Head\u27em off at the Impasse: A Victory for Management in the War to Implement Its Last Best Offer - Mountain Valley Educational Ass\u27n v. Maine SAD No. 43

The impasse doctrine in collective bargaining allows limited unilateral action by an employer when a good-faith deadlock in negotiations is reached between the employer and employees\u27 representatives. This doctrine is a judicial invention used to reconcile the dual mandate of the National Labor Relations Act: to enforce the duty of good-faith bargaining while not compelling parties to accept agreements or make concessions. Traditionally, the impasse doctrine has been viewed as a tool to promote an ongoing bargaining process; more recently, it has been viewed as a terminal point in the negotiation process. By broadening the definition of impasse, courts ascribing to the recent revision of the impasse doctrine have moved impasse away from its historical role in an ongoing bargaining system. This liberalization of the impasse doctrine has increased managerial discretion in the bargaining process by permitting an employer to safely resort to unilateral action in a wider variety of situations

Controlling ultracold atoms in multi-band optical lattices for simulation of Kondo physics

We show that ultracold atoms can be controlled in multi-band optical lattices through spatially periodic Raman pulses for investigation of a class of strongly correlated physics related to the Kondo problem. The underlying dynamics of this system is described by a spin-dependent fermionic or bosonic Kondo-Hubbard lattice model even if we have only spin-independent atomic collision interaction. We solve the bosonic Kondo-Hubbard lattice model through a mean-field approximation, and the result shows a clear phase transition from the ferromagnetic superfluid to the Kondo-signet insulator at the integer filling.Comment: 4 pages, 2 figure

Validity of a multidimensional comprehensive psychosocial screening instrument based on the ESC cardiovascular prevention guidelines:Evidence from the general and cardiovascular patient population

Aim To evaluate the psychometric properties and validity of the updated version of the Dutch multidimensional Comprehensive Psychosocial Screening Instrument in patients with coronary heart disease and the general population, based upon guideline recommendations from the European Society for Cardiology. Method 678 participants (Mage = 48.2, SD = 16.8; 46% male) of the Dutch general population and 312 cardiac patients (Mage = 65.9, SD = 9.9; 77% male) who recently received percutaneous coronary intervention completed the Comprehensive Psychosocial Screening Instrument and validated questionnaires for depression (PHQ-9), anxiety (GAD-7), Type D personality (DS14), hostility (CMHS), anger (STAS-T), trauma (SRIP), and chronic work and family stress (ERI, MMQ-6). Results Confirmatory factor analysis (CFA) confirmed that the eight screened risk factors were best measured as separate entities, rather than broader indications of distress. Inter-instrument agreement, assessed with the intraclass coefficient (ICC) and the screening accuracy indicators (receiving operator characteristic [ROC] curves, sensitivity, specificity, and the positive and negative predictive values [PPV; NPV]) were good for most screened risk factors. PPV was low in low prevalence risk factors like anxiety, trauma, and depression. Conclusion Overall, the current version of the Comprehensive Psychosocial Screening Instrument has an acceptable performance in both populations, with a fair to excellent level of agreement with established full questionnaires. Besides a few suggestions for further refinement, the screener may be implemented in primary care and cardiological practice

Mixtures of Bosonic and Fermionic Atoms in Optical Lattices

We discuss the theory of mixtures of Bosonic and Fermionic atoms in periodic potentials at zero temperature. We derive a general Bose--Fermi Hubbard Hamiltonian in a one--dimensional optical lattice with a superimposed harmonic trapping potential. We study the conditions for linear stability of the mixture and derive a mean field criterion for the onset of a Bosonic superfluid transition. We investigate the ground state properties of the mixture in the Gutzwiller formulation of mean field theory, and present numerical studies of finite systems. The Bosonic and Fermionic density distributions and the onset of quantum phase transitions to demixing and to a Bosonic Mott--insulator are studied as a function of the lattice potential strength. The existence is predicted of a disordered phase for mixtures loaded in very deep lattices. Such a disordered phase possessing many degenerate or quasi--degenerate ground states is related to a breaking of the mirror symmetry in the lattice.Comment: 11 pages, 8 figures; added discussions; conclusions and references expande

Senior management model applied to micro, small and medium business

Siendo Colombia un país cuya economía se soporta en empresas de pequeña escala, donde las MIPYMES en conjunto representando el 90%, sector que genera el 73% de empleos y el 53% de la producción bruta en los diferentes sectores industriales, comerciales y de los servicios. No obstante de la importancia de este sector en la economía, muchas de ellas enfrentan una problemática que interrumpen su crecimiento y desarrollo. Este trabajo de investigación tiene como finalidad estructurar un modelo gerencial, el cual recoge aspectos importantes y valiosos a tener en cuenta por los dueños, gerentes y administradores; producto de identificar las debilidades que han impedido su crecimiento y desarrollo de manera efectiva en el campo empresarial moderno. Por lo anterior se analizó como debilidades más sentidas el desconocimiento y aplicación de teorías actuales en materia gerencial, que pueden actuar en miras de un mayor crecimiento y diversificación de sus ofertas de bienes y servicios, en este caso en el campo de los cosméticos; Soportado en los conocimientos adquiridos durante la Especialización en Alta Gerencia, se define desde un punto de vista particular pero responsable, los temas que deberían ser revisados por este tipo de empresas, para lograr la mejor comprensión y aplicación de temas tan importantes como Pensamiento Complejo, Análisis y Estudios de Competencias, Planeamiento Estratégico y Financiero, Gerencia de Mercado y Talento Humano.Colombia is a country whose economy is supported in small scale enterprises, where MIPYMES altogether representing 90%, sector that generates 73% of jobs and 53% of gross in the various sectors of industrial, commercial production and services. But the importance of this sector in the economy, many of them face problems that disrupt their growth and development. This research paper aims to structure a management model, which collects valuable and important aspects to be considered by owners and managers; product identify the weaknesses that have prevented its growth and development effectively in the modern business field. Therefore analyzed as most pressing weaknesses lack of knowledge and application of current theories in the management field, which may act in view of further growth and diversification of its offers of goods and services, in this case in the field of cosmetics; Supported the knowledge gained during the specialization in senior management, defined from a point of view responsible, but particular issues that should be reviewed by this kind of companies, to achieve better understanding and application of such important topics as complex thought, analysis and studies of competencies, strategic planning and financial, market and human resource managemen

LCAA, a Novel Factor Required for Magnesium Protoporphyrin Monomethylester Cyclase Accumulation and Feedback Control of Aminolevulinic Acid Biosynthesis in Tobacco

Low Chlorophyll Accumulation A (LCAA) antisense plants were obtained from a screen for genes whose partial down-regulation results in a strong chlorophyll deficiency in tobacco (Nicotiana tabacum). The LCAA mutants are affected in a plastid-localized protein of unknown function, which is conserved in cyanobacteria and all photosynthetic eukaryotes. They suffer from drastically reduced light-harvesting complex (LHC) contents, while the accumulation of all other photosynthetic complexes per leaf area is less affected. As the disturbed accumulation of LHC proteins could be either attributable to a defect in LHC biogenesis itself or to a bottleneck in chlorophyll biosynthesis, chlorophyll synthesis rates and chlorophyll synthesis intermediates were measured. LCAA antisense plants accumulate magnesium (Mg) protoporphyrin monomethylester and contain reduced protochlorophyllide levels and a reduced content of CHL27, a subunit of the Mg protoporphyrin monomethylester cyclase. Bimolecular fluorescence complementation assays confirm a direct interaction between LCAA and CHL27. 5-Aminolevulinic acid synthesis rates are increased and correlate with an increased content of glutamyl-transfer RNA reductase. We suggest that LCAA encodes an additional subunit of the Mg protoporphyrin monomethylester cyclase, is required for the stability of CHL27, and contributes to feedback-control of 5-aminolevulinic acid biosynthesis, the rate-limiting step of chlorophyll biosynthesis

Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness.

Toxoplasma gondii is an obligate, intracellular apicomplexan protozoan parasite of both humans and animals that can cause fetal damage and abortion and severe disease in the immunosuppressed. Sphingolipids have indispensable functions as signaling molecules and are essential and ubiquitous components of eukaryotic membranes that are both synthesized and scavenged by the Apicomplexa. Ceramide is the precursor for all sphingolipids, and here we report the identification, localization and analyses of the Toxoplasma ceramide synthases TgCerS1 and TgCerS2. Interestingly, we observed that while TgCerS1 was a fully functional orthologue of the yeast ceramide synthase (Lag1p) capable of catalyzing the conversion of sphinganine to ceramide, in contrast TgCerS2 was catalytically inactive. Furthermore, genomic deletion of TgCerS1 using CRISPR/Cas-9 led to viable but slow-growing parasites indicating its importance but not indispensability. In contrast, genomic knock out of TgCerS2 was only accessible utilizing the rapamycin-inducible Cre recombinase system. Surprisingly, the results demonstrated that this "pseudo" ceramide synthase, TgCerS2, has a considerably greater role in parasite fitness than its catalytically active orthologue (TgCerS1). Phylogenetic analyses indicated that, as in humans and plants, the ceramide synthase isoforms found in Toxoplasma and other Apicomplexa may have arisen through gene duplication. However, in the Apicomplexa the duplicated copy is hypothesized to have subsequently evolved into a non-functional "pseudo" ceramide synthase. This arrangement is unique to the Apicomplexa and further illustrates the unusual biology that characterize these protozoan parasites. [Abstract copyright: © 2023 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.

Perceived Stress Levels in Adult Patients With Uveitis

Background: The aim of this study was to examine perceived stress levels in adult patients with uveitis. Patients and Methods: One hundred seventy-three adult consecutive uveitis patients (age range 18 to 85 years) were analyzed in a cross-sectional design for their perceived stress, according to the Perceived Stress Questionnaire (PSQ). Stress levels were classified into normal stress, moderate stress, and high stress. Results: In the majority of uveitis patients a normal stress level (82%) within the last 2 years was detected. In a subgroup analysis, perceived stress of the patients with active uveitis compared with patients with non-active uveitis was significantly higher within the last 2 years (n=80 active/n = 45 non-active; p = 0.005). Conclusions: Overall 18% of the uveitis patient had raised perceived stress, similar to the general population but patients with active uveitis were significantly more stressed. Therefore, consideration of stress levels may be important in the therapy of uveitis patients

Repetitive head injuries in German American football players do not change blood-based biomarker candidates for CTE during a single season

Background: Repetitive traumatic brain injuries in American football players (AFPs) can lead to the neurodegenerative disease chronic traumatic encephalopathy (CTE). Clinical symptoms of CTE range from mood and behavioral changes to cognitive impairment, depression, and suicidality. So far, CTE cannot be diagnosed in vivo and thus specific diagnostic parameters for CTE need to be found, to observe and treat exposed athletes as early as possible. Promising blood-based biomarkers for CTE include total tau (tTau), hyperphosphorylated tau (pTau), neurofilament light protein (NF-L), glial fibrillary acidic protein (GFAP), amyloid-β40 (Aβ40), amyloid-β42 (Aβ42) and calcium-binding protein B (S100-B). Previous studies have found elevated levels of these biomarkers in subjects exposed to TBIs, whereas cerebrospinal fluid (CSF) levels of Aβ40 and Aβ42 were decreased in CTE subjects. Here, we investigated whether young AFPs already exhibit changes of these biomarker candidates during the course of a single active season. Methods: Blood samples were drawn from n = 18 American Football Players before and after a full season and n = 18 male age-matched control subjects. The plasma titers of tTau, pTau, NF-L, GFAP, Aβ40, Aβ42 and S100-B were determined. Additionally, Apathy, Depression, and Health status as well as the concussion history and medical care were assessed and analyzed for correlations. Results: Here we show, that the selected biomarker candidates for CTE do not change significantly during the seven-month period of a single active season of American Football in blood samples of AFPs compared to healthy controls. But interestingly, they exhibit generally elevated pTau titers. Furthermore, we found correlations of depression, quality-of-life, career length, training participation and training continuation with headache after concussion with various titers. Conclusion: Our data indicates, that changes of CTE marker candidates either occur slowly over several active seasons of American Football or are exclusively found in CSF. Nevertheless, our results underline the importance of a long-term assessment of these biomarker candidates, which might be possible through repeated blood biomarker monitoring in exposed athletes in the future