57 research outputs found
Tratamiento quirúrgico de la pseudoartrosis de la apófisis odontoides: Presentación de dos casos
Se presenta nuestra experiencia de dos casos de pseudoartrosis de apófisis odontoides tratadas quirúrgicamente mediante atornillado directo a compresión por vía anterior paraesternomocleidomastoidea. El resultado final fue satisfactorio en el primer caso, teniendo que realizarse una artrodesis posterior C1-C2 en el segundo. Se discute la posibilidad de un exceso de angulación posterioSe presenta nuestra experiencia de dos casos de pseudoartrosis de apófisis odontoides tratadas quirúrgicamente mediante atornillado directo a compresión por vía anterior paraesternomocleidomastoidea. El resultado final fue satisfactorio en el primer caso, teniendo que realizarse una artrodesis posterior C1-C2 en el segundo. Se discute la posibilidad de un exceso de angulación posterior en la colocación del tornillo como causa del fracaso de la técnica.en la colocación del tornillo como causa del fracaso de la técnica.Two cases of odontoid process non-union treated by direct screw compression through an anterior approach are presented. The outcome was satisfactory in one case. The other required posterior C1-C2 union because of anterior screwing failure. An excessive posterior angulation of the screw thought to be the cause of anterior fusion failure
Análisis del plano sagital en las escoliosis idiopáticas tratadas con instrumentación Cotrel-Dubousset
Se analiza la evolución del plano sagital en 50 enfermos con escoliosis idiopática
intervenidos mediante artrodesis posterior con instrumentación de Cotrel-Dubousset con un seguimiento
medio de 72 meses. Se recogieron los valores evolutivos de cifosis torácica medida entre
T5 y T12 y de lordosis lumbar medida entre Ll y L5. Las curvas escolióticas fueron clasificadas
según King et al. Los resultados obtenidos mostraron que no existía una variación global significativa
de la cifosis torácica tras la cirugía. Sólo en aquellos enfermos que previamente existía
una hipocifosis torácica existía una mejoría estadísticamente significativa de la misma con la intervención.
Se evidenció una clara tendencia al incremento de la cifosis torácica con el tiempo.
La lordosis lumbar se mantuvo, en la mayoría de los casos, dentro de límites fisiológicos. La instrumentación
de Cotrel-Dubousset ofrece ventajas evidentes respecto a instrumentaciones previas
en lo que respecta a la obtención de una curva más fisiológica en el plano sagital. Permite
corregir la hipocifosis torácica severa y mantener la lordosis lumbar dentro de límites normales,
incluso en instrumentaciones por debajo de L3.Sagittal plane analysis of 50 patients with idiopathic scoliosis treated with Cotrel-
Dubousset instrumentation was performed. Mean follow-up was 72 months. The values of thoracic
kyphosis from T5 to T12 and lumbar lordosis from L1 to L5 were retrospectively reviewed.
Scoliotic curves were classified according to King et al. The results showed that there was not any
significant change in thoracic kyphosis after surgery. Only those patients with preoperative thoracic
hypokyphosis achieved a significant realignment. There was an obvious increase of thoracic
kyphosis with time. Lumbar lordosis was maintained within normal limits in the mayority of patients.
Cotrel-Dubousset instrumentation achieves better sagittal alignment than previous systems.
It corrects thoracic hypokyphosis and preserves lumbar lordosis, even when the instrumentation
is carried out lower than L3
Valoración del efecto de la calcitonina en la consolidación de la fractura de Colles
Se estudian cuarenta pacientes en que se ha producido una Fractura
de Epífisis Distal de Radio (Fractura de POUTEAU-COLLES) en pacientes
mayores de cincuenta años, con signos de osteoroporosis. Se han hecho
dos grupos aleatorios de veinte pacientes.
El grupo A se ha tratado con un programa de calcitonina y calcio que
cubre los tres primeros meses. El grupo B es tratado exclusivamente con
calcio, por igual período.
En ambos la reducción e inmovilización sigue los mismos criterios.
Se evalúan los resultados, observando que el grupo A presenta menos
secuelas dolorosas.The authors have studied 40 patients with fracture of distal
epiphysis of radius (POUTEAU-COLLES' fracture) all of them fifty
years old with signs of osteoporosis.
They have made two groups of patients (20 every one).
The group A has been treated with a program of calcitonin and
calcium during three months. The group B has been treated only
with calcium, three months, as well as the other group.
Both groups have the same criterion of reduction and inmovilization.
The evaluation of results in the first group showed less painful
consequences
Avances en la resolución conjunta de los procesos costeros y portuarios para la predicción de la agitación en la bahía de Algeciras
Se agradece a la APBA la financiación dentro del proyecto “Algeciras Safeport”
Accelerated inbreeding depression suggests synergistic epistasis for deleterious mutations in Drosophila melanogaster
Epistasis may have important consequences for a number of issues in quantitative genetics and evolutionary biology. In
particular, synergistic epistasis for deleterious alleles is relevant to the mutation load paradox and the evolution of sex and
recombination. Some studies have shown evidence of synergistic epistasis for spontaneous or induced deleterious mutations
appearing in mutation-accumulation experiments. However, many newly arising mutations may not actually be segregating
in natural populations because of the erasing action of natural selection. A demonstration of synergistic epistasis for naturally
segregating alleles can be achieved by means of inbreeding depression studies, as deleterious recessive allelic effects are
exposed in inbred lines. Nevertheless, evidence of epistasis from these studies is scarce and controversial. In this paper, we
report the results of two independent inbreeding experiments carried out with two different populations of Drosophila
melanogaster. The results show a consistent accelerated inbreeding depression for fitness, suggesting synergistic epistasis
among deleterious alleles. We also performed computer simulations assuming different possible models of epistasis and
mutational parameters for fitness, finding some of them to be compatible with the results observed. Our results suggest that
synergistic epistasis for deleterious mutations not only occurs among newly arisen spontaneous or induced mutations, but
also among segregating alleles in natural populationsWe acknowledge the support by Uvigo
Marine Research Centre funded by the “Excellence in Research
(INUGA)” Programme from the Regional Council of Culture, Education and Universities, with co-funding from the European Union
through the ERDF Operational Programme Galicia 2014-2020. This
work was funded by Agencia Estatal de Investigación (AEI) (CGL2016-75904-C2-1-P), Xunta de Galicia (ED431C 2016-037) and
Fondos Feder: “Unha maneira de facer Europa.” SD was founded by a
predoctoral (FPI) grant from Ministerio de Economía y
Competitividad, SpainS
MMP-8 Deficiency Increases TLR/RAGE Ligands S100A8 and S100A9 and Exacerbates Lung Inflammation during Endotoxemia
Matrix metalloproteinase-8, released mainly from neutrophils, is a critical regulator of the inflammatory response by its ability to cleave multiple mediators. Herein, we report the results of a model of endotoxemia after intraperitoneal LPS injection in mice lacking MMP-8 and their wildtype counterparts. Control, saline-treated animals showed no differences between genotypes. However, there was an increased lung inflammatory response, with a prominent neutrophilic infiltration in mutant animals after LPS treatment. Using a proteomic approach, we identify alarmins S100A8 and S100A9 as two of the main differences between genotypes. Mice lacking MMP-8 showed a significant increase in these two molecules in lung homogenates, but not in spleen and serum. Mice lacking MMP-8 also showed an increase in MIP-1α levels and a marked activation of the non-canonical NF-κB pathway, with no differences in CXC-chemokines such as MIP-2 or LIX. These results show that MMP-8 can modulate the levels of S100A8 and S100A9 and its absence promotes the lung inflammatory response during endotoxemia
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