Spectroscopic search for binaries among EHB stars in globular clusters

We performed a spectroscopic search for binaries among hot Horizontal Branch stars in globular clusters. We present final results for a sample of 51 stars in NGC6752, and preliminary results for the first 15 stars analyzed in M80. The observed stars are distributed along all the HBs in the range 8000 < Teff < 32000 K, and have been observed during four nights. Radial velocity variations have been measured with the cross-correlation technique. We carefully analyzed the statistical and systematic errors associated with the measurements in order to evaluate the statistical significance of the observed variations. No close binary system has been detected, neither among cooler stars nor among the sample of hot EHB stars (18 stars with Teff > 22000 K in NGC6752). The data corrected for instrumental effects indicate that the radial velocity variations are always below the 3sigma level of ~15 km/s. These results are in sharp contrast with those found for field hot subdwarfs, and open new questions about the formation of EHB stars in globular clusters, and possibly of the field subdwarfs.Comment: To appear in Baltic Astronomy. Proceedings of the 2nd meeting on Hot Subdwarf Stars, La Palma, June 2005. 4 pages, 2 figure

Farm waters run deep: a coupled positive multi-attribute utility programming and computable general equilibrium model to assess the economy-wide impacts of water buyback

Abstract Little is known about the economy-wide repercussions of water buyback, which may include relevant feedbacks on the output of economic sectors at a regional and supra-regional scale. Limited studies available rely on stand-alone Computable General Equilibrium (CGE) models that represent competition for water explicitly, but this approach presents significant data and methodological challenges in areas where mature water markets are not in place –the case of most regions worldwide. To bridge this gap, this paper couples a microeconomic Positive Multi-Attribute Utility Programming (PMAUP) model that elicits the value and price share to water with a macroeconomic, regionally-calibrated CGE model for Spain. Methods are illustrated with a case study in the Murcia Region in southeastern Spain. Economy-wide feedbacks amplify income losses in Murcia's agriculture from −20.5% in the PMAUP model up to −33% in the coupled PMAUP-CGE model. Compensations paid to irrigators enhance demand in the region, but supply contraction in agriculture and related sectors lead to overall GDP losses (up to −2.1%) in most scenarios. The supply gap is partially filled in by other Spanish regions, which experience a GDP gain through a substitution effect (up to +.034%). In all scenarios, aggregate GDP for Spain decreases (up to −.023%)

Decay of flux vacua to nothing

We construct instanton solutions describing the decay of flux compactifications of a $6d$ gauge theory by generalizing the Kaluza-Klein bubble of nothing. The surface of the bubble is described by a smooth magnetically charged solitonic brane whose asymptotic flux is precisely that responsible for stabilizing the 4d compactification. We describe several instances of bubble geometries for the various vacua occurring in a $6d$ Einstein-Maxwell theory namely, AdS_4 x S^2, R^{1,3} x S^2, and dS_4 x S^2. Unlike conventional solutions, the bubbles of nothing introduced here occur where a {\em two}-sphere compactification manifold homogeneously degenerates.Comment: 31 pages, 15 figure

The AMBRE Project: searching for the closest solar siblings

Finding solar siblings, that is, stars that formed in the same cluster as the Sun, will yield information about the conditions at the Sun's birthplace. We search for solar sibling candidates in AMBRE, the very large spectra database of solar vicinity stars. Since the ages and chemical abundances of solar siblings are very similar to those of the Sun, we carried out a chemistry- and age-based search for solar sibling candidates. We used high-resolution spectra to derive precise stellar parameters and chemical abundances of the stars. We used these spectroscopic parameters together with Gaia DR2 astrometric data to derive stellar isochronal ages. Gaia data were also used to study the kinematics of the sibling candidates. From the about 17000 stars that are characterized within the AMBRE project, we first selected 55 stars whose metallicities are closest to the solar value (-0.1 < [Fe/H] < 0.1 dex). For these stars we derived precise chemical abundances of several iron-peak, alpha- and neutron-capture elements, based on which we selected 12 solar sibling candidates with average abundances and metallicities between -0.03 to 0.03 dex. Our further selection left us with 4 candidates with stellar ages that are compatible with the solar age within observational uncertainties. For the 2 of the hottest candidates, we derived the carbon isotopic ratios, which are compatible with the solar value. HD186302 is the most precisely characterized and probably the most probable candidate of our 4 best candidates. Very precise chemical characterization and age estimation is necessary to identify solar siblings. We propose that in addition to typical chemical tagging, the study of isotopic ratios can give further important information about the relation of sibling candidates with the Sun. Ideally, asteroseismic age determinations of the candidates could solve the problem of imprecise isochronal ages.Comment: Accepted for publication in A&

Ambulatory surgery for perianal Crohn’s disease. Study of feasibility

Background. One-third of Crohn’s disease (CD) patients present perianal fistula. The gold standard in the diagnosis and treatment of symptomatic perianal disease (PAD) in CD is the exploration of the anal canal and distal rectum under anesthesia (EUA). This procedure is mainly conducted as a day case surgery. Unfortunately, it is not always possible to proceed within the ideal timing and any delay may well represent a relevant clinical issue. The aim of this study was to evaluate the feasibility of outpatient treatment of symptomatic perianal fistulas in CD patients. Methods. All CD patients under regular follow-up at our inflammatory bowel disease referral center, presenting with symptomatic perianal fistulas, were offered surgical consultation. The data of patients were prospectively collected for three years (February 2014 to February 2017) for the purpose of the study. All clinical information, including previous EUA and/or records from MRI and endoscopic ultrasound, was included. Outpatient anal canal and distal rectum exploration and treatment (OE) were undertaken during the specialist surgical consultation. Fistulas were classified according to Parks’s classification; the type of outpatient treatment and compliance of patients were recorded. Pain was assessed by VAS at the time of the procedure and during the first control. Patients were followed up in the surgical clinic in relation to the study. Results. Ninety-two CD patients with symptomatic perianal fistulas had surgical consultation during the study period. OE was offered to all but 18 patients who fulfilled the exclusion criteria or had an extremely severe disease; six patients refused the OE (8.11%). Of the 68 patients undergoing OE, eleven (16.18%) had previous surgery for perianal disease. The OE was accomplished in sixty-one patients (89.71%), while in 7 patients, it was abandoned for scarce compliance. Nine patients (14.75%) underwent drainage of perianal abscess; in 3 of them, it was possible to probe the fistula tract, find the internal orifice, and pass a loose seton. Overall, setonage was performed in 50 patients (81.97%). Rectovaginal setons were placed in 3 patients and more than one seton (up to 3) in 6 cases. Fistulotomy was performed in 4 simple subcutaneous fistulous tracts. Concordance with the preoperative findings was found in 54 out of 61 patients. EUA was scheduled at the time of OE for the 7 patients who did not complete the procedure. All sixty-one patients who had the OE were followed up for a minimum of 12 months. Conclusions. This preliminary study indicates that OE in CD patients with symptomatic perianal fistulas is safe and feasible in a high-volume referral center. It might provide several benefits, including patients’ logistics, reduce or remove patients’ symptoms and discomfort, allow for a timely start of medical therapy, and avoid further complications

Cheating, incentives, and money manipulation

We use different incentive schemes to study truth-telling in a die-roll task when people are asked to reveal the number rolled privately. We find no significant evidence of cheating when there are no financial incentives associated with the reports, but do find evidence of such when the reports determine financial gains or losses (in different treatments). We find no evidence of loss aversion in the standard case in which subjects receive their earnings in a sealed envelope at the end of the session. When subjects manipulate the possible earnings, we find evidence of less cheating, particularly in the loss setting; in fact, there is no significant difference in behavior between the non-incentivized case and the loss setting with money manipulation. We interpret our findings in terms of the moral cost of cheating and differences in the perceived trust and beliefs in the gain and the loss frames

Tratamiento quirúrgico de ptosis palpebral miogénica adquirida

Objective: To report the surgical outcome of aponeurosis surgery in patients with acquired myogenic eyelid ptosis and describe surgical guidelines for their correction. Methods: The clinical records of two patients with acquired myogenic eyelid ptosis after surgical correction were reviewed. Results: In two patients with acquired myogenic eyelid ptosis and barely good levator function, levator resection surgery was performed. Corneal complications appeared in both cases. Conclusion: Patients with acquired myogenic eyelid ptosis are at risk of post-operative surgical complications from corneal exposure. Surgical correction should be conservative and performed only when the visual axis is compromise

Cotton rat immune responses to virus-like particles containing the pre-fusion form of respiratory syncytial virus fusion protein

BACKGROUND: Virus-like particles (VLPs) based on Newcastle disease virus (NDV) core proteins, M and NP, and containing two chimera proteins, F/F and H/G, composed of the respiratory syncytial virus (RSV) fusion protein (F) and glycoprotein (G) ectodomains fused to the transmembrane and cytoplasmic domains of the NDV F and HN proteins, respectively, stimulate durable, protective anti-RSV neutralizing antibodies in mice. Furthermore, immunization of mice with a VLP containing a F/F chimera protein with modifications previously reported to stabilize the pre-fusion form of the RSV F protein resulted in significantly improved neutralizing antibody titers over VLPs containing the wild type F protein. The goal of this study was to determine if VLPs containing the pre-fusion form of the RSV F protein stimulated protective immune responses in cotton rats, a more RSV permissive animal model than mice. METHODS: Cotton rats were immunized intramuscularly with VLPs containing stabilized pre-fusion F/F chimera protein as well as the H/G chimera protein. The anti-RSV F and RSV G antibody responses were determined by ELISA. Neutralizing antibody titers in sera of immunized animals were determined in plaque reduction assays. Protection of the animals from RSV challenge was assessed. The safety of the VLP vaccine was determined by monitoring lung pathology upon RSV challenge of immunized animals. RESULTS: The Pre-F/F VLP induced neutralizing titers that were well above minimum levels previously proposed to be required for a successful vaccine and titers significantly higher than those stimulated by RSV infection. In addition, Pre-F/F VLP immunization stimulated higher IgG titers to the soluble pre-fusion F protein than RSV infection. Cotton rats immunized with Pre-F/F VLPs were protected from RSV challenge, and, importantly, the VLP immunization did not result in enhanced respiratory disease upon RSV challenge. CONCLUSIONS: VLPs containing the pre-fusion RSV F protein have characteristics required for a safe, effective RSV vaccine