Information system for tablet identification (ISTI)

Poster presented at the 4th International Congress of CiiEM - "Health, Well-being and Ageing in the XXI Century. 2-5 June 2019, Campus Egas Moniz, Monte de Caparica, PortugalN/

Information System for Tablets Identification (ISTI)

Abstract in proceedings of the Fourth International Congress of CiiEM: Health, Well-Being and Ageing in the 21st Century, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from 3–5 June 2019.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/publishedVersio

Prediction of peptide and protein propensity for amyloid formation

Understanding which peptides and proteins have the potential to undergo amyloid formation and what driving forces are responsible for amyloid-like fiber formation and stabilization remains limited. This is mainly because proteins that can undergo structural changes, which lead to amyloid formation, are quite diverse and share no obvious sequence or structural homology, despite the structural similarity found in the fibrils. To address these issues, a novel approach based on recursive feature selection and feed-forward neural networks was undertaken to identify key features highly correlated with the self-assembly problem. This approach allowed the identification of seven physicochemical and biochemical properties of the amino acids highly associated with the self-assembly of peptides and proteins into amyloid-like fibrils (normalized frequency of β-sheet, normalized frequency of β-sheet from LG, weights for β-sheet at the window position of 1, isoelectric point, atom-based hydrophobic moment, helix termination parameter at position j+1 and ΔGº values for peptides extrapolated in 0 M urea). Moreover, these features enabled the development of a new predictor (available at http://cran.r-project.org/web/packages/appnn/index.html) capable of accurately and reliably predicting the amyloidogenic propensity from the polypeptide sequence alone with a prediction accuracy of 84.9 % against an external validation dataset of sequences with experimental in vitro, evidence of amyloid formation

Inter-Group Perceptions and Representations in Two Barcelona Neighbourhoods: Poble Sec and Sagrada Família Compared

The main focus of this chapter is on two Barcelona neighbourhoods: Sagrada Família (situated in the Eixample District) and Poble Sec (in the Sants-Montjuïc District). Among the outcomes, it can be highlighted that in both neighbourhoods, schools, public libraries and civic centres emerge as spaces where encounters and interrelations occur. Furthermore, the existence of a well-knit network of social organizations at neighbourhood level is a very useful tool for social cohesion, especially in Poble Sec. In the Sagrada Família neighbourhood, both cooperation and conflict between groups are rather scarce, and they are not as important to the neighbourhood's life and to the residents' perceptions as in Poble Sec. In explaining these differences, while the difference in the percentage of foreigners is an important factor, the urban fabric is equally crucial. Place and space do not only play a secondary role as the setting of the interaction; rather the configuration of areas where encounters occur has a significant influence on conflict and cooperation in neighbourhoods. Thus, a clear practical direction emerging from our research in Barcelona is that immigrant integration policies should be designed with space and place in mind not only as settings but also as objects of those same policies

Taking stock of Roma health policies in Spain: Lessons for health governance

Roma health inequities are a wicked problem. Despite concerted efforts to reduce them under the Decade of Roma Inclusion initiative, the health gap between Roma and non-Roma populations in Europe persists. To address this problem, the European Commission devised the National Roma Integration Strategies (NRIS). This paper provides a critical assessment of the implementation of the NRIS’ health strand (NRIS-H) in Spain and proposes an evaluation tool to monitor Roma health policies – the Roma Health Integration Policy Index (RHIPEX). It also makes recommendations to promote Roma health governance. To achieve these goals, four community forums, 33 stakeholder interviews and a scoping review were conducted. Results show that the NRIS-H implementation is hindered by lack of political commitment and poor resource allocation. This has a negative impact on Roma’s entitlement to healthcare and on their participation in decision-making processes, jeopardising the elimination of the barriers that undermine their access to healthcare and potentially contributing to reproduce inequalities. These unintended effects point out the need to rethink Roma health governance by strengthening intersectional and intersectoral policies, enabling transformative Roma participation in policymaking and guaranteeing shared socio-political responsibility and accountability.info:eu-repo/semantics/acceptedVersio