Multi-criteria assessment of the Representative Elementary Watershed approach on the Donga catchment (Benin) using a downward approach of model complexity

International audienceThis study is part of the AMMA – African Multidisciplinary Monsoon Analysis – project and aims at a better understanding and modelling of the Donga catchment (580 km2, Benin) behaviour. For this purpose, we applied the REW concept proposed by Reggiani et al. (1998, 1999), which allows the description of the main local processes at the sub-watershed scale. Such distributed hydrological models, which represent hydrological processes at various scales, should be evaluated not only on the discharge at the outlet but also on each of the represented processes and in several points of the catchment. This kind of multi-criteria evaluation is of importance in order to assess the global behaviour of the models. We applied such multi-criteria strategy to the Donga catchment (586 km2), in Benin. The work is supported by a strategy of observation, undertaken since 1998 consisting in a network of 20 rain gauges, an automatic meteorological station, 6 discharge stations and 18 wells. The first goal of this study is to assess the model ability to reproduce the discharge at the outlet, the water table dynamics in several points of the catchment and the vadose zone dynamics at the sub-catchment scale. We tested two spatial discretisations of increasing resolution. To test the internal structure of the model, we looked at its ability to represent also the discharge at intermediary stations. After adjustment of soil parameters, the model is shown to accurately represent discharge down to a drainage area of 100 km2, whereas poorer simulation is achieved on smaller catchments. We introduced the spatial variability of rainfall by distributing the daily rainfall over the REW and obtained a very low sensitivity of the model response to this variability. Our results suggest that processes in the unsaturated zone should first be improved, in order to better simulate soil water dynamics and represent perched water tables which were not included in this first modelling study

Μελέτη και ανάπτυξη πλατφόρμας επεξεργαστή ανοικτού λογισμικού για την υλοποίηση μετεωρολογιακού δικτύου

This study aimed to gain insight into the microbial quality, safety and bacterial community composition of black soldier fly larvae (Hermetia illucens) reared at different facilities on a variety of organic waste streams. For seven rearing cycles, both on laboratory-scale and in large-scale facilities at several locations, the microbiota of the larvae was studied. Also samples of the substrate used and the residue (= leftover substrate after rearing, existing of non-consumed substrate, exuviae and faeces) were investigated. Depending on the sample, it was subjected to plate counting, Illumina Miseq sequencing and/or detection of specific food pathogens. The results revealed that the substrates applied at the various locations differed substantially in microbial numbers as well as in the bacterial community composition. Furthermore, little similarity was observed between the microbiota of the substrate and that of the larvae reared on that substrate. Despite substantial differences between the microbiota of larvae reared at several locations, 48 species-level operational taxonomic units (OTUs) were shared by all larvae, among which most belonged to the phyla Firmicutes and Proteobacteria. Although the substrate is assumed to be an important source of bacteria, our results suggest that a variety of supposedly interacting factors-both abiotic and biotic-are likely to affect the microbiota in the larvae. In some larvae and/or residue samples, potential foodborne pathogens such as Salmonella and Bacillus cereus were detected, emphasising that decontamination technologies are required when the larvae are used in feed, just as for other feed ingredients, or eventually in food

'Breaking the silence' : sexual victimisation in an old age psychiatry patient population in Flanders

Background: Sexual violence (SV) is linked to mental health problems in adulthood and old age. However, the extent of sexual victimisation in old age psychiatry patients is unknown. Due to insufficient communication skills in both patients and healthcare workers, assessing SV in old age psychiatry patients is challenging. Methods: Between July 2019 and March 2020, 100 patients at three old age psychiatry wards across Flanders participated in a face-to-face structured interview receiving inpatient treatment. The participation rate was 58%. We applied the WHO definition of SV, encompassing sexual harassment, sexual abuse with physical contact without penetration, and (attempted) rape. Outcomes: In 57% of patients (65% F, 42% M) SV occurred during their lifetime and 7% (6% F, 9% M) experienced SV in the past 12-months. Half of the victims disclosed their SV experience for the first time during the interview. Only two victims had disclosed SV to a mental health care professional before. Interpretation: Sexual victimisation appears to be common in old age psychiatry patients, yet it remains largely undetected. Although victims did reveal SV during a face-to-face interview to a trained interviewer, they do not seem to spontaneously disclose their experiences to mental health care professionals. In order to provide tailored care for older SV victims, professionals urgently need capacity building through training, screening tools and care procedures

hardRain: An R package for quick, automated rainfall detection in ecoacoustic datasets using a threshold-based approach

The increasing demand for cost-efficient biodiversity data at large spatiotemporal scales has led to an increase in the collection of large ecoacoustic datasets. Whilst the ease of collection and storage of audio data has rapidly increased and costs fallen, methods for robust analysis of the data have not developed so quickly. Identification and classification of audio signals to species level is extremely desirable, but reliability can be highly affected by non-target noise, especially rainfall. Despite this demand, there are few easily applicable pre-processing methods available for rainfall detection for conservation practitioners and ecologists. Here, we use threshold values of two simple measures, Power Spectrum Density (amplitude) and Signal-to-Noise Ratio at two frequency bands, to differentiate between the presence and absence of heavy rainfall. We assess the effect of using different threshold values on Accuracy and Specificity. We apply the method to four datasets from both tropical and temperate regions, and find that it has up to 99% accuracy on tropical datasets (e.g. from the Brazilian Amazon), but performs less well in temperate environments. This is likely due to the intensity of rainfall in tropical forests and its falling on dense, broadleaf vegetation amplifying the sound. We show that by choosing between different threshold values, informed trade-offs can be made between Accuracy and Specificity, thus allowing the exclusion of large amounts of audio data containing rainfall in all locations without the loss of data not containing rain. We assess the impact of using different sample sizes of audio data to set threshold values, and find that 200 15 s audio files represents an optimal trade-off between effort, accuracy and specificity in most scenarios. This methodology and accompanying R package ‘hardRain’ is the first automated rainfall detection tool for pre-processing large acoustic datasets without the need for any additional rain gauge data

Non-Invasive Molecular Imaging of Fibrosis Using a Collagen-Targeted Peptidomimetic of the Platelet Collagen Receptor Glycoprotein VI

Background: Fibrosis, which is characterized by the pathological accumulation of collagen, is recognized as an important feature of many chronic diseases, and as such, constitutes an enormous health burden. We need non-invasive specific methods for the early diagnosis and follow-up of fibrosis in various disorders. Collagen targeting molecules are therefore of interest for potential in vivo imaging of fibrosis. In this study, we developed a collagen-specific probe using a new approach that takes advantage of the inherent specificity of Glycoprotein VI (GPVI), the main platelet receptor for collagens I and III. Methodology/Principal: Findings An anti-GPVI antibody that neutralizes collagen-binding was used to screen a bacterial random peptide library. A cyclic motif was identified, and the corresponding peptide (designated collagelin) was synthesized. Solid-phase binding assays and histochemical analysis showed that collagelin specifically bound to collagen (Kd 10−7 M) in vitro, and labelled collagen fibers ex vivo on sections of rat aorta and rat tail. Collagelin is therefore a new specific probe for collagen. The suitability of collagelin as an in vivo probe was tested in a rat model of healed myocardial infarctions (MI). Injecting Tc-99m-labelled collagelin and scintigraphic imaging showed that uptake of the probe occurred in the cardiac area of rats with MI, but not in controls. Post mortem autoradiography and histological analysis of heart sections showed that the labeled areas coincided with fibrosis. Scintigraphic molecular imaging with collagelin provides high resolution, and good contrast between the fibrotic scars and healthy tissues. The capacity of collagelin to image fibrosis in vivo was confirmed in a mouse model of lung fibrosis. Conclusion/Significance: Collagelin is a new collagen-targeting agent which may be useful for non-invasive detection of fibrosis in a broad spectrum of diseases.Psycholog

A critical review of smaller state diplomacy

In The Peloponnesian War, Thucydides (1972: 402) highlights the effects of the general, overall weakness of smaller states vis-à-vis larger, more powerful ones in a key passage, where the Athenians remind the Melians that: “… since you know as well as we do that, as the world goes, right is only in question between equals in power. Meanwhile, the strong do what they can and the weak suffer what they must.” Concerns about the vulnerability of small, weak, isolated states have echoed throughout history: from Thucydides, through the review by Machiavelli (1985) of the risks of inviting great powers to intervene in domestic affairs, through 20th century US-led contemporary political science (Vital, 1971; Handel, 1990) and Commonwealth led scholarship (Commonwealth Secretariat, 1985). In the context of 20th century ‘Balkanization’, the small state could also prove unstable, even hostile and uncooperative, a situation tempting enough to invite the intrusion of more powerful neighbours: a combination, according to Brzezinski (1997: 123-124) of a power vacuum and a corollary power suction2: in the outcome, if the small state is ‘absorbed’, it would be its fault, and its destiny, in the grand scheme of things. In an excellent review of small states in the context of the global politics of development, Payne (2004: 623, 634) concludes that “vulnerabilities rather than opportunities are the most striking consequence of smallness”. It has been recently claimed that, since they cannot defend or represent themselves adequately, small states “lack real independence, which makes them suboptimal participants in the international system” (Hagalin, 2005: 1). There is however, a less notable and acknowledged but more extraordinary strand of argumentation that considers ‘the power of powerlessness’, and the ability of small states to exploit their smaller size in a variety of ways in order to achieve their intended, even if unlikely, policy outcomes. The pursuance of smaller state goals becomes paradoxically acceptable and achievable precisely because such smaller states do not have the power to leverage disputants or pursue their own agenda. A case in point concerns the smallest state of all, the Vatican, whose powers are both unique and ambiguous, but certainly not insignificant (The Economist, 2007). Smaller states have “punched above their weight” (e.g. Edis, 1991); and, intermittently, political scientists confront their “amazing intractability” (e.g. Suhrke, 1973: 508). Henry Kissinger (1982: 172) referred to this stance, with obvious contempt, as “the tyranny of the weak”3. This paper seeks a safe passage through these two, equally reductionist, propositions. It deliberately focuses first on a comparative case analysis of two, distinct ‘small state-big state’ contests drawn from the 1970s, seeking to infer and tease out the conditions that enable smaller ‘Lilliputian’ states (whether often or rarely) to beat their respective Goliaths. The discussion is then taken forward to examine whether similar tactics can work in relation to contemporary concerns with environmental vulnerability, with a focus on two other, small island states. Before that, the semiotics of ‘the small state’ need to be explored, since they are suggestive of the perceptions and expectations that are harboured by decision makers at home and abroad and which tend towards the self-fulfilling prophecy.peer-reviewe

Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas

Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these occurred at a different frequency compared to healthy individuals. Therefore, SNPs in these genes are not associated with the apoptotic defect and autoimmune phenomena in AILT