18,660 research outputs found
Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice
<p>Background: Dietary restriction (DR) extends lifespan and induces beneficial metabolic effects in many animals. What is far less clear is whether animals retain a metabolic memory to previous DR exposure, that is, can early-life DR preserve beneficial metabolic effects later in life even after the resumption of ad libitum (AL) feeding. We examined a range of metabolic parameters (body mass, body composition (lean and fat mass), glucose tolerance, fed blood glucose, fasting plasma insulin and insulin-like growth factor 1 (IGF-1), insulin sensitivity) in male C57BL/6 mice dietary switched from DR to AL (DR-AL) at 11 months of age (mid life). The converse switch (AL-DR) was also undertaken at this time. We then compared metabolic parameters of the switched mice to one another and to age-matched mice maintained exclusively on an AL or DR diet from early life (3 months of age) at 1 month, 6 months or 10 months post switch.</p>
<p>Results: Male mice dietary switched from AL-DR in mid life adopted the metabolic phenotype of mice exposed to DR from early life, so by the 10-month timepoint the AL-DR mice overlapped significantly with the DR mice in terms of their metabolic phenotype. Those animals switched from DR-AL in mid life showed clear evidence of a glycemic memory, with significantly improved glucose tolerance relative to mice maintained exclusively on AL feeding from early life. This difference in glucose tolerance was still apparent 10 months after the dietary switch, despite body mass, fasting insulin levels and insulin sensitivity all being similar to AL mice at this time.</p>
<p>Conclusions: Male C57BL/6 mice retain a long-term glycemic memory of early-life DR, in that glucose tolerance is enhanced in mice switched from DR-AL in mid life, relative to AL mice, even 10 months following the dietary switch. These data therefore indicate that the phenotypic benefits of DR are not completely dissipated following a return to AL feeding. The challenge now is to understand the molecular mechanisms underlying these effects, the time course of these effects and whether similar interventions can confer comparable benefits in humans.</p>
Co-firing of biomass with coals Part 1. Thermogravimetric kinetic analysis of combustion of fir (abies bornmulleriana) wood
The chemical composition and reactivity of fir (Abies bornmulleriana) wood under non-isothermal thermogravimetric (TG) conditions were studied. Oxidation of the wood sample at temperatures near 600 A degrees C caused the loss of aliphatics from the structure of the wood and created a char heavily containing C-O functionalities and of highly aromatic character. On-line FTIR recordings of the combustion of wood indicated the oxidation of carbonaceous and hydrogen content of the wood and release of some hydrocarbons due to pyrolysis reactions that occurred during combustion of the wood. TG analysis was used to study combustion of fir wood. Non-isothermal TG data were used to evaluate the kinetics of the combustion of this carbonaceous material. The article reports application of Ozawa-Flynn-Wall model to deal with non-isothermal TG data for the evaluation of the activation energy corresponding to the combustion of the fir wood. The average activation energy related to fir wood combustion was 128.9 kJ/mol, and the average reaction order for the combustion of wood was calculated as 0.30
Ocean temperature and salinity components of the Madden-Julian oscillation observed by Argo floats
New diagnostics of the Madden-Julian Oscillation (MJO) cycle in ocean temperature and, for the first time, salinity are presented. The MJO composites are based on 4 years of gridded Argo float data from 2003 to 2006, and extend from the surface to 1,400 m depth in the tropical Indian and Pacific Oceans. The MJO surface salinity anomalies are consistent with precipitation minus evaporation fluxes in the Indian Ocean, and with anomalous zonal advection in the Pacific. The Argo sea surface temperature and thermocline depth anomalies are consistent with previous studies using other data sets. The near-surface density changes due to salinity are comparable to, and partially offset, those due to temperature, emphasising the importance of including salinity as well as temperature changes in mixed-layer modelling of tropical intraseasonal processes. The MJO-forced equatorial Kelvin wave that propagates along the thermocline in the Pacific extends down into the deep ocean, to at least 1,400 m. Coherent, statistically significant, MJO temperature and salinity anomalies are also present in the deep Indian Ocean
Heavy-to-light baryonic form factors at large recoil
We analyze heavy-to-light baryonic form factors at large recoil and derive
the scaling behavior of these form factors in the heavy quark limit. It is
shown that only one universal form factor is needed to parameterize Lambda_b to
p and Lambda_b to Lambda matrix elements in the large recoil limit of light
baryons, while hadronic matrix elements of Lambda_b to Sigma transition vanish
in the large energy limit of Sigma baryon due to the space-time parity
symmetry. The scaling law of the soft form factor eta(P^{\prime} \cdot v),
P^{\prime} and v being the momentum of nucleon and the velocity of Lambda_b
baryon, responsible for Lambda_b to p transitions is also derived using the
nucleon distribution amplitudes in leading conformal spin. In particular, we
verify that this scaling behavior is in full agreement with that from
light-cone sum rule approach in the heavy-quark limit. With these form factors,
we further investigate the Lambda baryon polarization asymmetry alpha in
Lambda_b to Lambda gamma and the forward-backward asymmetry A_{FB} in Lambda_b
to Lambda l^{+} l^{-}. Both two observables (alpha and A_{FB}) are independent
of hadronic form factors in leading power of 1/m_b and in leading order of
alpha_s. We also extend the analysis of hadronic matrix elements for Omega_b to
Omega transitions to rare Omega_b to Omega gamma and Omega_b to Omega l^{+}
l^{-} decays and find that radiative Omega_b to Omega gamma decay is probably
the most promising FCNC b to s radiative baryonic decay channel. In addition,
it is interesting to notice that the zero-point of forward-backward asymmetry
of Omega_b to Omega l^{+} l^{-} is the same as the one for Lambda_b to Lambda
l^{+} l^{-} to leading order accuracy provided that the form factors
\bar{\zeta}_i (i=3, 4, 5) are numerically as small as indicated from the quark
model.Comment: 19 page
Magnetothermodynamics of BPS baby skyrmions
The magnetothermodynamics of skyrmion type matter described by the gauged BPS
baby Skyrme model at zero temperature is investigated. We prove that the BPS
property of the model is preserved also for boundary conditions corresponding
to an asymptotically constant magnetic field. The BPS bound and the
corresponding BPS equations saturating the bound are found. Further, we show
that one may introduce pressure in the gauged model by a redefinition of the
superpotential. Interestingly, this is related to non-extremal type solutions
in the so-called fake supersymmetry method. Finally, we compute the equation of
state of magnetized BSP baby skyrmions inserted into an external constant
magnetic field and under external pressure , i.e., , where
is the "volume" (area) occupied by the skyrmions. We show that the BPS baby
skyrmions form a ferromagnetic medium.Comment: Latex, 39 pages, 14 figures. v2: New results and references added,
physical interpretation partly change
Prenatal Vitamin D Supplementation and Child Respiratory Health: A Randomised Controlled Trial
PMCID: PMC3691177This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Transfer Functions for Protein Signal Transduction: Application to a Model of Striatal Neural Plasticity
We present a novel formulation for biochemical reaction networks in the
context of signal transduction. The model consists of input-output transfer
functions, which are derived from differential equations, using stable
equilibria. We select a set of 'source' species, which receive input signals.
Signals are transmitted to all other species in the system (the 'target'
species) with a specific delay and transmission strength. The delay is computed
as the maximal reaction time until a stable equilibrium for the target species
is reached, in the context of all other reactions in the system. The
transmission strength is the concentration change of the target species. The
computed input-output transfer functions can be stored in a matrix, fitted with
parameters, and recalled to build discrete dynamical models. By separating
reaction time and concentration we can greatly simplify the model,
circumventing typical problems of complex dynamical systems. The transfer
function transformation can be applied to mass-action kinetic models of signal
transduction. The paper shows that this approach yields significant insight,
while remaining an executable dynamical model for signal transduction. In
particular we can deconstruct the complex system into local transfer functions
between individual species. As an example, we examine modularity and signal
integration using a published model of striatal neural plasticity. The modules
that emerge correspond to a known biological distinction between
calcium-dependent and cAMP-dependent pathways. We also found that overall
interconnectedness depends on the magnitude of input, with high connectivity at
low input and less connectivity at moderate to high input. This general result,
which directly follows from the properties of individual transfer functions,
contradicts notions of ubiquitous complexity by showing input-dependent signal
transmission inactivation.Comment: 13 pages, 5 tables, 15 figure
Evolutionary relationships among barley and <i>Arabidopsis</i> core circadian clock and clock-associated genes
The circadian clock regulates a multitude of plant developmental and metabolic processes. In crop species, it contributes significantly to plant performance and productivity and to the adaptation and geographical range over which crops can be grown. To understand the clock in barley and how it relates to the components in the Arabidopsis thaliana clock, we have performed a systematic analysis of core circadian clock and clock-associated genes in barley, Arabidopsis and another eight species including tomato, potato, a range of monocotyledonous species and the moss, Physcomitrella patens. We have identified orthologues and paralogues of Arabidopsis genes which are conserved in all species, monocot/dicot differences, species-specific differences and variation in gene copy number (e.g. gene duplications among the various species). We propose that the common ancestor of barley and Arabidopsis had two-thirds of the key clock components identified in Arabidopsis prior to the separation of the monocot/dicot groups. After this separation, multiple independent gene duplication events took place in both monocot and dicot ancestors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00239-015-9665-0) contains supplementary material, which is available to authorized users
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