11,571 research outputs found
Is the bulbus arteriosus of fish homologous to the mamalian intrapericardial thoracic arteries?
El resumen aparece en el Program & Abstracts of the 10th International Congress of Vertebrate Morphology, Barcelona 2013.Anatomical Record, Volume 296, Special Feature — 1: P-089.Two major findings have significantly improved our understanding of the
embryology and evolution of the arterial pole of the vertebrate heart (APVH): 1) a
new embryonic presumptive cardiac tissue, named second heart field (SHF), forms
the myocardium of the outflow tract, and the walls of the ascending aorta (AA) and
the pulmonary trunk (PT) in mammals and birds; 2) the bulbus arteriosus (BA),
previously thought to be an actinopterygian apomorphy, is present in all basal
Vertebrates, and probably derives from the SHF. We hypothesized that the
intrapericardial portions of the AA and the PT of mammals are homologous to the
BA of basal vertebrates. To test this, we performed 1) a literature review of the
anatomy and embryology of the APVH; 2) novel anatomical, histomorphological,
and embryological analyses of the APVH, comparing basal (Galeus atlanticus), with
apical (Mus musculus and Mesocricetus auratus) vertrebrates. Evidence obtained:
1) Anatomically, BA, AA, and PT are muscular tubes into the pericardial cavity,
which connect the distal myocardial outflow tracts with the aortic arch system.
Coronary arteries run through or originate at these anatomical structures; 2)
Histologically, BA, AA, and PT show an inner layer of endothelium covered by
circumferentially oriented smooth muscle cells, collagen fibers, and lamellar
elastin. The histomorphological differences between the BA and the ventral aorta
parallel those between intrapericardial and extrapericardial great arteries; 3)
Embryologically, BA, AA, and PT are composed of smooth muscle cells derived
from the SHF. They show a similar mechanism of development: incorporation of
SHF‐derived cells into the pericardial cavity, and distal‐to‐proximal differentiation
into an elastogenic cell linage.
In conclusion, anatomical, histological and embryological evidence supports the
hypothesis that SHF is a developmental unit responsible for the formation of the
APVH. The BA and the intrapericardial portions of the great arteries must be
considered homologous structures.Proyecto P10-CTS-6068 (Junta de Andalucía); proyecto CGL-16417 (Ministerio de Ciencia e Innovación); Fondos FEDER
Incidence and type of bicuspid aortic valve in two model species
Incidence and type of bicuspid aortic
valve in two model species.
MC Fernández 1,2, A López-García 1,2, MT Soto 1,
AC Durán 1,2 and B Fernández 1,2.
1 Department of Animal Biology, Faculty of Science, University of Málaga, Spain.
2 Biomedical Research Institute of Málaga (IBIMA),
University of Málaga, Spain.
Bicuspid aortic valve (BAV) is the most frequent human congenital cardiac malformation, with an incidence of 1–2% worldwide. Two morphological types exist: type A (incidence 0.75–1.25%) and type B (incidence 0.25–0.5%), each with a distinct aetiology and natural history. Currently, ten animal models of BAV have been described in two different rodent species: one spontaneous Syrian hamster (Mesocricetus auratus) model of BAV type A and nine mutant laboratory mouse (Mus musculus) models of BAV type B. It remains to be elucidated whether the mutations leading to BAV in these models are typespecific or whether there are inter-specific differences regarding the type of BAV that hamsters, mice and humans may develop.
To solve this issue, we have characterized the incidence and types of BAVs in four inbred, two outbred and two hybrid lines of Syrian hamsters (n=4,340) and in three inbred, three outbred and one hybrid lines of laboratory mice (n=1,661) by means of stereomicroscopy and scanning electron microscopy. In addition, we have reviewed and calculated the incidence and type of BAVs in the published papers dealing with this anomaly in mice.
Our results indicate that the Syrian hamster develops BAVs type A and B including a variety of morphologies comparable to those of humans, whereas the mouse develops only BAVs type B with a short spectrum of valve morphologies. Thus, inter-specific differences between human and mouse aortic valves must be taken into consideration when studying valve disease in murine models.
This work was supported by P10-CTS-6068.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. P10-CTS-6068
Different laboratory mouse strains show distinct coronary artery patterns
Different laboratory mouse strains show distinct coronary artery patterns.
MC Fernández 1,2, A López-García 1,2, M Lorenzale 1, V Sans-Coma 1,2, AC Durán 1,2 and B Fernández 1,2.
1 Department of Animal Biology, Faculty of Science, University of Málaga, Spain.
2 Biomedical Research Institute of Málaga (IBIMA),
University of Málaga, Spain. The C57BL/6 (BL/6) mouse strain is one of the most
common models in research involving laboratory animals, particularly on studies of the cardiovascular system. It has been reported (Fernandez B, et al. J Anat 2008 212(1):12–18) that this strain presents an unusual coronary artery (CA) pattern, including congenital CA anomalies, which are clinically relevant in humans. The aim of the present study was to elucidate whether this pattern is strain-specific or appears in other mouse populations.
We used stereomicroscopy, scanning electron
microscopy, light microscopy, and a corrosion cast
technique in 597 adult mice belonging to three
inbred strains (BL/6, Balb/c, DBA/2), three outbred stocks (CD1, OF1, NMR1), two hybrid lines (129sv x BL/6, CD2F1) and wild mice.
Lock-like ostium was only detected in BL/6 mice,
whereas left septal artery, accessory ostium, high
take-off, intramural course, and solitary ostium of one CA in aorta were present in different laboratory strains and in wild mice. However, each mouse population showed a specific incidence of these coronary conditions.
These results should be taken into account when
studying the murine coronary system, especially in
CA occlusion experiments and in studies on cardiovascular development involving murine mutant lines. In addition, we propose that several laboratory mouse strains may serve as appropriate animal models to study several clinically relevant human congenital anomalies of the CAs. Our results suggest that some of these CA anomalies are subject to a simple mode of inheritance.
This work was supported by P10-CTS-6068 and PI-
0888-2012.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. P10-CTS-6068. PI-0888-201
Calentamiento y especificidad
El presente artículo trata el calentamiento desde una triple perspectiva, pues indaga en los beneficios o perjuicios que pueden suponer la presencia o ausencia de calentamiento y sobre la especificidad de este en cuanto a la movilidad articular empleada en su última fase. Se comparan dos grupos (n= 9 y n¿= 8) que se ejercitan en tareas de fuerza explosiva, sin calentamiento y con éste, a continuación los sujetos participantes se emplean en ejercicios de activación general, carrera continua y ejercicios de movilidad articular, diferenciándose en este último apartado entre movimientos activos libres y pasivos asistidos. Seguidamente ambos grupos se emplean en las mismas tareas de fuerza explosiva que vivenciaron antes del calentamiento. Los resultados muestran un ligera tendencia hacia el empleo del calentamiento con movimientos activos libres, cuando el ejercicio se halla muy localizado en las cadenas cinéticas superiores e inferiores, pero al requerir la participación de toda la musculatura, como es el caso de una carrera de 30 metros a máxima velocidad, no se han encontrado diferencias significativas ni antes ni tras el calentamiento ni según la especificidad de éste
Van der Waals spin valves
We propose spin valves where a 2D non-magnetic conductor is intercalated
between two ferromagnetic insulating layers. In this setup, the relative
orientation of the magnetizations of the insulating layers can have a strong
impact on the in-plane conductivity of the 2D conductor. We first show this for
a graphene bilayer, described with a tight-binding model, placed between two
ferromagnetic insulators. In the anti-parallel configuration, a band gap opens
at the Dirac point, whereas in the parallel configuration, the graphene bilayer
remains conducting. We then compute the electronic structure of graphene
bilayer placed between two monolayers of the ferromagnetic insulator CrI,
using density functional theory. Consistent with the model, we find that a gap
opens at the Dirac point only in the antiparallel configuration.Comment: 5 pages, 4 figure
Reaction Dynamics for the Systems 7Be,8B + 208Pb at Coulomb Barrier Energies
In this contribution we describe the first results obtained for the investigation of
the elastic scattering process in the reactions induced by the Radioactive Ion Beams 7Be and
8B on a 208Pb target at Coulomb barrier energies. The experimental data were analyzed within
the framework of the optical model in order to extract the total reaction cross section. The
comparison with data available in literature for reactions induced on 208Pb by light ions in the
mass range A = 6-8 shows that the loosely-bound 8B has the largest reactivity
Extended WKB method, resonances and supersymmetric radial barriers
Semiclassical approximations are implemented in the calculation of position
and width of low energy resonances for radial barriers. The numerical
integrations are delimited by t/T<<8, with t the period of a classical particle
in the barrier trap and T the resonance lifetime. These energies are used in
the construction of `haired' short range potentials as the supersymmetric
partners of a given radial barrier. The new potentials could be useful in the
study of the transient phenomena which give rise to the Moshinsky's diffraction
in time.Comment: 12 pages, 4 figures, 3 table
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