Activitatea antimicrobiană a unui bioprodus biologic activ obţinut din seminţele de struguri

At the Research Station for Viticulture and Enology Iasi, a polymeric condensed proanthocyanidins was obtained from Fetească neagră grape seeds, through a phase preparation, which under determined conditions with hydrogen peroxide, led to the production of a water-soluble bio product with antibacterial, antifungal and antioxidant properties. Evaluation of the antimicrobial activity of the bio product was performed by determining minimum inhibitory concentration (MIC) and minimal bactericidal concentration (CMB) against Staphylococcus aureus and Escherichia coli. From the analysis of the obtained data it was found that the bio product reacted differently from the tested species, being more active against Staphylococcus aureus (G +). The determined MIC was 1.5 mg/mL and the CMB 2.0 mg / mL. In the case of the Escherichia coli (G-) test, the MIC and CMB values were equal but increased to 3.0 mg/mL

Splenectomy through the laparoscopic approach and how I do it

Scopul lucrării. Studierea cazurilor de splenectomie prin abord laparoscopic și clasic în vederea stabilirii cauzalității tip procedurăincidente perioperatorii și demonstrării superiorității abordului laparoscopic. Materiale și metode. Au fost selectate cazurile de splenectomie efectuate prin abord clasic și laparoscopic în Clinica de Chirurgie Colțea, perioada 01.01.2019-31.12.2022. Am revăzut filmările intraoperatorii, am evaluat factorii generali și locali asociați abordului chirurgical preferat. Rezultate. Au fost selectate 29 de cazuri, vârsta medie 54.8 ani, 72.4% femei, 27.6% barbati, 55.2% (16) cu multiple comorbidități: antecedente chirurgicale majore, insuficiența cardiacă, asmul bronșic sever etc. Cazurile au fost împărțite în 2 grupe: Gr. I- cu abord laparoscopic 34.5% (10), Gr. II- cu abord clasic 65.5% (19). Incidența comorbidităților a fost de 10% (1) în Gr.I, cu dimensiunea medie a splinei de 13.2 cm (min 8.5 cm, max 21 cm) și 84.2 % (16) în Gr.II cu dimensiunea medie a splinei de 20.4 cm (min 10 cm, max 34 cm). Doar în Gr.II au fost înregistrate sângerări intraoperatorii în 78.9% (15), iar in 15.8% (3) au fost complicații postoperatorii. Pacienții din Gr.I au avut o perioadă de spitalizare postoperatorie medie de 4 zile, iar cei din Gr. II de 7 zile și au fost externați cu o evoluție postoperatorie favorabilă. Concluzie. Abordul laparoscopic are aceleași indicații ca abordul clasic conform EAES, cu avantajul complicațiilor perioperatorii mult reduse și o spitalizare postoperatorie mai mică comparativ cu abordul clasic, iar în cazul echipelor experimentate este posibil abordul laparoscopic inclusiv la pacienții cu splenomegalii masive (>20cm), care poate fi asistat manual.Aim of study. Study of cases of splenectomy by laparoscopic and classic approach in order to establish causality type procedureperioperative incidents and demonstrate the superiority of the laparoscopic approach. Materials and methods. The cases of splenectomy performed by classical and laparoscopic approach in the Colțea Surgery Clinic, period 01.01.2019-31.12.2022, were selected. We reviewed intraoperative films, assessed general and local factors associated with the preferred surgical approach. Results. 29 cases were selected, average age 54.8 years, 72.4% women, 27.6% men, 55.2% (16) with multiple comorbidities: major surgical antecedents, heart failure, severe bronchial asthma, etc. The cases were divided into 2 groups: Gr. I- with laparoscopic approach 34.5% (10), Gr. II- with classic approach 65.5% (19). The incidence of comorbidities was 10% (1) in Gr.I, with mean spleen size of 13.2 cm (min 8.5 cm, max 21 cm) and 84.2% (16) in Gr.II with mean spleen size of 20.4 cm (min 10 cm, max 34 cm). Only in Gr.II, intraoperative bleeding was recorded in 78.9% (15), and in 15.8% (3) there were postoperative complications. The patients in Gr. I had an average postoperative hospitalization period of 4 days, and those in Gr. II of 7 days, and were discharged with a favorable postoperative evolution. Conclusions. The laparoscopic approach has the same indications as the classic one according to EAES, with the advantage of reduced perioperative complications and a shorter postoperative hospitalization, and in the case of experienced teams, the laparoscopic approach is possible, including patients with massive splenomegaly (>20cm), being manually assisted

Separarea şi caracterizarea principalelor fracţiuni de proantocianidine din seminţele de struguri

Grape seeds, as waste products of the winemaking industry, contain large amounts of monomers, oligomers and more highly polymerised proanthocyanidins (PA), being a good source of phytochemicals for the production of antioxidative dietary supplements. PA from defatted grape seeds were extracted by precipitation with diethyl ether from the crude alcoholic extract and fractionated into monomers (FI), oligomers (FII) and polymers (FIII) of flavan-3-ols by their separation on C18 Sep-Pak cartridges. FIII was the predominant class of proanthocyanidins (82.22%), while monomeric PA has only 5.71% of total. The ratio PA (by vanillin assay) / tannins (Bate-Smith assay) indicates the highest degree of polymerisation (DP) in FIII fraction (1.28). Thin layer chromatography (TLC) confirmed the presence of monomers in FI, the DP increasing significantly for the next two fractions. Oligomeric and polymeric PA showed the highest antioxidant activity (% scavenged DPPH), but the synergic antioxidant effect of PA classes was also observed

Rheological properties of some complex polymers containing alicyclic structures

Paper presented at the 9th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Malta, 16-18 July, 2012.Two polyimides obtained from an alicyclic and flexible dianhydride, namely 5-(2,5-dioxotetrahydrofurfuryl)-3-methyl- 3-cyclohexene-1,2-dicarboxylic acid anhydride (DOCDA) and an aromatic diamines 4,4’-oxydianiline (ODA) or 4-(4-((4-(4- aminophenoxy) phenyl)sulfonyl)phenoxy (p-BAPS) were synthesized and analysed by rheological methods. The results were correlated with the chemical structure of polyimides and with other properties, such as flexibility, transparency, hydrophobicity and atomic force microscopy. It has been showed that the factors that contribute to the interactions in the polyimide systems can be controlled for improving the thermal, optical, and rheological properties, for subsequent microelectronic applications, in which relatively low permittivity and high thermal stability are required.dc201

Decision-making tool for enhancing the sustainable management of cultural institutions: season content programming at Palau de la música catalana

There has been an increasing relevance of the cultural sector in the economic and social development of different countries. However, this sector continues without much input from multi-criteria decision-making (MDCM) techniques and sustainability analysis, which are widely used in other sectors. This paper proposes an MCDM model to assess the sustainability of a musical institution’s program. To define the parameters of the proposed model, qualitative interviews with relevant representatives of Catalan cultural institutions and highly recognized professionals in the sector were performed. The content of the 2015–2016 season of the ‘Palau de la Música Catalana’, a relevant Catalan musical institution located in Barcelona, was used as a case study to empirically test the method. The method allows the calculation of a season value index (SVI), which serves to make more sustainable decisions on musical season programs according to the established criteria. The sensitivity analysis carried out for different scenarios shows the robustness of the method. The research suggests that more complex decision settings, such as MCDM methods that are widely used in other sectors, can be easily applied to the sustainable management of any type of cultural institution. To the best of the authors’ knowledge, this method was never applied to a cultural institution and with real data

Global sensitivity analysis and optimal control of Typhoid fever transmission dynamics

This paper presents a mathematical model aimed at studying the global behaviour and optimal control strategies for Typhoid fever. The primary objective of this study is to identify the most effective control strategy that minimizes the spread of the disease. To achieve this, we calculate the effective and basic reproduction numbers and utilize them to investigate the existence and stability of the equilibria. Furthermore, we investigate the global impact of each model parameter on the variables using Latin Hypercube Sampling and Partial Rank Correlation Coefficient. The necessary conditions of the optimal control problem are analyzed using Pontryagin’s maximum principle, and the numerical values of the model parameters are estimated using the maximum likelihood estimator. The results indicate that the optimal use of vaccination for susceptible individuals, as well as the screening and treatment of asymptomatic infected individuals, have a significant impact on reducing the spread of the disease in endemic regions

NANOTUBES BIOLOGICALLY ACTIVE IN MEDIA WITH HIGH SALT CONCENTRATION

ABSTRAC

Сравнительная оценка структуры заболеваемости студентов I курса Государственного Медицинского и Фармацевтического Университета им. Н. A. Тестемицану

Department of Family Medicine and Laboratory of Genetics, Nicolae Testemiţanu State Medical and Pharmaceutical University, Chisinau, Republic of Moldova, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica MoldovaThe purpose of this work was to comparatively evaluate the morbidity spectrum of the first year students of the SMPhU ”Nicolae Testemiţanu” enrolled in 2002-2004 and 2010-2011. Materials and methods: the data of medical examination performed at the University Clinic of Primary Care were analyzed in order to estimate the morbidity spectra. Results: the comparative analysis of the health status of students revealed an increase of students being “sick” from 24.0% in 2002-2004 to 35.0% in 2010-2011. The comparative analysis of morbidity spectra denotes a significant increase in proportions of eye pathology, pathologies of urinary and digestive tracts and endocrine system in the morbidity structure during 2002-2011 period. Conclusions: our data support the need of medical examination of first-year students in order to identify the existing chronic pathologies, proper treatment, and monitoring their diseases during the academic years.Целью настоящей работы была сравнительная оценка структуры заболеваемости студентов первого курса Государственного Медицинского и Фармацевтического Университета имени „Николая Тестемицану”, поступивших на учебу в 2002-2004 и 2010-2011 годы. Материал и методы: результаты медицинского осмотра студентов первого курса 2002-2004 и 2010-2011 годов поступления, для определения спектра заболеваемости. Результаты: сравнительный анализ состояния здоровья студентов показал увеличение группы студентов «больных» от 24,0% в 2002-2004 гг. до 35,0% в 2010-2011 гг. В структуре заболеваемости за период 2002-2011 годы произошло значительное увеличение доли глазной патологии, патологии мочеполового, пищеварительного трактов и эндокринной системы. Выводы: Для выявления существующих хронических заболеваний, своевременного их лечения и мониторинга динамики состояния здоровья студентов во время учебы, необходимо проведение медицинского осмотра студентов на первом курсе

The Human Homologue of Macaque Area V6A

In macaque monkeys, V6A is a visuomotor area located in the anterior bank of the POs, dorsal and anterior to retinotopically-organized extrastriate area V6 (Galletti et al 1996). Unlike V6, V6A represents both contra- and ipsilateral visual fields and is broadly retinotopically organized (Galletti et al 1999b). The contralateral lower visual field is over-represented in V6A. The central 20°-30° of the visual field are mainly represented dorsally (V6Ad) and the periphery ventrally (V6Av), at the border with V6. Both sectors of area V6A contain arm movement-related cells, active during spatially-directed reaching movements (Gamberini et al., 2011). In humans, we previously mapped the retinotopic organization of area V6 (Pitzalis et al., 2006). Here, using phase-encoded fMRI, cortical surface-based analysis and wide-field retinotopic mapping, we define a new cortical region that borders V6 anteriorly and shows a clear over-representation of the contralateral lower visual field and of the periphery. As with macaque V6A, the eccentricity increases moving ventrally within the area. The new region contains a non-mirror-image representation of the visual field. Functional mapping reveals that, as in macaque V6A, the new region, but not the nearby area V6, responds during finger pointing and reaching movements. Based on similarity in position, retinotopic properties, functional organization and relationship with the neighbouring extrastriate visual areas, we propose that the new cortical region is the human homologue of macaque area V6A