Pansharpening techniques to detect mass monument damaging in Iraq

The recent mass destructions of monuments in Iraq cannot be monitored with the terrestrial survey methodologies, for obvious reasons of safety. For the same reasons, it’s not advisable the use of classical aerial photogrammetry, so it was obvious to think to the use of multispectral Very High Resolution (VHR) satellite imagery. Nowadays VHR satellite images resolutions are very near airborne photogrammetrical images and usually they are acquired in multispectral mode. The combination of the various bands of the images is called pan-sharpening and it can be carried on using different algorithms and strategies. The correct pansharpening methodology, for a specific image, must be chosen considering the specific multispectral characteristics of the satellite used and the particular application. In this paper a first definition of guidelines for the use of VHR multispectral imagery to detect monument destruction in unsafe area, is reported. The proposed methodology, agreed with UNESCO and soon to be used in Libya for the coastal area, has produced a first report delivered to the Iraqi authorities. Some of the most evident examples are reported to show the possible capabilities of identification of damages using VHR images

Disuguaglianze variazionali: una presentazione a carattere elementare

The theory of Monotone Operators can be developped in various ways, but almost any presentation requires the use of some “fine” results of Functional Analysis (like the Brower’s fixed point Theorem, or the Ky Fan’s Lemma). We want to give here a treatment requiring only the Weierstrass Theorem and the characterization of compacts sets through the “finite intersection” property

Multiple primary malignancies of the liver and the colon: a complex diagnostic and decisional process with a final unanswered question

We herein present the case of a 78-year-old man with an incidental finding of a solid hepatic mass without symptoms and only a laparotomic cholecystectomy for acute cholecystitis in the past surgical history. A colonoscopy, a magnetic resonance imaging scan, a positron emission tomography scan, and a computed tomography scan completed the preoperative workup: a neoplastic lesion 4.3 × 3 cm in size was diagnosed at segments IV and V, associated with a neoplastic involvement of the splenic flexure without signs of colonic occlusion. After colonic resection, a frozen section on a granulomatous-like tissue at gastric border suggested a diagnosis of an adenocarcinoma of bilio-pancreatic type, changing the surgical strategy to include gastric resection and hepatic pedicle node dissection. The discussion turns around the idea that a final diagnosis of colon cancer with regional nodal involvement (pT3N1) and metastatic gallbladder cancer with multiple peritoneal seedings cannot be excluded

Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy

Introduction: Exploration in the field of epigenetics has revealed the diverse roles of the protein arginine methyltransferase (PRMT) family of proteins in multiple disease states. These findings have led to the development of specific inhibitors and discovery of several new classes of drugs with potential to treat both benign and malignant conditions. Areas covered: We provide an overview on the role of PRMT enzymes in healthy and malignant cells, highlighting the role of arginine methylation in specific pathways relevant to cancer pathogenesis. Additionally, we describe structure and catalytic activity of PRMT and discuss the mechanisms of action of novel small molecule inhibitors of specific members of the arginine methyltransferase family. Expert opinion: As the field of PRMT biology advances, it’s becoming clear that this class of enzymes is highly relevant to maintaining normal physiologic processes as well and disease pathogenesis. We discuss the potential impact of PRMT inhibitors as a broad class of drugs, including the pleiotropic effects, off target effects the need for more detailed PRMT-centric interactomes, and finally, the potential for targeting this class of enzymes in clinical development of experimental therapeutics for cancer. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.The study was funded by the Qatar National Research Fund (QNRF) through the National Priorities Research Program (NPRP) grant [NPRP8-617-3-131].Scopu

GEOMATIC METHODOLOGIES FOR THE STUDY OF TEATRO MASSIMO IN PALERMO (ITALY)

This work illustrates the use of geomatics techniques for the documentation of Teatro Massimo in Palermo (Italy), one of the most important and big in Italy and in Europe. The theatre is characterized by a very complex structure and is realized also using innovative solution, studied at the time of the project specifically for this building; for example, an original system was realized for a natural air-conditioning system of the auditorium. Due to his complexity, the documentation of the Teatro Massimo requires studying specific survey solutions for the different parts of the building. In this paper, some studies on two of the most representative parts of the building were described. In particular, a 3D survey of the auditorium was carried out to obtain a first 3D model of the most important internal part; a very accurate monitoring of structure inside the dome of the theatre was also carried out. The survey of the auditorium was realized by a Terrestrial Laser Scanning (TLS), that has allowed the creation of a digital archive of point clouds, showing, however, the some level of criticality due to the complex shapes of building and of architectural details. The work has highlighted that specific strategy to optimize the number of acquisitions needed for the complete documentation of the auditorium. The monitoring of the structure inside the dome was carried out by topographic and photogrammetric techniques. The monitoring was aimed at measuring the displacements of the support devices connecting the iron structure of the dome. The monitoring has allowed to understand and to test the proper functionality of this complex system. Some tests were carried out also by a thermal camera to correlate the displacements of the support devices with the dilatations produced by steel thermal gradients