operated Trawled Vehicle to cost-effectively deploy and recover lightweight oceanographic landers.

Landers are modular structures equipped with miscellaneous sensors and monitoring equipment which are positioned directly on the seabed to operate autonomously for a defined timeframe. A drawback of landers intended to operate for prolonged periods in the deep ocean is the high cost of recovery systems, typically depending on buoyancy modules plus expendable ballast, or requiring ROVs assistance. LanderPick concept consists of the design of a specific trawled vehicle to deploy and recover lightweight oceanographic landers not provided with recovery elements, but having a capture mesh that facilitates their hitching. The LanderPick vehicle is technically a ROTV (Remote Operated Trawled Vehicle) controlled through a standard coaxial electromechanical cable that allows real-time control from the vessel. Navigation is enabled by a low-light high-definition camera, aided by spotlights and laser pointers. Small propellers aid in the final precision approach maneuvers. A mechanical release allows the precise placement at the sea bottom of landers carried as a payload, as well as their recovery by means of a triple hook. First sea missions of the system were carried out successfully in 2021 in southern Biscay. A 4-month deployment of a lander array equipped with current-meters along an energetic canyon axis provided unprecedented detail in the progression of the internal tidal bore. Short (48-hours) deployments of a fully-instrumented lander, including lapse-time image and baits in a deep seamount summit within a marine protected area, provided insights on the biodiversity of a unique ecosystem. The LanderPick novel approach to cost-effectively and precisely deploy and recover lightweight oceanographic landers allows to conceive (i) monitoring systems based on the deployment of arrays or fleets of low-cost landers and (ii) experiments associated with deep habitats such as coral reefs in which it is necessary to locate landers with great precision

LanderPick, a Remote Operated Trawled Vehicle to cost-effectively deploy and recover lightweight oceanographic landers.

Landers are modular structures equipped with miscellaneous sensors and monitoring equipment which are positioned directly on the seabed to operate autonomously for a defined timeframe. A drawback of landers intended to operate for prolonged periods in the deep ocean is the high cost of recovery systems, typically depending on buoyancy modules plus expendable ballast, or requiring ROVs assistance. LanderPick concept consists of the design of a specific trawled vehicle to deploy and recover lightweight oceanographic landers not provided with recovery elements, but having a capture mesh that facilitates their hitching. The LanderPick vehicle is technically a ROTV (Remote Operated Trawled Vehicle) controlled through a standard coaxial electromechanical cable that allows real-time control from the vessel. Navigation is enabled by a low-light high-definition camera, aided by spotlights and laser pointers. Small propellers aid in the final precision approach maneuvers. A mechanical release allows the precise placement at the sea bottom of landers carried as a payload, as well as their recovery by means of a triple hook. First sea missions of the system were carried out successfully in 2021 in southern Biscay. A 4-month deployment of a lander array equipped with current-meters along an energetic canyon axis provided unprecedented detail in the progression of the internal tidal bore. Short (48-hours) deployments of a fully-instrumented lander, including lapse-time image and baits in a deep seamount summit within a marine protected area, provided insights on the biodiversity of a unique ecosystem. The LanderPick novel approach to cost-effectively and precisely deploy and recover lightweight oceanographic landers allows to conceive (i) monitoring systems based on the deployment of arrays or fleets of low-cost landers and (ii) experiments associated with deep habitats such as coral reefs in which it is necessary to locate landers with great precision

The Age of Constitutions in the Americas

The late eighteenth and nineteenth centuries have been aptly called the “Age of Codifications.” The same period was also the Age of Constitutions. Although a great deal is known about the migration of prenational and transnational legal sources and ideas that led to national codes of civil and criminal law in Europe and the Americas, much less is known about similar processes on the constitutional level. Constitutional historians have been more parochial than their private law counterparts, most likely because of the relationship between constitutions and nations. In the light of independence, nations immediately needed constitutions to solidify gains and to consolidate state power. The study of these processes becomes national narratives, often in conversation with the former colonial power, which are disconnected from more general or regional trends. As Linda Colley\u27s article in this issue illustrates, it is important to step back to view the constitution-making process from an Atlantic perspective that ties the Americas, North and South, into the area of study. The Age of Constitutions in the Americas must include Latin America and the Caribbean

Power struggles in the remembering of historical intergroup conflict: hegemonic and counter-narratives about the Argentine “Conquest of the Desert”

This work has been supported by funding from the research projects PICT-2012–1594 and PICT-2014–1003 (FONCyT-Argentina), and a grant from the Latin American Studies, University of Uta

Education can improve the negative perception of a threatened long-lived scavenging bird, the Andean condor

Human-wildlife conflicts currently represent one of the main conservation problems for wildlife species around the world. Vultures have serious conservation concerns, many of which are related to people's adverse perception about them due to the belief that they prey on livestock. Our aim was to assess local perception and the factors influencing people's perception of the largest scavenging bird in South America, the Andean condor. For this, we interviewed 112 people from Valle Fértil, San Juan province, a rural area of central west Argentina. Overall, people in the area mostly have an elementary education, and their most important activity is livestock rearing. The results showed that, in general, most people perceive the Andean condor as an injurious species and, in fact, some people recognize that they still kill condors. We identified two major factors that affect this perception, the education level of villagers and their relationship with livestock ranching. Our study suggests that conservation of condors and other similar scavengers depends on education programs designed to change the negative perception people have about them. Such programs should be particularly focused on ranchers since they are the ones who have the worst perception of these scavengers. We suggest that highlighting the central ecological role of scavengers and recovering their cultural value would be fundamental to reverse their persecution and their negative perception by people.Fil: Cailly Arnulphi, Verónica Beatríz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Centro de Investigaciones de la Geosfera y Biosfera. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones de la Geosfera y Biosfera; ArgentinaFil: Lambertucci, Sergio Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Borghi, Carlos Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Centro de Investigaciones de la Geosfera y Biosfera. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones de la Geosfera y Biosfera; Argentin

A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis

Background: Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive genetic disease characterized by the lack of reaction to noxious stimuli and anhidrosis. It is caused by mutations in the NTRK1 gene, which encodes the high affinity tyrosine kinase receptor I for Neurotrophic Growth Factor (NGF). -- Case Presentation: We present the case of a female patient diagnosed with CIPA at the age of 8 months. The patient is currently 6 years old and her psychomotor development conforms to her age (RMN, SPECT and psychological study are in the range of normality). PCR amplification of DNA, followed by direct sequencing, was used to investigate the presence of NTRK1 gene mutations. Reverse transcriptase (RT)-PCR amplification of RNA, followed by cloning and sequencing of isolated RT-PCR products was used to characterize the effect of the mutations on NTRK1 mRNA splicing. The clinical diagnosis of CIPA was confirmed by the detection of two splice-site mutations in NTRK1, revealing that the patient was a compound heterozygote at this gene. One of these alterations, c.574+1G > A, is located at the splice donor site of intron 5. We also found a second mutation, c.2206-2 A > G, not previously reported in the literature, which is located at the splice acceptor site of intron 16. Each parent was confirmed to be a carrier for one of the mutations by DNA sequencing analysis. It has been proposed that the c.574+1G > A mutation would cause exon 5 skipping during NTRK1 mRNA splicing. We could confirm this prediction and, more importantly, we provide evidence that the novel c.2206-2A > G mutation also disrupts normal NTRK1 splicing, leading to the use of an alternative splice acceptor site within exon 17. As a consequence, this mutation would result in the production of a mutant NTRK1 protein with a seven aminoacid in-frame deletion in its tyrosine kinase domain. --Conclusions: We present the first description of a CIPA-associated NTRK1 mutation causing a short interstitial deletion in the tyrosine kinase domain of the receptor. The possible phenotypical implications of this mutation are discussed.This investigation was supported by the Instituto de Salud Carlos III and the Fundacion Vasca de Innovacion e Investigacion Sanitarias (funds to ES)

Validation of a small-animal PET simulation using GAMOS: a Geant4-based framework

onte Carlo-based modelling is a powerful tool to help in the design and optimization of positron emission tomography (PET) systems. The performance of these systems depends on several parameters, such as detector physical characteristics, shielding or electronics, whose effects can be studied on the basis of realistic simulated data. The aim of this paper is to validate a comprehensive study of the Raytest ClearPET small-animal PET scanner using a new Monte Carlo simulation platform which has been developed at CIEMAT (Madrid, Spain), called GAMOS (GEANT4-based Architecture for Medicine-Oriented Simulations). This toolkit, based on the GEANT4 code, was originally designed to cover multiple applications in the field of medical physics from radiotherapy to nuclear medicine, but has since been applied by some of its users in other fields of physics, such as neutron shielding, space physics, high energy physics, etc. Our simulation model includes the relevant characteristics of the ClearPET system, namely, the double layer of scintillator crystals in phoswich configuration, the rotating gantry, the presence of intrinsic radioactivity in the crystals or the storage of single events for an off-line coincidence sorting. Simulated results are contrasted with experimental acquisitions including studies of spatial resolution, sensitivity, scatter fraction and count rates in accordance with the National Electrical Manufacturers Association (NEMA) NU 4-2008 protocol. Spatial resolution results showed a discrepancy between simulated and measured values equal to 8.4% (with a maximum FWHM difference over all measurement directions of 0.5 mm). Sensitivity results differ less than 1% for a 250–750 keV energy window. Simulated and measured count rates agree well within a wide range of activities, including under electronic saturation of the system (the measured peak of total coincidences, for the mouse-sized phantom, was 250.8 kcps reached at 0.95 MBq mL−1 and the simulated peak was 247.1 kcps at 0.87 MBq mL−1). Agreement better than 3% was obtained in the scatter fraction comparison study. We also measured and simulated a mini-Derenzo phantom obtaining images with similar quality using iterative reconstruction methods. We concluded that the overall performance of the simulation showed good agreement with the measured results and validates the GAMOS package for PET applications. Furthermore, its ease of use and flexibility recommends it as an excellent tool to optimize design features or image reconstruction techniques