Turning waves and breakdown for incompressible flows

We consider the evolution of an interface generated between two immiscible incompressible and irrotational fluids. Specifically we study the Muskat and water wave problems. We show that starting with a family of initial data given by (\al,f_0(\al)), the interface reaches a regime in finite time in which is no longer a graph. Therefore there exists a time $t^*$ where the solution of the free boundary problem parameterized as (\al,f(\al,t)) blows-up: \|\da f\|_{L^\infty}(t^*)=\infty. In particular, for the Muskat problem, this result allows us to reach an unstable regime, for which the Rayleigh-Taylor condition changes sign and the solution breaks down.Comment: 15 page

Cloreto de potássio na linha de semeadura pode causar danos à soja.

bitstream/item/24735/1/COT200264.pdfDocumento on-line

Lack of uniqueness for weak solutions of the incompressible porous media equation

In this work we consider weak solutions of the incompressible 2-D porous media equation. By using the approach of De Lellis-Sz\'ekelyhidi we prove non-uniqueness for solutions in $L^\infty$ in space and time.Comment: 23 pages, 2 fugure

Multimodal agent interfaces and system architectures for health and fitness companions

Multimodal conversational spoken dialogues using physical and virtual agents provide a potential interface to motivate and support users in the domain of health and fitness. In this paper we present how such multimodal conversational Companions can be implemented to support their owners in various pervasive and mobile settings. In particular, we focus on different forms of multimodality and system architectures for such interfaces

Alterações na biomassa microbiana do solo em cultivos de mandioca sob diferentes coberturas vegetais.

O presente estudo teve como objetivo avaliar o efeito do cultivo da mandioca em plantio direto sob diferentes coberturas vegetais na biomassa microbiana do solo e índices derivados. Tais parâmetros foram avaliados também em sistema sob preparo convencional (aração e gradagem) e sistema natural (mata nativa), para comparação. Os estudos foram conduzidos no Município de Glória de Dourados, MS,num Argissolo vermelho distrófico, de textura arenosabitstream/item/65168/1/BP200421.pd

DT-TTF Salts with [Cu(dcdmp)2]−: The Richness of Different Stoichiometries

(DT-TTF)[Cu(dcdmp)(2)] (1), (DT-TTF)(2)[Cu(dcdmp)(2)] (2), and (DT-TTF)(3)[Cu(dcdmp)(2)](2) (3) are three new charge transfer salts obtained by electrocrystallization of the donor DT-TTF (dithiophene-tetrathiafulvalene) with the diamagnetic copper complex [Cu(dcdmp)(2)](-) (dcdmp = 2,3-dicyano-5,6-dimercaptopyrazine). Compounds 1 and 3 crystallize in the triclinic system and consist of out-of-registry layers of mixed stacks of donor and acceptor molecules. (DT-TTF)(2)[Cu(dcdmp)(2)] presents a structure similar to the parent spin-ladder systems with donor stacks arranged in pairs; however, a magnetic spin-ladder behavior is not observed probably due to strong interactions between pairs. Compound 3, despite the mixed nature of the stacks, displays relatively high conductivity (7 S/cm) due to a one-dimensional network of interactions between donors.This work was supported by FCT (Portugal) through contracts PTDC/QEQ-SUP/1413/2012 and UID/Multi/04349/2013 and by DGI, Spain (CTQ2013-40480), the Generalitat de Catalunya (2014SGR0017), the CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), promoted by ISCIII, Spain. R. A. L. S. is thankful to FCT for the PhD grant SFRH/BD/86131/2012.Peer reviewe

Film bulk acoustic resonator pressure sensor with self temperature reference

A novel film bulk acoustic resonator (FBAR) with two resonant frequencies which have opposite reactions to temperature changes has been designed. The two resonant modes respond differently to changes in temperature and pressure, with the frequency shift being linearly correlated with temperature and pressure changes. By utilizing the FBAR's sealed back trench as a cavity, an on-chip single FBAR sensor suitable for measuring pressure and temperature simultaneously is proposed and demonstrated. The experimental results show that the pressure coefficient of frequency for the lower frequency peak of the FBAR sensors is approximately −17.4 ppm kPa−1, while that for the second peak is approximately −6.1 ppm kPa−1, both of them being much more sensitive than other existing pressure sensors. This dual mode on-chip pressure sensor is simple in structure and operation, can be fabricated at very low cost, and yet requires no specific package, therefore has great potential for applications

Estudio teórico de algunas propiedades termodinámicas de los ácidos grasos obtenidos como destilados en la desodorización de aceites comestibles

Nowadays the feasibility of a change of technology in the deodorization stage of edible vegetable oil refining is being investigated. The proposed technology involves a modification in the composition of the distillates coming from the deodorization stage and their further treatment To design the apparatus which are required by the proposed technology it is necessary to study the physical properties of the distillates. The thermodynamic properties of the fatty acids: palmitic, stearic, oleic and linoleic, which are the principal components produced at the deodorization stage have been studied. The properties that have been studied were those corresponding to the critical point (critical temperature, pressure and volume), the vapour pressure-temperature relation and the latent heat of vaporisation. Different methods to estimate the above mentioned properties and some experimental published data have been compared.Estudio teórico de algunas propiedades termodinámicas de los ácidos grasos obtenidos como destilados en la desodorización de aceites comestibles Actualmente se investiga la viabilidad de un cambio en la tecnología de la desodorización de aceites comestibles que afecta a la composición de los destilados que se obtienen en el proceso y al tratamiento de los mismos. El diseño de los equipos que conlleva este cambio de tecnología requiere el estudio de propiedades físicas de los destilados. Se han estudiado algunas propiedades termodinámicas de los ácidos palmítico, esteárico, oleico y linoleico, componentes mayoritarios resultantes del proceso de desodorización. Las propiedades estudiadas han sido las correspondientes al punto crítico (temperatura, presión y volumen críticos), las curvas de presión de vapor en función de la temperatura y el calor latente de vaporización. Se han recogido distintos métodos de estimación de las mencionadas propiedades y algunos datos experimentales, y se han comparado los resultados obtenidos

Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial

Background: Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity. In this trial we assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma. Methods: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited patients from 87 hospitals and cancer centres across 11 countries. Eligible patients were aged 18 years or older, had a platinum-sensitive, high-grade serous or endometrioid ovarian, primary peritoneal, or fallopian tube carcinoma, had received at least two previous platinum-based chemotherapy regimens, had achieved complete or partial response to their last platinum-based regimen, had a cancer antigen 125 concentration of less than the upper limit of normal, had a performance status of 0–1, and had adequate organ function. Patients were ineligible if they had symptomatic or untreated central nervous system metastases, had received anticancer therapy 14 days or fewer before starting the study, or had received previous treatment with a poly(ADP-ribose) polymerase inhibitor. We randomly allocated patients 2:1 to receive oral rucaparib 600 mg twice daily or placebo in 28 day cycles using a computer-generated sequence (block size of six, stratified by homologous recombination repair gene mutation status, progression-free interval after the penultimate platinum-based regimen, and best response to the most recent platinum-based regimen). Patients, investigators, site staff, assessors, and the funder were masked to assignments. The primary outcome was investigator-assessed progression-free survival evaluated with use of an ordered step-down procedure for three nested cohorts: patients with BRCA mutations (carcinoma associated with deleterious germline or somatic BRCA mutations), patients with homologous recombination deficiencies (BRCA mutant or BRCA wild-type and high loss of heterozygosity), and the intention-to-treat population, assessed at screening and every 12 weeks thereafter. This trial is registered with ClinicalTrials.gov, number NCT01968213; enrolment is complete. Findings: Between April 7, 2014, and July 19, 2016, we randomly allocated 564 patients: 375 (66%) to rucaparib and 189 (34%) to placebo. Median progression-free survival in patients with a BRCA-mutant carcinoma was 16·6 months (95% CI 13·4–22·9; 130 [35%] patients) in the rucaparib group versus 5·4 months (3·4–6·7; 66 [35%] patients) in the placebo group (hazard ratio 0·23 [95% CI 0·16–0·34]; p<0·0001). In patients with a homologous recombination deficient carcinoma (236 [63%] vs 118 [62%]), it was 13·6 months (10·9–16·2) versus 5·4 months (5·1–5·6; 0·32 [0·24–0·42]; p<0·0001). In the intention-to-treat population, it was 10·8 months (8·3–11·4) versus 5·4 months (5·3–5·5; 0·36 [0·30–0·45]; p<0·0001). Treatment-emergent adverse events of grade 3 or higher in the safety population (372 [99%] patients in the rucaparib group vs 189 [100%] in the placebo group) were reported in 209 (56%) patients in the rucaparib group versus 28 (15%) in the placebo group, the most common of which were anaemia or decreased haemoglobin concentration (70 [19%] vs one [1%]) and increased alanine or aspartate aminotransferase concentration (39 [10%] vs none). Interpretation: Across all primary analysis groups, rucaparib significantly improved progression-free survival in patients with platinum-sensitive ovarian cancer who had achieved a response to platinum-based chemotherapy. ARIEL3 provides further evidence that use of a poly(ADP-ribose) polymerase inhibitor in the maintenance treatment setting versus placebo could be considered a new standard of care for women with platinum-sensitive ovarian cancer following a complete or partial response to second-line or later platinum-based chemotherapy. Funding: Clovis Oncology

The Chub Mackerel (Scomber Colias) in the Atlantic Spanish Waters (ICES Divisions 8.c and 9.a): Biological, fishery and survey data

Atlantic chub mackerel (Scomber colias , Gmelin, 1978) is a middle-sized pelagic fish distributed in warm and temperate Northeast Atlantic waters. The bulk of the catches takes place in north western waters of Africa, but landing are significantly increased in the most recent years in the Iberian Peninsula, resulting a new target species for both Portuguese and Spanish purse seiner fleets which partially replaces the important drop of sardine landings in both countries. Given this increasing importance and the lack, for the time being, of any scientific assessment, nor management plan and in order to update the available biological and catch information on this specie in Spanish Atlantic waters, this paper working document compile, review and analyze the existing data of biology, fisheries, and surveys to further enhance knowledge on chub mackerel in Atlantic Iberian waters (ICES Subdivisions 9.a South & North and Division 8.c), specifically: (i) stock structure, (ii) spatial distribution (iii) growth and reproduction and (iv) fisheries exploitation. This analysis suggests an increasing trend in Atlantic waters (9a) in both spatial distribution and abundance, mainly due to the strength of the 2015 and 2016 cohorts. This area, besides, could be considered as a nursery area while the Cantabrian Sea (8c) is rather main spawning area. The increase of such availability is also discussed within the frame of the North East Atlantic warming