Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA – first small animal PET results

PURPOSE: This study was performed to compare the 2-nitroimidazole derivatives [124I]IAZA, [18F]FAZA and well known [18F]FMISO in visualization of tumor hypoxia in a mouse model of human cancer using small animal PET. METHODS: PET imaging of female Balb/c nude mice bearing A431 tumors on a Phillips Mosaic small animal PET scanner was performed 3 h p.i. for all three tracers. Mice injected with [124I]IAZA were scanned again after 24 h and 48 h. In addition to the mice breathing air, in the case of [18F]FAZA and [124I]IAZA a second group of mice for each tracer was kept in an atmosphere of carbogen gas (5% of CO2 + 95 % of O2; from 1 h before to 3 h after injection) to evaluate the oxygenation dependency on uptake (all experiments n = 4). After the final PET scan animals were sacrificed and biodistribution was studied. RESULTS: Mice injected with [18F]FAZA displayed significantly higher tumor-to background (T/B) ratios (5.19 +/- 0.73) compared to those injected with [18F]FMISO (3.98 +/- 0.66; P $lt; 0.05) or [124I]IAZA (2.06 +/- 0.26; P$lt; 0.001) 3 h p.i. Carbogen breathing mice showed lower ratios ([18F]FAZA: 4.06 +/- 0.59; [124I]IAZA: 2.02 +/- 0.36). The T/B ratios increased for [124I]IAZA with time (24 h: 3.83 +/- 0.61; 48 h: 4.20 +/- 0.80), but after these late time points the absolute whole body activity was very low, as could be seen from the biodistribution data (< 0.1 %ID/g for each investigated organ) and ratios were still lower than for [18F]FAZA 3 h p.i. Due to de-iodination uptake in thyroid was high. Biodistribution data were in good agreement with the PET results. CONCLUSIONS: [18F]FAZA showed superior biokinetics compared to [18F]FMISO and [124I]IAZA in this study. Imaging at later time points that are not possible with the short lived 18F labeled tracers resulted in no advantage for [124I]IAZA, i. e. tumor to normal tissue ratios could not be improved. © 1999 Canadian Society for Pharmaceutical Sciences

Building an inclusive cycling "movement": Exploring the charity-led mobilisation of recreational cycling in communities across Merseyside, England.

This article examines the charity-led implementation of an inclusive cycling programme across Merseyside in the North West of England. The project itself is delivered via a network of cycling 'hubs' that the charity has set up and run typically in deprived communities. Using resource mobilisation theory (RMT), the article specifically examines how the Cycling Projects charity mobilises a raft of diverse resources from the financial to the human, and from the cultural to the physical, to drive and sustain its Pedal Away product. To do this, the article utilises qualitative data captured from 15 in-depth semistructured interviews undertaken with stakeholders both internal and external to the charity, as well as focus group data yielded from programme participants (n=32). The findings illustrate how the charity is able to garner and exchange resources from its partners and funders, and the ways in which it mobilises both participants and personnel from within the communities it serves. As an original contribution to the sport management field, this article demonstrates both the value and applicability of RMT as a theoretical framework by which to understand how a non-profit organisation derives the resources it requires in order to deliver a network of community embedded recreational cycling programmes

Resolved SPLASH Chemodynamics in Andromeda's PHAT Stellar Halo and Disk: On the Nature of the Inner Halo Along the Major Axis

Stellar kinematics and metallicity are key to exploring formation scenarios for galactic disks and halos. In this work, we characterized the relationship between kinematics and photometric metallicity along the line-of-sight to M31's disk. We combined optical HST/ACS photometry from the Panchromatic Hubble Andromeda Treasury (PHAT) survey with Keck/DEIMOS spectra from the Spectroscopic and Photometric Landscape of Andromeda's Stellar Halo (SPLASH) survey. The resulting sample of 3536 individual red giant branch stars spans 4-19 projected kpc, making it a useful probe of both the disk and inner halo. We separated these stars into disk and halo populations by modeling the line-of-sight velocity distributions as a function of position across the disk region, where 70.9% stars have a high likelihood of belonging to the disk and 17.1% to the halo. Although stellar halos are typically thought to be metal-poor, the kinematically identified halo contains a significant population of stars (29.4%) with disk-like metallicity ([Fe/H]$_{\rm phot} \sim -0.10$). This metal-rich halo population lags the gaseous disk to a similar extent as the rest of the halo, indicating that it does not correspond to a canonical thick disk. Its properties are inconsistent with those of tidal debris originating from the Giant Stellar Stream merger event. Moreover, the halo is chemically distinct from the phase-mixed component previously identified along the minor axis (i.e., away from the disk), implying contributions from different formation channels. These metal-rich halo stars provide direct chemodynamical evidence in favor of the previously suggested "kicked-up'' disk population in M31's inner stellar halo.Comment: Submitted to AJ. Conclusions on page 20. 18 figures, 2 tables, 4 appendice

Twenty years of geomagnetic field observations at Mario Zucchelli Station (Antarctica)

During the 1986-87 austral summer a geomagnetic observatory was installed at Terra Nova Bay. During the first years both geomagnetic field time variation monitoring and absolute measurements were carried out only during summer. Since 1991 variometer measurements are automatically performed during the whole year, while absolute measurements are still performed only during summer. In spite of this, interesting observations were obtained during the life (quite long for Antarctica) of the geomagnetic observatory. In particular in this paper some of the most relevant results are briefly presented: studies about secular variation, daily variation (and its dependence from solar cycle and seasons) and geomagnetic higher frequency variations, such as geomagnetic pulsations

Reliability and tolerance comparison in water supply networks

The final publication is available at Springer via http://dx.doi.org/10.1007/s11269-010-9753-2Urban water supply is a high priority service and so looped networks are extensively used in order to considerably reduce the number of consumers affected by a failure. Looped networks may be redundant in connectivity and capacity. The concept of reliability has been introduced in an attempt to quantitatively measure the possibility of maintaining an adequate service for a given period. Numerous researchers have considered reliability as a measure of redundancy. This concept is usually implicit, but some researchers have even stated it explicitly. This paper shows why reliability cannot be considered a measure of redundancy given that branched networks can achieve high values of reliability and this would deny the fact that a looped network is more reliable than a branched network with a similar layout and size. To this end the paper discusses two quantitative indices for measuring expected network behavior: reliability and tolerance. These indices are calculated and a comparison is made between looped, branched, and mixed networks. © 2011 Springer Science+Business Media B.V.The authors wish to acknowledge the support received from project IDAWAS, DPI2009-11591, of the Directorate-General of Research at the Spanish Ministry of Education, the grant PAID-02-09 for a stay at the Universidad Politecnica de Valencia by the first author, and a grant MAEC-AECI 0000202066 awarded to the second author by the Ministerio de Asuntos Exteriores y Cooperacion of Spain. The use of English in this paper was revised by John Rawlins; and the revision was funded by the Universidad Politecnica de Valencia, Spain.Martínez-Rodríguez, JB.; Montalvo Arango, I.; Izquierdo Sebastián, J.; Pérez García, R. (2011). Reliability and tolerance comparison in water supply networks. 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