7,917 research outputs found
Predictors of disease-free and overall survival in retroperitoneal sarcomas: A modern 16-year multi-institutional study from the United States Sarcoma Collaboration (USSC)
Bell's Theorem from Moore's Theorem
It is shown that the restrictions of what can be inferred from
classically-recorded observational outcomes that are imposed by the no-cloning
theorem, the Kochen-Specker theorem and Bell's theorem also follow from
restrictions on inferences from observations formulated within classical
automata theory. Similarities between the assumptions underlying classical
automata theory and those underlying universally-unitary quantum theory are
discussed.Comment: 12 pages; to appear in Int. J. General System
Apollo telescope mount: A partial listing of scientific publications and presentations, supplement 3
Compilations of bibliographies from the principal investigator groups of the Skylab solar observatory facility that gathered data from May 28, 1973, to February 8, 1974 are presented. The analysis of these data is presently under way. The publications listed are divided into the following categories: (1) journal publications; (2) journal publications submitted; (3) other publications; (4) presentations-national and international meetings; and (5) other presentations
Analytical Models for the Energetics of Cosmic Accretion Shocks, their Cosmological Evolution, and the Effect of Environment
We present an analytical description of the energetics of the population of
cosmic accretion shocks, for a concordance cosmology. We calculate how the
shock-processed accretion power and mass current are distributed among
different shock Mach numbers, and how they evolve with cosmic time. We
calculate the cumulative energy input of cosmic accretion shocks of any Mach
number to the intergalactic medium as a function of redshift, and we compare it
with the energy output of supernova explosions as well as with the energy input
required to reionize the universe. In addition, we investigate and quantify the
effect of environmental factors, such as local clustering properties and
filament preheating on the statistical properties of these shocks. We find that
the energy processed by accretion shocks is higher than the supernova energy
output for z<3 and that it becomes more than an order of magnitude higher in
the local universe. The energy processed by accretion shocks alone becomes
comparable to the energy required to reionize the universe by z~3.5. Finally,
we establish both qualitative and quantitatively that both local clustering as
well as filament compression and preheating are important factors in
determining the statistical properties of the cosmic accretion shock
population.Comment: 13 pages, 5 figures, emulateap
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Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition.
Poor solute transport through the cartilage endplate (CEP) impairs disc nutrition and could be a key factor that limits the success of intradiscal biologic therapies. Here we demonstrate that treating the CEP with matrix metalloproteinase-8 (MMP-8) reduces the matrix constituents that impede solute uptake and thereby improves nutrient diffusion. Human CEP tissues harvested from four fresh cadaveric lumbar spines (age range: 38-66 years old) were treated with MMP-8. Treatment caused a dose-dependent reduction in sGAG, localized reductions to the amount of collagen, and alterations to collagen structure. These matrix modifications corresponded with 16-24% increases in the uptake of a small solute (376 Da). Interestingly, the effects of MMP-8 treatment depended on the extent of non-enzymatic glycation: treated CEPs with high concentrations of advanced glycation end products (AGEs) exhibited the lowest uptake compared to treated CEPs with low concentrations of AGEs. Moreover, AGE concentrations were donor-specific, and the donor tissues with the highest AGE concentrations appeared to have lower uptake than would be expected based on the initial amounts of collagen and sGAG. Finally, increasing solute uptake in the CEP improved cell viability inside diffusion chambers, which supports the nutritional relevance of enhancing the transport properties of the CEP. Taken together, our results provide new insights and in vitro proof-of-concept for a treatment approach that could improve disc nutrition for biologic therapy: specifically, matrix reduction by MMP-8 can enhance solute uptake and nutrient diffusion through the CEP, and AGE concentration appears to be an important, patient-specific factor that influences the efficacy of this approach
Two Archeological Surveys In The Texas Department Of Transportations Atlanta District: FM 450 At Little Cypress Bayou, Harrison County (CSJ 0843-02-012), And County Road 4114 At Brutons Creek, Morris County (CSJ 0919-20-030)
Prewitt and Associates, Inc., was contracted by the Texas Department of Transportation (TxDOT) to perform two intensive archeological surveys in TxDOTâs Atlanta District under Texas Antiquities Permit No. 6385. This work was completed prior to replacement of a bridge and realignment of approaches on Farm-to-Market Road (FM) 450 at Little Cypress Bayou in Harrison County (CSJ 0843-02-012) and replacement of a bridge and improvement of approaches on County Road 4114 at Brutons Creek in Morris County (CSJ 0919-20-030). The Area of Potential Effects (APE) for the FM 450 project is 50 acres and includes existing and new TxDOT right of way; approximately half of the APE was surveyed in 2010 (McKee 2010). The APE for the County Road 4114 project is 1.2 acres and includes a short segment of existing right of way and 0.9 acres of temporary construction easements. Prewitt and Associates archeologists surveyed the remaining 25 acres of the FM 450 APE and the County Road 4114 APE in December 2012 and January 2013. These investigations required a total of about 11 person-days of effort.
The FM 450 survey included the excavation of 50 shovel tests and 11 trenches. This effort identified a small amount of modern trash on the upland margin at the north end of the project area and prehistoric site 41HS973 on the floodplain near Little Cypress Bayou. Site 41HS973 consists of a diffuse scatter of seven pieces of lithic debitage identified on two sandy rises on the Little Cypress Bayou floodplain. The investigation indicated that the archeological deposits in the investigated part of the site lack both integrity and significance. Thus, Prewitt and Associates recommends that the recorded portion of 41HS973 is not eligible for listing in the National Register of Historic Places under Criterion D (36 CFR 60.4; 36 CFR 800.4, 5) or designation as a State Archeological Landmark (13 TAC 26.2, 8).
The County Road 4114 survey included the excavation of 15 shovel tests and 4 trenches in and adjacent to the temporary construction easements. No archeological materials or deposits were identified during this investigation.
Both surveys were conducted under no artifact collection policies. Identified artifacts were noted, briefly described, and returned to the point of recovery
Detection of solvents using a distributed fibre optic sensor
A fibre optic sensor that is capable of distributed detection of liquid solvents is presented. Sensor interrogation using optical time domain reflectometry (OTDR) provides the capability of locating solvent spills to a precision of ±2 m over a total sensor length that may extend to 20 km
Unresolved Unidentified Source Contribution to the Gamma-ray Background
The large majority of EGRET point sources remain without an identified
low-energy counterpart, and a large fraction of these sources are most likely
extragalactic. Whatever the nature of the extragalactic EGRET unidentified
sources, faint unresolved objects of the same class must have a contribution to
the diffuse extragalactic gamma-ray background (EGRB). Understanding this
component of the EGRB, along with other guaranteed contributions from known
sources, is essential if we are to use this emission to constrain exotic
high-energy physics. Here, we follow an empirical approach to estimate whether
a potential contribution of unidentified sources to the EGRB is likely to be
important, and we find that it is. Additionally, we show how upcoming GLAST
observations of EGRET unidentified sources, as well as of their fainter
counterparts, can be combined with GLAST observations of the Galactic and
extragalactic diffuse backgrounds to shed light on the nature of the EGRET
unidentified sources even without any positional association of such sources
with low-energy counterparts.Comment: 11 pages, 5 figures, submitted to Ap
Metastable Charged Sparticles and the Cosmological Li7 Problem
We consider the effects of metastable charged sparticles on Big-Bang
Nucleosynthesis (BBN), including bound-state reaction rates and chemical
effects. We make a new analysis of the bound states of negatively-charged
massive particles with the light nuclei most prominent in BBN, and present a
new code to track their abundances, paying particular attention to that of Li7.
Assuming, as an example, that the gravitino is the lightest supersymmetric
particle (LSP), and that the lighter stau slepton, stau_1, is the metastable
next-to-lightest sparticle within the constrained minimal supersymmetric
extension of the Standard Model (CMSSM), we analyze the possible effects on the
standard BBN abundances of stau_1 bound states and decays for representative
values of the gravitino mass. Taking into account the constraint on the CMSSM
parameter space imposed by the discovery of the Higgs boson at the LHC, we
delineate regions in which the fit to the measured light-element abundances is
as good as in standard BBN. We also identify regions of the CMSSM parameter
space in which the bound state properties, chemistry and decays of metastable
charged sparticles can solve the cosmological Li7 problem.Comment: 49 pages, 29 eps figure
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